Table 5 Downregulated genesa
Official symbol | Name | Fold change | Significance |
|---|---|---|---|
CTHRC1 | Collagen triple-helix repeat containing 1 | 37.5 | Inhibitor of TGF-β |
INHBA | Inhibin, βA | 26.4 | Part of TGF-β superfamily with mitogenic effects on osteoblasts |
GRB14 | Growth factor receptor-bound protein 14 | 23.8 | Negative regulator of insulin receptor signaling |
SCRG1 | Stimulator of chondrogenesis 1 | 15.6 | Cartilage formation |
PDE1C | Phosphodiesterase 1C, calmodulin-dependent | 10.8 | Phosphodiesterase highly expressed in heart and brain |
SRY-BOX 11 | SRY (sex-determining region Y) box 11 | 9.1 | Possible role in developing nervous system |
COL4A | Collagen type IV, α1 | 8.3 | Basement membrane collagen |
DOCK 10 | Dedicator of cytokinesis 10 | 7.8 | G protein exchange factor with widespread expression |
PDLIM7 | PDZ and LIM domain 7 | 7.8 | Mediator of protein exchange with ubiquitous expression |
CYP4V2 | Cytochrome P450, family 4, subfamily V polypeptide 2 | 7.3 | Mutated in Bietti crystalline dystrophy |
CD44 | CD44 molecule | 2.2 | Crucial for stem cell niche interactions |