Figure 1
From: Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment
Hematopoietic stem and progenitor mobilization converges on the CXCR4/SDF-1α signaling axis within the hematopoietic niche. Many of the proposed mechanisms for hematopoietic stem and progenitor mobilization function by altering the marrow microenvironmental CXC4 chemokine receptor (CXCR4)/stromal cell-derived factor 1α (SDF-1α) signaling axis. Shown are representative mobilization mechanisms and their relationship to the CXCR4/SDF-1α axis. Question marks denote hypothetical linkage to the CXCR4/SDF-1α axis. G-CSF, granulocyte colony-stimulating factor; HSC, hematopoietic stem cell; HSPC, hematopoietic stem and progenitor cell; ROS, reactive oxygen species.