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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Human liver stem cells and derived extracellular vesicles improve recovery in a murine model of acute kidney injury

Figure 1

Effects of intravenous injection of HLSCs in AKI mice. (A) and (B) Creatinine and blood urea nitrogen (BUN) values on day 5 after glycerol administration in mice injected with vehicle alone, with HLSCs (0.75 × 105; 3.5 × 105) and in healthy (ctrl) SCID mice. Data are expressed as mean ± SD; ANOVA with Dunnet’s multicomparison test: *P <0.05 HLSC-treated (0.75 × 105; 3.5 × 105) AKI mice versus vehicle-treated AKI mice. (C) Effect of HLSCs injection on renal morphology at day 5 after AKI induction. The number of hyaline casts and tubular necrosis observed under high power (original magnification: ×400) is expressed as mean ± SD. ANOVA with Dunnet’s multicomparison test: *P <0.05 HLSC-treated (0.75 × 105; 3.5 × 105) AKI mice versus vehicle-treated AKI mice. (D) Representative micrographs of renal histology of healthy SCID mice (ctrl) and of AKI mice treated with vehicle alone or with different quantities of HLSCs (0.75 × 105; 3.5 × 105) and sacrificed at day 5. Original magnification: ×200. The typical aspect of hyaline cast formations and tubular necrosis are, respectively, shown by asterisks and head arrows. AKI, acute kidney injury; ANOVA, analysis of variance; HLSCs, human liver stem cells; SD, standard deviation.

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