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  1. Advances in the field of stem cells have led to novel avenues for generating induced pluripotent stem cells (iPSCs) from differentiated somatic cells. iPSCs are typically obtained by the introduction of four f...

    Authors: Christopher B Driscoll, Jason M Tonne, Moustafa El Khatib, Roberto Cattaneo, Yasuhiro Ikeda and Patricia Devaux

    Citation: Stem Cell Research & Therapy 2015 6:48

    Content type: Research

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  2. Understanding the mechanism of stem cell mobilization into injured skeletal muscles is a prerequisite step for the development of muscle disease therapies. Many of the currently studied stem cell types present...

    Authors: Edyta Brzoska, Kamil Kowalski, Agnieszka Markowska-Zagrajek, Magdalena Kowalewska, Rafał Archacki, Izabela Plaskota, Władysława Stremińska, Katarzyna Jańczyk-Ilach and Maria A Ciemerych

    Citation: Stem Cell Research & Therapy 2015 6:46

    Content type: Research

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  3. Bone marrow mesenchymal stem cells (BMSCs) have been studied extensively because of their potential use in clinical therapy, regenerative medicine, and tissue engineering. However, their application in tumor t...

    Authors: Lei Zhang, Xiao San Su, Jun Song Ye, Yi Yin Wang, Zheng Guan and Yan Feng Yin

    Citation: Stem Cell Research & Therapy 2015 6:45

    Content type: Research

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  4. Mesenchymal stem cells (MSCs) have potent stabilising effects on vascular endothelium injury, inhibiting endothelial permeability in lung injury via paracrine hepatocyte growth factor (HGF). Recently, it has b...

    Authors: Qi-Hong Chen, Ai-Ran Liu, Hai-Bo Qiu and Yi Yang

    Citation: Stem Cell Research & Therapy 2015 6:44

    Content type: Research

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  5. There is a practical need for the identification of robust cell-surface markers that can be used to enrich for living keratinocyte progenitor cells. Breast cancer resistance protein (ABCG2), a member of the AT...

    Authors: Dongrui Ma, Alvin Wen Choong Chua, Ennan Yang, Peiyun Teo, Yixin Ting, Colin Song, Ellen Birgitte Lane and Seng Teik Lee

    Citation: Stem Cell Research & Therapy 2015 6:43

    Content type: Research

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  6. Mouse fibroblasts could be directly converted into induced neural stem cells (iNSCs), by introducing a set of known transcription factors (TFs). This process, known as direct reprogramming, is an alternative s...

    Authors: Moein Yaqubi, Abdulshakour Mohammadnia and Hossein Fallahi

    Citation: Stem Cell Research & Therapy 2015 6:42

    Content type: Research

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  7. The loss of oligodendrocytes in a lesion of the central nervous system causes demyelination and therefore impairs axon function and survival. Transplantation of neural stem cell-derived oligodendrocyte precurs...

    Authors: Yongchao Li, Pei-Shan Wang, George Lucas, Rong Li and Li Yao

    Citation: Stem Cell Research & Therapy 2015 6:41

    Content type: Research

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  8. Acute liver failure (ALF) is a highly lethal disease, for which effective therapeutic methods are limited. Although allogeneic liver transplantation is a viable treatment method for ALF, there is a serious sho...

    Authors: Guangfeng Chen, Yinpeng Jin, Xiujuan Shi, Yu Qiu, Yushan Zhang, Mingliang Cheng, Xiaojin Wang, Chengwei Chen, Yinxia Wu, Fuzhu Jiang, Li Li, Heng Zhou, Qingchun Fu and Xiaoqing Liu

    Citation: Stem Cell Research & Therapy 2015 6:40

    Content type: Research

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  9. Type 1 long QT syndrome (LQT1) is a common type of cardiac channelopathy associated with loss-of-function mutations of KCNQ1. Currently there is a lack of drugs that target the defected slowly activating delayed ...

    Authors: Dongrui Ma, Heming Wei, Jun Lu, Dou Huang, Zhenfeng Liu, Li Jun Loh, Omedul Islam, Reginald Liew, Winston Shim and Stuart A Cook

    Citation: Stem Cell Research & Therapy 2015 6:39

    Content type: Research

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  10. Successful stem cell therapy relies on large-scale generation of stem cells and their maintenance in a proliferative multipotent state. This study aimed to establish a three-dimension culture system for large-...

