Figure 5From: Human mesenchymal stem cells possess different biological characteristics but do not change their therapeutic potential when cultured in serum free mediumUpregulated and downregulated genes in the cell cycle pathway after expansion in serum-free medium. BUB1, BUB1B, CCNA2, CCNB1, CCNB2, CCNE2, Cdc20, Cdc23, Cdc25A, Cdc25C, Cdc45L, Cdc6, Cdc2, CDK2, CDKN2C, CHEK1, ESPL1, MAD2L1, MCM2, MCM7, MCM3, MCM4, MCM5, MCM7, ORC1L, PLK1, PTTG1, SKP2, SMAD3, TFDP1, TGFB1, TGFB2, WEE1, YWHAH and YWHAZ were downregulated after culture in serum-free medium (SFM). Only Cdc14 was upregulated during expansion in SFM. Red, genes that were upregulated; green, genes that were downregulated. MAPK, mitogen-activated protein kinase; MCM, Mini-Chromosome Maintenance.Back to article page