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  1. The different distribution of T cells among activation/differentiation stages in immune disorders may condition the outcome of mesenchymal stromal cell (MSC)-based therapies. Indeed, the effect of MSCs in the ...

    Authors: Paula Laranjeira, Monia Pedrosa, Susana Pedreiro, Joana Gomes, Antonio Martinho, Brigida Antunes, Tania Ribeiro, Francisco Santos, Helder Trindade and Artur Paiva

    Citation: Stem Cell Research & Therapy 2015 6:3

    Content type: Research

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  2. Pluripotent stem cells are increasingly used to build therapeutic models, including the transplantation of neural progenitors derived from human embryonic stem cells (hESCs). Recently, long non-coding RNAs (ln...

    Authors: Chu-Fan Mo, Fang-Chun Wu, Kang-Yu Tai, Wei-Chun Chang, Kai-Wei Chang, Hung-Chih Kuo, Hong-Nerng Ho, Hsin-Fu Chen and Shau-Ping Lin

    Citation: Stem Cell Research & Therapy 2015 6:1

    Content type: Research

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  3. Microcomputed tomography (microCT) has become a standard and essential tool for quantifying structure-function relationships, disease progression, and regeneration in preclinical models and has facilitated num...

    Authors: Joel D Boerckel, Devon E Mason, Anna M McDermott and Eben Alsberg

    Citation: Stem Cell Research & Therapy 2014 5:144

    Content type: Review

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  4. Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothel...

    Authors: Sushma Bartaula-Brevik, Torbjorn O Pedersen, Anna L Blois, Panagiota Papadakou, Anna Finne-Wistrand, Ying Xue, Anne Isine Bolstad and Kamal Mustafa

    Citation: Stem Cell Research & Therapy 2014 5:143

    Content type: Research

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  5. Mesenchymal cells are emerging as a promising cell platform for regenerative therapies. However, the fate of cells after transplantation in many different disease settings and tissue beds remains unclear.

    Authors: Hitesh Agrawal, Hulan Shang, Anna Parker Sattah, Ning Yang, Shayn M Peirce and Adam J Katz

    Citation: Stem Cell Research & Therapy 2014 5:142

    Content type: Research

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  6. Heart disease remains the number one cause of death in developed countries. Loss of cardiomyocytes (CMs) due to aging or pathophysiological conditions (for example, myocardial infarction) is generally consider...

    Authors: Ronald A Li

    Citation: Stem Cell Research & Therapy 2014 5:141

    Content type: Editorial

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  7. Bone marrow mesenchymal stem cells/multipotent stromal cells (MSCs) are recruited to sites of injury and subsequently support regeneration through differentiation or paracrine activity. During periods of stres...

    Authors: Austin Nuschke, Melanie Rodrigues, Donna B Stolz, Charleen T Chu, Linda Griffith and Alan Wells

    Citation: Stem Cell Research & Therapy 2014 5:140

    Content type: Research

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  8. Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstra...

    Authors: Orly Ravid, Ofer Shoshani, Meirav Sela, Ada Weinstock, Tommy Weiss Sadan, Eyal Gur, Dov Zipori and Nir Shani

    Citation: Stem Cell Research & Therapy 2014 5:139

    Content type: Research

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  9. Scleroderma is characterized by cutaneous manifestations that mainly affect the hands, arms and face. As of today, there is no treatment for fibrotic skin lesions of scleroderma. Previously we generated and va...

    Authors: Nicolas Serratrice, Laurie Bruzzese, Jérémy Magalon, Julie Véran, Laurent Giraudo, Houssein Aboudou, Djaffar Ould-Ali, Pierre Sébastien Nguyen, Olivier Bausset, Aurélie Daumas, Dominique Casanova, Brigitte Granel, Lucile Andrac-Meyer, Florence Sabatier and Guy Magalon

    Citation: Stem Cell Research & Therapy 2014 5:138

    Content type: Research

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  10. Mesenchymal stem cells (MSCs) are considered to play important roles in wound repair and tissue remodeling. Hypertrophic scar (HTS) is a cutaneous condition characterized by deposits of excessive amount of col...

