Figure 3
Lung mechanics. (A) Lung static elastance (Est,L), (B) resistive (ΔP1, white bar), viscoelastic (ΔP2, gray bar), and total pressures (ΔPtot = ΔP1 + ΔP2), and (C) airway hyperresponsiveness. Control, mice sensitized and challenged with saline; OVA, mice sensitized and challenged with ovalbumin; SAL, mice sensitized and challenged with ovalbumin and treated with saline; BMMC-Control, mice sensitized and challenged with ovalbumin and treated with bone marrow mononuclear cells (BMMCs) obtained from control donors 24 hours after last challenge (2 × 106 cells/mouse); BMMC-OVA, mice sensitized and challenged with ovalbumin and treated with BMMCs obtained from OVA donors 24 hours after last challenge (2 × 106 cells/mouse). *Significantly different from control (P < 0.05). **Significantly different from OVA-SAL mice (P < 0.05). #Significantly different from BMMC-Control mice (P < 0.05). One-way analysis of variance followed by Tukey’s test. PBS, phosphate-buffered saline.