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  1. Content type: Commentary

    Reprogramming strategies allow for the generation of virtually any cell type of the human body, which could be useful for cell-based therapy. Among the different reprogramming technologies available, direct li...

    Authors: Emmanuel Nivet, Ignacio Sancho-Martinez and Juan Carlos Izpisua Belmonte

    Citation: Stem Cell Research & Therapy 2013 4:2

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  2. Content type: Research

    A feature which makes stem cells promising candidates for cell therapy is their ability to migrate effectively into damaged or diseased tissues. Recent reports demonstrated the increased motility of human mese...

    Authors: Grigory Vertelov, Ludmila Kharazi, M G Muralidhar, Givon Sanati, Timothy Tankovich and Alex Kharazi

    Citation: Stem Cell Research & Therapy 2013 4:5

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  3. Content type: Research

    Stimulating the commitment of implanted dystrophin+ muscle-derived stem cells (MDSCs) into myogenic, as opposed to lipofibrogenic lineages, is a promising therapeutic strategy for Duchenne muscular dystrophy (...

    Authors: James Tsao, Dolores A Vernet, Robert Gelfand, Istvan Kovanecz, Gaby Nolazco, Kevin W Bruhn and Nestor F Gonzalez-Cadavid

    Citation: Stem Cell Research & Therapy 2013 4:4

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  4. Content type: Research

    Nervous system injuries comprise a diverse group of disorders that include traumatic brain injury (TBI). The potential of mesenchymal stem cells (MSCs) to differentiate into neural cell types has aroused hope ...

    Authors: Joan E Nichols, Jean A Niles, Douglas DeWitt, Donald Prough, Margaret Parsley, Stephanie Vega, Andrea Cantu, Eric Lee and Joaquin Cortiella

    Citation: Stem Cell Research & Therapy 2013 4:3

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  5. Content type: Research

    This study investigated the promising effect of a new Platelet Glue obtained from Cryoprecipitation of Apheresis Platelet products (PGCAP) used in combination with Mesenchymal Stromal Cells (MSC) loaded on cer...

    Authors: Marina Trouillas, Marie Prat, Christelle Doucet, Isabelle Ernou, Corinne Laplace-Builhé, Patrick Saint Blancard, Xavier Holy and Jean-Jacques Lataillade

    Citation: Stem Cell Research & Therapy 2013 4:1

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  6. Content type: Research

    Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) are self-renewing multipotent progenitors with the potential to differentiate into multiple lineages of mesoderm, in addition to generating ecto...

    Authors: Mundackal S Divya, George E Roshin, Thulasi S Divya, Vazhanthodi Abdul Rasheed, Thankayyan R Santhoshkumar, Kandathil E Elizabeth, Jackson James and Radhakrishna M Pillai

    Citation: Stem Cell Research & Therapy 2012 3:57

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  7. Content type: Commentary

    Human embryonic stem cells (hESCs) have been reported to confer cytoprotection in the context of tissue injury. This is somewhat counterintuitive given that microenvironmental factors such as hypoxia and oxida...

    Authors: Eoin P Cummins

    Citation: Stem Cell Research & Therapy 2012 3:52

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  8. Content type: Research

    Transplantation of neural stem cells (NSCs) is increasingly suggested to become part of future therapeutic approaches to improve functional outcome of various central nervous system disorders. However, recentl...

    Authors: Kristien Reekmans, Nathalie De Vocht, Jelle Praet, Erik Fransen, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Annemie Van der Linden, Zwi Berneman and Peter Ponsaerts

    Citation: Stem Cell Research & Therapy 2012 3:56

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  9. Content type: Review

    Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. To maintain their capacities for division and differentiation and thereby build, maintain, and regenerate organ structure ...

    Authors: Anthony Conway and David V Schaffer

    Citation: Stem Cell Research & Therapy 2012 3:50

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  10. Content type: Research

    One of the most challenging safety issues in the manufacture of cell based medicinal products is the control of microbial risk as cell-based products cannot undergo terminal sterilization. Accordingly, sensiti...

