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  1. Skeletal disorders are among the leading debilitating factors affecting millions of people worldwide. The use of stem cells for tissue repair has raised many promises in various medical fields, including skele...

    Authors: Parisa Kangari, Tahereh Talaei-Khozani, Iman Razeghian-Jahromi and Mahboobeh Razmkhah
    Citation: Stem Cell Research & Therapy 2020 11:492
    Content type: Review Published on:

  3. Fat grafting, as a standard treatment for numerous soft tissue defects, remains unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are promising candidates for cell-assisted thera...

    Authors: Fei Yu, Nevin Witman, Dan Yan, Siyi Zhang, Meng Zhou, Yan Yan, Qinke Yao, Feixue Ding, Bingqian Yan, Huijing Wang, Wei Fu, Yang Lu and Yao Fu
    Citation: Stem Cell Research & Therapy 2020 11:490
    Content type: Research Published on:

  4. Over the last decades, the cancer survival rate has increased due to personalized therapies, the discovery of targeted therapeutics and novel biological agents, and the application of palliative treatments. De...

    Authors: Fiorella Rossi, Hunter Noren, Richard Jove, Vladimir Beljanski and Karl-Henrik Grinnemo
    Citation: Stem Cell Research & Therapy 2020 11:489
    Content type: Review Published on:

  5. Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes. Three-dimensional (3D) culture is important for the acq...

    Authors: Xiaofang Liu, Jinhua Qin, Mingyang Chang, Shuyong Wang, Yali Li, Xuetao Pei and Yunfang Wang
    Citation: Stem Cell Research & Therapy 2020 11:488
    Content type: Research Published on:

  6. Osteoporosis is a common metabolic bone disease without effective treatment. Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into multiple cell types. Increased adipogeni...

    Authors: Guilin Chen, Yujuan Zhuo, Bo Tao, Qian Liu, Wenlong Shang, Yinxiu Li, Yuhong Wang, Yanli Li, Lei Zhang, Yanwen Fang, Xin Zhang, Zhicai Fang and Ying Yu
    Citation: Stem Cell Research & Therapy 2020 11:487
    Content type: Research Published on:

  7. Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, mechanistic studies of the function of these cells have...

    Authors: Jong Ho Choi, Jin Seok, Seung Mook Lim, Tae Hee Kim and Gi Jin Kim
    Citation: Stem Cell Research & Therapy 2020 11:486
    Content type: Research Published on:

  8. Stroke is the leading cause of long-term motor disability and cognitive impairment. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. It is important to understand th...

    Authors: Zhaoli Hu, Fengying Li, Xiaoling Zhou, Feng Zhang, Linyan Huang, Bing Gu, Jiangang Shen and Suhua Qi
    Citation: Stem Cell Research & Therapy 2020 11:485
    Content type: Research Published on:

  10. During the last years, several strategies have been made to obtain mature erythrocytes or red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB-derived hematopoietic stem cells...

    Authors: Mohsen Ebrahimi, Mehdi Forouzesh, Setareh Raoufi, Mohammad Ramazii, Farhoodeh Ghaedrahmati and Maryam Farzaneh
    Citation: Stem Cell Research & Therapy 2020 11:483
    Content type: Review Published on:

  11. Human dermal mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter ABCB5 represent an easily accessible MSC population that, based on preclinical and first-in-human data...

    Authors: Seda Ballikaya, Samar Sadeghi, Elke Niebergall-Roth, Laura Nimtz, Jens Frindert, Alexandra Norrick, Nicole Stemler, Nicole Bauer, Yvonne Rosche, Vanessa Kratzenberg, Julia Pieper, Tina Ficek, Markus H. Frank, Christoph Ganss, Jasmina Esterlechner and Mark A. Kluth
    Citation: Stem Cell Research & Therapy 2020 11:482
    Content type: Research Published on:

  12. Human induced pluripotent stem cells (hiPSCs) offer a renewable source of cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and drug screening. However, current serum/fe...

