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  1. Mesenchymal stem cells (MSCs) have the potential for treatment of diabetic cardiomyopathy; however, the repair capability of MSCs declines with age and disease. MSCs from diabetic animals exhibit impaired surv...

    Authors: Mohsin Khan, Fatima Ali, Sadia Mohsin, Shoaib Akhtar, Azra Mehmood, Mahmood S Choudhery, Shaheen N Khan and Sheikh Riazuddin

    Citation: Stem Cell Research & Therapy 2013 4:58

    Content type: Research

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  2. Neural stem cells (NSCs) are among the most promising candidates for cell replacement therapy in neuronal injury and neurodegenerative diseases. One of the remaining obstacles for NSC therapy is to overcome th...

    Authors: Eun Mi Lee, Sunghoon Hurh, Bumrae Cho, Kook-Hwan Oh, Seung U Kim, Charles D Surh, Jonathan Sprent, Jaeseok Yang, Jae Young Kim and Curie Ahn

    Citation: Stem Cell Research & Therapy 2013 4:56

    Content type: Research

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  3. The main aim of this study is to evaluate potential human stem cells, such as dental pulp stem cells and amniotic fluid stem cells, combined with collagen scaffold to reconstruct critical-size cranial bone def...

    Authors: Tullia Maraldi, Massimo Riccio, Alessandra Pisciotta, Manuela Zavatti, Gianluca Carnevale, Francesca Beretti, Giovanni B La Sala, Antonella Motta and Anto De Pol

    Citation: Stem Cell Research & Therapy 2013 4:53

    Content type: Research

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  4. A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and osteogenic gene-...

    Authors: Torbjorn O Pedersen, Anna L Blois, Zhe Xing, Ying Xue, Yang Sun, Anna Finne-Wistrand, Lars A Akslen, James B Lorens, Knut N Leknes, Inge Fristad and Kamal Mustafa

    Citation: Stem Cell Research & Therapy 2013 4:52

    Content type: Research

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  5. Neurons have the intrinsic capacity to produce insulin, similar to pancreatic cells. Adult neural stem cells (NSCs), which give rise to functional neurons, can be established and cultured not only by intracere...

    Authors: Ryo Hidaka, Masanao Machida, Shin Fujimaki, Kazuyuki Terashima, Makoto Asashima and Tomoko Kuwabara

    Citation: Stem Cell Research & Therapy 2013 4:51

    Content type: Research

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  6. Sufficient uterine blood supply is essential for the fetus to develop normally in the uterus. Several mechanisms are involved in the process of vessel development in deciduas and villus. We focus on whether fi...

    Authors: Qiushi Wang, Licong Shen, Wei Huang, Yong Song, Li Xiao, Wenming Xu and Ying Liu

    Citation: Stem Cell Research & Therapy 2013 4:50

    Content type: Research

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  7. SALL4 and BMI-1 are important factors in hematopoiesis. Placental tissue (PT) and umbilical cord blood (CB) are rich in hematopoietic stem/progenitor cells (HSCs/HPCs), but their SALL4 and BMI-1 expression levels...

    Authors: Shaohua Chen, Sichu Liu, Ling Xu, Lijian Yang, Zhenyi Jin, Yu Ma, Bo Li, Xiuli Wu, Jianchang Yang, Yupo Ma and Yangqiu Li

    Citation: Stem Cell Research & Therapy 2013 4:49

    Content type: Research

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  8. Administration of mesenchymal stem cells (MSCs) has been shown to improve renal function in rodent models of chronic kidney disease (CKD), in part by reducing intrarenal inflammation and suppressing fibrosis. ...

    Authors: Jessica M Quimby, Tracy L Webb, Lauren M Habenicht and Steven W Dow

    Citation: Stem Cell Research & Therapy 2013 4:48

    Content type: Research

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  9. Mesenchymal stem cells (MSCs) have attracted increasing interest in the field of oncology because of their inherent capacity to migrate and home tumor tissues. The remarkable tropism of MSCs for tumor microenv...

