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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington’s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number

Figure 4

Assessment of spatial memory in R6/2 mice following bone marrow mesenchymal stem cell transplantation. Untreated R6/2 mice displayed significant impairment in spatial memory at 5, 8, 9, 10, and 11 weeks of age when compared with wild-type (WT) mice. Mice receiving either low-passage or high-passage bone marrow mesenchymal stem cells (BM MSCs) displayed an intermediate sparing of spatial memory at 8 and 9 weeks of age. *Significant from WT; #significant from R6/2; †significant from high-passage BM MSCs. Bar graph represents mean value; error bars represent standard error of the mean.

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Stem Cell Research & Therapy

ISSN: 1757-6512