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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes

Figure 1

Schematic diagram illustrating developmental factors that potentially impact the in vitro maturation process from human pluripotent stem cell (hPSC)-derived cardiomyocytes to an adult-like phenotype with highly organized sarcomeres and intercellular junctions. This review focuses on physical developmental cues from electrical stimulation and mechanical loading, and also mentions factors including genetics, supporting cells and substrate, metabolism, and both circulating and membrane bound signaling molecules.

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