    Authors: Yi-Lun Liu, Wei-Hua Liu, Jin Sun, Tuan-Jie Hou, Yue-Ming Liu, Hai-Rong Liu, Yong-Hui Luo, Ning-Ning Zhao, Ying Tang and Feng-Mei Deng

    Citation: Stem Cell Research & Therapy 2014 5:136

    Content type: Research

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  11. Dental follicle gives rise to one or several tissues of the periodontium including the periodontal ligament, cementum and/or alveolar bone. Whether Wnt5a is expressed in the postnatal periodontium or regulates...

    Authors: Lusai Xiang, Mo Chen, Ling He, Bin Cai, Yu Du, Xinchun Zhang, Chen Zhou, Chenglin Wang, Jeremy J Mao and Junqi Ling

    Citation: Stem Cell Research & Therapy 2014 5:135

    Content type: Research

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  12. Mesenchymal stem cells (MSCs) are a multipotent population of adult stem cells, which may represent a promising therapeutic approach for neurological autoimmune diseases such as multiple sclerosis. The mouse i...

    Authors: Carmen Marin-Bañasco, Margarita Suardíaz García, Issac Hurtado Guerrero, Rafael Maldonado Sánchez, Guillermo Estivill-Torrús, Laura Leyva Fernández and Oscar Fernández Fernández

    Citation: Stem Cell Research & Therapy 2014 5:134

    Content type: Research

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  13. Rhinosinusitis is characterized by inflammation extending from the mucosa of the nasal cavity into the paranasal sinuses. There are some aggravating features, such as immunosuppression, that can cause the nasa...

    Authors: Erica Ortiz, Albina Altemani, Afonso Celso Vigorito, Eulalia Sakano and Ester Maria Danielli Nicola

    Citation: Stem Cell Research & Therapy 2014 5:133

    Content type: Research

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  14. Mesenchymal stem cells (MSCs) are widely investigated in clinical researches to treat various diseases. Classic culture medium for MSCs, even for clinical use, contains fetal bovine serum. The serum-containing...

    Authors: Youwei Wang, Hehe Wu, Zhouxin Yang, Ying Chi, Lei Meng, Aibin Mao, Shulin Yan, Shanshan Hu, Jianzhong Zhang, Yun Zhang, Wenbo Yu, Yue Ma, Tao Li, Yan Cheng, Yongjuan Wang, Shanshan Wang…

    Citation: Stem Cell Research & Therapy 2014 5:132

    Content type: Research

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  15. The present study aimed to elucidate the therapeutic effects of mesenchymal stem cells (MSCs) derived from the bone marrow of rats (BM) against toxic effects of lead (Pb) on the male gonads of experimental rats.

    Authors: Amal I Hassan and Sally S Alam

    Citation: Stem Cell Research & Therapy 2014 5:131

    Content type: Research

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    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:32

  16. Mesenchymal stem cells (MSCs) transplantation has been demonstrated to be an effective strategy for the treatment of cardiovascular disease. However, the low survival rate of MSCs at local diseased tissue redu...

    Authors: Yue Xing, Jingying Hou, Tianzhu Guo, Shaoxin Zheng, Changqing Zhou, Hui Huang, Yuyang Chen, Kan Sun, Tingting Zhong, Jingfeng Wang, Honghao Li and Tong Wang

    Citation: Stem Cell Research & Therapy 2014 5:130

    Content type: Research

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  17. Clinically, a good deal of injury from stroke results from ischemic-reperfusion. There is a loss of cerebral parenchyma and its associated cells, disruption of neuronal connections, compromise of the blood-bra...

    Authors: Lei Huang, Sunnie Wong, Evan Y Snyder, Milton H Hamblin and Jean-Pyo Lee

    Citation: Stem Cell Research & Therapy 2014 5:129

    Content type: Research

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  18. There is a growing interest in the therapeutic utility of compounds derived from Curcuma longa, an herb of the Zingiberaceae family that has been part of traditional medicine for centuries. Recent reports suggest...

    Authors: Steven W Poser and Andreas Androutsellis-Theotokis

    Citation: Stem Cell Research & Therapy 2014 5:127

    Content type: Commentary

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  19. The administration of stem cells holds promise as a potential therapy for spinal cord injury (SCI). Mesenchymal stem cells have advantages for clinical applications, since they can be easily obtained, are suit...

