Table 4 Phenotypes for loss of function of Oct4-associated proteins that are not known to be transcriptional regulators
From: In silico tandem affinity purification refines an Oct4 interaction list
Gene | Loss-of-function phenotype |
|---|---|
Cdk1 | Death prior to embryonic day 1.5 |
Igf2bp1 | Increased neonatal lethality associated with multiple abnormalities |
Lbr | Impaired growth and skin defects |
Nup155 | Embryonic lethality associated with atrial fibrillation |
Rad50 | Embryonic death. Hypomorphic mutant shows predisposition toward cancer and loss of spermatogenic and hematopoietic stem cells, leading to death. |
Tjp2 | Embryonic lethality associated with gastrulation defect |