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  1. Systemic delivery of bone marrow-derived mesenchymal stem cells (MSC) seems to be of benefit in the treatment of multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) sustained by ...

    Authors: Federica Benvenuto, Adriana Voci, Enrico Carminati, Francesca Gualandi, Gianluigi Mancardi, Antonio Uccelli and Laura Vergani

    Citation: Stem Cell Research & Therapy 2015 6:245

    Content type: Research

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  2. Mesenchymal stem cells (MSCs) have been identified as a viable treatment for inflammatory bowel disease (IBD). MSCs derived from bone marrow (BM-MSCs) have predominated in experimental models whereas the major...

    Authors: Rhian Stavely, Ainsley M. Robinson, Sarah Miller, Richard Boyd, Samy Sakkal and Kulmira Nurgali

    Citation: Stem Cell Research & Therapy 2015 6:244

    Content type: Research

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  3. For expansion of human mesenchymal stem cells (MSCs), autologous human serum is safer than fetal bovine serum in clinical situations. One of the problems with the use of autologous human serum is that its prol...

    Authors: Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yukie Matsumoto, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Akifumi Matsuyama and Ichiro Sekiya

    Citation: Stem Cell Research & Therapy 2015 6:243

    Content type: Research

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  4. Human mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into fat, muscle, bone and cartilage cells. Exposure of subcutaneous abdominal adipose tissue derived AD-MSCs to high glucose (H...

    Authors: Sabyasachi Sen, Cleyton C. Domingues, Carol Rouphael, Cyril Chou, Chul Kim and Nagendra Yadava

    Citation: Stem Cell Research & Therapy 2015 6:242

    Content type: Research

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  5. The use of stem cells from adipose tissue or adipose-derived stem cells (ASCs) in regenerative medicine could be an interesting alternative to bone marrow stem cells because they are easily accessible and avai...

    Authors: Jonathan Rodriguez, Fabien Boucher, Charlotte Lequeux, Audrey Josset-Lamaugarny, Ondine Rouyer, Orianne Ardisson, Héléna Rutschi, Dominique Sigaudo-Roussel, Odile Damour and Ali Mojallal

    Citation: Stem Cell Research & Therapy 2015 6:241

    Content type: Research

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  6. Treating a myocardial infarction (MI), the most frequent cause of death worldwide, remains one of the most exciting medical challenges in the 21st century. Cardiac tissue engineering, a novel emerging treatmen...

    Authors: Isaac Perea-Gil, Cristina Prat-Vidal and Antoni Bayes-Genis

    Citation: Stem Cell Research & Therapy 2015 6:248

    Content type: Review

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  7. Pathophysiological changes associated with chronic kidney disease impair angiogenic processes and increase renal fibrosis. Progenitor-like cells derived from adult kidney have been previously used to promote r...

    Authors: CL Chen, KJ Chou, HC Fang, CY Hsu, WC Huang, CW Huang, CK Huang, HY Chen and PT Lee

    Citation: Stem Cell Research & Therapy 2015 6:239

    Content type: Research

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  8. Extracellular vesicles (EVs) are a heterogeneous population of naturally occurring secreted small vesicles, with distinct biophysical properties and different functions both in physiology and under pathologica...

    Authors: Almudena Fuster-Matanzo, Florian Gessler, Tommaso Leonardi, Nunzio Iraci and Stefano Pluchino

    Citation: Stem Cell Research & Therapy 2015 6:227

    Content type: Review

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  9. Stem cells are considered an important resource for tissue repair and regeneration. Their utilization in regenerative medicine will be aided by mechanistic insight into their responsiveness to external stimuli...

    Authors: Natasha Baker, Jihee Sohn and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2015 6:238

    Content type: Research

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  10. Mesenchymal stem/stromal cells (MSCs) improve the metabolic function of co-cultured hepatocytes. The present study aimed to further enhance the trophic effects of co-culture with hepatocytes using hypoxic prec...