    Authors: Ratchapong Netsrithong, Siriwal Suwanpitak, Bootsakorn Boonkaew, Kongtana Trakarnsanga, Lung-Ji Chang, Chartsiam Tipgomut, Chinnavuth Vatanashevanopakorn, Kovit Pattanapanyasat and Methichit Wattanapanitch
    Citation: Stem Cell Research & Therapy 2020 11:481
    Content type: Research Published on:

  13. Nontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator inhibitor 1 (PAI-1) has been reported to be positively associated wit...

    Authors: Lu Li, Yikai Wang, Xiaobing Yu, Yongming Bao, Lijia An, Xiaowei Wei, Weiting Yu, Baoyi Liu, Junlei Li, Jiahui Yang, Yan Xia, Ge Liu, Fang Cao, Xiuzhi Zhang and Dewei Zhao
    Citation: Stem Cell Research & Therapy 2020 11:480
    Content type: Research Published on:

  14. Intrauterine adhesions (IUAs) are manifestations of endometrial fibrosis characterized by inflammation and fibrinogen aggregation in the extracellular matrix (ECM). The available therapeutic interventions for ...

    Authors: Limin Liu, Guobin Chen, Taoliang Chen, Wenjuan Shi, Haiyan Hu, Kaijing Song, Ruichun Huang, Huihua Cai and Yuanli He
    Citation: Stem Cell Research & Therapy 2020 11:479
    Content type: Research Published on:

  15. Our previous studies demonstrated that adipose-derived mesenchymal stromal cells (ASCs) have immunomodulatory effects that prolong allograft survival in a rodent hind-limb allotransplant model. In this study, ...

    Authors: Chien-Chang Chen, Rong-Fu Chen, Jheng-Syuan Shao, Yun-Ting Li, Yu-Chi Wang, Gerald Brandacher, Jiin-Haur Chuang and Yur-Ren Kuo
    Citation: Stem Cell Research & Therapy 2020 11:478
    Content type: Research Published on:

  16. Idiopathic pulmonary fibrosis is a kind of diffuse interstitial lung disease, the pathogenesis of which is unclear, and there is currently a lack of good treatment to improve the survival rate. Human menstrual...

    Authors: Xin Chen, Yi Wu, Yanling Wang, Lijun Chen, Wendi Zheng, Sining Zhou, Huikang Xu, Yifei Li, Li Yuan and Charlie Xiang
    Citation: Stem Cell Research & Therapy 2020 11:477
    Content type: Research Published on:

  17. Dentigerous cyst (DC) is a bone destructive disease and remains a challenge for clinicians. Marsupialization enables the bone to regenerate with capsule maintaining, making it a preferred therapeutic means for...

    Authors: Yejia Yu, Mengyu Li, Yuqiong Zhou, Yueqi Shi, Wenjie Zhang, Geehun Son, Jing Ge, Jun Zhao, Zhiyuan Zhang, Dongxia Ye, Chi Yang and Shaoyi Wang
    Citation: Stem Cell Research & Therapy 2020 11:476
    Content type: Research Published on:

  18. Complex cryptoglandular perianal fistula (CPAF) is a kind of anal fistula that may cause anal incontinence after surgery. Minimally invasive surgery of anal fistula is constantly emerging. Over the past 20 yea...

    Authors: Yang Zhang, Min Ni, Chungen Zhou, Yehuang Wang, Yaxian Wang, Yang Shi, Jing Jin, Rui Zhang and Bin Jiang
    Citation: Stem Cell Research & Therapy 2020 11:475
    Content type: Research Published on:

  19. Small molecule compounds have been well recognized for their promising power in the generation, expansion, and maintenance of embryonic or adult stem cells. The aim of this study was to identify a novel combin...

