Figure 4
From: Microcomputed tomography: approaches and applications in bioengineering
Correlation of local tissue strains with regions of bone formation and resorption by longitudinal in vivo microcomputed tomography (microCT) and finite element (FE) analysis. The sixth caudal vertebra of mice were loaded by pinned compression of the fifth and seventh vertebrae, resulting in a cyclic load of 9Â N. Serial, co-registered microCT scans were analyzed to determine locations of bone formation and resorption (A) and correlated with locations of high/low strain energy density (SED) (B), calculated by FE analysis. Bone formation and resorption were significantly more likely in regions of high and low SED, respectively. Reproduced with permission from PLOS [39].