    Authors: Guifang Zhao, Feilin Liu, Shaowei Lan, Pengdong Li, Li Wang, Junna Kou, Xiaojuan Qi, Ruirui Fan, Deshun Hao, Chunling Wu, Tingting Bai, Yulin Li and Jin Yu Liu

    Citation: Stem Cell Research & Therapy 2015 6:38

    Content type: Research

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  11. Unstable atherosclerotic plaques are prone to rupture, which leads to atherothrombosis. Endothelial progenitor cells (EPCs) are bone marrow-derived precursor cells that may repair vascular injury in atheroscle...

    Authors: Zhongwen Zhang, Jianjun Dong, Corrinne G Lobe, Peiyun Gong, Ju Liu and Lin Liao

    Citation: Stem Cell Research & Therapy 2015 6:36

    Content type: Research

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  12. Local delivery of mesenchymal stem cells (MSCs) to the acutely injured or osteoarthritic joint retards cartilage destruction. However, in the absence of assistive materials the efficiency of engraftment of MSC...

    Authors: Sarah E Bulman, Cynthia M Coleman, J Mary Murphy, Nicholas Medcalf, Aideen E Ryan and Frank Barry

    Citation: Stem Cell Research & Therapy 2015 6:34

    Content type: Research

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  13. Stem cells isolated from menstrual fluid (MenSCs) exhibit mesenchymal stem cell (MSCs)-like properties including multi-lineage differentiation capacity. Besides, menstrual fluid has important advantages over o...

    Authors: Francisca Alcayaga-Miranda, Jimena Cuenca, Patricia Luz-Crawford, Carolina Aguila-Díaz, Ainoa Fernandez, Fernando E Figueroa and Maroun Khoury

    Citation: Stem Cell Research & Therapy 2015 6:32

    Content type: Research

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  14. Mesenchymal stromal/stem cells (MSCs) are multipotent cells that have the ability to express and secrete a wide range of immunomodulatory molecules, cytokines, growth factors and antiapoptotic proteins. MSCs m...

    Authors: Juliana Navarro Ueda Yaochite, Carolina Caliari-Oliveira, Lucas Eduardo Botelho de Souza, Lourenço Sbragia Neto, Patrícia Vianna Bonini Palma, Dimas Tadeu Covas, Kelen Cristina Ribeiro Malmegrim, Julio César Voltarelli and Eduardo Antônio Donadi

    Citation: Stem Cell Research & Therapy 2015 6:31

    Content type: Research

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  15. Globoid cell leukodystrophy (GLD) is a severe disorder of the central and peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity. Cell-based therapies are highly promising stra...

    Authors: Xiao Ling Kuai, Run Zhou Ni, Guo Xiong Zhou, Zheng Biao Mao, Jian Feng Zhang, Nan Yi, Zhao Xiu Liu, Nan Shao, Wen Kai Ni and Zhi Wei Wang

    Citation: Stem Cell Research & Therapy 2015 6:30

    Content type: Research

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  16. Retinitis pigmentosa (RP) is a severe neurodegenerative disease of the retina that can lead to blindness. Even without treatment, a clinical study with the use of stem cells is currently underway and the resul...

    Authors: Rubens C Siqueira, Andre Messias, Katharina Messias, Rafael S Arcieri, Milton A Ruiz, Neiglene F Souza, Lia C Martins and Rodrigo Jorge

    Citation: Stem Cell Research & Therapy 2015 6:29

    Content type: Research

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  17. Fetal bovine serum (FBS) is an animal product used as a medium supplement. The animal origin of FBS is a concern if cultured stem cells are to be utilized for human cell therapy. Therefore, a substitute for FB...

    Authors: José M Díez, Ewa Bauman, Rodrigo Gajardo and Juan I Jorquera

    Citation: Stem Cell Research & Therapy 2015 6:28

    Content type: Research

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  18. Although there is an increase in clinical trials assessing the efficacy of cell therapy in structural and functional regeneration after stroke, there are not enough data in the literature describing the best c...

    Authors: Leopoldo P Nucci, Helio R Silva, Viviana Giampaoli, Javier B Mamani, Mariana P Nucci and Lionel F Gamarra

    Citation: Stem Cell Research & Therapy 2015 6:27

    Content type: Research

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  19. Bone marrow derived cellular therapies are an emerging approach to promoting therapeutic angiogenesis in ischemic cardiovascular disease. However, the percentage of regenerative cells in bone marrow mononuclea...

