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  1. The generation of human induced pluripotent stem cells (hiPSCs) has opened a world of opportunities for stem cell-based therapies in regenerative medicine. Currently, several human kidney organoid protocols ar...

    Authors: Loes E. Wiersma, M. Cristina Avramut, Ellen Lievers, Ton J. Rabelink and Cathelijne W. van den Berg
    Citation: Stem Cell Research & Therapy 2022 13:208
  2. The meniscus is a semilunar fibrocartilage between the tibia and femur that is essential for the structural and functional integrity of the keen joint. In addition to pain and knee joint dysfunction, meniscus ...

    Authors: Yixin Bian, Han Wang, Xiuli Zhao and Xisheng Weng
    Citation: Stem Cell Research & Therapy 2022 13:207
  3. Mesenchymal stem cells (MSCs) have shown promising results in stimulating cartilage repair and in the treatment of osteoarthritis (OA). However, the fate of the MSCs after intra-articular injection and their r...

    Authors: Camilla Andersen, Kristina Uvebrant, Yuki Mori, Stacie Aarsvold, Stine Jacobsen, Lise Charlotte Berg, Evy Lundgren-Åkerlund and Casper Lindegaard
    Citation: Stem Cell Research & Therapy 2022 13:206
  4. Muscle denervation from trauma and motor neuron disease causes disabling morbidities. A limiting step in functional recovery is the regeneration of neuromuscular junctions (NMJs) for reinnervation. Stem cells ...

    Authors: LeeAnn K. Li, Wen-Chin Huang, Yuan-Yu Hsueh, Ken Yamauchi, Natalie Olivares, Raul Davila, Jun Fang, Xili Ding, Weikang Zhao, Jennifer Soto, Mahdi Hasani, Bennett Novitch and Song Li
    Citation: Stem Cell Research & Therapy 2022 13:205
  5. Mesenchymal stem cells (MSCs) therapy is showing potential therapeutic effects on liver function improvement in patients with chronic liver disease; however, the consensus on efficacy and safety of MSCs has no...

    Authors: Yuwei Liu, Yutong Dong, Xiaojing Wu, Xiaotong Xu and Junqi Niu
    Citation: Stem Cell Research & Therapy 2022 13:204
  6. The effect of transplantation of bone-marrow mononuclear cells (BM-MNCs) and mesenchymal stem cells (MSCs) on ejection fraction (LVEF) has been studied in patients with acute myocardial infarction (AMI) in cli...

    Authors: Alireza Hosseinpour, Fatemeh Kheshti, Asma Kazemi and Armin Attar
    Citation: Stem Cell Research & Therapy 2022 13:203
  7. Bone marrow mesenchymal stromal cells (MSCs) play a crucial role in the regulation of hematopoiesis. These cells affect the process through direct cell–cell contact, as well as releasing various trophic factor...

    Authors: Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh and Karim Shamsasenjan
    Citation: Stem Cell Research & Therapy 2022 13:202
  8. As global aging accelerates, the prevention and treatment of age-related bone diseases are becoming a critical issue. In the process of senescence, bone marrow mesenchymal stem cells (BMSCs) gradually lose the...

    Authors: Yi Zhao, Jiawei He, Tao Qiu, Haoyu Zhang, Li Liao and Xiaoxia Su
    Citation: Stem Cell Research & Therapy 2022 13:201
  9. The circadian clock refers to the intrinsic biological rhythms of physiological functions and behaviours. It synergises with the solar cycle and has profound effects on normal metabolism and organismal fitness...

    Authors: Wenzhen Gao, Rong Li, Meilin Ye, Lanxin Zhang, Jiawen Zheng, Yuqing Yang, Xiaoyu Wei and Qing Zhao
    Citation: Stem Cell Research & Therapy 2022 13:200
  10. Mammalian lens regeneration holds great potential as a cataract therapy. However, the mechanism of mammalian lens regeneration is unclear, and the methods for optimization remain in question.

    Authors: Xiaomin Liu, Qingjun Zhou, Yusen Huang, Zheng Fan, Haoyun Duan, Menghan Wang, Zongyi Li and Lixin Xie
    Citation: Stem Cell Research & Therapy 2022 13:198
  11. Chemoresistance often causes the failure of treatment and death of patients with advanced non-small-cell lung cancer. However, there is still no resistance genes signature and available enriched signaling deri...

