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  1. Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF)....

    Authors: Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan and Hongqin Zhang

    Citation: Stem Cell Research & Therapy 2018 9:37

    Content type: Research

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  2. Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effect...

    Authors: Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma and Hong-Fei Xia

    Citation: Stem Cell Research & Therapy 2018 9:36

    Content type: Research

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  3. Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering. Still, to tra...

    Authors: Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl and Wolfgang Holnthoner

    Citation: Stem Cell Research & Therapy 2018 9:35

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:261

  4. CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed...

    Authors: Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte and Sara Teresinha Olalla Saad

    Citation: Stem Cell Research & Therapy 2018 9:34

    Content type: Letter

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  5. Several studies have focused on umbilical cord-derived mesenchymal stem cells (UC-MSCs) due to their potential therapeutic effects in a cluster of diseases. However, there has been no bibliometric analysis eva...

    Authors: Jian Zhao, Guanyu Yu, Mengxi Cai, Xiao Lei, Yanyong Yang, Qijin Wang and Xiao Zhai

    Citation: Stem Cell Research & Therapy 2018 9:32

    Content type: Review

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  6. Mesenchymal stromal cells (MSCs) are an attractive therapeutic agent in regenerative medicine. Recently, there has been a paradigm shift from differentiation of MSCs to their paracrine effects at the injury si...

    Authors: Apeksha Damania, Deepika Jaiman, Arun Kumar Teotia and Ashok Kumar

    Citation: Stem Cell Research & Therapy 2018 9:31

    Content type: Research

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  7. Doxorubicin (Dox) is a chemotherapy drug with limited application due to cardiotoxicity that may progress to heart failure. This study aims to evaluate the role of cardiomyocytes derived from mouse embryonic s...

    Authors: Danúbia Silva dos Santos, Guilherme Visconde Brasil, Isalira Peroba Rezende Ramos, Fernanda Cristina Paccola Mesquita, Tais Hanae Kasai-Brunswick, Michelle Lopes Araújo Christie, Gustavo Monnerat Cahli, Raiana Andrade Quintanilha Barbosa, Sandro Torrentes da Cunha, Jonathas Xavier Pereira, Emiliano Medei, Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho and Regina Coeli dos Santos Goldenberg

    Citation: Stem Cell Research & Therapy 2018 9:30

    Content type: Research

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  8. Mature human hepatocytes are critical in preclinical research and therapy for liver disease, but are difficult to manipulate and expand in vitro. Hepatic stem cells (HpSCs) may be an alternative source of func...

    Authors: Ran-Ran Zhang, Yun-Wen Zheng, Bin Li, Yun-Zhong Nie, Yasuharu Ueno, Tomonori Tsuchida and Hideki Taniguchi

    Citation: Stem Cell Research & Therapy 2018 9:29

    Content type: Research

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  9. Studies in which mesenchymal stromal cells (MSC) from the placenta are compared with multiple MSC types from other sources are rare. The chorionic plate of the human placenta is mainly composed of fetal blood ...

    Authors: Mónica S. Ventura Ferreira, Michaela Bienert, Katrin Müller, Björn Rath, Tamme Goecke, Christian Opländer, Till Braunschweig, Petra Mela, Tim H. Brümmendorf, Fabian Beier and Sabine Neuss

    Citation: Stem Cell Research & Therapy 2018 9:28

    Content type: Research

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  10. The study aimed to evaluate the efficacy and safety of gingival mesenchymal stem cells (GMSCs) from human fetal gingival tissue used for treating gingival defects in a rat model.

    Authors: Jing Li, Shi-qing Xu, Kai Zhang, Wen-jian Zhang, Hong-lin Liu, Zhen Xu, Hong Li, Jin-ning Lou, Li-hong Ge and Bao-hua Xu

    Citation: Stem Cell Research & Therapy 2018 9:27

    Content type: Research

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  11. Currently, ex-vivo handling of stem cells, including transport after harvest and therapeutic preparation, is generally done in culture media containing fetal bovine serum (FBS), which promotes cell attachment,...