    Authors: Kelly J Ledford, Nikki Murphy, Frank Zeigler, Ronnda L Bartel and Ross Tubo

    Citation: Stem Cell Research & Therapy 2015 6:25

    Content type: Research

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  20. Recent evidence has shown that bone marrow cells play critical roles during the inflammatory, proliferative and remodeling phases of cutaneous wound healing. Among the bone marrow cells delivered to wounds are...

    Authors: Luis Rodriguez-Menocal, Shahjahan Shareef, Marcela Salgado, Arsalan Shabbir and Evangelos Van Badiavas

    Citation: Stem Cell Research & Therapy 2015 6:24

    Content type: Research

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  21. Depletion of limbal stem cells leads to a debilitating condition known as limbal stem cell deficiency, characterised by impaired corneal wound healing and poor vision. The aim of this study was to determine wh...

    Authors: Samantha Bobba, Sharron Chow, Stephanie Watson and Nick Di Girolamo

    Citation: Stem Cell Research & Therapy 2015 6:23

    Content type: Research

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  22. The objective of the present study was to evaluate the capacity of a tissue-engineered complex of human osteoprotegerin (hOPG)-transfected periodontal ligament stem cells (PDLSCs) seeding on beta-tricalcium ph...

    Authors: Fang Su, Shi-Sen Liu, Jun-Li Ma, Dong-Sheng Wang, Ling-Ling E and Hong-Chen Liu

    Citation: Stem Cell Research & Therapy 2015 6:22

    Content type: Research

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  23. Bone marrow-derived mesenchymal stem cells (BMSCs, also known as bone marrow-derived mesenchymal stromal cells) are known to be a component of the tumor microenvironment. BMSCs are multipotent stromal cells th...

    Authors: Chen Jiang, Jun Sun, Yafei Dai, Pengfei Cao, Liyang Zhang, Shuping Peng, Yanhong Zhou, Guiyuan Li, Jingqun Tang and Juanjuan Xiang

    Citation: Stem Cell Research & Therapy 2015 6:21

    Content type: Research

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  24. Tumor necrosis factor-inducible gene 6 protein (TSG-6), one of the cytokines released by human mesenchymal stem/stromal cells (hMSC), has an anti-inflammatory effect and alleviates several pathological conditi...

    Authors: Sihyung Wang, Ji-Seon Lee, Jeongeun Hyun, Jieun Kim, Seung U Kim, Hyuk-Jin Cha and Youngmi Jung

    Citation: Stem Cell Research & Therapy 2015 6:20

    Content type: Research

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  25. Mesenchymal stromal cells (MSC) have well defined immunomodulatory properties including the suppression of lymphocyte proliferation and inhibition of dendritic cell (DC) maturation involving both cell contact ...

    Authors: Emer F Cahill, Laura M Tobin, Fiona Carty, Bernard P Mahon and Karen English

    Citation: Stem Cell Research & Therapy 2015 6:19

    Content type: Research

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  26. Microparticles (MPs) derived from kidney-derived mesenchymal stem cells (KMSCs) have recently been reported to ameliorate rarefaction of peritubular capillaries (PTC) in ischemic kidneys via delivery of proang...

    Authors: Hoon Young Choi, Hyun Gyu Lee, Beom Seok Kim, Sun Hee Ahn, Ara Jung, Mirae Lee, Jung Eun Lee, Hyung Jong Kim, Sung Kyu Ha and Hyeong Cheon Park

    Citation: Stem Cell Research & Therapy 2015 6:18

    Content type: Research

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  27. Bone marrow mesenchymal stem cells (BMSCs), which have the ability to self-renew and to differentiate into multiple cell types, have recently become a novel strategy for cell-based therapies. The differentiati...

    Authors: Zhenzhen Li, Shichao Han, Xingqin Wang, Fu Han, Xiongxiang Zhu, Zhao Zheng, Hongtao Wang, Qin Zhou, Yunchuan Wang, Linlin Su, Jihong Shi, Chaowu Tang and Dahai Hu

    Citation: Stem Cell Research & Therapy 2015 6:17

    Content type: Research

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  28. Developing cartilage constructs with injectability, appropriate matrix composition and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Bone marrow derived mesenchymal stem...

    Authors: Ruikai Ba, Jianhua Wei, Man Li, Xiaobing Cheng, Yimin Zhao and Wei Wu

    Citation: Stem Cell Research & Therapy 2015 6:16

    Content type: Research

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  29. In recent years, mesenchymal stem cells (MSCs) have been demonstrated to play an important role in carcinogenesis. However, the effect of MSCs on tumor and metastasis development and the mechanisms underlying ...

