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  1. Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide suffic...

    Authors: Shumei Zhao, Kui Duan, Zongyong Ai, Baohua Niu, Yanying Chen, Ruize Kong and Tianqing Li
    Citation: Stem Cell Research & Therapy 2020 11:431
    Content type: Research Published on:

  2. Bronchioalveolar stem cells (BASCs) located at the bronchioalveolar-duct junction (BADJ) are stem cells residing in alveoli and terminal bronchioles that can self-renew and differentiate into alveolar type (AT...

    Authors: Naoya Kawakita, Hiroaki Toba, Keiko Miyoshi, Shinichi Sakamoto, Daisuke Matsumoto, Mika Takashima, Mariko Aoyama, Seiya Inoue, Masami Morimoto, Takeshi Nishino, Hiromitsu Takizawa and Akira Tangoku
    Citation: Stem Cell Research & Therapy 2020 11:430
    Content type: Research Published on:

  3. Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate...

    Authors: Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda and Toshihiro Akisue
    Citation: Stem Cell Research & Therapy 2020 11:429
    Content type: Research Published on:

  4. Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. Validated quality controls must confirm this activity in the context of clinical trials. This study p...

    Authors: Tess Nicotra, Aurélie Desnos, Justine Halimi, Hélène Antonot, Loïc Reppel, Thomas Belmas, Alice Freton, Floriane Stranieri, Miryam Mebarki, Jérôme Larghero, Audrey Cras and Lionel Faivre
    Citation: Stem Cell Research & Therapy 2020 11:426
    Content type: Research Published on:

  5. As a critical cellular component in the hepatic stem cell niche, hepatic stellate cells (HSCs) play critical roles in regulating the expansion of hepatic stem cells, liver regeneration, and fibrogenesis. Howev...

    Authors: Jian-Yun Ge, Yun-Wen Zheng, Tomonori Tsuchida, Kinji Furuya, Hiroko Isoda, Hideki Taniguchi, Nobuhiro Ohkohchi and Tatsuya Oda
    Citation: Stem Cell Research & Therapy 2020 11:425
    Content type: Research Published on:

  6. Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted growing attention during the...

    Authors: Jiangmei Wang, Jie Xia, Ruoqiong Huang, Yaoqin Hu, Jiajie Fan, Qiang Shu and Jianguo Xu
    Citation: Stem Cell Research & Therapy 2020 11:424
    Content type: Review Published on:

  7. Currently, numerous animal studies have shown that exposure to commonly used general anesthetics during pregnancy may cause neurocognitive impairment in the offspring. Reportedly, exposure to sevoflurane durin...

    Authors: Yi Zhang, Ziyi Wu, Xingyue Li, Yuxiao Wan, Yinong Zhang and Ping Zhao
    Citation: Stem Cell Research & Therapy 2020 11:423
    Content type: Research Published on:

  8. Renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of chronic kidney disease (CKD) and its pathogenesis involves epithelial-to-mesenchymal transition (EMT) upon renal injury. Re...

    Authors: Mirae Lee, Seok-hyung Kim, Jong Hyun Jhee, Tae Yeon Kim, Hoon Young Choi, Hyung Jong Kim and Hyeong Cheon Park
    Citation: Stem Cell Research & Therapy 2020 11:422
    Content type: Research Published on:

  9. Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes...

    Authors: Golara Nasiri, Negar Azarpira, Aliakbar Alizadeh, Sanaz Goshtasbi and Lobat Tayebi
    Citation: Stem Cell Research & Therapy 2020 11:421
    Content type: Review Published on:

  10. Patients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical burden worldwide. We previously found that mesenchymal stem cells (MSCs)...

    Authors: Guodong Song, Jia Zhou, Ruimei Song, Dalu Liu, Weidi Yu, Wangcheng Xie, Zhilong Ma, Jian Gong, Hongbo Meng, Tingsong Yang and Zhenshun Song
    Citation: Stem Cell Research & Therapy 2020 11:420
    Content type: Research Published on:

  11. Stem cell therapy is becoming an emerging therapeutic option for chronic liver disease (CLD). However, whether stem cell therapy is more effective than conventional treatment remains questionable. We performed...