    Authors: Yujia Zhang, Fengjun Qiu, Tingjie Ye, Sau Har Lee, Jiatuo Xu, Lingyan Jia, Rui Zeng, Xiaoling Wang, Xudong Hu, Xiaofeng Yan, Hua Li, Yanlin Lu, Xiaoling Wang, Rilei Jiang and Wei Xu
    Citation: Stem Cell Research & Therapy 2022 13:197
  12. Extracellular vesicles (EVs) are a potential cell-free regenerative medicine. Human amniotic epithelial cells (hAECs) are a viable source of cell therapy for diseases like bronchopulmonary dysplasia (BPD). How...

    Authors: Dandan Zhu, Mirja Krause, Tamara Yawno, Gina D. Kusuma, Renate Schwab, Mehri Barabadi, Amina S. Maleken, Siow T. Chan, Rod Hunt, David Greening, Euan M. Wallace and Rebecca Lim
    Citation: Stem Cell Research & Therapy 2022 13:196
  13. Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow thera...

    Authors: Li Zhou, Huimin Zhu, Xue Bai, Jiagui Huang, Yue Chen, Jun Wen, Xuemei Li, Bowen Wu, Yongjun Tan, Mingfen Tian, Jiangxia Ren, Mengxia Li and Qin Yang
    Citation: Stem Cell Research & Therapy 2022 13:195
  14. Exosomes are extracellular vesicles found in various tissues, blood circulation, and tissue fluids, secreted into the extracellular environment by fusing a multivesicular body with a plasma membrane. Various c...

    Authors: Mehdi Jahedi Zargar, Saeid Kaviani, Mohammad Vasei, Mina Soufi Zomorrod, Saeed Heidari Keshel and Masoud Soleimani
    Citation: Stem Cell Research & Therapy 2022 13:194
  15. Recently, mesenchymal stromal cells (MSCs) and their derivative exosome have become a promising approach in the context of liver diseases therapy, in particular, acute liver failure (ALF). In addition to their...

    Authors: Samin Shokravi, Vitaliy Borisov, Burhan Abdullah Zaman, Firoozeh Niazvand, Raheleh Hazrati, Meysam Mohammadi Khah, Lakshmi Thangavelu, Sima Marzban, Armin Sohrabi and Amir Zamani
    Citation: Stem Cell Research & Therapy 2022 13:192
  16. Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicle...

    Authors: Zhumei Gao, Chuyue Zhang, Fei Peng, Qianqian Chen, Yinghua Zhao, Liangmei Chen, Xu Wang and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2022 13:191
  17. Functional electrospun membranes are promising dressings for promoting wound healing. However, their microstructure and drug loading capacity need further improvements. It is the first time to design a novel m...

    Authors: Jieyu Xiang, Ling Zhou, Yuanlong Xie, Yufan Zhu, Lingfei Xiao, Yan Chen, Wei Zhou, Danyang Chen, Min Wang, Lin Cai and Liang Guo
    Citation: Stem Cell Research & Therapy 2022 13:190
  18. Trophoblast stem cells (TSCs), the precursors of trophoblast cells of placenta, possess the potential to differentiate into various trophoblastic subtypes in vitro. Establishment of extraembryonic trophoblasti...

    Authors: Trishita Basak and Rupasri Ain
    Citation: Stem Cell Research & Therapy 2022 13:189
  19. Accumulating evidence supports that prostate cancer stem-like cells (PCSCs) play significant roles in therapy resistance and metastasis of prostate cancer. Many studies also show that nitric oxide (NO) synthes...

    Authors: Weijie Gao, Yuliang Wang, Shan Yu, Zhu Wang, Taiyang Ma, Andrew Man-Lok Chan, Peter Ka-Fung Chiu, Chi-Fai Ng, Dinglan Wu and Franky Leung Chan
    Citation: Stem Cell Research & Therapy 2022 13:188
  20. Adipose-derived stem cells (ASCs) are obtained from a variety of sources in vivo where they present in large quantities. These cells are suitable for use in autologous transplantation and the construction of t...

    Authors: Rongmei Qu, Kai He, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Wenhua Huang, Jun Ouyang, Xinghua Pan and Jingxing Dai
    Citation: Stem Cell Research & Therapy 2022 13:187
  21. This experimental study was designed as a preclinical study for testing the hypothesis that intrarenal arterial (IRA) transfusion of human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) therapy prese...