    Authors: Célia Maria Freitas Gomes

    Citation: Stem Cell Research & Therapy 2013 4:42

    Content type: Commentary

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  10. Understanding the multiple biological functions played by human mesenchymal stem cells (hMSCs) as well as their development as therapeutics in regenerative medicine or in cancer treatment are major fields of r...

    Authors: Michelle Kéramidas, Florence de Fraipont, Anastassia Karageorgis, Anaïck Moisan, Virginie Persoons, Marie-Jeanne Richard, Jean-Luc Coll and Claire Rome

    Citation: Stem Cell Research & Therapy 2013 4:41

    Content type: Research

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  11. Administration of bone marrow mesenchymal stem cells (MSCs) or secreted microvesicles improves recovery from acute kidney injury (AKI). However, the potential roles and mechanisms are not well understood. In t...

    Authors: Ying Zhou, Huitao Xu, Wenrong Xu, Bingying Wang, Huiyi Wu, Yang Tao, Bin Zhang, Mei Wang, Fei Mao, Yongmin Yan, Shuo Gao, Hongbing Gu, Wei Zhu and Hui Qian

    Citation: Stem Cell Research & Therapy 2013 4:34

    Content type: Research

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  12. Differentiation of vascular endothelial cells (ECs) in clinically relevant numbers for injection into ischaemic areas could offer therapeutic potential in the treatment of cardiovascular conditions, including ...

    Authors: Lynsey Howard, Ruth M Mackenzie, Nikolay A Pchelintsev, Tony McBryan, John D McClure, Martin W McBride, Nicole M Kane, Peter D Adams, Graeme Milligan and Andrew H Baker

    Citation: Stem Cell Research & Therapy 2013 4:36

    Content type: Research

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  13. No comparative study of adipose-derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) by using superparamagnetic iron oxide nanoparticles (SPIOs)-labeling and magnetic resonance imaging (MR...

    Authors: Jingjing Fan, Yanbin Tan, Liyong Jie, Xinying Wu, Risheng Yu and Minming Zhang

    Citation: Stem Cell Research & Therapy 2013 4:44

    Content type: Research

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  14. Administration of bone marrow-derived mesenchymal stem cells (MSCs) after myocardial infarction (MI) results in modest functional improvements. However; the effect of microenvironment changes after MI, such as...

    Authors: Archana V Boopathy, Karl D Pendergrass, Pao Lin Che, Young-Sup Yoon and Michael E Davis

    Citation: Stem Cell Research & Therapy 2013 4:43

    Content type: Research

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  15. In the event of chronic diabetes or burn wounds, accomplishing skin regeneration is a major concern. Autologous skin grafting is the most effective remedy, but the tissue harvest may create more nonhealing wou...

    Authors: Renjith P Nair and Lissy K Krishnan

    Citation: Stem Cell Research & Therapy 2013 4:38

    Content type: Research

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  16. Invariant left-right (LR) patterning or chirality is critical for embryonic development. The loss or reversal of LR asymmetry is often associated with malformations and disease. Although several theories have ...

    Authors: Leo Q Wan, Kacey Ronaldson, Mark Guirguis and Gordana Vunjak-Novakovic

    Citation: Stem Cell Research & Therapy 2013 4:24

    Content type: Review

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  17. Recently, cell-based therapy has gained significant attention for the treatment of central nervous system diseases. Although bone marrow stromal cells (BMSCs) are considered to have good engraftment potential,...

    Authors: Takafumi Mitsuhara, Masaaki Takeda, Satoshi Yamaguchi, Tomotaka Manabe, Masaya Matsumoto, Yumi Kawahara, Louis Yuge and Kaoru Kurisu

    Citation: Stem Cell Research & Therapy 2013 4:35

    Content type: Research

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  18. The field of regenerative medicine is approaching translation to clinical practice, and significant safety concerns and knowledge gaps have become clear as clinical practitioners are considering the potential ...