    Authors: Harry H. Qin, Céline Filippi, Song Sun, Sharon Lehec, Anil Dhawan and Robin D. Hughes

    Citation: Stem Cell Research & Therapy 2015 6:237

    Content type: Research

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  11. The inherent immunomodulatory capacity of mesenchymal stem/progenitor cells (MSPCs) encouraged initiation of multiple clinical trials. Release criteria for therapeutic MSPCs cover identity, purity and safety b...

    Authors: Nina Ketterl, Gabriele Brachtl, Cornelia Schuh, Karen Bieback, Katharina Schallmoser, Andreas Reinisch and Dirk Strunk

    Citation: Stem Cell Research & Therapy 2015 6:236

    Content type: Method

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  12. Bone marrow-derived mesenchymal stem cells (BM-MSCs) for clinical use should not be grown in media containing fetal bovine serum (FBS), because of serum-related concerns over biosafety and batch-to-batch varia...

    Authors: Rubie Rakian, Travis J. Block, Shannan M. Johnson, Milos Marinkovic, Junjie Wu, Qiuxia Dai, David D. Dean and Xiao-Dong Chen

    Citation: Stem Cell Research & Therapy 2015 6:235

    Content type: Research

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  13. Mesenchymal stem cells (MSCs) are ideal for cell-based therapy in various inflammatory diseases because of their immunosuppressive and tissue repair properties. Moreover, their immunosuppressive properties and...

    Authors: Jun Zhang, Xiaowen Huang, Haijun Wang, Xiaoyan Liu, Tao Zhang, Yunchuan Wang and Dahai Hu

    Citation: Stem Cell Research & Therapy 2015 6:234

    Content type: Review

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  14. Equine superficial digital flexor tendon injury is a well-accepted model of human tendon injury and is routinely treated with local injections of autologous mesenchymal stem cells (MSCs). Identification of a c...

    Authors: Alexis Mitchell, Kristen A. Rivas, Roger Smith III and Ashlee E. Watts

    Citation: Stem Cell Research & Therapy 2015 6:231

    Content type: Research

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  15. Endothelial progenitor cells (EPCs) improve survival and reduce organ failure in cecal ligation and puncture-induced sepsis; however, expanded EPCs may represent an even better approach for vascular repair. To...

    Authors: Andreas Güldner, Tatiana Maron-Gutierrez, Soraia Carvalho Abreu, Debora Gonçalves Xisto, Alexandra Cristina Senegaglia, Patty Rose da Silva Barcelos, Johnatas Dutra Silva, Paulo Brofman, Marcelo Gama de Abreu and Patricia Rieken Macedo Rocco

    Citation: Stem Cell Research & Therapy 2015 6:230

    Content type: Short report

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  16. Mesenchymal stem cells can potentially be used in therapy for spinal cord injury (SCI). Methylprednisolone sodium succinate (MPSS) has been used as a scavenging agent in acute SCI treatment, but its use no lon...

    Authors: Yongsun Kim, Sung-ho Jo, Wan Hee Kim and Oh-Kyeong Kweon

    Citation: Stem Cell Research & Therapy 2015 6:229

    Content type: Research

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  17. Although mesenchymal stem cells (MSCs) from different sources share many similar characteristics, they also exhibit individual properties. In this study, we compared MSCs derived from Wharton’s jelly in the um...

    Authors: Gecai Chen, Aihuan Yue, Zhongbao Ruan, Yigang Yin, Ruzhu Wang, Yin Ren and Li Zhu

    Citation: Stem Cell Research & Therapy 2015 6:228

    Content type: Research

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  18. Human mesenchymal stem cells (hMSCs) have been approved for therapeutic applications. Despite the advances in this field, in vitro approaches are still required to improve the essential indices that would pave...

    Authors: Maryam Hafizi, Atena Hajarizadeh, Amir Atashi, Somayeh Kalanaky, Saideh Fakharzadeh, Zahra Masoumi, Mohammad Hassan Nazaran and Masoud Soleimani

    Citation: Stem Cell Research & Therapy 2015 6:226

    Content type: Research

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  19. Human mesenchymal stem cells (hMSCs), also called mesenchymal stromal cells, have been of great interest in regenerative medicine applications because of not only their differentiation potential but also their...

