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  1. Content type: Commentary

    Chronic ischemic heart disease is a major cause of patient morbidity and healthcare expenditure. The development of therapies aimed to enhance angiogenesis is targeted for patients with severe ischemic symptom...

    Authors: Peter J Psaltis and Robert D Simari

    Citation: Stem Cell Research & Therapy 2011 2:43

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  2. Content type: Review

    Owing to their potential for differentiation into multiple cell types, multipotent stem cells extracted from many adult tissues are an attractive stem cell resource for the replacement of damaged tissues in re...

    Authors: María Berdasco and Manel Esteller

    Citation: Stem Cell Research & Therapy 2011 2:42

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  3. Content type: Review

    There are many similarities between health issues affecting military and civilian patient populations, with the exception of the relatively small but vital segment of active soldiers who experience high-energy...

    Authors: Gregory T Christopherson and Leon J Nesti

    Citation: Stem Cell Research & Therapy 2011 2:40

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  4. Content type: Commentary

    Amyloid precursor protein (APP) fascinates cell biologists because it is proteolytically processed to generate multiple peptides, including amyloid-β, which is implicated in Alzheimer's disease. However, a lar...

    Authors: Sanjay W Pimplikar and Kaushik Ghosal

    Citation: Stem Cell Research & Therapy 2011 2:39

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  5. Content type: Research

    Stem cell transplantation is a promising therapeutic strategy for the treatment of stroke. Mesenchymal stem cells (MSCs) are a potential cell source for clinical application because they can be easily obtained...

    Authors: Jung Yeon Lim, Chang Hyun Jeong, Jin Ae Jun, Seong Muk Kim, Chung Heon Ryu, Yun Hou, Wonil Oh, Jong Wook Chang and Sin-Soo Jeun

    Citation: Stem Cell Research & Therapy 2011 2:38

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  6. Content type: Research

    Soluble amyloid precursor protein α (sAPPα) is a proteolyte of APP cleavage by α-secretase. The significance of the cleavage and the physiological role of sAPPα are unknown. A crystal structure of a region of ...

    Authors: Michael P Demars, Amelia Bartholomew, Zuzana Strakova and Orly Lazarov

    Citation: Stem Cell Research & Therapy 2011 2:36

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  7. Content type: Review

    Mesenchymal stem (stromal) cells (MSCs) are rare, multipotent progenitor cells that can be isolated and expanded from bone marrow and other tissues. Strikingly, MSCs modulate the functions of immune cells, inc...

    Authors: Michelle M Duffy, Thomas Ritter, Rhodri Ceredig and Matthew D Griffin

    Citation: Stem Cell Research & Therapy 2011 2:34

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  8. Content type: Commentary

    A great number of patients around the world experience tooth loss that is attributed to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases or irreversible trauma. The p...

    Authors: Hidefumi Maeda, Atsushi Tomokiyo, Shinsuke Fujii, Naohisa Wada and Akifumi Akamine

    Citation: Stem Cell Research & Therapy 2011 2:33

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  9. Content type: Review

    We have found that when muscle-derived stem cells (MDSCs) are implanted into a variety of tissues only a small fraction of the donor cells can be found within the regenerated tissues and the vast majority of c...

    Authors: Burhan Gharaibeh, Mitra Lavasani, James H Cummins and Johnny Huard

    Citation: Stem Cell Research & Therapy 2011 2:31

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  10. Content type: Review

    The MRL (Murphy Roths Large) mouse has provided a unique model of adult mammalian regeneration as multiple tissues show this important phenotype. Furthermore, the healing employs a blastema-like structure simi...

    Authors: Larry Matthew Arthur and Ellen Heber-Katz

    Citation: Stem Cell Research & Therapy 2011 2:30

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  11. Content type: Commentary

    Wong and Reiter have explored the possibility that hair follicle stem cells can give rise to basal cell carcinoma (BCC). They expressed in mice an inducible human BCC-derived oncogenic allele of Smoothened, SmoM2

    Authors: Maya Sieber-Blum

    Citation: Stem Cell Research & Therapy 2011 2:29

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  12. Content type: Commentary

    Amphibians and zebrafish are able to regenerate lost myocardial tissue without loss of cardiac function; whereas mammals, in response to myocardial injury, develop scar and lose cardiac function. This dichotom...