    Authors: Guang-Peng Zhou, Yi-Zhou Jiang, Li-Ying Sun and Zhi-Jun Zhu
    Citation: Stem Cell Research & Therapy 2020 11:419
    Content type: Research Published on:

  12. Immune system disorders play important roles in acute lung injury (ALI), and mesenchymal stem cell (MSC) treatment can reduce inflammation during ALI. In this study, we compared the changes in lung B cells dur...

    Authors: Bing Feng, Jiaqi Zhu, Yanping Xu, Wenyi Chen, Xinyu Sheng, Xudong Feng, Xiaowei Shi, Jingqi Liu, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao
    Citation: Stem Cell Research & Therapy 2020 11:418
    Content type: Research Published on:

  13. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show tremendous promise for cardiac regeneration, but the successful development of hESC-CM-based therapies requires improved tools to investigate th...

    Authors: Dominic Filice, Wahiba Dhahri, Joell L. Solan, Paul D. Lampe, Erin Steele, Nikita Milani, Benjamin Van Biber, Wei-Zhong Zhu, Tamilla Sadikov Valdman, Rocco Romagnuolo, José David Otero-Cruz, Kip D. Hauch, Matthew W. Kay, Narine Sarvazyan and Michael A. Laflamme
    Citation: Stem Cell Research & Therapy 2020 11:417
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:66

  14. Mesenchymal stem cells (MSCs) have been recognized for their regenerative and anti-inflammatory capacity which makes them very attractive to cell therapy, especially those ones to treat inflammatory and autoim...

    Authors: Mónica Kurte, Ana María Vega-Letter, Patricia Luz-Crawford, Farida Djouad, Danièle Noël, Maroun Khoury and Flavio Carrión
    Citation: Stem Cell Research & Therapy 2020 11:416
    Content type: Research Published on:

  15. Millions suffer from skin diseases. Functional interfollicular epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional interfollicular epidermal stem cells with intac...

    Authors: Ling Leng, Jie Ma, Luye Lv, Wenjuan Wang, Dunqin Gao, Yunping Zhu and Zhihong Wu
    Citation: Stem Cell Research & Therapy 2020 11:415
    Content type: Short report Published on:

  16. The therapeutic role of mesenchymal stem cells (MSCs) has been widely confirmed in several animal models of premature infant diseases. Micromolecule peptides have shown promise for the treatment of premature i...

    Authors: Yu Wang, Lin Zhang, Yun Wu, Rongping Zhu, Yan Wang, Yan Cao, Wei Long, Chenbo Ji, Huaiyan Wang and Lianghui You
    Citation: Stem Cell Research & Therapy 2020 11:414
    Content type: Research Published on:

  17. Ischaemic stroke has become the main cause of death and severe neurological disorders, for which effective restorative treatments are currently limited. While stem cell transplantation offers therapeutic poten...

    Authors: Xuemei Zhang, Hao Tang, Senlin Mao, Bing Li, Yinglian Zhou, Hui Yue, Duo Wang, Yifei Wang and Jin Fu
    Citation: Stem Cell Research & Therapy 2020 11:413
    Content type: Research Published on:

  18. Cell therapy is one of the most promising therapeutic interventions for retinitis pigmentosa. In the current study, we aimed to assess if peripheral blood-derived monocytes which are highly abundant and access...

    Authors: Alaknanda Mishra, K. Varsha Mohan, Perumal Nagarajan, Srikanth Iyer, Ashwani Kesarwani, Madhu Nath, Laxmi Moksha, Jashdeep Bhattacharjee, Barun Das, Kshama Jain, Parul Sahu, Prakriti Sinha, T. Velapandian and Pramod Upadhyay
    Citation: Stem Cell Research & Therapy 2020 11:412
    Content type: Research Published on:

  19. Retinal pigment epithelium (RPE) replacement has been proposed as an efficacious treatment for age-related macular degeneration (AMD), which is the primary cause of vision loss in the elderly worldwide. The em...

    Authors: Jiahui Liu, Liu Yang, Xiaoran Wang, Shoubi Wang, Zheqian Huang, Chaoyang Li, Ying Liu, Yaqi Cheng, Chengxiu Liu and Zhichong Wang
    Citation: Stem Cell Research & Therapy 2020 11:411
    Content type: Research Published on:

  20. Acute kidney injury (AKI) is a common clinical disease with complex pathophysiology and limited therapeutic choices. This prompts the need for novel therapy targeting multiple aspects of this disease. Human am...