    Authors: Ya Yue, Jui-Ning Yeh, John Y. Chiang, Pei-Hsun Sung, Yi-Ling Chen, Fanna Liu and Hon-Kan Yip
    Citation: Stem Cell Research & Therapy 2022 13:186
  22. Pluripotent stem cells (PSCs) can be an ideal source of differentiation of cardiomyocytes in vitro and during transplantation to induce cardiac regeneration. However, differentiation of PSCs into a heterogeneo...

    Authors: Ramakanth Satthenapalli, Scott Lee, Jayanthi Bellae Papannarao, Timothy A. Hore, Akash Chakraborty, Peter P. Jones, Regis R. Lamberts and Rajesh Katare
    Citation: Stem Cell Research & Therapy 2022 13:185
  23. To investigate current situation of minimal information implementation highlighted by minimal information for studies of extracellular vesicles 2018 (MISEV2018) guidelines, and explore technological advances t...

    Authors: Jianguo Chen, Ruiquan Liu, Tianyu Huang, Hengyun Sun and Haiyue Jiang
    Citation: Stem Cell Research & Therapy 2022 13:182
  24. To determine the efficacy and safety of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in Chinese adults with type 2 diabetes mellitus (T2DM).

    Authors: Li Zang, Yijun Li, Haojie Hao, Jiejie Liu, Yu Cheng, Bing Li, Yaqi Yin, Qian Zhang, Fei Gao, Haibin Wang, Shi Gu, Jia Li, Fengxiang Lin, Yingfei Zhu, Guanglei Tian, Yulong Chen…
    Citation: Stem Cell Research & Therapy 2022 13:180
  25. There is unmet need for effective therapies of intrauterine adhesions (IUAs) that are common cause of menstrual disturbance and infertility, since current clinical procedures do not improve prognosis for patie...

    Authors: Siyu Xia, Ming Wu, Xinhao Zhou, Xiu Zhang, Lina Ye, Kang Zhang, Yiyi Kang, Jun Liu, Yunci Zhang, Wang Wu, Dirong Dong, Hong Chen and Hui Li
    Citation: Stem Cell Research & Therapy 2022 13:178
  26. Synovial mesenchymal stem cells (MSCs) have high freeze–thaw tolerance, whereas human umbilical vein endothelial cells (HUVECs) have low freezing tolerance. The differences in cell type-specific freeze–thaw to...

    Authors: Mitsuru Mizuno, Takahisa Matsuzaki, Nobutake Ozeki, Hisako Katano, Hideyuki Koga, Takanori Takebe, Hiroshi Y. Yoshikawa and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2022 13:177
  27. This review aims at becoming a guide which will help to plan the experimental design and to choose adequate methods to assess the outcomes when testing cell-based products in the treatment of the damaged vocal...

    Authors: Mikhail V. Svistushkin, Svetlana Kotova, Anastasia Shpichka, Svetlana Starostina, Anatoliy Shekhter, Polina Bikmulina, Anna Nikiforova, Anna Zolotova, Valery Royuk, P. A. Kochetkov, Serge Timashev, Victor Fomin, Massoud Vosough, Valery Svistushkin and Peter Timashev
    Citation: Stem Cell Research & Therapy 2022 13:176
  28. Stem cells are distinctive cells that have self-renewal potential and unique ability to differentiate into multiple functional cells. Stem cell is a frontier field of life science research and has always been ...

    Authors: Cong Zhao, Wen Xie, Hecheng Zhu, Ming Zhao, Weidong Liu, Zhaoping Wu, Lei Wang, Bin Zhu, Shasha Li, Yao Zhou, Xingjun Jiang, Qiang Xu and Caiping Ren
    Citation: Stem Cell Research & Therapy 2022 13:175
  29. Ocular surface and retinal diseases are widespread problems that cannot be ignored in today’s society. However, existing prevention and treatment still have many shortcomings and limitations, and fail to effec...

    Authors: Shisi Ma, Xiao Liu, Jiayang Yin, Lili Hao, Yuyao Diao and Jingxiang Zhong
    Citation: Stem Cell Research & Therapy 2022 13:174
  30. Diabetic nephropathy (DN) is a severe complication of diabetes mellitus and a common cause of end-stage renal disease (ESRD). Mesenchymal stem cells (MSCs) possess potent anti-inflammatory and immunomodulatory...