    Authors: Mika Pietilä, Kaarina Lähteenmäki, Siri Lehtonen, Hannu-Ville Leskelä, Marko Närhi, Maarit Lönnroth, Jaana Mättö, Petri Lehenkari and Katrina Nordström

    Citation: Stem Cell Research & Therapy 2012 3:53

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  11. Content type: Research

    We previously found that mesenchymal stem cells (MSCs) injected intravenously could attenuate peritoneal adhesion by secreting tumor necrosis alpha-stimulating gene (TSG)-6, while MSCs injected intraperitoneal...

    Authors: Nan Wang, Yeqing Shao, Yan Mei, Li Zhang, Qinggang Li, Diangeng Li, Suozhu Shi, Quan Hong, Hongli Lin and Xiangmei Chen

    Citation: Stem Cell Research & Therapy 2012 3:51

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  12. Content type: Research

    This prospective cohort study aimed to assess the influence of stem cell therapy (SCT) on health-related quality of life (HRQOL) by using the SF-36 v2 and to elucidate the influence of objective clinical varia...

    Authors: Hosny Salama, Abdel-Rahamn N Zekri, Rasha Ahmed, Iman Medhat, El Sayed Abdallah, Tarneem Darwish, Ola S Ahmed and Abeer Bahnassy

    Citation: Stem Cell Research & Therapy 2012 3:49

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  13. Content type: Research

    Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent cells that can differentiate into different cell lineages and have emerged as a promising tool for cell-targeted therapies and tissue engineering. T...

    Authors: Serena Redaelli, Angela Bentivegna, Dana Foudah, Mariarosaria Miloso, Juliana Redondo, Gabriele Riva, Simona Baronchelli, Leda Dalprà and Giovanni Tredici

    Citation: Stem Cell Research & Therapy 2012 3:47

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  14. Content type: Review

    Controlled expansion and differentiation of pluripotent stem cells (PSCs) using reproducible, high-throughput methods could accelerate stem cell research for clinical therapies. Hydrodynamic culture systems fo...

    Authors: Krista M Fridley, Melissa A Kinney and Todd C McDevitt

    Citation: Stem Cell Research & Therapy 2012 3:45

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  15. Content type: Review

    The assembly of cells into tissues is a complex process controlled by numerous signaling pathways to ensure the fidelity of the final structure. Tissue assembly is also very dynamic, as exemplified by the form...

    Authors: Sriram Manivannan and Celeste M Nelson

    Citation: Stem Cell Research & Therapy 2012 3:42

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  16. Content type: Review

    Stem cells interact with biochemical and biophysical signals in their extracellular environment. The biophysical signals are transduced to the stem cells either through the underlying extracellular matrix or e...

    Authors: Evelyn KF Yim and Michael P Sheetz

    Citation: Stem Cell Research & Therapy 2012 3:41

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  17. Content type: Research

    Induced pluripotent stem cells (iPSCs) are a potent cell source for neurogenesis. Previously we have generated iPSCs from human dental stem cells carrying transgene vectors. These exogenous transgenes may affe...

    Authors: Xiao-Ying Zou, Hsiao-Ying Yang, Zongdong Yu, Xiao-Bing Tan, Xing Yan and George T-J Huang

    Citation: Stem Cell Research & Therapy 2012 3:43

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  18. Content type: Research

    Bone marrow mesenchymal stem cells (BMMSCs) are a heterogeneous population of postnatal precursor cells with the capacity of adhering to culture dishes generating colony-forming unit-fibroblasts (CFU-F). Here ...

    Authors: Kentaro Akiyama, Yong-Ouk You, Takayoshi Yamaza, Chider Chen, Liang Tang, Yan Jin, Xiao-Dong Chen, Stan Gronthos and Songtao Shi

    Citation: Stem Cell Research & Therapy 2012 3:40

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  19. Content type: Research

    X-linked adrenoleukodystrophy (X-ALD) is a complex disorder with variable expressivity that affects the nervous, adrenocortical and male reproductive systems. Although ABCD1 mutations are known to provide the gen...