    Authors: Yifei Ren, Ying Chen, Xizi Zheng, Hui Wang, Xin Kang, Jiawei Tang, Lei Qu, Xiaoyan Shao, Suxia Wang, Shuangling Li, Gang Liu and Li Yang
    Citation: Stem Cell Research & Therapy 2020 11:410
    Content type: Research Published on:

  21. Endothelial cells (ECs) are essential regulators of the vasculature, lining arteries, veins, and capillary beds. While all ECs share a number of structural and molecular features, heterogeneity exists dependin...

    Authors: Kelly Mulfaul, Joseph C. Giacalone, Andrew P. Voigt, Megan J. Riker, Dalyz Ochoa, Ian C. Han, Edwin M. Stone, Robert F. Mullins and Budd A. Tucker
    Citation: Stem Cell Research & Therapy 2020 11:409
    Content type: Method Published on:

  22. This study is designed to generate and propagate human spermatogonial stem cells (SSCs) derived from human pluripotent stem cells (hPSCs).

    Authors: Huiming Xu, Mengbo Yang, Ruhui Tian, Yonghui Wang, Linhong Liu, Zijue Zhu, Shi Yang, Qingqing Yuan, Minghui Niu, Chencheng Yao, Erlei Zhi, Peng Li, Chenhao Zhou, Zuping He, Zheng Li and Wei-Qiang Gao
    Citation: Stem Cell Research & Therapy 2020 11:408
    Content type: Research Published on:

  23. Human platelet lysate (HPL) is emerging as the preferred xeno-free supplement for the expansion of mesenchymal stromal cells (MSCs) for bone tissue engineering (BTE) applications. Due to a growing demand, the ...

    Authors: Siddharth Shanbhag, Samih Mohamed-Ahmed, Turid Helen Felli Lunde, Salwa Suliman, Anne Isine Bolstad, Tor Hervig and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2020 11:351
    Content type: Research Published on:

  24. In recent years, significant progress has been made in developing highly complex tissue-engineered skin substitutes (TESSs) for wound healing. However, the lack of skin appendages, such as hair follicles and s...

    Authors: Qun Zhang, Jie Wen, Chang Liu, Chuan Ma, Fuxiang Bai, Xue Leng, Zhihong Chen, Zhiwei Xie, Jun Mi and Xunwei Wu
    Citation: Stem Cell Research & Therapy 2020 11:407
    Content type: Research Published on:

  25. A major challenge for the clinical use of human pluripotent stem cells is the development of safe, robust and controlled differentiation protocols. Adaptation of research protocols using reagents designated as...

    Authors: Loriana Vitillo, Catherine Durance, Zoe Hewitt, Harry Moore, Austin Smith and Ludovic Vallier
    Citation: Stem Cell Research & Therapy 2020 11:406
    Content type: Research Published on:

  26. The aim of this study was to examine the effect of a three-step approach that utilizes the application of adipose tissue-derived mesenchymal stem cells (AD-MSCs), encapsulation, and pulsed focused ultrasound (...

    Authors: Mehdi Razavi, Tanchen Ren, Fengyang Zheng, Arsenii Telichko, Jing Wang, Jeremy J. Dahl, Utkan Demirci and Avnesh S. Thakor
    Citation: Stem Cell Research & Therapy 2020 11:405
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:526

  29. Tendon stem cells (TSCs) have been reported to hold promises for tendon repair and regeneration. However, less is known about the effects of exosomes derived from TSCs. Therefore, we aimed to clarify the heali...

    Authors: Mingzhao Zhang, Hengchen Liu, Qingbo Cui, Peilin Han, Shulong Yang, Manyu Shi, Tingting Zhang, Zenan Zhang and Zhaozhu Li
    Citation: Stem Cell Research & Therapy 2020 11:402
    Content type: Research Published on:

  30. Globally, 1 in 11 adults have diabetes mellitus, and 90% of the cases are type 2 diabetes mellitus. Insulin resistance is a central defect in type 2 diabetes mellitus, and although multiple drugs have been dev...