    Authors: Marcus Vinícius Pinheiro Mendonça, Ticiana Ferreira Larocca, Bruno Solano de Freitas Souza, Cristiane Flora Villarreal, Luiz Flávio Maia Silva, André Costa Matos, Marco Antonio Novaes, Cláudia Maria Pinheiro Bahia, Ana Carine de Oliveira Melo Martinez, Carla Martins Kaneto, Sissi Brandão Carneiro Furtado, Geraldo Pedral Sampaio, Milena Botelho Pereira Soares and Ricardo Ribeiro dos Santos

    Citation: Stem Cell Research & Therapy 2014 5:126

    Content type: Research

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  20. Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, t...

    Authors: Yao Li, Ming Yan, Zilu Wang, Yangyu Zheng, Junjun Li, Shu Ma, Genxia Liu and Jinhua Yu

    Citation: Stem Cell Research & Therapy 2014 5:125

    Content type: Research

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  21. Several cellular sources of stem cells have been tested in the attempt to yield innovative interventions in acute kidney injury (AKI). Human liver stem cells (HLSCs) are cells isolated from the normal adult hu...

    Authors: Maria Beatriz Herrera Sanchez, Stefania Bruno, Cristina Grange, Marta Tapparo, Vincenzo Cantaluppi, Ciro Tetta and Giovanni Camussi

    Citation: Stem Cell Research & Therapy 2014 5:124

    Content type: Research

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  22. Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible fibrotic lung disease, resulting in respiratory insufficiency and reduced survival. Pulmonary fibrosis is a result of repeated alveolar epi...

    Authors: Amiq Gazdhar, Iwona Grad, Luca Tamò, Mathias Gugger, Anis Feki and Thomas Geiser

    Citation: Stem Cell Research & Therapy 2014 5:123

    Content type: Research

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  23. Fibrosis, or scar formation, is a pathological condition characterized by excessive production and accumulation of collagen, loss of tissue architecture, and organ failure in response to uncontrolled wound hea...

    Authors: Alexander Birbrair, Tan Zhang, Daniel Clark Files, Sandeep Mannava, Thomas Smith, Zhong-Min Wang, Maria Laura Messi, Akiva Mintz and Osvaldo Delbono

    Citation: Stem Cell Research & Therapy 2014 5:122

    Content type: Research

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  24. The use of hematopoietic cell transplantation (HCT) has previously been shown to ameliorate cutaneous blistering in pediatric patients with recessive dystrophic epidermolysis bullosa (RDEB), an inherited skin ...

    Authors: Christopher Perdoni, John A McGrath and Jakub Tolar

    Citation: Stem Cell Research & Therapy 2014 5:121

    Content type: Research

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  25. Ocular trauma is defined as a trauma caused by blunt or penetrating mechanisms on the eyeball and its peripheral structures, causing damage with different degrees of affection with temporary or permanent visua...

    Authors: Gustavo Jesús Vázquez-Zapién, Marlon Rojas-López, Raúl Jacobo Delgado-Macuil, Luis Rubén Martínez-Nava, David Guillermo Pérez-Ishiwara and Mónica Maribel Mata-Miranda

    Citation: Stem Cell Research & Therapy 2014 5:119

    Content type: Research

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  26. In the field of skin tissue engineering, gelatin-chondroitin-6-sulfate-hyaluronic acid (Gel-C6S-HA) stents are a suitable bio skin substitute. The purpose was to investigate the effect of genetically-modified ...

    Authors: Renfu Quan, Xuan Zheng, Shichao Xu, Liang Zhang and Disheng Yang

    Citation: Stem Cell Research & Therapy 2014 5:118

    Content type: Research

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  27. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are the most promising source of cardiomyocytes (CMs) for experimental and clinical applications, but their use is largely limited by a structurall...

    Authors: Renjun Zhu, Adriana Blazeski, Ellen Poon, Kevin D Costa, Leslie Tung and Kenneth R Boheler

    Citation: Stem Cell Research & Therapy 2014 5:117

    Content type: Review

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  28. The existence of cancer stem cells (CSCs) has been associated with tumor initiation, therapy resistance, tumor relapse, angiogenesis, and metastasis. Curcumin, a plant ployphenol, has several anti-tumor effect...

