Recombinant human TSG-6 protein (rhTSG-6) attenuates LPS induced lung inflammation. A total of 25 μg of rhTSG-6 protein was administered by OA 1 h and again 10 h after LPS-induced lung injury. Total cell counts (a) and MPO activity (b) in BAL fluid are significantly lower in rhTSG-6 treated mouse lung. Data are shown as mean ± SEM (n = 5, LPS + PBS or n = 8 LPS + rhTSG-6). * P < 0.05 compared with LPS + PBS.