    Authors: John Harding, R Michael Roberts and Oleg Mirochnitchenko

    Citation: Stem Cell Research & Therapy 2013 4:23

    Content type: Review

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  19. Loss of adult stem cell function during aging contributes to impaired tissue regeneration. Here, we tested the aging-related decline in regeneration potential of adult stem cells residing in the skeletal muscle.

    Authors: Minjung Song, Mitra Lavasani, Seth D Thompson, Aiping Lu, Bahar Ahani and Johnny Huard

    Citation: Stem Cell Research & Therapy 2013 4:33

    Content type: Research

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  20. Cell therapy using adipose-derived stem cells has been reported to improve chronic wounds via differentiation and paracrine effects. One such strategy is to deliver stem cells in hydrogels, which are studied i...

    Authors: Waqar Hassan, Yixiao Dong and Wenxin Wang

    Citation: Stem Cell Research & Therapy 2013 4:32

    Content type: Research

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  21. We hypothesized that dipeptidyl peptidase-IV (DPP4) may impair angiogenesis, endothelial function, and the circulating number of endothelial progenitor cells (EPC) in a model of critical limb ischemia (CLI) th...

    Authors: Cheuk-Kwan Sun, Steve Leu, Jiunn-Jye Sheu, Tzu-Hsien Tsai, Hsin-Chin Sung, Yung-Lung Chen, Sheng-Ying Chung, Sheung-Fat Ko, Hsueh-Wen Chang and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2013 4:31

    Content type: Research

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  22. Prior in vivo murine studies suggest circadian oscillations for hematopoietic stem cell release, which are maintained following administration of granulocyte colony-stimulating factor (G-CSF) or plerixafor. Furth...

    Authors: Patricia A Shi, Luis M Isola, Janice L Gabrilove, Erin L Moshier, James H Godbold, Lorraine K Miller and Paul S Frenette

    Citation: Stem Cell Research & Therapy 2013 4:30

    Content type: Research

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  23. Heme oxygenase (HO), a major cytoprotective enzyme, attenuates oxidative stress and obesity. The canonical Wnt signaling cascade plays a pivotal role in the regulation of adipogenesis. The present study examin...

    Authors: Luca Vanella, Komal Sodhi, Dong Hyun Kim, Nitin Puri, Mani Maheshwari, Terry D Hinds Jr, Lars Bellner, Dov Goldstein, Stephen J Peterson, Joseph I Shapiro and Nader G Abraham

    Citation: Stem Cell Research & Therapy 2013 4:28

    Content type: Research

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  24. Adipose tissue is an attractive and abundant source of multipotent stem cells. Human adipose stem cells (ASCs) have shown to have therapeutic relevancy in diverse clinical applications. Nevertheless, expansion...

    Authors: Mimmi Patrikoski, Miia Juntunen, Shayne Boucher, Andrew Campbell, Mohan C Vemuri, Bettina Mannerström and Susanna Miettinen

    Citation: Stem Cell Research & Therapy 2013 4:27

    Content type: Research

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  25. The acute respiratory distress syndrome (ARDS), affects up to 150,000 patients per year in the United States. We and other groups have demonstrated that bone marrow derived mesenchymal stromal stem cells preve...

    Authors: Mauricio Rojas, Richard E Parker, Natalie Thorn, Claudia Corredor, Smita S Iyer, Marta Bueno, Lyle Mroz, Nayra Cardenes, Ana L Mora, Arlene A Stecenko and Kenneth L Brigham

    Citation: Stem Cell Research & Therapy 2013 4:26

    Content type: Research

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  26. Endothelial progenitor cells (EPCs) play a critical role in restoration of ischemic diseases. However, the actual status of EPC development and the mechanisms of EPC dysfunctions in patients with various ische...