    Authors: Krishna M. Panchalingam, Sunghoon Jung, Lawrence Rosenberg and Leo A. Behie

    Citation: Stem Cell Research & Therapy 2015 6:225

    Content type: Review

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  20. In previous study the streptavidin interleukin-2 (SA-IL-2)-modified MB49 vaccine was effective against bladder cancer in a mouse model. However, a small portion of tumors regrew because the vaccine could not e...

    Authors: Yong-tong Zhu, Shi-yu Pang, Cheng-yong Lei, Yang Luo, Qing-jun Chu and Wan-long Tan

    Citation: Stem Cell Research & Therapy 2015 6:224

    Content type: Research

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  21. Human induced pluripotent stem cells (hiPSCs) are considered as one of the most promising seed cell sources in regenerative medicine. Now hiPSC-based clinical trials are underway. To ensure clinical safety, ce...

    Authors: Juan Wang, Jie Hao, Donghui Bai, Qi Gu, Weifang Han, Lei Wang, Yuanqing Tan, Xia Li, Ke Xue, Pencheng Han, Zhengxin Liu, Yundan Jia, Jun Wu, Lei Liu, Liu Wang, Wei Li…

    Citation: Stem Cell Research & Therapy 2015 6:223

    Content type: Research

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  22. Mesenchymal stem (stromal) cells (MSCs) possess self-renewal, differentiation and immunoregulatory properties, and therefore are being evaluated as cellular therapy for inflammatory and autoimmune diseases, an...

    Authors: Mahesh Khatri, Timothy D. O’Brien, Kuldeep S. Chattha and Linda J. Saif

    Citation: Stem Cell Research & Therapy 2015 6:222

    Content type: Research

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  23. This study was aimed at deciphering the secretome of adipose-derived mesenchymal stromal cells (ADSCs) cultured in standard and hypoxic conditions to reveal proteins, which may be responsible for regenerative ...

    Authors: Natalia Kalinina, Daria Kharlampieva, Marina Loguinova, Ivan Butenko, Olga Pobeguts, Anastasia Efimenko, Luidmila Ageeva, George Sharonov, Dmitry Ischenko, Dmitry Alekseev, Olga Grigorieva, Veronika Sysoeva, Ksenia Rubina, Vassiliy Lazarev and Vadim Govorun

    Citation: Stem Cell Research & Therapy 2015 6:221

    Content type: Research

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  24. Spinal V3 interneurons (INs) are a commissural, glutamatergic, propriospinal neuron population that holds great potential for understanding locomotion circuitry and local rewiring after spinal cord injury. Emb...

    Authors: Hao Xu, Nisha Iyer, James E. Huettner and Shelly E. Sakiyama-Elbert

    Citation: Stem Cell Research & Therapy 2015 6:220

    Content type: Research

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  25. Degenerative retinal diseases like age-related macular degeneration (AMD) are the leading cause of blindness. Cell transplantation showed promising therapeutic effect for such diseases, and embryonic stem cell...

    Authors: Zepeng Qu, Yuan Guan, Lu Cui, Jian Song, Junjie Gu, Hanzhi Zhao, Lei Xu, Lixia Lu, Ying Jin and Guo-Tong Xu

    Citation: Stem Cell Research & Therapy 2015 6:219

    Content type: Research

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  26. During endochondral ossification, both the production of a cartilage template and the subsequent vascularisation of that template are essential precursors to bone tissue formation. Recent studies have found th...

    Authors: Fiona E. Freeman, Ashley B. Allen, Hazel Y. Stevens, Robert E. Guldberg and Laoise M. McNamara

    Citation: Stem Cell Research & Therapy 2015 6:218

    Content type: Research

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  27. Adult stem cell-derived hepatocytes transplantation holds considerable promise for future clinical individualized therapy of liver failure or dysfunction. However, the low engraftment of the available hepatocy...