    Authors: Aleksandra V Meleshina, Elena I Cherkasova, Marina V Shirmanova, Natalia V Klementieva, Ekaterina V Kiseleva, Ludmila В Snopova, Natalia N Prodanets and Elena V Zagaynova

    Citation: Stem Cell Research & Therapy 2015 6:15

    Content type: Research

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  30. Human induced pluripotent stem cells (hiPSCs) have been derived from various somatic cell types. Granulosa cells, a group of cells which surround oocytes and are obtained from the (normally discarded) retrieve...

    Authors: Ching-Yu Chuang, Mei-Chi Huang, Hsin-Fu Chen, Li-Hui Tseng, Chun-Ying Yu, Lee Stone, Hsiang-Po Huang, Hong-Nerng Ho and Hung-Chih Kuo

    Citation: Stem Cell Research & Therapy 2015 6:14

    Content type: Research

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  31. High-risk neuroblastoma (HR-NB) presenting with hematogenous metastasis is one of the most difficult cancers to cure. Patient survival is poor. Aggressive tumors contain populations of rapidly proliferating cl...

    Authors: Vijayabaskar Pandian, Satishkumar Ramraj, Faizan H Khan, Tasfia Azim and Natarajan Aravindan

    Citation: Stem Cell Research & Therapy 2015 6:400

    Content type: Research

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    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:32

  32. Follicular fluid is important for follicular development and oocyte maturation. Evidence suggests that follicular fluid is not only rich in proteins but cells. Besides oocytes, the follicular fluid contains gr...

    Authors: Dongmei Lai, Minhua Xu, Qiuwan Zhang, Yifei Chen, Ting Li, Qian Wang, Yimeng Gao and Chunsheng Wei

    Citation: Stem Cell Research & Therapy 2015 6:13

    Content type: Research

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  33. Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum ...

    Authors: Julien Rossignol, Kyle D Fink, Andrew T Crane, Kendra K Davis, Matthew C Bombard, Steven Clerc, Angela M Bavar, Steven A Lowrance, Cheng Song, Steven Witte, Laurent Lescaudron and Gary L Dunbar

    Citation: Stem Cell Research & Therapy 2015 6:9

    Content type: Research

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  34. An increasing number of private clinics in Australia are marketing and providing autologous stem cell therapies to patients. Although advocates point to the importance of medical innovation and the primacy of ...

    Authors: Alison K McLean, Cameron Stewart and Ian Kerridge

    Citation: Stem Cell Research & Therapy 2015 6:33

    Content type: Review

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  35. An increasing number of private clinics in Australia are marketing and providing autologous stem cell therapies to patients. Although advocates point to the importance of medical innovation and the primacy of ...

    Authors: Alison K McLean, Cameron Stewart and Ian Kerridge

    Citation: Stem Cell Research & Therapy 2015 6:12

    Content type: Review

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    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:69

  36. The immunomodulatory properties of human amnion epithelial cells (hAECs) have been previously described in several disease models. We previously reported on the ability of hAECs to influence macrophage phenoty...

    Authors: Jean L Tan, Siow T Chan, Camden Y Lo, James A Deane, Courtney A McDonald, Claude CA Bernard, Euan M Wallace and Rebecca Lim

    Citation: Stem Cell Research & Therapy 2015 6:8

    Content type: Research

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  37. Intra-arterial cell infusion is an efficient delivery route with which to target organs such as the ischemic brain. However, adverse events including microembolisms and decreased cerebral blood flow were recen...

    Authors: Li-li Cui, Erja Kerkelä, Abdulhameed Bakreen, Franziska Nitzsche, Anna Andrzejewska, Adam Nowakowski, Miroslaw Janowski, Piotr Walczak, Johannes Boltze, Barbara Lukomska and Jukka Jolkkonen

    Citation: Stem Cell Research & Therapy 2015 6:11

    Content type: Research

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  38. Percutaneous transluminal renal angioplasty (PTRA) fails to fully improve cardiac injury and dysfunction in patients with renovascular hypertension (RVH). Mesenchymal stem cells (MSCs) restore renal function, ...

    Authors: Alfonso Eirin, Xiang-Yang Zhu, Christopher M Ferguson, Scott M Riester, Andre J van Wijnen, Amir Lerman and Lilach O Lerman

    Citation: Stem Cell Research & Therapy 2015 6:7

    Content type: Research

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  39. Mesenchymal stem cells (MSCs) are a promising source of cells for regenerative therapies. Although they can be isolated easily from several tissues, cell expansion is limited since their properties are lost wi...