    Authors: Xiao-Ming Wang, Wing Yan Yik, Peilin Zhang, Wange Lu, Patricia K Dranchak, Darryl Shibata, Steven J Steinberg and Joseph G Hacia

    Citation: Stem Cell Research & Therapy 2012 3:39

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  20. Content type: Review

    Cellular therapy products are an emerging medical product class undergoing rapid scientific and clinical innovation worldwide. These products pose unique regulatory challenges both for countries with existing ...

    Authors: Judith A Arcidiacono, Joan W Blair and Kimberly A Benton

    Citation: Stem Cell Research & Therapy 2012 3:38

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  21. Content type: Review

    Therapeutic strategies using stem cells for treating neurological diseases are receiving more attention as the scientific community appreciates cell-autonomous contributions to several diseases of the central ...

    Authors: Akshata A Almad and Nicholas J Maragakis

    Citation: Stem Cell Research & Therapy 2012 3:37

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  22. Content type: Research

    A number of questions remain unanswered in the field of cell therapy for acute myocardial infarction, including what is the optimal cell type, and can therapeutic efficacy be enhanced by conditioning regimens....

    Authors: Aidan Flynn, Xizhe Chen, Enda O'Connell and Timothy O'Brien

    Citation: Stem Cell Research & Therapy 2012 3:36

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  23. Content type: Review

    The recent derivation of disease-specific induced pluripotent stem cells (iPSCs) from somatic cells of patients with familial and sporadic forms of diseases and the demonstration of their ability to give rise ...

    Authors: Hsiang-Po Huang, Ching-Yu Chuang and Hung-Chih Kuo

    Citation: Stem Cell Research & Therapy 2012 3:34

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  24. Content type: Research

    Adipose stem cells (ASCs) secrete many trophic factors that can stimulate tissue repair, including angiogenic factors, but little is known about how ASCs and their secreted factors influence cartilage regenera...

    Authors: Christopher SD Lee, Olivia A Burnsed, Vineeth Raghuram, Jonathan Kalisvaart, Barbara D Boyan and Zvi Schwartz

    Citation: Stem Cell Research & Therapy 2012 3:35

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  25. Content type: Review

    Ischaemia-related diseases such as peripheral artery disease and coronary heart disease constitute a major issue in medicine as they affect millions of individuals each year and represent a considerable econom...

    Authors: Christina L O'Neill, Michelle T O'Doherty, Sarah EJ Wilson, Amer A Rana, Claire E Hirst, Alan W Stitt and Reinhold J Medina

    Citation: Stem Cell Research & Therapy 2012 3:31

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  26. Content type: Research

    The adult mammalian brain retains niches for neural stem cells (NSCs), which can generate glial and neuronal components of the brain tissue. However, it is barely established how chronic neuroinflammation, as ...

    Authors: Maik MA Worlitzer, Eva C Bunk, Kathrin Hemmer and Jens C Schwamborn

    Citation: Stem Cell Research & Therapy 2012 3:33

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  27. Content type: Research

    The influence of genetic background on the ability to generate induced pluripotent stem cells (iPSCs) has the potential to impact future applications, but has yet to be examined in detail. The purpose of this ...

    Authors: Lauren V Schnabel, Christian M Abratte, John C Schimenti, Teresa L Southard and Lisa A Fortier

    Citation: Stem Cell Research & Therapy 2012 3:30

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  28. Content type: Research

    Embryonic stem cells (ESCs) provide an attractive cell source for basic research and disease treatment. Currently, the common culture system for mouse ESC requires mouse embryonic fibroblast (MEF) as a feeder ...