    Authors: Jie Yuan, Weihong Li, Jieqiong Huang, Xinyue Guo, Xueyang Li, Xin Lu, Xiaowu Huang and Haiyan Zhang

    Citation: Stem Cell Research & Therapy 2015 6:217

    Content type: Research

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  28. Because of their ease of isolation and relative abundance, adipose-derived mesenchymal stem cells (ASCs) are a particularly attractive autologous cell source for various therapeutic purposes. ASCs retain a hig...

    Authors: Morikuni Tobita, Satoshi Tajima and Hiroshi Mizuno

    Citation: Stem Cell Research & Therapy 2015 6:215

    Content type: Review

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  29. Radiation myelitis is a rather rare but devastating complication following therapeutic irradiation to neoplasms when the spinal cord is included within the radiation field. Symptoms of radiation myelitis with ...

    Authors: Jun Liang, Fan Wang, Dandan Wang, Huayong Zhang, Cheng Zhao, Shiying Wang and Lingyun Sun

    Citation: Stem Cell Research & Therapy 2015 6:213

    Content type: Short report

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  30. Stem cells from adult tissues were considered for a long time as promising tools for regenerative therapy of neurological diseases, including spinal cord injuries (SCI). Indeed, mesenchymal (MSCs) and neural c...

    Authors: Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion, Bernard Rogister, Rachelle Franzen and Sabine Wislet

    Citation: Stem Cell Research & Therapy 2015 6:211

    Content type: Research

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  31. Stem cells have great therapeutic potential due to their capacity for self-renewal and their potential for differentiating into multiple cell lineages. It has been recently shown that the host immune system ha...

    Authors: Yu Cao, Jimin Xiong, Shenghui Mei, Fu Wang, Zhigang Zhao, Songlin Wang and Yi Liu

    Citation: Stem Cell Research & Therapy 2015 6:210

    Content type: Research

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  32. Endothelial dysfunction is found in different pathologies such as diabetes and renal and heart diseases, representing one of the major health problems. The reduced vasodilation of impaired endothelium starts a...

    Authors: Andrea Alex Schiavo, Chiara Franzin, Mattia Albiero, Martina Piccoli, Giovanna Spiro, Enrica Bertin, Luca Urbani, Silvia Visentin, Erich Cosmi, Gian Paolo Fadini, Paolo De Coppi and Michela Pozzobon

    Citation: Stem Cell Research & Therapy 2015 6:209

    Content type: Research

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  33. Effective therapies for obesity and diabetes are still lacking. The aim of this study was to evaluate whether a single intravenous infusion of syngeneic adipose-derived mesenchymal stem cells (ASCs) can reduce...

    Authors: Mingjun Cao, Qingjie Pan, Huansheng Dong, Xinxu Yuan, Yang Li, Zhen Sun, Xiao Dong and Hongjun Wang

    Citation: Stem Cell Research & Therapy 2015 6:208

    Content type: Research

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  34. Despite the strong appeal of ferritin as a magnetic resonance imaging (MRI) reporter for stem cell research, no attempts have been made to apply this genetic imaging reporter in stem cells in an inducible mann...

    Authors: Xiaoya He, Jinhua Cai, Bo Liu, Yi Zhong and Yong Qin

    Citation: Stem Cell Research & Therapy 2015 6:207

    Content type: Research

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  35. The fate and whereabouts of the allogenic mesenchymal stem cells (MSCs) following their transplantation are not well understood. The present study investigated the fate of systemically administrated allogeneic...

    Authors: Shuo Huang, Liangliang Xu, Yuxin Sun, Yifeng Zhang and Gang Li

    Citation: Stem Cell Research & Therapy 2015 6:206

    Content type: Research

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  36. The mammalian adult heart maintains a continuous, low cardiomyocyte turnover rate throughout life. Although many cardiac stem cell populations have been studied, the natural source for homeostatic repair has n...

    Authors: Iñigo Valiente-Alandi, Carmen Albo-Castellanos, Diego Herrero, Elvira Arza, Maria Garcia-Gomez, José C. Segovia, Mario Capecchi and Antonio Bernad

    Citation: Stem Cell Research & Therapy 2015 6:205

    Content type: Research

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  37. Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. Administration technique is crucial and among others minimal constructs -...