    Authors: Mai Mochizuki and Taka Nakahara

    Citation: Stem Cell Research & Therapy 2018 9:25

    Content type: Research

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  12. Radiation-induced gastrointestinal syndrome (RIGS) results from the acute loss of intestinal stem cells (ISC), impaired epithelial regeneration, and subsequent loss of the mucosal barrier, resulting in electro...

    Authors: Payel Bhanja, Andrew Norris, Pooja Gupta-Saraf, Andrew Hoover and Subhrajit Saha

    Citation: Stem Cell Research & Therapy 2018 9:26

    Content type: Research

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  13. Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily from extracted teeth and are now considered to be ...

    Authors: Yasuyuki Fujii, Yoko Kawase-Koga, Hironori Hojo, Fumiko Yano, Marika Sato, Ung-il Chung, Shinsuke Ohba and Daichi Chikazu

    Citation: Stem Cell Research & Therapy 2018 9:24

    Content type: Research

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  14. In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influ...

    Authors: Sunita Sharma, Dipak Sapkota, Ying Xue, Saroj Rajthala, Mohammed A. Yassin, Anna Finne-Wistrand and Kamal Mustafa

    Citation: Stem Cell Research & Therapy 2018 9:23

    Content type: Research

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  15. During tumorigenesis and development, participation of the tumor microenvironment is not negligible. As an important component in the tumor microenvironment, mesenchymal stem cells (MSCs) have been corroborate...

    Authors: Ying Zheng, Gangyang Wang, Ruiling Chen, Yingqi Hua and Zhengdong Cai

    Citation: Stem Cell Research & Therapy 2018 9:22

    Content type: Review

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  16. Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-me...

    Authors: Zhi Yang, Chengmin He, Jinyang He, Jing Chu, Hanping Liu and Xiaoyuan Deng

    Citation: Stem Cell Research & Therapy 2018 9:21

    Content type: Research

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  17. This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone r...

    Authors: Hongqin Zhang, Qianqian Luo, Xueyan Lu, Na Yin, Dongli Zhou, Lianshuang Zhang, Wei Zhao, Dong Wang, Pengchao Du, Yun Hou, Yan Zhang and Wendan Yuan

    Citation: Stem Cell Research & Therapy 2018 9:20

    Content type: Research

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  18. The underlying pathophysiology in intellectual disability (ID) involves abnormalities in dendritic branching and connectivity of the neuronal network. This limits the ability of the brain to process informatio...

    Authors: Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Suhasini Pai, Pooja Kulkarni, Vaishali Ganwir, Maitree Maheshwari, Ridhima Sharma, Meenakshi Raichur, Samson Nivins and Prerna Badhe

    Citation: Stem Cell Research & Therapy 2018 9:19

    Content type: Research

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  19. Since radiotherapy is widely used in managing thoracic tumors, physicians have begun to realize that radiation-induced lung injury (RILI) seriously limits the effects of radiotherapy. Unfortunately, there are ...

    Authors: Tiankai Xu, Yuyu Zhang, Pengyu Chang, Shouliang Gong, Lihong Shao and Lihua Dong

    Citation: Stem Cell Research & Therapy 2018 9:18

    Content type: Review

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  20. Mesenchymal stem (stromal) cells (MSCs) mediate their immunoregulatory and tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs). In several animal models of human dise...

    Authors: Mahesh Khatri, Levi Arthur Richardson and Tea Meulia

    Citation: Stem Cell Research & Therapy 2018 9:17

    Content type: Research

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  21. Deciphering molecular mechanisms underlying the division of hematopoietic stem cells (HSCs) and malignant precursors would improve our understanding of the basis of stem cell-fate decisions and oncogenic trans...