    Authors: Morteza Zarrabi, Elaheh Afzal, Mohammad Hassan Asghari and Marzieh Ebrahimi
    Citation: Stem Cell Research & Therapy 2020 11:474
    Content type: Research Published on:

  20. After traumatic skeletal muscle injury, muscle healing is often incomplete and produces extensive fibrosis. The sequence of M1 and M2 macrophage accumulation and the duration of each subtype in the injured are...

    Authors: Leonardo Martins, Camila Congentino Gallo, Tâmisa Seeko Bandeira Honda, Patrícia Terra Alves, Roberta Sessa Stilhano, Daniela Santoro Rosa, Timothy Jon Koh and Sang Won Han
    Citation: Stem Cell Research & Therapy 2020 11:473
    Content type: Research Published on:

  21. Aging has detrimental effects on the ovary, such as a progressive reduction in fertility and decreased hormone production, that greatly reduce the quality of life of women. Thus, the current study was undertak...

    Authors: Kyeoung-Hwa Kim, Eun-Young Kim, Gi Jin Kim, Jung-Jae Ko, Kwang Yul Cha, Mi Kyung Koong and Kyung-Ah Lee
    Citation: Stem Cell Research & Therapy 2020 11:472
    Content type: Research Published on:

  22. Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cells, were identified as an attractive candidate for immunoregulation and induction of cardiac allograft tolerance. However, the un...

    Authors: Yiming Zhao, Xiang Li, Dingding Yu, Yonghao Hu, Wang Jin, Yafei Qin, Dejun Kong, Hongda Wang, Guangming Li, Alessandro Alessandrini and Hao Wang
    Citation: Stem Cell Research & Therapy 2020 11:471
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:150

  23. Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan—increasing clinical case repor...

    Authors: Rui Liu, Dong Li, Fangxu Sun, Antonio Rampoldi, Joshua T. Maxwell, Ronghu Wu, Peter Fischbach, Sharon M. Castellino, Yuhong Du, Haian Fu, Anant Mandawat and Chunhui Xu
    Citation: Stem Cell Research & Therapy 2020 11:470
    Content type: Research Published on:

  24. Placenta-derived mesenchymal stem cells (PD-MSCs) have unique immunomodulatory properties. Phosphatase of regenerating liver-1 (PRL-1) regulates the self-renewal ability of stem cells and promotes proliferatio...

    Authors: Jae Yeon Kim, Sohae Park, Hyun-Jung Lee, Helen Lew and Gi Jin Kim
    Citation: Stem Cell Research & Therapy 2020 11:469
    Content type: Research Published on:

  25. Mesenchymal stem cells (MSCs) were considered a regenerative therapeutic approach in both acute and chronic diseases. However, whether MSCs regulate the antioxidant metabolism of CD4+ T cells and weaken immunosen...

    Authors: Yanlian Xiong, Yueming Wang, Jiashen Zhang, Nannan Zhao, Hengchao Zhang, Aiping Zhang, Dongmei Zhao, Zhenhai Yu, Yancun Yin, Lele Song, Yanlei Xiong and Xiying Luan
    Citation: Stem Cell Research & Therapy 2020 11:468
    Content type: Research Published on:

  26. Although mitochondrial functions are essential for cell survival, their critical roles in stem cell fate, including proliferation, differentiation, and senescence, remain elusive. Ginsenoside Rg3 exhibits vari...

    Authors: Taeui Hong, Moon Young Kim, Dat Da Ly, Su Jung Park, Young Woo Eom, Kyu-Sang Park and Soon Koo Baik
    Citation: Stem Cell Research & Therapy 2020 11:467
    Content type: Short report Published on:

  27. Premature ovarian insufficiency (POI) is an ovarian dysfunction that seriously affects a woman’s physiological health and reproduction. Mesenchymal stem cell (MSC) transplantation offers a promising treatment ...

