Figure 4

Impact of chorionic plate mesenchymal stem cell (cp-MSC) injection on infarct area. (A) Representative example of scar formation 39 days after the first injection in mice treated with cp-MSCs or placebo. Macroscopic infarct area was assessed in each group by Sirius Red staining. Fibrous scar tissue is shown in red, whereas myocardium is stained in yellow. Serial sections of the same heart are shown from apex (i) to base (iii). (B) Infarct area (red-stained tissue) was quantified as a percentage of total area. The graph shows an average of infarct area calculated from the three serial sections. No statistical difference was observed in the scar formation between cp-MSC and placebo groups.