Figure 4
Morphometric parameters. (A) Fractional area of normal (white bar) and collapsed alveoli (gray bar), (B) mononuclear (MN, white bar) and polymorphonuclear (PMN, gray bar) cells, and (C) bronchoconstriction index. All values were computed in 10 random, noncoincident fields of view per mouse. Control, mice sensitized and challenged with saline; OVA, mice sensitized and challenged with ovalbumin; SAL, mice sensitized and challenged with ovalbumin and treated with saline; BMMC-Control, mice sensitized and challenged with ovalbumin and treated with bone marrow mononuclear cells (BMMCs) obtained from control donors, 24 hours after last challenge (2 × 106 cells/mouse); BMMC-OVA, mice sensitized and challenged with ovalbumin and treated with BMMCs obtained from OVA donors, 24 hours after last challenge (2 × 106 cells/mouse). *Significantly different from control (P < 0.05). **Significantly different from OVA-SAL mice (P < 0.05). #Significantly different from BMMC-Control mice (P < 0.05). One-way analysis of variance followed by Tukey’s test.