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  1. A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential if MS...

    Authors: Lisa McGinley, Jill McMahon, Padraig Strappe, Frank Barry, Mary Murphy, Daniel O'Toole and Timothy O'Brien

    Citation: Stem Cell Research & Therapy 2011 2:12

    Content type: Research

    Published on:

  2. The controlled expression of many genes, including G-protein coupled receptors (GPCRs), is important for delineating gene functions in complex model systems. Binary systems for inducible regulation of transgen...

    Authors: Edward C Hsiao, Trieu D Nguyen, Jennifer K Ng, Mark J Scott, Wei Chun Chang, Hengameh Zahed and Bruce R Conklin

    Citation: Stem Cell Research & Therapy 2011 2:11

    Content type: Research

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  3. The stem cell field in veterinary medicine continues to evolve rapidly both experimentally and clinically. Stem cells are most commonly used in clinical veterinary medicine in therapeutic applications for the ...

    Authors: Lisa A Fortier and Alexander J Travis

    Citation: Stem Cell Research & Therapy 2011 2:9

    Content type: Review

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  4. Pluripotent, human stem cells hold tremendous promise as a source of progenitor and terminally differentiated cells for application in future regenerative therapies. However, such therapies will be dependent u...

    Authors: Yulia Shamis, Kyle J Hewitt, Mark W Carlson, Mariam Margvelashvilli, Shumin Dong, Catherine K Kuo, Laurence Daheron, Christophe Egles and Jonathan A Garlick

    Citation: Stem Cell Research & Therapy 2011 2:10

    Content type: Research

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  5. Mesenchymal progenitor cells, a multipotent adult stem cell population, have the ability to differentiate into cells of connective tissue lineages, including fat, cartilage, bone and muscle, and therefore gene...

    Authors: Janice O'Sullivan, Sinéad D'Arcy, Frank P Barry, JMary Murphy and Cynthia M Coleman

    Citation: Stem Cell Research & Therapy 2011 2:8

    Content type: Review

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  6. Endogenous cell proliferation and gliogenesis have been extensively documented in spinal cord injury, particularly in terms of proliferating oligodendrocyte progenitor cells. Despite the characterization of di...

    Authors: Dana M McTigue and FRezan Sahinkaya

    Citation: Stem Cell Research & Therapy 2011 2:7

    Content type: Commentary

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  7. The control of differential gene expression is central to all metazoan biology. Haematopoiesis represents one of the best understood developmental systems where multipotent blood stem cells give rise to a rang...

    Authors: Nicola K Wilson, Fernando J Calero-Nieto, Rita Ferreira and Berthold Göttgens

    Citation: Stem Cell Research & Therapy 2011 2:6

    Content type: Review

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  8. Recent development of a synthetic mRNA-based technology for efficient reprogramming to pluripotency and cell fate conversion without any modification to the genome has generated great interest among researcher...

    Authors: Mo Li, Ignacio Sancho-Martinez and Juan Carlos Izpisua Belmonte

    Citation: Stem Cell Research & Therapy 2011 2:5

    Content type: Commentary

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  9. In the body, tissue homeostasis is established and maintained by resident tissue-specific adult stem cells (aSCs). Through preservation of bidirectional communications with the surrounding niche and integratio...

    Authors: Penny M Gilbert and Helen M Blau

    Citation: Stem Cell Research & Therapy 2011 2:3

    Content type: Review

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  10. Tendon injury is a common problem in athletes, with poor tissue regeneration and a high rate of re-injury. Stem cell therapy is an attractive treatment modality as it may induce tissue regeneration rather than...

    Authors: Ashlee E Watts, Amy E Yeager, Oleg V Kopyov and Alan J Nixon

    Citation: Stem Cell Research & Therapy 2011 2:4

    Content type: Research

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  11. The ability to predetermine the fate of transplanted neural progenitor cells (NPCs) and specifically to direct their maturation has the potential to enhance the efficiency of cell-transplantation therapy for n...

    Authors: Elena M Vazey and Bronwen Connor

    Citation: Stem Cell Research & Therapy 2010 1:41

    Content type: Research

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  12. The use of tissue engineering therapies for treating damaged articular cartilage has traditionally focused on cell-based therapies for the repair of focal chondral or osteochondral defects. A recent study by L...

    Authors: Farshid Guilak

    Citation: Stem Cell Research & Therapy 2010 1:40

    Content type: Commentary

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  13. Almost every laboratory that grows mammalian cells today grows their cells on tissue culture plastic, which was introduced to cell culture decades ago based on properties such as inertness, transparency, and s...

    Authors: Matthew Raab, Jae-Won Shin and Dennis E Discher

    Citation: Stem Cell Research & Therapy 2010 1:38

    Content type: Commentary

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  14. Stem cells offer an enormous pool of resources for the understanding of the human body. One proposed use of stem cells has been as an autologous therapy. The use of stem cells for neurodegenerative diseases ha...