    Authors: Yan Zhao, Jiao Ma, Peiye Yi, Jun Wu, Feiyan Zhao, Wan Tu, Wenjing Liu, Tianda Li, Yan Deng, Jie Hao, Hongmei Wang and Long Yan
    Citation: Stem Cell Research & Therapy 2020 11:466
    Content type: Research Published on:

  28. Inflammatory smooth muscle cells (iSMCs) generated from adventitial stem/progenitor cells (AdSPCs) have been recognised as a new player in cardiovascular disease, and microRNA-214-3p (miR-214-3p) has been impl...

    Authors: Shiping He, Feng Yang, Mei Yang, Weiwei An, Eithne Margaret Maguire, Qishan Chen, Rui Xiao, Wei Wu, Li Zhang, Wen Wang and Qingzhong Xiao
    Citation: Stem Cell Research & Therapy 2020 11:465
    Content type: Research Published on:

  29. The aim of this study was to determine whether the combination of MSC implantation with miRNA-126-3p overexpression would further improve the surgical results after vein grafting.

    Authors: Qingxi Qu, Limei Wang, Weidong Bing, Yanwen Bi, Chunmei Zhang, Xuanxuan Jing and Linghong Liu
    Citation: Stem Cell Research & Therapy 2020 11:464
    Content type: Research Published on:

  30. Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness. The two most prevalent forms of CMD, collagen VI-related ...

    Authors: Vitali Alexeev, Jacquelyn Olavarria, Paolo Bonaldo, Luciano Merlini and Olga Igoucheva
    Citation: Stem Cell Research & Therapy 2020 11:463
    Content type: Research Published on:

  31. Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells ...

    Authors: Maitane Ortiz-Virumbrales, Ramón Menta, Laura M. Pérez, Ornella Lucchesi, Pablo Mancheño-Corvo, Álvaro Avivar-Valderas, Itziar Palacios, Angel Herrero-Mendez, Wilfried Dalemans, Olga de la Rosa and Eleuterio Lombardo
    Citation: Stem Cell Research & Therapy 2020 11:462
    Content type: Research Published on:

  32. Osteogenesis is a complex biological process which requires the coordination of multiple molecular mechanisms. This research aimed to explore the biological role and underlying regulatory mechanism of circSIPA...

    Authors: Yuzhi Li, Minxia Bian, Zhou Zhou, Xiao Wu, Xingyun Ge, Tong Xiao and Jinhua Yu
    Citation: Stem Cell Research & Therapy 2020 11:461
    Content type: Research Published on:

  33. Adipose-derived stem cells (ADSCs) promote tissue regeneration and repair. Cryoprotective agents (CPAs) protect cells from cryodamage during cryopreservation. Safe and efficient cryopreservation of ADSCs is cr...

    Authors: Tian-Yu Zhang, Poh-Ching Tan, Yun Xie, Xiao-Jie Zhang, Pei-Qi Zhang, Yi-Ming Gao, Shuang-Bai Zhou and Qing-Feng Li
    Citation: Stem Cell Research & Therapy 2020 11:460
    Content type: Research Published on:

  35. Previous studies have demonstrated that no-option angiitis-induced critical limb ischemia (NO-AICLI) could be significantly improved by transplantation of peripheral blood-derived stem cells (PBDSCs). Addition...

    Authors: Gang Fang, Xiaolang Jiang, Yuan Fang, Tianyue Pan, Hao Liu, Bichen Ren, Zheng Wei, Shiyang Gu, Bin Chen, Junhao Jiang, Yun Shi, Daqiao Guo, Peng Liu, Weiguo Fu and Zhihui Dong
    Citation: Stem Cell Research & Therapy 2020 11:458
    Content type: Research Published on:

  36. Bladder cancer (BLCA) is the fifth most common type of cancer worldwide, with high recurrence and progression rates. Although considerable progress has been made in the treatment of BLCA through accurate typin...

