Table 1 Systemic characteristics and cardiac function of study groups (n = 7 each) four weeks after PTRA or sham
Parameter | NORMAL | RVH | RVH + PTRA + Vehicle | RVH + PTRA + MSC |
|---|---|---|---|---|
Degree of stenosis (%) | 0 | 78.3 ± 13.3*†| 0 | 0 |
Body weight (Kg) | 48.3 ± 1.0 | 51.3 ± 3.6 | 50.7 ± 3.9 | 54.1 ± 3.7 |
Mean blood pressure (mmHg) | 97.8 ± 9.5 | 137.9 ± 5.5*†| 99.0 ± 9.0 | 96.4 ± 2.6 |
Cholesterol (mg/dl): Total | 92.2 ± 4.8 | 483.7 ± 34.8* | 425.5 ± 14.4* | 407.3 ± 26.8* |
   HDL | 105.3 ± 33.2 | 159.0 ± 15.8 | 155.5 ± 13.1 | 144.6 ± 16.7 |
   LDL | 46.0 ± 11.3 | 341.5 ± 48.2* | 279.2 ± 22.3* | 250.5 ± 23.5* |
Triglycerides (mg/dl) | 7.5 (5–10) | 6 (4–8) | 5.5 (4–17) | 8 (3–9) |
Serum creatinine (mg/dl) | 1.3 ± 0.04 | 1.9 ± 0.1*†| 1.9 ± 0.1*†| 1.4 ± 0.1 |
GFR (ml/min) | 77.9 ± 3.9 | 52.2 ± 2.7*†| 56.9 ± 3.2*†| 72.3 ± 3.1 |
Plasma renin activity (ng/ml/hour) | 0.2 (0.07-0.25) | 0.19 (0.02-0.30) | 0.21 (0.06-0.24) | 0.13 (0.06-0.25) |
Isoprostane (pg/ml) | 109.1 ± 7.3 | 231.6 ± 38.3*†| 212.1 ± 22.6*†| 130.4 ± 11.7 |
Heart rate (bpm) | 72.5 (63–104) | 84.0 (69–123) | 75.3 (70–96) | 78.0 (66–119) |
Stroke volume (ml) | 40.8 ± 2.0 | 44.3 ± 1.7 | 43.0 ± 1.0 | 44.7 ± 3.4 |
Ejection fraction (%) | 63.9 ± 2.4 | 59.7 ± 2.3 | 62.6 ± 2.2 | 65.1 ± 4.7 |
Cardiac output (L/min) | 3.2 ± 0.3 | 3.6 ± 0.2 | 3.5 ± 0.2 | 3.4 ± 0.2 |
LVMM (g/kg body weight) | 1.6 ± 0.1 | 2.4 ± 0.2*†| 1.8 ± 0.1 | 1.8 ± 0.1 |
E/A ratio | 1.2 ± 0.1 | 0.7 ± 0.1*†| 0.8 ± 0.1*†| 1.1 ± 0.1 |
EDV (ml) | 84.3 ± 2.2 | 66.0 ± 2.7*†| 65.6 ± 2.4*†| 80.6 ± 4.5 |
Myocardial perfusion (ml/min/g): | Â | Â | Â | Â |
Baseline | 0.9 ± 0.1 | 0.7 ± 0.04*†| 0.7 ± 0.04*†| 0.8 ± 0.1 |
Response to adenosine | 1.0 ± 0.1‡ | 0.7 ± 0.04*†| 0.7 ± 0.1*†| 0.9 ± 0.1‡ |