    Authors: Marc S Penn, Martiza E Mayorga and Feng Dong

    Citation: Stem Cell Research & Therapy 2011 2:24

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  13. Content type: Research

    Multipotent stromal cells (MSCs) are currently in clinical trials for a number of inflammatory diseases. Recent studies have demonstrated the ability of MSCs to attenuate inflammation in rodent models of acute...

    Authors: Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop and Deborah E Sullivan

    Citation: Stem Cell Research & Therapy 2011 2:27

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  14. Content type: Research

    Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the blastocyst and ...

    Authors: Clara Yujing Cheong, Patricia Miang Lon Ng, Rhonda Ponnampalam, Heng-Hang Tsai, Guillaume Bourque and Thomas Lufkin

    Citation: Stem Cell Research & Therapy 2011 2:26

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  15. Content type: Review

    Mesenchymal stem cells (MSCs) are now known to display not only adult stem cell multipotency but also robust anti-inflammatory and regenerative properties. After widespread in vitro and in vivo preclinical testin...

    Authors: Flavio A Carrion and Fernando E Figueroa

    Citation: Stem Cell Research & Therapy 2011 2:23

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  16. Content type: Research

    Owing to wide availability, low cost and avoidance of ethical concerns, umbilical cord blood (UCB) provides an attractive source of stem cells for investigational and therapeutic uses. In this study, we sought...

    Authors: Michael J Berger, Sharon R Minnerath, Sheryl D Adams, Barbara M Tigges, Stacey L Sprague and David H McKenna Jr

    Citation: Stem Cell Research & Therapy 2011 2:19

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  17. Content type: Research

    Unrestricted somatic stem cells (USSC) derived from umbilical cord blood are an attractive alternative to human embryonic stem cells (hESC) for cellular therapy. USSC are capable of forming cells representativ...

    Authors: Caitlin E Filby, Robert Williamson, Peter van Kooy, Alice Pébay, Mirella Dottori, Ngaire J Elwood and Faten Zaibak

    Citation: Stem Cell Research & Therapy 2011 2:16

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  18. Content type: Review

    Growing knowledge on the biology of mesenchymal stem cells (MSCs) has provided new insights into their potential clinical applications, particularly for rheumatologic disorders. Historically, their potential t...

    Authors: Marie Maumus, David Guérit, Karine Toupet, Christian Jorgensen and Danièle Noël

    Citation: Stem Cell Research & Therapy 2011 2:14

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  19. Content type: Research

    Local synthesis of interferon within B16 tumors mediates anti-tumor effects. Based on reports that stem cells are recruited to tumors, and because systemic administration of interferon causes dose-limiting und...

    Authors: Christopher D Krause, Lara S Izotova, Gwangwen Ren, Zeng-Rong Yuan, Yufang Shi, Chiann-Chyi Chen, Yacov Ron and Sidney Pestka

    Citation: Stem Cell Research & Therapy 2011 2:15

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  20. Content type: Research

    A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential if MS...

    Authors: Lisa McGinley, Jill McMahon, Padraig Strappe, Frank Barry, Mary Murphy, Daniel O'Toole and Timothy O'Brien

    Citation: Stem Cell Research & Therapy 2011 2:12

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  21. Content type: Research

    The controlled expression of many genes, including G-protein coupled receptors (GPCRs), is important for delineating gene functions in complex model systems. Binary systems for inducible regulation of transgen...

    Authors: Edward C Hsiao, Trieu D Nguyen, Jennifer K Ng, Mark J Scott, Wei Chun Chang, Hengameh Zahed and Bruce R Conklin

    Citation: Stem Cell Research & Therapy 2011 2:11

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  22. Content type: Review

    The stem cell field in veterinary medicine continues to evolve rapidly both experimentally and clinically. Stem cells are most commonly used in clinical veterinary medicine in therapeutic applications for the ...

    Authors: Lisa A Fortier and Alexander J Travis

    Citation: Stem Cell Research & Therapy 2011 2:9

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  23. Content type: Research

    Pluripotent, human stem cells hold tremendous promise as a source of progenitor and terminally differentiated cells for application in future regenerative therapies. However, such therapies will be dependent u...

    Authors: Yulia Shamis, Kyle J Hewitt, Mark W Carlson, Mariam Margvelashvilli, Shumin Dong, Catherine K Kuo, Laurence Daheron, Christophe Egles and Jonathan A Garlick

    Citation: Stem Cell Research & Therapy 2011 2:10

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  24. Content type: Review

    Mesenchymal progenitor cells, a multipotent adult stem cell population, have the ability to differentiate into cells of connective tissue lineages, including fat, cartilage, bone and muscle, and therefore gene...