    Authors: Yuchen Wang, Hong Tian, Wenzhi Cai, Zhaorui Lian, Dheeraj Bhavanasi, Chao Wu, Tomohiko Sato, Mineo Kurokawa, Depei Wu, Li Fu, Hong Wang, Hao Shen, Dong Liang and Jian Huang

    Citation: Stem Cell Research & Therapy 2018 9:16

    Content type: Research

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  22. Pancreatic progenitors (PPs) co-expressing the two transcription factors (TFs) PDX1 and NKX6.1 are recognized as the indispensable precursors of functional pancreatic β cells. Here, we aimed to establish an ef...

    Authors: Bushra Memon, Manale Karam, Sara Al-Khawaga and Essam M. Abdelalim

    Citation: Stem Cell Research & Therapy 2018 9:15

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:262

  23. Autologous transplantation of endothelial progenitor cells (EPCs) is a promising therapeutic approach in the treatment of various vascular diseases. We previously reported a two-step culture system for scalabl...

    Authors: Meng Qin, Xin Guan, Yu Zhang, Bin Shen, Fang Liu, Qingyu Zhang, Yupo Ma and Yongping Jiang

    Citation: Stem Cell Research & Therapy 2018 9:14

    Content type: Research

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  24. Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived mesenchymal stem cells (BM-MSCs) are multipotent stro...

    Authors: Zhongyu Xie, Su’an Tang, Guiwen Ye, Peng Wang, Jinteng Li, Wenjie Liu, Ming Li, Shan Wang, Xiaohua Wu, Shuizhong Cen, Guan Zheng, Mengjun Ma, Yanfeng Wu and Huiyong Shen

    Citation: Stem Cell Research & Therapy 2018 9:13

    Content type: Research

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  25. Runt-related transcription factor 2 (RUNX2) haploinsufficiency causes cleidocranial dysplasia (CCD) which is characterized by supernumerary teeth, short stature, clavicular dysplasia, and osteoporosis. At pres...

    Authors: Akiko Saito, Akio Ooki, Takashi Nakamura, Shoko Onodera, Kamichika Hayashi, Daigo Hasegawa, Takahito Okudaira, Katsuhito Watanabe, Hiroshi Kato, Takeshi Onda, Akira Watanabe, Kenjiro Kosaki, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Teruo Sakamoto…

    Citation: Stem Cell Research & Therapy 2018 9:12

    Content type: Research

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  26. Mesenchymal stem cells (MSCs) are one of the most promising candidates for the treatment of major neurological disorders. Desirable therapeutic properties of MSCs include reparative and regenerative potential ...

    Authors: Elena Redondo-Castro, Catriona J. Cunningham, Jonjo Miller, Helena Brown, Stuart M. Allan and Emmanuel Pinteaux

    Citation: Stem Cell Research & Therapy 2018 9:11

    Content type: Research

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  27. Mesenchymal stromal cells (MSC) are a heterogeneous population of multipotent progenitors used in the clinic because of their immunomodulatory properties and their ability to differentiate into multiple mesode...

    Authors: Eliana Amati, Omar Perbellini, Gianluca Rotta, Martina Bernardi, Katia Chieregato, Sabrina Sella, Francesco Rodeghiero, Marco Ruggeri and Giuseppe Astori

    Citation: Stem Cell Research & Therapy 2018 9:10

    Content type: Research

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  28. Recent studies have shown that autophagy plays a central role in mesenchymal stem cells (MSCs), and many studies have shown that human umbilical cord MSCs (huMSCs) can treat Alzheimer’s disease (AD) through a ...

    Authors: Wen Li, Kai Li, Jing Gao and Zhuo Yang

    Citation: Stem Cell Research & Therapy 2018 9:9

    Content type: Research

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  29. Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicit...

    Authors: Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun and Xiaobing Fu

    Citation: Stem Cell Research & Therapy 2018 9:8

    Content type: Research

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  30. Renal fibrosis is characterized by infiltration of interstitial inflammatory cells and release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition of excessive extracellular ...

    Authors: Bo Liu, Fengxia Ding, Dong Hu, Yu Zhou, Chunlan Long, Lianju Shen, Yuanyuan Zhang, Deying Zhang and Guanghui Wei

    Citation: Stem Cell Research & Therapy 2018 9:7

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:76

  31. Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal st...

    Authors: S. Oja, P. Komulainen, A. Penttilä, J. Nystedt and M. Korhonen

    Citation: Stem Cell Research & Therapy 2018 9:6

    Content type: Research

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  32. Acute liver failure (ALF) is a life-threatening disease with a high mortality rate. However, there are limited treatments or devices available for ALF therapy. Here, we aimed to develop a new strategy for ALF ...

    Authors: Yun-Zhong Nie, Yun-Wen Zheng, Miyuki Ogawa, Etsuko Miyagi and Hideki Taniguchi

    Citation: Stem Cell Research & Therapy 2018 9:5

    Content type: Research

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  33. Mesenchymal stem cell therapy is a promising treatment for perianal Crohn’s fistulas refractory to conventional therapy, which are an extremely morbid complication and a true therapeutic challenge. Autologous ...

    Authors: Cécile Philandrianos, Mélanie Serrero, Fanny Grimaud, Jérémy Magalon, Carine Visée, Mélanie Velier, Pauline Francois, Pierre Orsoni, Guy Magalon, Jean-Charles Grimaud, Ariadne Desjeux, Julie Véran and Florence Sabatier

    Citation: Stem Cell Research & Therapy 2018 9:4

    Content type: Short report

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  34. Pluripotent stem cells hold great promise for regenerative medicine. However, before clinical application, reproducible protocols for pluripotent stem cell differentiation should be established. Extracellular ...

    Authors: Yang Yu, Xiaoxiao Wang, Xiaoxin Zhang, Yanhua Zhai, Xukun Lu, Haixia Ma, Kai Zhu, Tongbiao Zhao, Jianwei Jiao, Zhen-Ao Zhao and Lei Li

    Citation: Stem Cell Research & Therapy 2018 9:2

    Content type: Research

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  35. Bone marrow mesenchymal stem cells (MSCs) are promising candidates for the treatment of various inflammatory disorders due to their profound immunomodulatory properties. However, the immunosuppressive capacity...

    Authors: Binsheng Wang, Yu Lin, Yongxian Hu, Wei Shan, Senquan Liu, Yulin Xu, Hao Zhang, Shuyang Cai, Xiaohong Yu, Zhen Cai and He Huang

    Citation: Stem Cell Research & Therapy 2017 8:292

    Content type: Research

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  36. Human pluripotent stem cells (hPSCs) provide a promising cell source for ocular cell replacement therapy, but often lack standardized and xenogeneic-free culture and differentiation protocols. We aimed to deve...

    Authors: Heidi Hongisto, Tanja Ilmarinen, Meri Vattulainen, Alexandra Mikhailova and Heli Skottman

    Citation: Stem Cell Research & Therapy 2017 8:291

    Content type: Research

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  37. Retinal degeneration (RD) is a leading cause of irreversible blindness, affecting millions of people worldwide. Stem cell transplantation has been considered a promising therapy for retinal degenerative diseas...

    Authors: Li Huang, Zongyi Li, Haibin Tian, Weiguo Wang, Dawei Cui, Zhe Zhou, Xiao Chen, Herman S. Cheung, Guo-tong Xu and Yu Chen

    Citation: Stem Cell Research & Therapy 2017 8:290

    Content type: Research

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  38. Sepsis is a severe medical condition that ranks among the top 10 causes of death worldwide and which has permanently high incidence rates. Mesenchymal stem cells (MSCs) have been found to be potent modulators ...

    Authors: Leonardo Pedrazza, Monica Cubillos-Rojas, Fernanda Cristina de Mesquita, Carolina Luft, Aline Andrea Cunha, Jose Luis Rosa and Jarbas Rodrigues de Oliveira

    Citation: Stem Cell Research & Therapy 2017 8:289

    Content type: Research

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  39. Autologous and allogeneic adult mesenchymal stem/stromal cells (MSCs) are increasingly being investigated for treating a wide range of clinical diseases. Allogeneic MSCs are especially attractive due to their ...

