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Figure 7 | Stem Cell Research & Therapy

Figure 7

From: Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington’s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number

Figure 7

Immunohistochemical analyses of the transplanted bone marrow mesenchymal stem cells. (A) No neuronal or glial differentiation was observed from the transplanted bone marrow mesenchymal stem cells (BM MSCs) as seen by the lack of colocalization between the BM MSCs (blue) with neuronal nuclei (NeuN; red) or glial fibrillary acid protein (GFAP; green), respectively in either low-passage (left panel) or high-passage (right panel) BM MSC.(B) No significant differences were observed in the amount of surviving BM MSCs between low-passage and high-passage BM MSCs. (C) Also, no significant differences were observed between all groups in densitometric measures of GFAP around the transplant site.

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