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Table 4 Upregulated genesa

From: Gene expression changes with differentiation of cord blood stem cells to respiratory epithelial cells: a preliminary observation

Official symbol

Name

Fold change

Significance

ALDH3A1

Aldehyde dehydrogenase 3 family member A1

13.2

Expressed in rat lung and non-small cell lung cancers. May contribute to cyclophosphamide resistance.

FDXR

Ferredoxin reductase

9.8

Higher expression levels seen in metastatic colorectal cancer than in normal controls.

GADD45B

Growth arrest and DNA damage-inducible β

7.6

Induced by differentiation-inducing cytokines.

SGK1

Serum/glucocorticoid-regulated kinase 1

5.0

Expressed in lung, functioning in water and sodium balance. Mineralocorticoid-responsive.

VDR

Vitamin D (1,25-dihydroxyvitamin D3) receptor

4.6

Hypothesized to play a key role in ATII maturation and surfactant synthesis.

HSP90B1

Heat shock protein 90 kDa β (Grp94)

4.2

Increased expression seen in mesothelioma and squamous cell lung cancer.

HDS17B1

Hydroxysteroid (17β) dehydrogenase 11

3.6

Expressed in distal bronchioles and ATII cells.

CHKA

Choline kinase α

3.4

Expressed in adult rat ATII cells. Forms part of synthesis pathway for phosphatidylcholine (pulmonary surfactant synthesis).

  1. aATII, alveolar type II pneumocyte. Expression change (expressed as fold change relative to control cells) and significance of selected upregulated genes.