    Authors: Shravanti Mukherjee, Minakshi Mazumdar, Samik Chakraborty, Argha Manna, Shilpi Saha, Poulami Khan, Pushpak Bhattacharjee, Deblina Guha, Arghya Adhikary, Sanhita Mukhjerjee and Tanya Das

    Citation: Stem Cell Research & Therapy 2014 5:116

    Content type: Research

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  29. Avascular necrosis of femoral head (ANFH) is a progressive disease that often leads to hip joint dysfunction and even disability in young patients. Although the standard treatment, which is core decompression,...

    Authors: Yuanchen Ma, Tao Wang, Junxing Liao, Honglin Gu, Xinpeng Lin, Qing Jiang, Max K Bulsara, Minghao Zheng and Qiujian Zheng

    Citation: Stem Cell Research & Therapy 2014 5:115

    Content type: Research

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  30. Repair of large bone defects remains a significant clinical challenge. Bone marrow stromal cells (BMSCs), a subset of which is known as bone marrow-derived mesenchymal stem cells, show therapeutic potential fo...

    Authors: Meadhbh Á Brennan, Audrey Renaud, Jérôme Amiaud, Markus T Rojewski, Hubert Schrezenmeier, Dominique Heymann, Valerie Trichet and Pierre Layrolle

    Citation: Stem Cell Research & Therapy 2014 5:114

    Content type: Research

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  31. Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cel...

    Authors: Angela Fülbier, Reinhild Schnabel, Stefanie Michael, Peter M Vogt, Sarah Strauß, Kerstin Reimers and Christine Radtke

    Citation: Stem Cell Research & Therapy 2014 5:113

    Content type: Research

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  32. Mesenchymal stem cells have been increasingly used for cell-based therapies. Adipose-derived stem/stromal cells (ASCs) from the stromal vascular fraction (SVF) of fat tissue are a particularly attractive optio...

    Authors: Hetal D Marble, Bryan A Sutermaster, Manisha Kanthilal, Vera C Fonseca and Eric M Darling

    Citation: Stem Cell Research & Therapy 2014 5:145

    Content type: Research

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  33. Mesenchymal stem cells (MSCs) have the ability to differentiate into osteoblasts, chondroblasts, adipocytes, and even myoblasts. Most studies have focused on finding MSCs in different parts of the body for med...

    Authors: Eduardo Branco de Sousa, Priscila Ladeira Casado, Vivaldo Moura Neto, Maria Eugenia Leite Duarte and Diego Pinheiro Aguiar

    Citation: Stem Cell Research & Therapy 2014 5:112

    Content type: Review

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  34. Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative...

    Authors: Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger

    Citation: Stem Cell Research & Therapy 2014 5:100

    Content type: Research

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  35. Poor cell survival and limited functional benefits have restricted the efficacy of bone marrow mesenchymal stem cells (BMSCs) in the treatment of myocardial infarction. We showed recently that hypoxia precondi...

    Authors: Xian-Bao Liu, Jian-An Wang, Xiao-Ya Ji, Shan Ping Yu and Ling Wei

    Citation: Stem Cell Research & Therapy 2014 5:111

    Content type: Research

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  36. Myocardial infarction is accompanied by a significant loss of cardiomyocytes (CMs). Functional CMs, differentiated from human embryonic stem cells (hESCs), offer a potentially unlimited cell source for cardiac...

    Authors: Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jian Li, William R Birch, Shaul Reuveny and Steve Kah-Weng Oh

    Citation: Stem Cell Research & Therapy 2014 5:110

    Content type: Research

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  37. Systemic administration of mesenchymal stem (stromal) cells (MSCs) has shown benefit in a range of experimental models of acute kidney injury, although the reported mechanisms of action and requirement for MSC...

    Authors: Michelle M Duffy and Matthew D Griffin

    Citation: Stem Cell Research & Therapy 2014 5:109

    Content type: Commentary

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  38. Asthma is characterized by a chronic inflammatory process which may lead to several changes in bone marrow cell composition. We hypothesized that bone marrow mononuclear cells (BMMCs) obtained from ovalbumin (...

