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  1. Degenerative diseases are a major public health concern for the aging population and mesenchymal stem cells (MSCs) have great potential for treating many of these diseases. However, the quantity and quality of...

    Authors: Travis J. Block, Milos Marinkovic, Olivia N. Tran, Aaron O. Gonzalez, Amanda Marshall, David D. Dean and Xiao-Dong Chen

    Citation: Stem Cell Research & Therapy 2017 8:239

    Content type: Research

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  2. For years, sufficient progress has been made in treating heart failure following myocardial infarction; however, the social and economic burdens and the costs to world health systems remain high. Moreover, tre...

    Authors: Santiago Roura, Carolina Gálvez-Montón, Clémentine Mirabel, Joaquim Vives and Antoni Bayes-Genis

    Citation: Stem Cell Research & Therapy 2017 8:238

    Content type: Review

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  3. Endothelial progenitor cell (EPC) differentiation is considered crucial for vascular repair. Vascular endothelial growth factor (VEGF) induces EPC differentiation, but the underlying mechanism of this phenomen...

    Authors: Lufeng Li, Huanyun Liu, Chunxin Xu, Mengyang Deng, Mingbao Song, Xuejun Yu, Shangcheng Xu and Xiaohui Zhao

    Citation: Stem Cell Research & Therapy 2017 8:237

    Content type: Research

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  4. The use of stem cells, including mesenchymal stem cells (MSCs), for regenerative medicine is gaining interest for the clinical benefits so far obtained in patients. This study investigates the use of adipose a...

    Authors: Francesco Virzì, Paola Bianca, Alessandro Giammona, Tiziana Apuzzo, Simone Di Franco, Laura Rosa Mangiapane, Maria Luisa Colorito, Dario Catalano, Emanuela Scavo, Annalisa Nicotra, Antonina Benfante, Giuseppe Pistone, Valentina Caputo, Francesco Dieli, Roberto Pirrello and Giorgio Stassi

    Citation: Stem Cell Research & Therapy 2017 8:236

    Content type: Research

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  5. Gastric mucosal defect could result from several causative factors including the use of nonsteroidal anti-inflammatory drugs, Helicobacter pylori infection, gastrointestinal and spinal cord diseases, and neoplasi...

    Authors: Haithem A. Farghali, Naglaa A. AbdElKader, Marwa S. Khattab and Huda O. AbuBakr

    Citation: Stem Cell Research & Therapy 2017 8:235

    Content type: Research

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  6. Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cell...

    Authors: Samantha C. Fisch, María L. Gimeno, Julia D. Phan, Ariel A. Simerman, Daniel A. Dumesic, Marcelo J. Perone and Gregorio D. Chazenbalk

    Citation: Stem Cell Research & Therapy 2017 8:227

    Content type: Review

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  7. Severe burn results in a systemic response that leads to significant muscle wasting. It is believed that this rapid loss in muscle mass occurs due to increased protein degradation combined with reduced protein...

    Authors: Yusef Yousuf, Marc G. Jeschke, Ahmed Shah, Ali-Reza Sadri, Andrea-kaye Datu, Pantea Samei and Saeid Amini-Nik

    Citation: Stem Cell Research & Therapy 2017 8:234

    Content type: Research

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  8. Melatonin is a pleiotropic hormone with powerful antioxidant activity both in vivo and in vitro. The present study aimed to investigate the effects of melatonin on the proliferation efficiency of neonatal mous...

    Authors: Shadan Navid, Mehdi Abbasi and Yumi Hoshino

    Citation: Stem Cell Research & Therapy 2017 8:233

    Content type: Research

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  9. The present study was conducted to evaluate new methods to repair the reproductive function of the oviduct, thereby allowing gametes to combine and grow in vivo under natural circumstances.

    Authors: Zhe Li, Zhao Zhang, Xin Chen, Juan Zhou and Xiao-min Xiao

    Citation: Stem Cell Research & Therapy 2017 8:232

    Content type: Research

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  10. Several cell-based therapies for adjunctive treatment of acute myocardial infarction have been investigated in multiple clinical trials, but the timing of transplantation remains controversial. We conducted a ...

    Authors: Jia-ying Xu, Dai Liu, Yang Zhong and Rong-chong Huang

    Citation: Stem Cell Research & Therapy 2017 8:231

    Content type: Research

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  11. Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain el...