    Authors: Yu Ma, Junjie Gu, Chunliang Li, Xiaoyuan Wei, Fan Tang, Guilai Shi, Jing Jiang, Ying Kuang, Jinsong Li, Zhugang Wang, Xin Xie and Ying Jin

    Citation: Stem Cell Research & Therapy 2012 3:29

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  29. Content type: Editorial

    The remarkable speed with which the field of stem cell biology has evolved is unprecedented and has already changed the way we do science. In this series of articles we have invited leading experts to present ...

    Authors: Mahendra Rao

    Citation: Stem Cell Research & Therapy 2012 3:27

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  30. Content type: Review

    Aastrom Biosciences has developed a proprietary cell-processing technology that enables the manufacture of ixmyelocel-T, a patient-specific multicellular therapy expanded from a small sample of a patient's own...

    Authors: Ronnda L Bartel, Caryn Cramer, Kelly Ledford, Amy Longcore, Christopher Parrish, Theresa Stern, Sharon Watling and Frank Zeigler

    Citation: Stem Cell Research & Therapy 2012 3:26

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  31. Content type: Review

    Osteoarthritis (OA) is a degenerative disease of the connective tissue and progresses with age in the older population or develops in young athletes following sports-related injury. The articular cartilage is ...

    Authors: Pawan K Gupta, Anjan K Das, Anoop Chullikana and Anish S Majumdar

    Citation: Stem Cell Research & Therapy 2012 3:25

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  32. Content type: Review

    Injury and disease of the spinal cord are generally met with a poor prognosis. This poor prognosis is due not only to the characteristics of the diseases but also to our poor ability to deliver therapeutics to...

    Authors: Eleanor M Donnelly, Jason Lamanna and Nicholas M Boulis

    Citation: Stem Cell Research & Therapy 2012 3:24

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  33. Content type: Research

    Endothelial progenitor cells (EPC) capable of initiating or augmenting vascular growth were recently identified within the small population of CD34-expressing cells that circulate in human peripheral blood and...

    Authors: G Robin Barclay, Olga Tura, Kay Samuel, Patrick WF Hadoke, Nicholas L Mills, David E Newby and Marc L Turner

    Citation: Stem Cell Research & Therapy 2012 3:23

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  34. Content type: Research

    Transplantation of genetically modified human bone marrow-derived mesenchymal stem cells (hMSCs) with an accurate potential for chondrogenic differentiation may be a powerful means to enhance the healing of ar...

    Authors: Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn and Magali Cucchiarini

    Citation: Stem Cell Research & Therapy 2012 3:22

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  35. Content type: Commentary

    Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important...

    Authors: Karl JA McCullagh

    Citation: Stem Cell Research & Therapy 2012 3:19

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  36. Content type: Research

    It is hypothesized that administration of stromal/stem cells isolated from the adipose tissue (ASCs) and umbilical cord (HUCPVCs) can ameliorate the injured central nervous system (CNS). It is still not clear,...

    Authors: Carlos A Ribeiro, Joana S Fraga, Mário Grãos, Nuno M Neves, Rui L Reis, Jeffrey M Gimble, Nuno Sousa and António J Salgado

    Citation: Stem Cell Research & Therapy 2012 3:18

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  37. Content type: Commentary

    The clinical use of stem cells, such as bone marrow-derived and, more recently, resident cardiac stem cells, offers great promise for treatment of myocardial infarction and heart failure. The epicardium-derive...

    Authors: Nenad Bursac

    Citation: Stem Cell Research & Therapy 2012 3:15

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  38. Content type: Review

    Stem cells have tremendous applications in the field of regenerative medicine and tissue engineering. These are pioneering fields that aim to create new treatments for disease that currently have limited thera...

    Authors: Ian Wimpenny, Hareklea Markides and Alicia J El Haj

    Citation: Stem Cell Research & Therapy 2012 3:13

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  39. Content type: Research

    Down syndrome (DS), a major cause of mental retardation, is caused by trisomy of some or all of human chromosome 21 and includes three basic karyotypes: trisomy 21, translocation, and mosaicism. The derivation...

    Authors: Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma and Hao Zhang

    Citation: Stem Cell Research & Therapy 2012 3:14

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