Figure 6
From: Immunomodulatory properties of stem cells from human exfoliated deciduous teeth
SHED transplantation reconstructed trabecular bone and inhibited osteoclast activity. (A) SHED transplantation showed the same effect in regenerating trabecular bone as seen in BMMSC transplanted MRL/lpr mice (n = 6) ([[P < 0.01). (B) TRAP staining showed that the number of TRAP positive osteoclasts was significantly reduced in SHED and BMMSC transplanted mice (n = 6, [P < 0.05). (C, D) ELISA revealed that SHED and BMMSC transplantations were capable of significantly reducing the levels (mean ± SD) of soluble RANKL (sRANKL) (C) and C-terminal telopeptides of type I collagen (CTX) (D) in serum of MRL/lpr mice (n = 6)(*P < 0.05, **P < 0.01).