    Authors: Lingjun Wang, Elizabeth M. Meier, Shuo Tian, Ienglam Lei, Liu Liu, Shaoxiang Xian, Mai T. Lam and Zhong Wang

    Citation: Stem Cell Research & Therapy 2017 8:230

    Content type: Research

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  12. Human induced pluripotent stem cells (hiPSC) harbor the potential to differentiate into diverse cardiac cell types. Previous experimental efforts were primarily directed at the generation of hiPSC-derived cell...

    Authors: Patrick A. Schweizer, Fabrice F. Darche, Nina D. Ullrich, Pascal Geschwill, Boris Greber, Rasmus Rivinius, Claudia Seyler, Karin Müller-Decker, Andreas Draguhn, Jochen Utikal, Michael Koenen, Hugo A. Katus and Dierk Thomas

    Citation: Stem Cell Research & Therapy 2017 8:229

    Content type: Research

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  13. Adult mesenchymal stem cells (MSCs) have been shown to increase nerve regeneration in animal models of nerve injury. Traumatized muscle-derived multipotent progenitor cells (MPCs) share important characteristi...

    Authors: Heidi R. H. Zupanc, Peter G. Alexander and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2017 8:226

    Content type: Research

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  14. Treatment of meniscus tears within the avascular region represents a significant challenge, particularly in a situation of early osteoarthritis. Cell-based tissue engineering approaches have shown promising re...

    Authors: Johannes Zellner, Girish Pattappa, Matthias Koch, Siegmund Lang, Johannes Weber, Christian G. Pfeifer, Michael B. Mueller, Richard Kujat, Michael Nerlich and Peter Angele

    Citation: Stem Cell Research & Therapy 2017 8:225

    Content type: Research

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  15. Mesenchymal stem cells (MSCs) are emerging as an extremely promising therapeutic agent for tissue repair. However, limitations exist such as the low numbers of MSCs obtained from donors, and the poor survival ...

    Authors: Li Yin, Dan Huang, Xinxin Liu, Yongshun Wang, Jingjin Liu, Fang Liu and Bo Yu

    Citation: Stem Cell Research & Therapy 2017 8:224

    Content type: Research

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  16. Stem cell transplantation has been documented to promote functional recovery in animal models of stroke; however, the underlying mechanisms are not yet fully understood. As netrin-1 and its receptor deleted in...

    Authors: Huan Huang, Fan Lin, Jingjing Jiang, Yan Chen, Ainong Mei and Pengli Zhu

    Citation: Stem Cell Research & Therapy 2017 8:223

    Content type: Research

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  17. Mesenchymal stem cells (MSCs) hold promising translational potential in cartilage regeneration. However, the efficacy of MSC-based tissue engineering is not satisfactory in the treatment of cartilage defect be...

    Authors: Sien Lin, Wayne Yuk Wai Lee, Qian Feng, Liangliang Xu, Bin Wang, Gene Chi Wai Man, Yuanfeng Chen, Xiaohua Jiang, Liming Bian, Liao Cui, Bo Wei and Gang Li

    Citation: Stem Cell Research & Therapy 2017 8:221

    Content type: Research

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  18. Experimental research has reported beneficial effects of mesenchymal stromal cell (MSC) therapy in pulmonary arterial hypertension (PAH). However, these studies either were based on prophylactic protocols or a...

    Authors: Lucas de Mendonça, Nathane S. Felix, Natália G. Blanco, Jaqueline S. Da Silva, Tatiana P. Ferreira, Soraia C. Abreu, Fernanda F. Cruz, Nazareth Rocha, Patrícia M. Silva, Vanessa Martins, Vera L. Capelozzi, Gizele Zapata-Sudo, Patricia R. M. Rocco and Pedro L. Silva

    Citation: Stem Cell Research & Therapy 2017 8:220

    Content type: Research

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  19. The therapeutic potential of mesenchymal stem cells (MSCs) may be attributed partly to humoral factors such as growth factors, cytokines, and chemokines. Human term placental tissue-derived MSCs (PlaMSCs), or ...

    Authors: Motohiro Komaki, Yuri Numata, Chikako Morioka, Izumi Honda, Masayuki Tooi, Naoki Yokoyama, Hirohito Ayame, Kengo Iwasaki, Atsuko Taki, Noriko Oshima and Ikuo Morita

    Citation: Stem Cell Research & Therapy 2017 8:219

    Content type: Research

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  20. The dog represents an excellent large animal model for translational cell-based studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal tissue source for specific transla...

