Gene expression changes with differentiation of cord blood stem cells to respiratory epithelial cells: a preliminary observation

Table 3 Molecular functions of downregulated genes as defined in the Swiss-Prot and TrEMBL databases, expressed as a percentage of the total downregulated group and compared to molecular functions of all known genes in the genome^a

Molecular function	MLPCs (induced)	Genome
Transcription regulator	6.5	10.4
Developmental	6.5	2.8
Receptor	6.5	4.7
Signaling	4.6	21.1
Hydrolase	4.6	8.7
Cell adhesion	4.6	0.4
Transport	4.6	5.9
Muscle differentiation-related	4.6
Unknown function	4.6
Extracellular matrix	3.7	1.4
RNA binding	3.7
Protein binding	3.7
Cytoskeletal	3.7
Oxidoreductase	2.8	3.8
GTPase	2.8	10.6
Transferase	2.8	8.2
Calcium binding	2.8	3.1
Isomerase	1.9	0.7
Chromatin regulator	1.9
Binding	1.9
Ligase	1.9
Cell junction	1.9
Metal binding	1.9	6.2
Kinase	1.9	1.1
Growth factor	0.9
Secreted	0.9
Calmodulin-binding	0.9	1
G protein exchange	0.9
Membrane protein	0.9
Cytokine	0.9
Motor protein	0.9
ATP binding	0.9	7.3
Hormone	0.9
Tumor antigen	0.9
RNA splicing	0.9
Endosomal trafficking	0.9
ATP synthesis	0.9
Ion channel	0.9	0.2
Lysase	0.9	0.9

^aMLPC, multilineage progenitor cell. Molecular functions for which no genome value is listed reflect updates in the Swiss-Prot/TrEMBL databases and author discretion in assigning function if no clear function is listed in the above-mentioned databases (see Wade et al. [8]).

ISSN: 1757-6512