    Authors: Guang Chen, Xiao-yan Fan, Xiao-peng Zheng, Yue-lei Jin, Ying Liu and Shuang-chun Liu
    Citation: Stem Cell Research & Therapy 2020 11:401
    Content type: Research Published on:

  31. Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patient...

    Authors: Fatemeh Mirershadi, Mahdi Ahmadi, Aysa Rezabakhsh, Hadi Rajabi, Reza Rahbarghazi and Rana Keyhanmanesh
    Citation: Stem Cell Research & Therapy 2020 11:400
    Content type: Review Published on:

  32. Lung disease is a leading cause of morbidity and mortality. A breach in the lung alveolar-epithelial barrier and impairment in lung function are hallmarks of acute and chronic pulmonary illness. This review is...

    Authors: Alvaro Moreira, Rija Naqvi, Kristen Hall, Chimobi Emukah, John Martinez, Axel Moreira, Evan Dittmar, Sarah Zoretic, Mary Evans, Delanie Moses and Shamimunisa Mustafa
    Citation: Stem Cell Research & Therapy 2020 11:399
    Content type: Review Published on:

  33. Acute kidney injury (AKI) is characterized by rapid failure of renal function and has no curative therapies. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) are known to carry therapeutic f...

    Authors: Mujib Ullah, Daniel D. Liu, Sravanthi Rai, Mehdi Razavi, Waldo Concepcion and Avnesh S. Thakor
    Citation: Stem Cell Research & Therapy 2020 11:398
    Content type: Research Published on:

  35. Regenerative medicine plays a major role in biomedicine, and given the ever-expanding boundaries of this knowledge, numerous ethical considerations have been raised.

    Authors: Leila Afshar, Hamid-Reza Aghayan, Jila Sadighi, Babak Arjmand, Seyed-Mahmoud Hashemi, Mohsen Basiri, Reza Omani Samani, Mohammad Kazemi Ashtiani, Seyed-Ali Azin, Ensiyeh Hajizadeh-Saffar, Ehsan Shamsi Gooshki, Amir-Ali Hamidieh, Mohammad-Reza Rezania Moallem, Seyed-Mohammad Azin, Sadegh Shariatinasab, Mehdi Soleymani-Goloujeh…
    Citation: Stem Cell Research & Therapy 2020 11:396
    Content type: Commentary Published on:

  37. Diabetic foot is one of the severest complications of diabetes. In severe cases, this disease may be lead to amputation or even death due to secondary infection and ischemic necrosis. Since the ineffectiveness...

    Authors: Xiansheng Zhao, Jiamin Guo, Fangfang Zhang, Jue Zhang, Delin Liu, Wenjun Hu, Han Yin and Liang Jin
    Citation: Stem Cell Research & Therapy 2020 11:394
    Content type: Review Published on:

  38. Hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (iPSCs) hold great promise in toxicological applications as well as in regenerative medicine. Previous efforts on hepatocyte diffe...

    Authors: Xiugong Gao, Rong Li, Patrick Cahan, Yang Zhao, Jeffrey J. Yourick and Robert L. Sprando
    Citation: Stem Cell Research & Therapy 2020 11:393
    Content type: Research Published on:

  39. Human bone marrow-derived mesenchymal stem cells (hBMSCs) have chondrocyte differentiation potential and are considered to be a cell source for cell-transplantation-mediated repair of cartilage defects, includ...

    Authors: Shuang Lv, Jinying Xu, Lin Chen, Haitao Wu, Wei Feng, Yangyang Zheng, Pengdong Li, Haiying Zhang, Lihong Zhang, Guangfan Chi and Yulin Li
    Citation: Stem Cell Research & Therapy 2020 11:392
    Content type: Research Published on:

  40. Mesenchymal stem cells (MSCs) serve as an attractive vehicle for cell-directed enzyme prodrug therapy (CDEPT) due to their unique tumour-nesting ability. Such approach holds high therapeutic potential for trea...

