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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington’s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number

Figure 6

Measures of brain area and evidence of integrity of the metabolic tissue in the striata of mice receiving bone marrow mesenchymal stem cell transplantations. (A) Gross morphology of the brain near the area of transplantation can be visualized with cytochrome oxidase (CYO) labeling. (B) Untreated R6/2 mice had a significant decrease in total brain area (outlined in solid black) when compared with WT mice. Optical densitometric measures of CYO in the labeled tissue of the striata (outlined in dashed line) revealed significantly less metabolically active area in untreated R6/2 mice when compared with wild-type (WT) mice at the time of necropsy. (C) R6/2 mice that received transplantation of high-passage bone marrow mesenchymal stem cells (BM MSCs) had significantly higher levels of CYO labeling in the striata than did untreated R6/2 mice. *Significant from WT; #significant from R6/2. Data points on line graph represent mean value; error bars represent standard error of the mean.

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Stem Cell Research & Therapy

ISSN: 1757-6512