Leukocyte transmigration into tissue-engineered constructs is influenced by endothelial cells through Toll-like receptor signaling

Table 2 Up- and downregulated genes from microarray gene ontology analysis comparing MSC (control) and MSC/EC (test)

PROBE_ID	Gene symbol	Fold change	FDR[i]	PROBE_ID	Gene symbol	Fold change	FDR[i]
Downregulated				Upregulated
ILMN_1791447	CXCL12/SDF-1	−5.075	0	ILMN_1686109	CCL23	3.983	0.597
ILMN_1699651	IL6	−4.942	0	ILMN_1740609	CCL15	3.701	0.828
ILMN_1676663	TNFRSF11B	−5.002	0	ILMN_2313672	IL1RL1	9.2	0.224
ILMN_2175912	ITGB2	−2.561	0	ILMN_2184373	IL8	9.954	0
ILMN_1685009	ITGAM	−1.001	77.022	ILMN_1775501	IL1B	1.081	65.3
ILMN_1671353	IL12A	−1.534	10.383	ILMN_2242900	IL1RL1	5.534	0.587
ILMN_1671509	CCL3/ MIP-1α	−1.005	73.358	ILMN_1689518	PECAM1	6.288	0
ILMN_1700353	TRAF6	−1.056	36.202	ILMN_1719236	CDH5	12.865	0
ILMN_1772387	TLR2	−1.024	62.406	ILMN_1801584	CXCR4	1.772	0.67
ILMN_1722981	TLR5	−1.112	11.32	ILMN_1731048	TLR1	1.035	55.07
ILMN_1654560	TLR6	−1.004	75.359	ILMN_2155708	TLR3	1.043	15.787
ILMN_1677827	TLR7	−1.038	33.053	ILMN_1706217	TLR4	1.243	13.508
ILMN_1679798	TLR9	−1.046	44.43	ILMN_1682251	TLR8	1.034	63.84
ILMN_2298366	TLR10	−1.045	57.183	ILMN_1724533	LY96/MD-2	1.006	76.228
ILMN_1740015	CD14	−1.292	11.398	ILMN_1738523	MYD88	1.086	15.187
ILMN_1765523	TOLLIP	−1.078	27.851	ILMN_1651346	TICAM2/TRAM	1.027	70.63
ILMN_1776703	TIRAP	−1.044	10.91	ILMN_2379130	IRAK1	1.138	4.854
ILMN_1724863	TICAM1	−1.069	18.947	ILMN_1692352	IRAK4	1.162	9.159

EC, endothelial cell; FDR[i], false discovery rate; MSC, multipotent stromal cell.

ISSN: 1757-6512