    Authors: Soraia C Abreu, Mariana A Antunes, Lucas Mendonça, Vivian C Branco, Elga Bandeira de Melo, Priscilla C Olsen, Bruno L Diaz, Daniel J Weiss, Bruno D Paredes, Debora G Xisto, Marcelo M Morales and Patricia RM Rocco

    Citation: Stem Cell Research & Therapy 2014 5:108

    Content type: Research

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  39. Preterm newborns often require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lun...

    Authors: Courtney A McDonald, Jacqueline M Melville, Graeme R Polglase, Graham Jenkin and Timothy JM Moss

    Citation: Stem Cell Research & Therapy 2014 5:107

    Content type: Research

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  40. Despite numerous research efforts, mechanisms underlying regeneration of pancreas remains controversial. Views are divided whether stem cells are involved during pancreatic regeneration or it involves duplicat...

    Authors: Deepa Bhartiya, Akash Mundekar, Vaibhav Mahale and Hiren Patel

    Citation: Stem Cell Research & Therapy 2014 5:106

    Content type: Research

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  41. Osteoporosis is a disease characterized by low bone mineral density (BMD) and increased risk of fractures. Studies have demonstrated the use of phytoestrogens, or plant-derived estrogens, such as genistein and...

    Authors: Amy L Strong, Jason F Ohlstein, Quan Jiang, Qiang Zhang, Shilong Zheng, Stephen M Boue, Steven Elliott, Jeffrey M Gimble, Matthew E Burow, Guangdi Wang and Bruce A Bunnell

    Citation: Stem Cell Research & Therapy 2014 5:105

    Content type: Research

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  42. Mesenchymal stem cells (MSCs) have the ability to repair and regenerate tissue, home to sites of inflammation, and evade the host immune system. As such, they represent an attractive therapy for the treatment ...

    Authors: Catherine B Sullivan, Ryan M Porter, Chris H Evans, Thomas Ritter, Georgina Shaw, Frank Barry and Josephine Mary Murphy

    Citation: Stem Cell Research & Therapy 2014 5:104

    Content type: Research

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  43. The transplantation of genetically modified progenitor cells such as bone marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the natural healing of articular cartilage defects. I...

    Authors: Janina Frisch, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Henning Madry and Magali Cucchiarini

    Citation: Stem Cell Research & Therapy 2014 5:103

    Content type: Research

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  44. The objective of this work was to evaluate the efficacy of placenta-derived mesenchymal stem cell (MSC) therapy in a mouse model of myocardial infarction (MI). Since MSCs can be obtained from two different reg...

    Authors: Juliana A Passipieri, Tais H Kasai-Brunswick, Grazielle Suhett, Andreza B Martins, Guilherme V Brasil, Dilza B Campos, Nazareth N Rocha, Isalira P Ramos, Debora B Mello, Deivid C Rodrigues, Beatriz B Christie, Bernardo J Silva-Mendes, Alex Balduíno, Renato M Sá, Laudelino M Lopes, Regina C Goldenberg…

    Citation: Stem Cell Research & Therapy 2014 5:102

    Content type: Research

    Published on:

  45. Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection o...

    Authors: Li Xing, Rui Cui, Lei Peng, Jing Ma, Xiao Chen, Ru-Juan Xie and Bing Li

    Citation: Stem Cell Research & Therapy 2014 5:101

    Content type: Research

    Published on:

  46. Mesenchymal stem cells (MSCs) are an adult stromal cell population possessing potent differentiation capacity and a potential for use across major histocompatibility complex barriers. Although allogeneic MSCs ...

    Authors: Paul Lohan, Cynthia M Coleman, J Mary Murphy, Matthew D Griffin, Thomas Ritter and Aideen E Ryan

    Citation: Stem Cell Research & Therapy 2014 5:99

    Content type: Review

    Published on:

  47. It has long been established that germline stem cells (GSCs) are responsible for lifelong gametogenesis in males, and some female invertebrates (for example, Drosophila) and lower vertebrates (for example, teleos...

    Authors: Cheryl E Dunlop, Evelyn E Telfer and Richard A Anderson

    Citation: Stem Cell Research & Therapy 2014 5:98

    Content type: Review

    Published on:

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