    Authors: Janice O'Sullivan, Sinéad D'Arcy, Frank P Barry, JMary Murphy and Cynthia M Coleman

    Citation: Stem Cell Research & Therapy 2011 2:8

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  25. Content type: Commentary

    Endogenous cell proliferation and gliogenesis have been extensively documented in spinal cord injury, particularly in terms of proliferating oligodendrocyte progenitor cells. Despite the characterization of di...

    Authors: Dana M McTigue and FRezan Sahinkaya

    Citation: Stem Cell Research & Therapy 2011 2:7

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  26. Content type: Review

    The control of differential gene expression is central to all metazoan biology. Haematopoiesis represents one of the best understood developmental systems where multipotent blood stem cells give rise to a rang...

    Authors: Nicola K Wilson, Fernando J Calero-Nieto, Rita Ferreira and Berthold Göttgens

    Citation: Stem Cell Research & Therapy 2011 2:6

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  27. Content type: Commentary

    Recent development of a synthetic mRNA-based technology for efficient reprogramming to pluripotency and cell fate conversion without any modification to the genome has generated great interest among researcher...

    Authors: Mo Li, Ignacio Sancho-Martinez and Juan Carlos Izpisua Belmonte

    Citation: Stem Cell Research & Therapy 2011 2:5

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  28. Content type: Review

    In the body, tissue homeostasis is established and maintained by resident tissue-specific adult stem cells (aSCs). Through preservation of bidirectional communications with the surrounding niche and integratio...

    Authors: Penny M Gilbert and Helen M Blau

    Citation: Stem Cell Research & Therapy 2011 2:3

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  29. Content type: Research

    Tendon injury is a common problem in athletes, with poor tissue regeneration and a high rate of re-injury. Stem cell therapy is an attractive treatment modality as it may induce tissue regeneration rather than...

    Authors: Ashlee E Watts, Amy E Yeager, Oleg V Kopyov and Alan J Nixon

    Citation: Stem Cell Research & Therapy 2011 2:4

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  30. Content type: Research

    The ability to predetermine the fate of transplanted neural progenitor cells (NPCs) and specifically to direct their maturation has the potential to enhance the efficiency of cell-transplantation therapy for n...

    Authors: Elena M Vazey and Bronwen Connor

    Citation: Stem Cell Research & Therapy 2010 1:41

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  31. Content type: Commentary

    The use of tissue engineering therapies for treating damaged articular cartilage has traditionally focused on cell-based therapies for the repair of focal chondral or osteochondral defects. A recent study by L...

    Authors: Farshid Guilak

    Citation: Stem Cell Research & Therapy 2010 1:40

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  32. Content type: Commentary

    Almost every laboratory that grows mammalian cells today grows their cells on tissue culture plastic, which was introduced to cell culture decades ago based on properties such as inertness, transparency, and s...

    Authors: Matthew Raab, Jae-Won Shin and Dennis E Discher

    Citation: Stem Cell Research & Therapy 2010 1:38

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  33. Content type: Review

    Stem cells offer an enormous pool of resources for the understanding of the human body. One proposed use of stem cells has been as an autologous therapy. The use of stem cells for neurodegenerative diseases ha...

    Authors: Elise Dantuma, Stephanie Merchant and Kiminobu Sugaya

    Citation: Stem Cell Research & Therapy 2010 1:37

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  34. Content type: Research

    Regulated neurotransmitter actions in the mammalian central nervous system determine brain function and control peripheral organs and behavior. Although drug-seeking behaviors, including alcohol consumption, d...

    Authors: Tom N Grammatopoulos, Susan M Jones, Masami Yoshimura, Brian R Hoover, Mita Das, Evan Y Snyder, Gaynor A Larson, Nancy R Zahniser, Boris Tabakoff and WMichael Zawada

    Citation: Stem Cell Research & Therapy 2010 1:36

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  35. Content type: Research

    Delivered systemically or natively circulating mesenchymal stem cells accumulate in injured tissues. During homing mesenchymal stem cells adhere to endothelial cells and infiltrate underlying tissue. Previousl...

    Authors: Irina A Potapova, Ira S Cohen and Sergey V Doronin

    Citation: Stem Cell Research & Therapy 2010 1:35

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