Skip to main content

Table 1 Clinical trials using autologous bone marrow mononuclear cells in patients with acute myocardial infarction

From: Bone marrow mononuclear cells and acute myocardial infarction

Study Study design Cell type Delivery method Timing post-infarction Adjunct procedure Outcome
Meluzin et al. [93] RCT BMMNC IC 5-9 days PCI Dose-dependent improvement of regional myocardial function by PET
Fernandez-Aviles et al. [94] NR BMMNC IC 13.5 ± 5.5 days PCI Decrease in end systolic volume, improvement in regional and global function
Janssens et al. [19] RCT BMMNC IC 1 day PCI No effect on global LVEF, but may favourably affect infarct remodelling
Lunde et al. [12] (ASTAMI) RCT BMMNC IC 6 days PCI No effect on global LVEF
Schächinger et al. [17] (REPAIR-AMI) RCT BMMNC IC 3-7 days PCI Improvement in global LVEF
Ge et al. [16] RCT BMMNC IC Immediately PCI Improvement in LVEF
De Lezo et al. [95] RCT BMMNC or GCSF IC 7 days IV fibrinolytics + PCI Improvement in LVEF
Zhan-quan et al. [96] NRC PBSC IC 6 days PCI Improvement in LVEF
Wollert et al. [14] (BOOST) RCT BMMNC IC 4.8 days PCI Improvement in LV systolic function
Lipiec et al. [97] RCT BMMNC IC 4-11 days PCI Improvement in myocardial perfusion with no effect on global LVEF
Huikuri et al. [98] (FINCELL) RCT BMMNC IC 2-6 days IV thrombolysis + PCI Improvement in global LVEF
Kang et al. [99] RCT PBSC and GCSF IC   PCI Improvement in myocardial perfusion and systolic function
Assmus et al. [10] (TOPCARE-AMI) NR BMMNC or CPC IC 3-7 days PCI Improvement in LVEF
Schächinger et al. [11] (TOPCARE-AMI) NR BMMNC or CPC IC 3-7 days PCI Improvement in EF
Strauer et al. [9] NRC BMMNC IC 5-9 days PCI Reduction in infarct region
Bartunek et al. [100] NRC BMMNC (CD133) IC 11.6 days PCI Improvement in LVEF
Hirsch et al. [21] RCT BMMNC IC 3-8 days PCI No effect on global or regional LV function
Tendera et al. [20] RCT BMMNC IC 3-12 days PCI No significant improvement in LVEF
Chen et al. [101] RCT BMMNC IC 18 days PCI Improvement in LVEF
Yousef et al. [15] (BALANCE) NRC BMMNC IC 7 days PCI Improvement in LVEF, exercise capacity and mortality
  1. Time from myocardial infarction to transplantation and outcomes measured are listed. ASTAMI, Autologous Stem-Cell Transplantation in Acute Myocardial Infarction; BMMNC, bone marrow-derived mononuclear cell; BOOST, Bone Marrow Transfer to Enhance ST-Elevation Infarct Regeneration; CPC, circulating progenitor cell; EF, ejection fraction; GCSF, granulocyte-colony stimulating factor; IC, intracoronary; IM, intramyocardial; LVEF, left ventricular ejection fraction; NR, non-randomised; NRC, non-randomised with control group; PBSC, peripheral blood stem cell; PCI, percutaneous coronary intervention; PET, positron emission tomography; RCT, randomised controlled trial; REPAIR-AMI, Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction; TOPCARE-AMI, Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction.