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  1. Previously, we established a simple method for deriving mesenchymal stem cells (MSCs) from human induced pluripotent stem cells (iPSC-MSCs). These iPSC-MSCs were capable of forming osteogenic structures in sca...

    Authors: Ran Kang, Yan Zhou, Shuang Tan, Guangqian Zhou, Lars Aagaard, Lin Xie, Cody Bünger, Lars Bolund and Yonglun Luo

    Citation: Stem Cell Research & Therapy 2015 6:144

    Content type: Research

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  2. An effective immune response to severe bacterial infections requires a robust production of the innate immunity cells from hematopoietic stem and progenitor cells (HSPCs) in a process called emergency myelopoi...

    Authors: Tomasz Skirecki, Jerzy Kawiak, Eugeniusz Machaj, Zygmunt Pojda, Danuta Wasilewska, Jarosław Czubak and Grażyna Hoser

    Citation: Stem Cell Research & Therapy 2015 6:142

    Content type: Research

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  3. To this end human MSCs were isolated from adipose tissue and the MSC:CD4+ T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 ...

    Authors: Ozge Kizilay Mancini, Dominique Shum-Tim, Ursula Stochaj, José A. Correa and Inés Colmegna

    Citation: Stem Cell Research & Therapy 2015 6:140

    Content type: Short report

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    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:35

  4. Endothelial colony-forming cells (ECFCs) significantly improve tissue repair by providing regeneration potential within injured cardiovascular tissue. However, ECFC transplantation into ischemic tissue exhibit...

    Authors: Sang Hun Lee, Jun Hee Lee, Yong-Seok Han, Jung Min Ryu, Yeo Min Yoon and Ho Jae Han

    Citation: Stem Cell Research & Therapy 2015 6:139

    Content type: Research

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  5. Therapeutic angiogenesis by transplantation of autologous/allogeneic adipose-derived stem cells (ADSCs) is a potential approach for severe ischemic diseases. However, poor viability, adhesion, migration and di...

    Authors: Jinbao Qin, Fukang Yuan, Zhiyou Peng, Kaichuang Ye, Xinrui Yang, Lijia Huang, Mier Jiang and Xinwu Lu

    Citation: Stem Cell Research & Therapy 2015 6:138

    Content type: Research

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  6. Crohn’s disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subjects. Growing evidence highlights the safety ...

    Authors: Rachele Ciccocioppo, Giuseppina C. Cangemi, Peter Kruzliak, Alessandra Gallia, Elena Betti, Carla Badulli, Miryam Martinetti, Marila Cervio, Alessandro Pecci, Valeria Bozzi, Paolo Dionigi, Livia Visai, Antonella Gurrado, Costanza Alvisi, Cristina Picone, Manuela Monti…

    Citation: Stem Cell Research & Therapy 2015 6:137

    Content type: Research

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  7. Bone marrow-derived stromal cells (BMSCs), also known as mesenchymal stem cells, are the focus of intensive efforts worldwide to elucidate their function and biology. Despite the importance of BMSC migration f...

    Authors: Caroline M. Ryan, James A. L. Brown, Emer Bourke, Áine M. Prendergast, Claire Kavanagh, Zhonglin Liu, Peter Owens, Georgina Shaw, Walter Kolch, Timothy O’Brien and Frank P. Barry

    Citation: Stem Cell Research & Therapy 2015 6:136

    Content type: Research

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  8. Tumor microenvironment conferred by stromal (mesenchymal) stem cells (MSCs) plays a key role in tumor development, progression, and response to therapy. Defining the role of MSCs in tumorigenesis is crucial fo...

    Authors: Mashael Al-toub, Radhakrishnan Vishnubalaji, Rimi Hamam, Moustapha Kassem, Abdullah Aldahmash and Nehad M. Alajez

    Citation: Stem Cell Research & Therapy 2015 6:135

    Content type: Research

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  9. The aim of our study is to identify the contribution of hematopoietic-derived cells to burn-wound healing in a non-severe injury. There are many conflicting reports of the contribution of bone marrow-derived c...

