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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells

Figure 5

Predicted biologic functions influenced by miRNA expression in adipose stem cells (ASCs) and bone marrow stem cells (BMSCs). Major biologic functions influenced by miRNA action on gene expression are shown from Ingenuity Pathways Assessment (IPA) analysis of MSCs from old and young donors. Involvement of biologic functions is determined from network and focus molecule association with miRNA targets in IPA. (a) Downregulated miRNA in BMSCs from old donors, compared with young donors. (b) Upregulated miRNA in M-MSCs from old donors, compared with young donors. (c) Downregulated miRNA in ASCs from old donors, compared with young donors. (d) Upregulated miRNA in ASCs from old donors, compared with young donors. The yellow line represents P-value cutoff (P < 0.05).

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Stem Cell Research & Therapy

ISSN: 1757-6512