    Authors: Robert N. Bearden, Shannon S. Huggins, Kevin J. Cummings, Roger Smith, Carl A. Gregory and William B. Saunders

    Citation: Stem Cell Research & Therapy 2017 8:218

    Content type: Research

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  21. Dysfunction of the retinal pigment epithelium (RPE) is implicated in numerous forms of retinal degeneration. The readily accessible environment of the eye makes it particularly suitable for the transplantation...

    Authors: Roni A. Hazim, Saravanan Karumbayaram, Mei Jiang, Anupama Dimashkie, Vanda S. Lopes, Douran Li, Barry L. Burgess, Preethi Vijayaraj, Jackelyn A. Alva-Ornelas, Jerome A. Zack, Donald B. Kohn, Brigitte N. Gomperts, April D. Pyle, William E. Lowry and David S. Williams

    Citation: Stem Cell Research & Therapy 2017 8:217

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:52

  22. To maximize the translational utility of human induced pluripotent stem cells (iPSCs), the ability to precisely modulate the differentiation of iPSCs to target phenotypes is critical. Although the effects of t...

    Authors: Maricela Maldonado, Rebeccah J. Luu, Gerardo Ico, Alex Ospina, Danielle Myung, Hung Ping Shih and Jin Nam

    Citation: Stem Cell Research & Therapy 2017 8:216

    Content type: Short report

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  23. Cardiac stem cells (CSCs) transplantation has been regarded as an optimal therapeutic approach for cardiovascular disease. However, inferior survival and low differentiation efficiency of these cells in the lo...

    Authors: Jingying Hou, Lei Wang, Huibao Long, Hao Wu, Quanhua Wu, Tingting Zhong, Xuxiang Chen, Changqing Zhou, Tianzhu Guo and Tong Wang

    Citation: Stem Cell Research & Therapy 2017 8:215

    Content type: Research

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  24. Introduction of the transcription factors Oct4, Sox2, Klf4, and c-Myc (OSKM) is able to ‘reprogram’ somatic cells to become induced pluripotent stem cells (iPSCs). Several microRNAs (miRNAs) are known to enhan...

    Authors: Phan Nguyen Nhi Nguyen, Kong Bung Choo, Chiu-Jung Huang, Shigeki Sugii, Soon Keng Cheong and Tunku Kamarul

    Citation: Stem Cell Research & Therapy 2017 8:214

    Content type: Research

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  25. Health is dependent on the homeostasis of both inner and external microenvironments. The microbiota as the external microenvironment plays a critical role in regulation of several organ systems in mammals. How...

    Authors: E Xiao, Linhai He, Qiong Wu, Junxiang Li, Yang He, Lu Zhao, Shuo Chen, Jingang An, Yansong Liu, Chider Chen and Yi Zhang

    Citation: Stem Cell Research & Therapy 2017 8:213

    Content type: Short report

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  26. The main goal of bone tissue engineering has been the generation of healthy bone in order to replace affected tissue. Therefore, optimized biomaterials are needed which allow the survival and growth of mesench...

    Authors: Anastasia Gabrielyan, Elena Neumann, Michael Gelinsky and Angela Rösen-Wolff

    Citation: Stem Cell Research & Therapy 2017 8:212

    Content type: Research

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  27. Mesenchymal stem cells microvesicles (MSC-MVs) stabilize endothelial barrier function in acute lung injury (ALI); however, the detailed mechanism remains to be further defined. Hepatocyte growth factor (HGF), ...

    Authors: Hualing Wang, Ruiqiang Zheng, Qihong Chen, Jun Shao, Jiangquan Yu and Shuling Hu

    Citation: Stem Cell Research & Therapy 2017 8:211

    Content type: Research

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  28. Periodontitis is a widespread infectious disease ultimately resulting in tooth loss. The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired. Res...

    Authors: Nannan Han, Fengqiu Zhang, Guoqing Li, Xiuli Zhang, Xiao Lin, Haoqing Yang, Lijun Wang, Yangyang Cao, Juan Du and Zhipeng Fan

    Citation: Stem Cell Research & Therapy 2017 8:210

    Content type: Research

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  29. Retinitis pigmentosa is a common genetic disease that causes retinal degeneration and blindness for which there is currently no curable treatment available. Vision preservation was observed in retinitis pigmen...

    Authors: Yong Liu, Shao Jun Chen, Shi Ying Li, Ling Hui Qu, Xiao Hong Meng, Yi Wang, Hai Wei Xu, Zhi Qing Liang and Zheng Qin Yin

    Citation: Stem Cell Research & Therapy 2017 8:209

    Content type: Research

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  30. Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs. Hypo...

