Figure 1
From: A zinc finger protein Zfp521 directs neural differentiation and beyond
Zfp521 structure and function. (a) In mouse embryonic stem (ES) cells, Zfp521 is essential for directing epiblasts to neuroectoderm cells, which is inhibited by bone morphogenetic protein (BMP) signaling pathways. (b) Schematic presentation of the Zfp521 protein, which contains a nuclear remodeling and histone deacetylation complex (NuRD) motif (●) at the N-terminal end, 30 C2H2 zinc fingers (ZF1 to ZF30, ■) throughout the protein, and a putative nuclear localization signal (▲) between ZF8 and ZF9. (c) Zfp521 recruits histone deacetylase (HDAC1/HDAC3/HDAC4) through the NuRD motif, associates with co-activator p300 via ZF1 to ZF8, and inhibits GATA-1 and EBF1 by the C-terminal regions, and binds RunX2 through ZF6 to ZF26. LIF, leukemia inhibitory factor.