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Table 1 Effects on differentiation potential of multipotent/pluripotent stem cells after treatment with epigenetic drugs

From: DNA methylation in stem cell renewal and multipotency

Stem cell classification Epigenetic drug Differentiation after treatment Reference
Multipotent stem cells    
   Adipose-derived stem cells 5-aza-2'-deoxycytidine Cardiomyocytes [38]
   Adipose-derived stem cells 5-aza-2'-deoxycytidine; trichostatin A Cardiomyocytes [57]
   Bone marrow mesenchymal stem cells 5-aza-2'-deoxycytidine Osteocytes [39, 40]
   Bone marrow mesenchymal stem cells 5-aza-2'-deoxycytidine Cardiomyocytes [45, 58]
   Bone marrow mesenchymal stem cells 5-aza-2'-deoxycytidine; trichostatin A Osteocytes; chondrocytes [41]
   Bone marrow mesenchymal stem cells 5-aza-2'-deoxycytidine; trichostatin A Neural-like cells [42]
   Bone marrow mesenchymal stem cells Sodium butyrate Osteocytes [59]
   Cardiac progenitor stem cells 5-aza-2'-deoxycytidine Cardiomyocytes [60]
   Neural progenitor stem cells Trichostatin A Neuronal cells [61]
   Neural progenitor stem cells Valproic acid Neuronal cells [62]
   Umbilical cord mesenchymal stem cells 5-aza-2'-deoxycytidine Cardiomyocytes [63]
Pluripotent stem cells    
   Embryonic stem cells 5-aza-2'-deoxycytidine Cardiomyocytes [64, 65]
   Embryonic stem cells 5-aza-2'-deoxycytidine Endothelial cells [66]
   Embryonic stem cells Trichostatin A Cardiomyocytes [67, 68]
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Stem Cell Research & Therapy

ISSN: 1757-6512