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Table 2 Lead nitrate-induced changes in sperm characteristics and their response to administration of MSCs/BM in rats after 21, 30 and 60 days of exposure

From: Evaluation of mesenchymal stem cells in treatment of infertility in male rats

Groups

Parameters

Mean control value

LN

LN + MSCs/BM

21 days

30 days

60 days

21 days

30 days

60 days

Sperm count (10 6 /ml)

110.5a ±2.48

52.44d ±1.83

66.5cd ±2.14

82.3bc ±2.35

89.85b ±3.11

97.65b ±2.58

107.93ab ±4.01

Sperm motility (%)

98.73a ±2.33

44.06d ±1.25

50.41c ±1.62

72.5b ±0.48

81.61a ±2.55

90.48a ±1.54

96.86a ±2.43

Abnormal sperm (%)

9.75f ±1.42

63.78a ±3.0

48.55b ±2.31

35.23c ±2.41

20.72d ±1.33

11.25e ±1.80

9.09f ±0.75

Sperm morphology (%)

91.25a ±1.35

36.22d ±0.05

51.45c ±0.07

64.77c ± 0.11

79.28b ±2.33

88.75ab ±2.90

90.91a ±2.00

  1. Values are mean ± S.E. of 10 individuals. Mean values with same superscripts do not differ significantly from each other. P <0.05. LN, lead nitrate; MSCs/BM, bone marrow-derived mesenchymal stem cells; S.E., standard error.