    Authors: Pavel I. Makarevich, Maria A. Boldyreva, Evgeny V. Gluhanyuk, Anastasia Yu Efimenko, Konstantin V. Dergilev, Evgeny K. Shevchenko, Georgy V. Sharonov, Julia O. Gallinger, Polina A. Rodina, Stepan S. Sarkisyan, Yu-Chen Hu and Yelena V. Parfyonova

    Citation: Stem Cell Research & Therapy 2015 6:204

    Content type: Research

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  38. Mesenchymal stem cells (MSCs) hold great promise for regenerative therapies in the musculoskeletal system. Although MSCs from bone marrow (BM-MSCs) and adipose tissue (AD-MSCs) have been extensively characteri...

    Authors: Joseph S. Fernandez-Moure, Bruna Corradetti, Paige Chan, Jeffrey L. Van Eps, Trevor Janecek, Pranela Rameshwar, Bradley K. Weiner and Ennio Tasciotti

    Citation: Stem Cell Research & Therapy 2015 6:203

    Content type: Research

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  39. Mesenchymal stem cells (MSCs) can protect bone marrow transplantation (BMT) recipients from the lethal acute graft-versus-host disease (aGVHD) development. However, the mechanisms underlying the anti-inflammat...

    Authors: Kyoung-Woon Kim, Su-Jin Moon, Min-Jung Park, Bo-Mi Kim, Eun-Kyung Kim, Sung-Hee Lee, Eun-Jung Lee, Byung-Ha Chung, Chul-Woo Yang and Mi-La Cho

    Citation: Stem Cell Research & Therapy 2015 6:202

    Content type: Research

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    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:80

  40. Ex vivo expansion of umbilical cord blood (UCB) is attempted to increase cell numbers to overcome the limitation of cell dose. Presently, suspension cultures or feeder mediated co-cult...

    Authors: Darshana Kadekar, Vaijayanti Kale and Lalita Limaye

    Citation: Stem Cell Research & Therapy 2015 6:201

    Content type: Research

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  41. Osteoporosis is a syndrome of excessive skeletal fragility characterized by the loss of mass and deterioration of microarchitecture in bone. Single use of aspirin or adipose-derived stromal cells (ASCs) has be...

    Authors: Hao Liu, Wei Li, Yunsong Liu, Xiao Zhang and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2015 6:200

    Content type: Research

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  42. Sepsis is a clinical syndrome associated with a severe systemic inflammation induced by infection. Although different anti-microbial drugs have been used as treatments, morbidity and mortality rates remain hig...

    Authors: Francisca Alcayaga-Miranda, Jimena Cuenca, Aldo Martin, Luis Contreras, Fernando E. Figueroa and Maroun Khoury

    Citation: Stem Cell Research & Therapy 2015 6:199

    Content type: Research

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  43. Cancer stem cells (CSCs) possess characteristics associated with normal stem cells, specifically the abilities to renew themselves and to give rise to all cell types (differentiation). It is assumed that induc...

    Authors: Shuqiang Yuan, Yunxin Lu, Jing Yang, Gang Chen, Sangbae Kim, Li Feng, Marcia Ogasawara, Naima Hammoudi, Weiqin Lu, Hui Zhang, Jinyun Liu, Howard Colman, Ju-Seog Lee, Xiao-Nan Li, Rui-hua Xu, Peng Huang…

    Citation: Stem Cell Research & Therapy 2015 6:198

    Content type: Research

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  44. There is a clinical need for developing systemic transplantation protocols for use of human skeletal stem cells (also known bone marrow stromal stem cells) (hBMSC) in tissue regeneration. In systemic transplan...

    Authors: Rikke K. Andersen, Walid Zaher, Kenneth H. Larsen, Nicholas Ditzel, Katharina Drews, Wasco Wruck, James Adjaye, Basem M. Abdallah and Moustapha Kassem

    Citation: Stem Cell Research & Therapy 2015 6:196

    Content type: Research

    Published on:

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