    Authors: Carlos Luzzani, Gabriel Neiman, Ximena Garate, María Questa, Claudia Solari, Darío Fernandez Espinosa, Marcela García, Ana Lía Errecalde, Alejandra Guberman, María Elida Scassa, Gustavo Emilio Sevlever, Leonardo Romorini and Santiago Gabriel Miriuka

    Citation: Stem Cell Research & Therapy 2015 6:6

    Content type: Research

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  40. Urine-derived stem cells (USCs) have the ability to differentiate into osteogenic lineage. Previous studies have raised the possibility that USCs could be used for bone repair. To harness the power of USCs in ...

    Authors: Junjie Guan, Jieyuan Zhang, Zhenzhong Zhu, Xin Niu, Shangchun Guo, Yang Wang and Changqing Zhang

    Citation: Stem Cell Research & Therapy 2015 6:5

    Content type: Research

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  41. Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the role of Ang II receptor type 2 (AT2R) remains poorly...

    Authors: Izuagie Attairu Ikhapoh, Christopher J Pelham and Devendra K Agrawal

    Citation: Stem Cell Research & Therapy 2015 6:4

    Content type: Research

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  42. The different distribution of T cells among activation/differentiation stages in immune disorders may condition the outcome of mesenchymal stromal cell (MSC)-based therapies. Indeed, the effect of MSCs in the ...

    Authors: Paula Laranjeira, Monia Pedrosa, Susana Pedreiro, Joana Gomes, Antonio Martinho, Brigida Antunes, Tania Ribeiro, Francisco Santos, Helder Trindade and Artur Paiva

    Citation: Stem Cell Research & Therapy 2015 6:3

    Content type: Research

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  43. Autologous fat grafting is commonly used to correct soft-tissue contour deformities. However, results are impaired by a variable and unpredictable resorption rate. Autologous adipose-derived stromal cells in c...

    Authors: Rossana Domenis, Lara Lazzaro, Sarah Calabrese, Damiano Mangoni, Annarita Gallelli, Evgenia Bourkoula, Ivana Manini, Natascha Bergamin, Barbara Toffoletto, Carlo A Beltrami, Antonio P Beltrami, Daniela Cesselli and Pier Camillo Parodi

    Citation: Stem Cell Research & Therapy 2015 6:2

    Content type: Research

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  44. Pluripotent stem cells are increasingly used to build therapeutic models, including the transplantation of neural progenitors derived from human embryonic stem cells (hESCs). Recently, long non-coding RNAs (ln...

    Authors: Chu-Fan Mo, Fang-Chun Wu, Kang-Yu Tai, Wei-Chun Chang, Kai-Wei Chang, Hung-Chih Kuo, Hong-Nerng Ho, Hsin-Fu Chen and Shau-Ping Lin

    Citation: Stem Cell Research & Therapy 2015 6:1

    Content type: Research

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  45. Microcomputed tomography (microCT) has become a standard and essential tool for quantifying structure-function relationships, disease progression, and regeneration in preclinical models and has facilitated num...

    Authors: Joel D Boerckel, Devon E Mason, Anna M McDermott and Eben Alsberg

    Citation: Stem Cell Research & Therapy 2014 5:144

    Content type: Review

    Published on:

  46. Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothel...

    Authors: Sushma Bartaula-Brevik, Torbjorn O Pedersen, Anna L Blois, Panagiota Papadakou, Anna Finne-Wistrand, Ying Xue, Anne Isine Bolstad and Kamal Mustafa

    Citation: Stem Cell Research & Therapy 2014 5:143

    Content type: Research

    Published on:

  47. Mesenchymal cells are emerging as a promising cell platform for regenerative therapies. However, the fate of cells after transplantation in many different disease settings and tissue beds remains unclear.

    Authors: Hitesh Agrawal, Hulan Shang, Anna Parker Sattah, Ning Yang, Shayn M Peirce and Adam J Katz

    Citation: Stem Cell Research & Therapy 2014 5:142

    Content type: Research

    Published on:

  48. Heart disease remains the number one cause of death in developed countries. Loss of cardiomyocytes (CMs) due to aging or pathophysiological conditions (for example, myocardial infarction) is generally consider...

    Authors: Ronald A Li

    Citation: Stem Cell Research & Therapy 2014 5:141

    Content type: Editorial

    Published on:

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