    Authors: Geraldine Xue En Tu, Yoon Khei Ho, Zhi Xu Ng, Ke Jia Teo, Tseng Tsai Yeo and Heng-Phon Too
    Citation: Stem Cell Research & Therapy 2020 11:391
    Content type: Research Published on:

  41. β-Thalassemias represent a group of genetic disorders caused by human hemoglobin beta (HBB) gene mutations. The radical curative approach is to correct the mutations causing the disease. CRISPR-CAS9 is a novel ge...

    Authors: Hala Gabr, Mona Kamal El Ghamrawy, Abdulrahman H. Almaeen, Ahmed Samir Abdelhafiz, Aya Osama Saad Hassan and Maha Hamdi El Sissy
    Citation: Stem Cell Research & Therapy 2020 11:390
    Content type: Research Published on:

  42. Cell therapy has been evaluated pre-clinically and clinically as a means to improve wound vascularization and healing. While translation of this approach to clinical practice ideally requires the availability ...

    Authors: Bart Vaes, Ellen Van Houtven, Ellen Caluwé and Aernout Luttun
    Citation: Stem Cell Research & Therapy 2020 11:389
    Content type: Research Published on:

  43. Embryonic stem cells (ESCs) derived from somatic cell nuclear transfer (SCNT) and induced pluripotent stem cells (iPSCs) are promising tools for meeting the personalized requirements of regenerative medicine. ...

    Authors: Zhi-ping Zhang, Jun-tao Zhang, Shu-cheng Huang, Xiu-yuan He and Li-xin Deng
    Citation: Stem Cell Research & Therapy 2020 11:388
    Content type: Review Published on:

  44. It is difficult to immediately use mesenchymal stem cells (MSCs) for the patient with rotator cuff disease because isolation and culture time are required. Thus, the MSCs would be prepared in advanced in cryop...

    Authors: Ji-Hye Yea, Jin-Kyung Park, In Ja Kim, Gayoung Sym, Tae-Soo Bae and Chris Hyunchul Jo
    Citation: Stem Cell Research & Therapy 2020 11:387
    Content type: Research Published on:

  45. The basic pathological changes of primary ovarian insufficiency (POI) include ovarian tissue fibrosis and follicular development disorders. The human umbilical cord mesenchymal stem cell (hUMSC) transplantatio...

    Authors: Linlu Cui, Hongchu Bao, Zhongfeng Liu, Xuejing Man, Hongyuan Liu, Yun Hou, Qianqian Luo, Siyuan Wang, Qiang Fu and Hongqin Zhang
    Citation: Stem Cell Research & Therapy 2020 11:386
    Content type: Research Published on:

  46. Local anesthetics (LAs) are widely used to control pain during various clinical treatments. One of the side effects of LAs, cytotoxicity, has been investigated in various cells including stem/progenitor cells....

    Authors: Young Hoon Kim, Ga Young Park, Nechama Rabinovitch, Solaiman Tarafder and Chang H. Lee
    Citation: Stem Cell Research & Therapy 2020 11:385
    Content type: Research Published on:

  47. We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) may ameliorate sepsis-induced acute lung injury (ALI) and change microorganism populations in the gut microbiota, such as that of Firmicutes...

    Authors: Junyi Sun, Xianfei Ding, Shaohua Liu, Xiaoguang Duan, Huoyan Liang and Tongwen Sun
    Citation: Stem Cell Research & Therapy 2020 11:384
    Content type: Research Published on:

  48. Stem cell therapies have gained great attention for providing novel solutions for treatment of various injuries and diseases due to stem cells’ self-renewal, ability to differentiate into various cell types, a...

    Authors: Wei Lin, Xiaoyang Qi, Wenjing Guo, Danyang Liang, Heting Chen, Baoping Lin and Xiaoyuan Deng
    Citation: Stem Cell Research & Therapy 2020 11:383
    Content type: Research Published on:

  50. Mesenchymal stem cells (MSCs) can be isolated from not only bone marrow, but also various adult mesenchymal tissues such as periosteum, skeletal muscle, and adipose tissue. MSCs from different tissue sources h...

    Authors: Na Li, Jinfang Gao, Liangyu Mi, Gailian Zhang, Liyun Zhang, Na Zhang, Rongxiu Huo, Junping Hu and Ke Xu
    Citation: Stem Cell Research & Therapy 2020 11:381
    Content type: Review Published on:
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