    Authors: Suzanne Rea, Andrew Stevenson, Natalie L. Giles, Fiona M. Wood and Mark W. Fear

    Citation: Stem Cell Research & Therapy 2015 6:134

    Content type: Research

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  10. The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application...

    Authors: Fábio G. Teixeira, Krishna M. Panchalingam, Sandra Isabel Anjo, Bruno Manadas, Ricardo Pereira, Nuno Sousa, António J. Salgado and Leo A. Behie

    Citation: Stem Cell Research & Therapy 2015 6:133

    Content type: Research

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  11. Histone H3 lysine 27 trimethylation (H3K27me3) and H3 lysine 36 trimethylation (H3K36me3) are important epigenetic modifications correlated with transcription repression and activation, respectively. These two...

    Authors: Hailei Mao, Gang Han, Longyong Xu, Duming Zhu, Hanqing Lin, Xiongwen Cao, Yi Yu and Charlie Degui Chen

    Citation: Stem Cell Research & Therapy 2015 6:132

    Content type: Research

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  12. Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Current...

    Authors: Maria-Adelaide Micci, Debbie R. Boone, Margaret A. Parsley, Jingna Wei, Igor Patrikeev, Massoud Motamedi and Helen L. Hellmich

    Citation: Stem Cell Research & Therapy 2015 6:131

    Content type: Research

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  13. Cell replacement therapy may be considered as an alternate approach to provide therapeutic dose of plasma factor VIII (FVIII) in patients with hemophilia A (HA). However, immune rejection limits the use of all...

    Authors: Veena Kochat, Sumod Kanjirakkuzhiyil, Prakash Baligar, Perumal Nagarajan and Asok Mukhopadhyay

    Citation: Stem Cell Research & Therapy 2015 6:129

    Content type: Research

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  14. Peripheral nerves may fail to regenerate across tube implants because these lack the microarchitecture of native nerves. Bone marrow mesenchymal stem cells (MSC) secrete soluble factors that improve the regene...

    Authors: A. Carrier-Ruiz, F. Evaristo-Mendonça, R. Mendez-Otero and V. T. Ribeiro-Resende

    Citation: Stem Cell Research & Therapy 2015 6:128

    Content type: Research

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  15. In light of pioneering findings in the 1980s and an estimation of more than 130 million global annual births, umbilical cord blood (UCB) is considered to be the most plentiful reservoir of cells and to have re...

    Authors: Santiago Roura, Josep-Maria Pujal, Carolina Gálvez-Montón and Antoni Bayes-Genis

    Citation: Stem Cell Research & Therapy 2015 6:123

    Content type: Review

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  16. Administration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological and degenerative disorders. Accumulating evidence indicates that the healing ef...

    Authors: Serena Rubina Baglio, Koos Rooijers, Danijela Koppers-Lalic, Frederik J. Verweij, M Pérez Lanzón, Nicoletta Zini, Benno Naaijkens, Francesca Perut, Hans W. M. Niessen, Nicola Baldini and D. Michiel Pegtel

    Citation: Stem Cell Research & Therapy 2015 6:127

    Content type: Research

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  17. Autologous blood-derived biologicals, including autologous conditioned serum (ACS), are frequently used to treat tendinopathies in horses despite limited evidence for their efficacy. The purpose of this study ...

    Authors: Florian Geburek, Maren Lietzau, Andreas Beineke, Karl Rohn and Peter M. Stadler

    Citation: Stem Cell Research & Therapy 2015 6:126

    Content type: Research

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  18. Induced pluripotent stem cells (iPSCs) have emerged as a promising cell source for immune-compatible cell therapy. Although a variety of somatic cells have been tried for iPSC generation, it is still of great ...

    Authors: Jinsoo Oh, Kang-In Lee, Hyeong-Taek Kim, Youngsang You, Do Heum Yoon, Ki Yeong Song, Eunji Cheong, Yoon Ha and Dong-Youn Hwang

    Citation: Stem Cell Research & Therapy 2015 6:125

    Content type: Research

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  19. Chemotherapy has made an essential contribution to cancer treatment in recent decades despite its adverse effects. As cancer survivors have increased, concern about ex-patient lifespan has become more importan...