    Authors: Chaozhi Tang, Jiakang Ma, Xiuli Liu and Zhengchun Liu
    Citation: Stem Cell Research & Therapy 2020 11:457
    Content type: Research Published on:

  37. Efficient osteogenic differentiation of mesenchymal stem cells (MSCs) is a critical step in the treatment of bone defects and skeletal disorders, which present challenges for cell-based therapy and regenerativ...

    Authors: Mahsa Ghorbaninejad, Maliheh Khademi-Shirvan, Samaneh Hosseini and Mohamadreza Baghaban Eslaminejad
    Citation: Stem Cell Research & Therapy 2020 11:456
    Content type: Review Published on:

  38. Cervical cancer is the most prevalent gynecological malignancies accompanied by high mortality, where finding a more effective therapeutic option for cervical cancer is necessary. The inhibitory role of microR...

    Authors: Feng Ding, Jinhua Liu and Xiaofei Zhang
    Citation: Stem Cell Research & Therapy 2020 11:455
    Content type: Research Published on:

  39. Human hair follicle mesenchymal stem cells (hHFMSCs) isolated from hair follicles possess multilineage differentiation potential. OCT4 is a gene critically associated with pluripotency properties. The cell mor...

    Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu
    Citation: Stem Cell Research & Therapy 2020 11:454
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:61

  40. Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both. Some of these rare diseases are caused by aberration...

    Authors: C. Eguizabal, L. Herrera, M. Inglés-Ferrándiz and J. C. Izpisua Belmonte
    Citation: Stem Cell Research & Therapy 2020 11:453
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:250

  41. We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. ...

    Authors: Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi and Ji Bihl
    Citation: Stem Cell Research & Therapy 2020 11:330
    Content type: Research Published on:

  42. Scar formation, which may be caused by myofibroblast aggregations, is the greatest challenge during skin wound healing in the clinical setting. Studies have indicated that epidermal stem cells (EPSC) improve w...

    Authors: Mengna Duan, Yan Zhang, Haiyang Zhang, Yupeng Meng, Ming Qian and Guokun Zhang
    Citation: Stem Cell Research & Therapy 2020 11:452
    Content type: Research Published on:

  43. Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic ...

    Authors: Angelo Trivisonno, Dania Nachira, Ivo Boškoski, Venanzio Porziella, Giuliana Di Rocco, Silvia Baldari and Gabriele Toietta
    Citation: Stem Cell Research & Therapy 2020 11:451
    Content type: Review Published on:

  45. Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor o...

    Authors: Defu Kong, Huiming Xu, Mo Chen, Yeping Yu, Yongbing Qian, Tian Qin, Ying Tong, Qiang Xia and Hualian Hang
    Citation: Stem Cell Research & Therapy 2020 11:449
    Content type: Research Published on:

  46. Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral vector for gene deli...

    Authors: Helena Meyer-Berg, Lucia Zhou Yang, María Pilar de Lucas, Alberto Zambrano, Stephen C. Hyde and Deborah R. Gill
    Citation: Stem Cell Research & Therapy 2020 11:448
    Content type: Short report Published on:

  48. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2020 11:446
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:340

  49. Osteonecrosis of femoral head (ONFH) is a seriously degenerative disease with no effective therapies to slow its progression. Several studies have reported short-term efficacy of stem cells on early-stage ONFH...

    Authors: Lianghao Mao, Pan Jiang, Xuan Lei, Chenlie Ni, Yiming Zhang, Bing Zhang, Qiping Zheng and Dapeng Li
    Citation: Stem Cell Research & Therapy 2020 11:445
    Content type: Review Published on:

  50. Dysfunction of the DNA methylation was associated with stem cell reprogramming. Moreover, DNA methyltransferase 1 (DNMT1) deficiency was involved in the differentiation of hair follicle stem cell (HFSc), but t...

    Authors: Fangcao Jin, Min Li, Xuyang Li, Yunpeng Zheng, Kun Zhang, Xiaojun Liu, Bingjie Cai and Guangwen Yin
    Citation: Stem Cell Research & Therapy 2020 11:444
    Content type: Research Published on:
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