    Authors: Shizu Tsukada, Sang-Mo Kwon, Takenori Matsuda, Seok-Yun Jung, Jun-Hee Lee, Sang-Hun Lee, Haruchika Masuda and Takayuki Asahara

    Citation: Stem Cell Research & Therapy 2013 4:20

    Content type: Research

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  27. Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. Its invasive nature currently represents the most challenging hurdle to surgical resection. The mechanism adopted by GBM cells to car...

    Authors: Barbara Ortensi, Matteo Setti, Daniela Osti and Giuliana Pelicci

    Citation: Stem Cell Research & Therapy 2013 4:18

    Content type: Review

    Published on:

  28. The work presented in this study focuses on evaluating health-related quality of life using the International Short Form 36-Item Health Survey in chronic liver disease patients in Cairo, Egypt, who received ei...

    Authors: Adeeb M AlZoubi and Farah Khalifeh

    Citation: Stem Cell Research & Therapy 2013 4:16

    Content type: Commentary

    Published on:

  29. Currently, human adipose stem cells (hASCs) are differentiated towards osteogenic lineages using culture medium supplemented with L-ascorbic acid 2-phosphate (AsA2-P), dexamethasone (Dex) and beta-glycerophosp...

    Authors: Laura Kyllönen, Suvi Haimi, Bettina Mannerström, Heini Huhtala, Kristiina M Rajala, Heli Skottman, George K Sándor and Susanna Miettinen

    Citation: Stem Cell Research & Therapy 2013 4:17

    Content type: Research

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  30. The OCT4 transcription factor is involved in many cellular processes, including development, reprogramming, maintaining pluripotency and differentiation. Synthetic OCT4 mRNA was recently used (in conjunction with...

    Authors: Jason P Awe, Agustin Vega Crespo, You Li, Megerditch Kiledjian and James A Byrne

    Citation: Stem Cell Research & Therapy 2013 4:15

    Content type: Research

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  31. Bone is a load-bearing tissue and physical forces play key roles in the development and maintenance of its structure. Mechanical cues can stimulate the expression of an osteogenic phenotype, enhance matrix and...

    Authors: Ben P Hung, Daphne L Hutton and Warren L Grayson

    Citation: Stem Cell Research & Therapy 2013 4:10

    Content type: Review

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  32. Adipose-derived stem cells (ASCs) have emerged as important regulators of inflammatory/immune responses in vitro and in vivo and represent attractive candidates for cell-based therapies for diseases that involve ...

    Authors: Shijia Zhang, Svitlana D Danchuk, Kathleen MP Imhof, Julie A Semon, Brittni A Scruggs, Ryan W Bonvillain, Amy L Strong, Jeffrey M Gimble, Aline M Betancourt, Deborah E Sullivan and Bruce A Bunnell

    Citation: Stem Cell Research & Therapy 2013 4:13

    Content type: Research

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  33. Mesenchymal stem cells (MSCs) are immunosuppressive, but we lack an understanding of how these adult stem cells are in turn affected by immune cells and the surrounding tissue environment. As MSCs have stromal...

    Authors: Zul'atfi Rahmat, Shinsmon Jose, Rajesh Ramasamy and Sharmili Vidyadaran

    Citation: Stem Cell Research & Therapy 2013 4:12

    Content type: Research

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  34. Stem cell therapy can promote good recovery from stroke. Several studies have demonstrated that mesenchymal stem cells (MSC) are safe and effective. However, more information regarding appropriate cell type is...

    Authors: María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, M Teresa Vallejo-Cremades, Blanca Fuentes, Sebastián Cerdán and Exuperio Díez-Tejedor

    Citation: Stem Cell Research & Therapy 2013 4:11

    Content type: Research

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  35. Neural stem cell transplantation is a promising tool for the restoration of the enteric nervous system in a variety of motility disorders. However, limited cell viability after transplantation has restricted i...

    Authors: Wei Liu, Weiming Yue and Rongde Wu

    Citation: Stem Cell Research & Therapy 2013 4:7

    Content type: Research

    Published on:

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