    Authors: Victor G. Martinez, Imelda Ontoria-Oviedo, Carolina P. Ricardo, Sian E. Harding, Rosa Sacedon, Alberto Varas, Agustin Zapata, Pilar Sepulveda and Angeles Vicente

    Citation: Stem Cell Research & Therapy 2017 8:208

    Content type: Research

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  31. Human fibroblasts can be directly converted to several subtypes of neurons, but cortical projection neurons have not been generated.

    Authors: Giedre Miskinyte, Karthikeyan Devaraju, Marita Grønning Hansen, Emanuela Monni, Daniel Tornero, Niels Bjarne Woods, Johan Bengzon, Henrik Ahlenius, Olle Lindvall and Zaal Kokaia

    Citation: Stem Cell Research & Therapy 2017 8:207

    Content type: Research

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  32. Mesenchymal/stromal stem cells (MSCs) are favorably regarded in anti-cancer cytotherapies for their spontaneous chemotaxis toward inflammatory and tumor environments associated with an intrinsic cytotoxicity a...

    Authors: Paola Cafforio, Luigi Viggiano, Francesco Mannavola, Eleonora Pellè, Concetta Caporusso, Eugenio Maiorano, Claudia Felici and Francesco Silvestris

    Citation: Stem Cell Research & Therapy 2017 8:206

    Content type: Research

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  33. The injection of mesenchymal stem cells (MSCs) directly into the bone of osteoporotic (OP) patients for rapid recovery has been studied worldwide. Scaffolds associated with MSCs are used to maintain and avoid ...

    Authors: Patrícia Rodrigues Orsi, Fernanda Cruz Landim-Alvarenga, Luis Antônio Justulin Jr, Ramon Kaneno, Marjorie de Assis Golim, Daniela Carvalho dos Santos, Camila Fernanda Zorzella Creste, Eunice Oba, Leandro Maia, Benedito Barraviera and Rui Seabra Ferreira Jr

    Citation: Stem Cell Research & Therapy 2017 8:205

    Content type: Research

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  34. Hepatitis B virus (HBV) carriers worldwide number approximately 240 million people and around 780,000 people die every year from HBV infection. HBV entry and uptake are functionally linked to the presence of t...

    Authors: Camillo Sargiacomo, Hoda El-Kehdy, Kai Dallmeier, Joery de Kock, Clara Hernandez-Kelly, Vera Rogiers, Arturo Ortega, Johan Neyts, Etienne Sokal and Mustapha Najimi

    Citation: Stem Cell Research & Therapy 2017 8:204

    Content type: Research

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  35. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSC) show remarkable therapeutic potential to repair tissue upon injury via paracrine signaling by secreting diverse trophic factors that promote angiogenesis...

    Authors: Gabriela Zavala, Catalina P. Prieto, Andrea A. Villanueva and Verónica Palma

    Citation: Stem Cell Research & Therapy 2017 8:203

    Content type: Research

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  36. Most infarctions occur in the left anterior descending coronary artery and cause myocardium damage of the left ventricle. Although current pluripotent stem cells (PSCs) and directed cardiac differentiation tec...

    Authors: Bin Li, Hui Yang, Xiaochen Wang, Yongkun Zhan, Wei Sheng, Huanhuan Cai, Haoyang Xin, Qianqian Liang, Ping Zhou, Chao Lu, Ruizhe Qian, Sifeng Chen, Pengyuan Yang, Jianyi Zhang, Weinian Shou, Guoying Huang…

    Citation: Stem Cell Research & Therapy 2017 8:202

    Content type: Research

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  37. Mesenchymal stem cells (MSCs) are a mixture of progenitors that are heterogeneous in their regenerative potential. Development of MSC therapies with consistent efficacy is hindered by the absence of an immunop...

    Authors: Sean D. Madsen, Katie C. Russell, H. Alan Tucker, Julie Glowacki, Bruce A. Bunnell and Kim C. O’Connor

    Citation: Stem Cell Research & Therapy 2017 8:201

    Content type: Research

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  38. Although tissue-resident mesenchymal stromal cells (MSCs) in the larynx have been described, their distinct characteristics and roles have not been thoroughly explored. Therefore, we investigated stem cell cha...

    Authors: Songyi Lee, Yeseulmi Kim, Hyun-Soo Shin and Jae-Yol Lim

    Citation: Stem Cell Research & Therapy 2017 8:200

    Content type: Research

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  39. Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the func...