    Authors: Alix K. Berglund, Lisa A. Fortier, Douglas F. Antczak and Lauren V. Schnabel

    Citation: Stem Cell Research & Therapy 2017 8:288

    Content type: Review

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  40. Corneal endothelial dysfunction causes severe impairment of vision. The only solution is corneal transplantation. However, this treatment is hampered by a worldwide shortage of donor corneas. New therapies may...

    Authors: Peng Sun, Lin Shen, Canwei Zhang, Liqun Du and Xinyi Wu

    Citation: Stem Cell Research & Therapy 2017 8:287

    Content type: Research

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  41. Type 2 diabetes (T2D) is closely associated with liver fibrosis, but no effective treatments are currently available. This study was designed to investigate the therapeutic effects of ADSCs on insulin resistan...

    Authors: Naishun Liao, Youshi Zheng, Haihua Xie, Bixing Zhao, Yongyi Zeng, Xiaolong Liu and Jingfeng Liu

    Citation: Stem Cell Research & Therapy 2017 8:286

    Content type: Research

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  42. Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of the graft would be the major unmet deal in order ...

    Authors: Sophie Domingues, Yolande Masson, Aurore Marteyn, Jennifer Allouche, Anselme L. Perrier, Marc Peschanski, Cecile Martinat, Christine Baldeschi and Gilles Lemaître

    Citation: Stem Cell Research & Therapy 2017 8:285

    Content type: Short report

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  43. Mesenchymal stem cells (MSCs) hold great promise for cartilage repair given their relative abundance, ease of isolation, and chondrogenic potential. To enhance MSC chondrogenesis, extracellular matrix componen...

    Authors: Tianyi Wang and Fan Yang

    Citation: Stem Cell Research & Therapy 2017 8:284

    Content type: Research

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  44. Human amnion-derived mesenchymal stem cells (hAD-MSCs) have the features of mesenchymal stem cells (MSCs). Low-intensity pulsed ultrasound (LIPUS) can promote the expression of various growth factors and anti-...

    Authors: Li Ling, Xiushan Feng, Tianqin Wei, Yan Wang, Yaping Wang, Wenqian Zhang, Lianli He, Ziling Wang, Qianru Zeng and Zhengai Xiong

    Citation: Stem Cell Research & Therapy 2017 8:283

    Content type: Research

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  45. Strontium is a widely used anti-osteoporotic agent due to its dual effects on inhibiting bone resorption and stimulating bone formation. Thus, we studied the dose response of strontium on osteo-inductive effic...

    Authors: Abudousaimi Aimaiti, Asihaerjiang Maimaitiyiming, Xu Boyong, Kaisaier Aji, Cao Li and Lei Cui

    Citation: Stem Cell Research & Therapy 2017 8:282

    Content type: Research

    Published on:

  46. Low-intensity pulsed ultrasound (LIPUS) is a mechanical stimulus that plays a key role in regulating the differentiation of bone marrow mesenchymal stem cells (BMSCs). However, the way in which it affects the ...

    Authors: Peng Xia, Xiaoju Wang, Yanping Qu, Qiang Lin, Kai Cheng, Mingxia Gao, Shasha Ren, Tingting Zhang and Xueping Li

    Citation: Stem Cell Research & Therapy 2017 8:281

    Content type: Research

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  47. The stiffness of the myocardial extracellular matrix (ECM) and the transplanted cell type are vitally important in promoting angiogenesis. However, the combined effect of the two factors remains uncertain. The...

    Authors: Shuning Zhang, Xin Ma, Junjie Guo, Kang Yao, Cong Wang, Zhen Dong, Hong Zhu, Fan Fan, Zheyong Huang, Xiangdong Yang, Juying Qian, Yunzeng Zou, Aijun Sun and Junbo Ge

    Citation: Stem Cell Research & Therapy 2017 8:280

    Content type: Research

    Published on:

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