    Authors: Fernando Ezquer, Jaime Gutiérrez, Marcelo Ezquer, Christian Caglevic, Helio C Salgado and Sebastián D Calligaris

    Citation: Stem Cell Research & Therapy 2015 6:116

    Content type: Review

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  20. Surface modification of titanium (Ti) implants promotes bone formation and shortens the osseointegration period. The aim of this study was to promote bone regeneration and stability around implants using atmos...

    Authors: Masahiro Omori, Shuhei Tsuchiya, Kenji Hara, Kensuke Kuroda, Hideharu Hibi, Masazumi Okido and Minoru Ueda

    Citation: Stem Cell Research & Therapy 2015 6:124

    Content type: Research

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  21. The prospect of therapeutic applications of the induced pluripotent stem cells (iPSCs) is based on their ability to generate virtually any cell type present in human body. Generation of iPSCs from somatic cell...

    Authors: Anna M. Drozd, Maciej P. Walczak, Sylwester Piaskowski, Ewelina Stoczynska-Fidelus, Piotr Rieske and Dawid P. Grzela

    Citation: Stem Cell Research & Therapy 2015 6:122

    Content type: Research

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  22. Despite its high incidence, nerve fiber (axon and myelin) damage after cerebral infarct has not yet been extensively investigated. The aim of this study was to investigate white matter repair after adipose-der...

    Authors: Laura Otero-Ortega, María Gutiérrez-Fernández, Jaime Ramos-Cejudo, Berta Rodríguez-Frutos, Blanca Fuentes, Tomás Sobrino, Teresa Navarro Hernanz, Francisco Campos, Juan Antonio López, Sebastián Cerdán, Jesús Vázquez and Exuperio Díez-Tejedor

    Citation: Stem Cell Research & Therapy 2015 6:121

    Content type: Research

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  23. Wnt and Notch signaling pathways are critically involved in relative cell fate decisions within the development of cutaneous tissues. Moreover, several studies identified the above two pathways as having a sig...

    Authors: Yan Shi, Bin Shu, Ronghua Yang, Yingbin Xu, Bangrong Xing, Jian Liu, Lei Chen, Shaohai Qi, Xusheng Liu, Peng Wang, Jinming Tang and Julin Xie

    Citation: Stem Cell Research & Therapy 2015 6:120

    Content type: Research

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    The Erratum to this article has been published in Stem Cell Research & Therapy 2015 6:254

  24. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging disease. One of...

    Authors: Jesús Mateos, Arancha Landeira-Abia, Juan Antonio Fafián-Labora, Pablo Fernández-Pernas, Iván Lesende-Rodríguez, Patricia Fernández-Puente, Mercedes Fernández-Moreno, Aitor Delmiro, Miguel A. Martín, Francisco J. Blanco and María C. Arufe

    Citation: Stem Cell Research & Therapy 2015 6:119

    Content type: Research

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  25. The worldwide shortage of donor livers has prompted the search for alternative cell therapies. Previous data from our laboratory proved a supportive role for stem cell therapy in the treatment of end-stage liv...

    Authors: Abdel-Rahman N. Zekri, Hosny Salama, Eman Medhat, Sherief Musa, Hanan Abdel-Haleem, Ola S. Ahmed, Hanan Abdel Hafez Khedr, Mai M. Lotfy, Khaled S. Zachariah and Abeer A. Bahnassy

    Citation: Stem Cell Research & Therapy 2015 6:118

    Content type: Research

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  26. The increasing interest in 99m-technetium (99mTc)-labeled stem cells encouraged us to study the 99mTc binding sites in stem cell compartments.

    Authors: Grazielle Dias Suhett, Sergio Augusto Lopes de Souza, Adriana Bastos Carvalho, Rachel de Pinho Rachid, Narcisa Leal da Cunha-E-Silva, Antonio Carlos Campos de Carvalho, Lea Mirian Barbosa da Fonseca, Regina Coeli dos Santos Goldenberg and Bianca Gutfilen

    Citation: Stem Cell Research & Therapy 2015 6:115

    Content type: Research

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  27. The bursa subacromialis (BS) provides the gliding mechanism of the shoulder and regenerates itself after surgical removal. Therefore, we explored the presence of mesenchymal stem cells (MSCs) within the human ...