    Authors: Elisa Montanari, Raphael P. H. Meier, Redouan Mahou, Jörg D. Seebach, Christine Wandrey, Sandrine Gerber-Lemaire, Leo H. Buhler and Carmen Gonelle-Gispert

    Citation: Stem Cell Research & Therapy 2017 8:199

    Content type: Research

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  40. Traumatic brain injury (TBI) is one of the major causes of mortality and disability for all ages worldwide. Mesenchymal stem cells (MSCs)-originated exosomes have provided therapeutic effects. However, as an i...

    Authors: Ye Li, Yuan-Yuan Yang, Jia-Li Ren, Feng Xu, Fa-Ming Chen and Ang Li

    Citation: Stem Cell Research & Therapy 2017 8:198

    Content type: Research

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  41. Haploid cells are excellent tools to study gene function as they contain a single copy of the genome and are thus unable to mask the effect of mutations. Recently, haploid embryonic stem cells, which are capab...

    Authors: Yanni Li and Ling Shuai

    Citation: Stem Cell Research & Therapy 2017 8:197

    Content type: Review

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  42. Human induced pluripotent stem cells (iPSCs) have been verified as a powerful cell model for the study of pathogenesis in hereditary disease. Autosomal dominant polycystic kidney disease (ADPKD) is caused by m...

    Authors: Jiahui Huang, Shumin Zhou, Xin Niu, Bin Hu, Qing Li, Feng Zhang, Xue Zhang, Xiujuan Cai, Yuanlei Lou, Fen Liu, Chenming Xu and Yang Wang

    Citation: Stem Cell Research & Therapy 2017 8:196

    Content type: Research

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  43. The paracrine effect is likely the major mechanism of the adipose-derived stem cell (ASC)-mediated cardioprotective effect. However, the exact composition and nature of ASC-released paracrine factors remain el...

    Authors: Jiyun Lee, Seahyung Lee, Chang Youn Lee, Hyang-Hee Seo, Sunhye Shin, Jung-Won Choi, Sang Woo Kim, Jong-Chul Park, Soyeon Lim and Ki-Chul Hwang

    Citation: Stem Cell Research & Therapy 2017 8:195

    Content type: Short report

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  44. Over the past years, vascular diseases have continued to threaten human health and increase financial burdens worldwide. Transplantation of allogeneic and autologous blood vessels is the most convenient treatm...

    Authors: Ying Wang, Pei Yin, Guang-Liang Bian, Hao-Yue Huang, Han Shen, Jun-Jie Yang, Zi-Ying Yang and Zhen-Ya Shen

    Citation: Stem Cell Research & Therapy 2017 8:194

    Content type: Review

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  45. Transplantation of mesenchymal stem cells (MSC) has been proposed to improve wound healing. However, as these cells only transiently survive in the implantation site, the mechanisms underlying this beneficial ...

    Authors: Cecelia C. Yates, Melanie Rodrigues, Austin Nuschke, Zariel I Johnson, Diana Whaley, Donna Stolz, Joseph Newsome and Alan Wells

    Citation: Stem Cell Research & Therapy 2017 8:193

    Content type: Research

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  46. Chronic pancreatitis has surgical options including total pancreatectomy to control pain. To avoid surgical diabetes, the explanted pancreas can have islets harvested and transplanted. Immediately following to...

    Authors: Lili Song, Zhen Sun, Do-sung Kim, Wenyu Gou, Charlie Strange, Huansheng Dong, Wanxing Cui, Gary Gilkeson, Katherine A. Morgan, David B. Adams and Hongjun Wang

    Citation: Stem Cell Research & Therapy 2017 8:192

    Content type: Research

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  47. Stem cells have demonstrated encouraging potential as reparative therapy for patients suffering from post-stroke disability. Reperfusion interventions in the acute phase of stroke have shown significant benefi...

    Authors: Anjali Nagpal, Fong Chan Choy, Stuart Howell, Susan Hillier, Fiona Chan, Monica A. Hamilton-Bruce and Simon A. Koblar

    Citation: Stem Cell Research & Therapy 2017 8:191

    Content type: Review

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  48. Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of th...

    Authors: Roksana Moraghebi, Agnete Kirkeby, Patricia Chaves, Roger E. Rönn, Ewa Sitnicka, Malin Parmar, Marcus Larsson, Andreas Herbst and Niels-Bjarne Woods

    Citation: Stem Cell Research & Therapy 2017 8:190

    Content type: Research

    Published on:

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