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Figure 8 | Stem Cell Research & Therapy

Figure 8

From: Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington’s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number

Figure 8

In vivo quantitative RT-PCR of BDNF, TrkB, NGF, and TNFα mRNA expression (fold increase over tail-tip fibroblast) following transplantation of bone marrow mesenchymal stem cells. (A) Untreated R6/2 mice had significantly lower expression of brain-derived neurotrophic factor (BDNF) than wild-type (WT) mice, R6/2 mice receiving low-passage bone marrow mesenchymal stem cells (BM MSCs), and R6/2 mice receiving high-passage BM MSCs. No significant differences were observed in the expression levels of (B) tyrosine receptor kinase type 2 (TrkB), (C) nerve growth factor (NGF), or (D) tumor necrosis factor alpha (TNFα) between groups. *Significant from WT; #significant from R6/2. Data points on line graph represent mean value; error bars represent standard error of the mean. TTF, tail-tip fibroblast.

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Stem Cell Research & Therapy

ISSN: 1757-6512