    Authors: Andre F. Steinert, Manuela Kunz, Patrick Prager, Sascha Göbel, Ludger Klein-Hitpass, Regina Ebert, Ulrich Nöth, Franz Jakob and Frank Gohlke

    Citation: Stem Cell Research & Therapy 2015 6:114

    Content type: Research

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  28. Irreversible end-stage organ failure represents one of the leading causes of death, and organ transplantation is currently the only curative solution. Donor organ shortage and adverse effects of immunosuppress...

    Authors: Andrea Peloso, Abritee Dhal, Joao P Zambon, Peng Li, Giuseppe Orlando, Anthony Atala and Shay Soker

    Citation: Stem Cell Research & Therapy 2015 6:107

    Content type: Review

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  29. Testicular torsion is a urological emergency and infertility is a common complication due to ischemic injury. Surgical reduction and orchiopexy is indicated, but to date there is no effective method for restor...

    Authors: Chi-Hao Hsiao, Andrea Tung-Qian Ji, Chih-Cheng Chang, Chien-Jui Cheng, Liang-Ming Lee and Jennifer Hui-Chun Ho

    Citation: Stem Cell Research & Therapy 2015 6:113

    Content type: Research

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  30. Most studies on intracoronary bone marrow mononuclear cell transplantation for acute myocardial infarction involve treatment 3–7 days after primary percutaneous coronary intervention (PCI); however, the optima...

    Authors: Rongchong Huang, Kang Yao, Aijun Sun, Juying Qian, Lei Ge, Yiqi Zhang, Yuhong Niu, Keqiang Wang, Yunzeng Zou and Junbo Ge

    Citation: Stem Cell Research & Therapy 2015 6:112

    Content type: Research

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  31. The release of trophic factors from mesenchymal stem cells (MSCs) is critical for tissue regeneration. A systematic investigation of the regenerative potential of trophic factors from different MSCs, however, ...

    Authors: Y Hayashi, M Murakami, R Kawamura, R Ishizaka, O Fukuta and M Nakashima

    Citation: Stem Cell Research & Therapy 2015 6:111

    Content type: Research

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    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:86

  32. Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an option for improving joint function in osteonecrosis of the femoral head (ONFH). Bone marrow-derived mesenchymal stromal cell (MSC) nu...

    Authors: Gildasio Cerqueira Daltro, Vitor Fortuna, Eliane Silva de Souza, Marcela Miranda Salles, Ana Claudia Carreira, Roberto Meyer, Songeli Menezes Freire and Radovan Borojevic

    Citation: Stem Cell Research & Therapy 2015 6:110

    Content type: Research

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  33. Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovas...

    Authors: Carolina Gálvez-Montón, M. Teresa Fernandez-Figueras, Mercè Martí, Carolina Soler-Botija, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Aida Llucià-Valldeperas, Ángel Raya and Antoni Bayes-Genis

    Citation: Stem Cell Research & Therapy 2015 6:108

    Content type: Short report

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  34. Severe spinal cord injury often causes temporary or permanent damages in strength, sensation, or autonomic functions below the site of the injury. So far, there is still no effective treatment for spinal cord ...

    Authors: Xue-Cheng Qiu, Hui Jin, Rong-Yi Zhang, Ying Ding, Xiang Zeng, Bi-Qin Lai, Eng-Ang Ling, Jin-Lang Wu and Yuan-Shan Zeng

    Citation: Stem Cell Research & Therapy 2015 6:105

    Content type: Research

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  35. Secondary osteoporosis is common in systemic lupus erythematosus and leads to a reduction in quality of life due to fragility fractures, even in patients with improvement of the primary disorder. Systemic tran...