    Authors: Yaqi Zhang, Xi Le, Shuo Zheng, Ke Zhang, Jing He, Mengting Liu, Chengshu Tu, Wei Rao, Hongyuan Du, Yu Ouyang, Changyong Li and Dongcheng Wu
    Citation: Stem Cell Research & Therapy 2022 13:171
  31. Developmental pluripotency-associated 3 (Dppa3, also called Stella or PGC7) is a principal maternal protein specially expressed in pre-implantation embryos, embryonic stem cells (ES cells) and primordial germ ...

    Authors: Shuang Zhao, Chuanyu Zhang, Jia Xu, Siying Liu, Lu Yu, Shang Chen, Hang Wen, Zongjin Li and Na Liu
    Citation: Stem Cell Research & Therapy 2022 13:169
  32. Fully functional regeneration of skeletal defects by multipotent progenitor cells requires that differentiating cells gain the specific mechano-competence needed in the target tissue. Using cartilage neogenesi...

    Authors: Janine Lückgen, Elisabeth Raqué, Tobias Reiner, Solvig Diederichs and Wiltrud Richter
    Citation: Stem Cell Research & Therapy 2022 13:168
  33. Mesenchymal Stromal Cells (MSC) have been widely used for their therapeutic properties in many clinical applications including myocardial infarction. Despite promising preclinical results and evidences of safe...

    Authors: Charlotte Sarre, Rafael Contreras-Lopez, Nitirut Nernpermpisooth, Christian Barrere, Sarah Bahraoui, Claudia Terraza, Gautier Tejedor, Anne Vincent, Patricia Luz-Crawford, Kantapich Kongpol, Sarawut Kumphune, Christophe Piot, Joel Nargeot, Christian Jorgensen, Farida Djouad and Stéphanie Barrere-Lemaire
    Citation: Stem Cell Research & Therapy 2022 13:167
  34. Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro passaging leads to stemness loss of MSCs, resulting in failure of MSC therapy. ...

    Authors: Aili Aierken, Balun Li, Peng Liu, Xuedi Cheng, Zheng Kou, Ning Tan, Mengfei Zhang, Shuai Yu, Qiaoyan Shen, Xiaomin Du, Bold Bayar Enkhbaatar, Juqing Zhang, Rui Zhang, Xiaolong Wu, Ruibin Wang, Xin He…
    Citation: Stem Cell Research & Therapy 2022 13:164
  35. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Whether extracellular vesicles are effective in treating IPF and what is the optimal administrative route is not clear....

    Authors: Shengnan Yang, Peipei Liu, Tingting Gao, Dingyun Song, Xinyu Zhao, Yupeng Li, Jun Wu, Liu Wang, Zai Wang, Jie Hao, Chen Wang and Huaping Dai
    Citation: Stem Cell Research & Therapy 2022 13:163
  36. Mitofusin-2 (MFN2) is a kind of GTPase that participates in the regulation of mitochondrial fusion, which is related to a variety of physiological and pathological processes, including energy metabolism, cell dif...

    Authors: Lidi Deng, Siqi Yi, Xiaohui Yin, Yang Li and Qingxian Luan
    Citation: Stem Cell Research & Therapy 2022 13:162
  37. Various methods have been developed to generate hepatic cells from human pluripotent stem cells (hPSCs) that rely on the combined use of multiple expensive growth factors, limiting industrial-scale production ...

    Authors: Tingcai Pan, Ning Wang, Jiaye Zhang, Fan Yang, Yan Chen, Yuanqi Zhuang, Yingying Xu, Ji Fang, Kai You, Xianhua Lin, Yang Li, Shao Li, Kangyan Liang, Yin-xiong Li and Yi Gao
    Citation: Stem Cell Research & Therapy 2022 13:159
  38. Tissue engineering is an innovative field with enormous developments in recent years. These advances are not only in the understanding of how stem cells can be isolated, cultured and manipulated but also in th...

    Authors: Souzan Salemi, Jenny A. Prange, Valentin Baumgartner, Deana Mohr-Haralampieva and Daniel Eberli
    Citation: Stem Cell Research & Therapy 2022 13:156
  39. Immunosuppressive properties grant mesenchymal stromal cells (MSCs) promising potential for treating autoimmune diseases. As autologous MSCs suffer from limited availability, the readily available allogeneic M...

    Authors: Yonghai Li, Haiyao Gao, Tobias M. Brunner, Xiaoxi Hu, Yushan Yan, Yanli Liu, Liang Qiao, Peihua Wu, Meng Li, Qing Liu, Fen Yang, Juntang Lin, Max Löhning and Ping Shen
    Citation: Stem Cell Research & Therapy 2022 13:155

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