    Authors: Lan Ma, Reona Aijima, Yoshihiro Hoshino, Haruyoshi Yamaza, Erika Tomoda, Yosuke Tanaka, Soichiro Sonoda, Guangtai Song, Wei Zhao, Kazuaki Nonaka, Songtao Shi and Takayoshi Yamaza

    Citation: Stem Cell Research & Therapy 2015 6:104

    Content type: Research

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  36. Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this...

    Authors: Hongwei Lv, Lisha Li, Meiyu Sun, Yin Zhang, Li Chen, Yue Rong and Yulin Li

    Citation: Stem Cell Research & Therapy 2015 6:103

    Content type: Review

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  37. Malaria is the most relevant parasitic disease worldwide, and still accounts for 1 million deaths each year. Since current antimalarial drugs are unable to prevent death in severe cases, new therapeutic strate...

    Authors: Mariana C Souza, Johnatas D Silva, Tatiana A Pádua, Natália D Torres, Mariana A Antunes, Debora G Xisto, Thiago P Abreu, Vera L Capelozzi, Marcelo M Morales, Ana A. Sá Pinheiro, Celso Caruso-Neves, Maria G Henriques and Patricia RM Rocco

    Citation: Stem Cell Research & Therapy 2015 6:102

    Content type: Research

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  38. The purpose of this study was to investigate the expression of Wnt and Notch signaling pathway-related genes in inflammatory bowel disease (IBD) treated with mesenchymal stem cell transplantation (MSCT).

    Authors: Yanfen Xing, Xiaojie Chen, Yanwen Cao, Jianyun Huang, Xuhong Xie and Yaming Wei

    Citation: Stem Cell Research & Therapy 2015 6:101

    Content type: Research

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  39. Mesenchymal stem cells (MSCs) play a central role in the remediation of cell and tissue damage. Erythropoietin (EPO) may enhance the beneficial influence of MSCs during recovery from tissue and organ injuries....

    Authors: Yan Wang, Xingyan Lu, Juan He and Weihong Zhao

    Citation: Stem Cell Research & Therapy 2015 6:100

    Content type: Research

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  40. Osteopontin (OPN) is a phosphoglycoprotein with important roles in tissue homeostasis, wound healing, immune regulation, and stress responses. It is expressed constitutively in the brain and upregulated during...

    Authors: Monika Rabenstein, Joerg Hucklenbroich, Antje Willuweit, Anne Ladwig, Gereon Rudolf Fink, Michael Schroeter, Karl-Josef Langen and Maria Adele Rueger

    Citation: Stem Cell Research & Therapy 2015 6:99

    Content type: Research

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  41. Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired vi...

    Authors: Jiaojiao Wang, Yong Zhao, Xiaoyun Wu, Shande Yin, Yunhai Chuai and Aiming Wang

    Citation: Stem Cell Research & Therapy 2015 6:98

    Content type: Research

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  42. Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with great therapeutic potential for the trea...

    Authors: Ying-Wei Lan, Kong-Bung Choo, Chuan-Mu Chen, Tsai-Hsien Hung, Young-Bin Chen, Chung-Hsing Hsieh, Han-Pin Kuo and Kowit-Yu Chong

    Citation: Stem Cell Research & Therapy 2015 6:97

    Content type: Research

    Published on:

  43. Mouse pancreas has a remarkable ability to regenerate after partial pancreatectomy, and several investigators have studied the underlying mechanisms involved in this regeneration process; however, the field re...

    Authors: Deepa Bhartiya and Hiren Patel

    Citation: Stem Cell Research & Therapy 2015 6:96

    Content type: Review

    Published on:

  44. Adipose-derived stem cells (ADSC) are non-hematopoietic mesenchymal stem cells that have shown great promise in their ability to differentiate into multiple cell lineages. Their ubiquitous nature and the ease ...

    Authors: Haitao Shen, Enchen Zhou, Xiujing Wei, Zhiwei Fu, Chenguang Niu, Yang Li, Bing Pan, Anna V Mathew, Xu Wang, Subramaniam Pennathur, Lemin Zheng and Yongyu Wang

    Citation: Stem Cell Research & Therapy 2015 6:95

    Content type: Research

    Published on:

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