    Authors: Elise Dantuma, Stephanie Merchant and Kiminobu Sugaya

    Citation: Stem Cell Research & Therapy 2010 1:37

    Content type: Review

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  15. Regulated neurotransmitter actions in the mammalian central nervous system determine brain function and control peripheral organs and behavior. Although drug-seeking behaviors, including alcohol consumption, d...

    Authors: Tom N Grammatopoulos, Susan M Jones, Masami Yoshimura, Brian R Hoover, Mita Das, Evan Y Snyder, Gaynor A Larson, Nancy R Zahniser, Boris Tabakoff and WMichael Zawada

    Citation: Stem Cell Research & Therapy 2010 1:36

    Content type: Research

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  16. Delivered systemically or natively circulating mesenchymal stem cells accumulate in injured tissues. During homing mesenchymal stem cells adhere to endothelial cells and infiltrate underlying tissue. Previousl...

    Authors: Irina A Potapova, Ira S Cohen and Sergey V Doronin

    Citation: Stem Cell Research & Therapy 2010 1:35

    Content type: Research

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  17. Pluripotent stem cells are able to form any terminally differentiated cell. They have opened new doors for experimental and therapeutic studies to understand early development and to cure degenerative diseases...

    Authors: Jie Na, Jordan Plews, Jianliang Li, Patompon Wongtrakoongate, Timo Tuuri, Anis Feki, Peter W Andrews and Christian Unger

    Citation: Stem Cell Research & Therapy 2010 1:33

    Content type: Review

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  18. Ischemic heart disease is the single greatest killer of Americans and its complications are a major cause of congestive heart failure and ventricular arrhythmias while signifiicantly contributing to increased ...

    Authors: Quang T Bui, Zachary M Gertz and Robert L Wilensky

    Citation: Stem Cell Research & Therapy 2010 1:29

    Content type: Review

    Published on:

  19. The physiological signals that direct the division and differentiation of the zygote to form a blastocyst, and subsequent embryonic stem cell division and differentiation during early embryogenesis, are unknown. ...

    Authors: Miguel J Gallego, Prashob Porayette, Maria M Kaltcheva, Richard L Bowen, Sivan Vadakkadath Meethal and Craig S Atwood

    Citation: Stem Cell Research & Therapy 2010 1:28

    Content type: Research

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  20. Cellular commitment during vertebrate embryogenesis is controlled by an interplay of intrinsic regulators and morphogenetic signals. These mechanisms recruit a subset of cells in the developing organism to bec...

    Authors: CFlorian Bentzinger, Julia von Maltzahn and Michael A Rudnicki

    Citation: Stem Cell Research & Therapy 2010 1:27

    Content type: Review

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  21. Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investi...

    Authors: Roisin M Dwyer, Sonja Khan, Frank P Barry, Timothy O'Brien and Michael J Kerin

    Citation: Stem Cell Research & Therapy 2010 1:25

    Content type: Review

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  22. The study of pluripotent stem cells has generated much interest in both biology and medicine. Understanding the fundamentals of biological decisions, including what permits a cell to maintain pluripotency, tha...

    Authors: Ahmi Ben-Yehudah, Charles A Easley IV, Brian P Hermann, Carlos Castro, Calvin Simerly, Kyle E Orwig, Shoukhrat Mitalipov and Gerald Schatten

    Citation: Stem Cell Research & Therapy 2010 1:24

    Content type: Review

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  23. Genetic manipulation of human embryonic stem cells (hESC) has been limited by their general resistance to common methods used to introduce exogenous DNA or RNA. Efficient and high throughput transfection of nu...

    Authors: Jennifer C Moore, Kristin Atze, Percy L Yeung, Alana J Toro-Ramos, Cynthia Camarillo, Kevin Thompson, Christopher L Ricupero, Mark A Brenneman, Rick I Cohen and Ronald P Hart

    Citation: Stem Cell Research & Therapy 2010 1:23

    Content type: Research

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  24. Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding...

    Authors: Peter Satir

    Citation: Stem Cell Research & Therapy 2010 1:21

    Content type: Commentary

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  25. On the basis of the recently recognized potential of hematopoietic stem cells (HSCs) to give rise to hepatocytes, we have assessed the potential of granulocyte colony-stimulating factor (G-CSF)-mobilized bone ...

    Authors: Ning Li, Li Zhang, Huixiang Li and Baijun Fang

    Citation: Stem Cell Research & Therapy 2010 1:22

    Content type: Research

    Published on:

  26. Amniotic fluid harbors cells indicative of all three germ layers, and pluripotent fetal amniotic fluid stem cells (AFSs) are considered potentially valuable for applications in cellular therapy and tissue engi...

    Authors: Petra AB Klemmt, Vida Vafaizadeh and Bernd Groner

    Citation: Stem Cell Research & Therapy 2010 1:20

    Content type: Research

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  27. Mesenchymal stem cells (MSCs) offer promise for intervertebral disc (IVD) repair and regeneration because they are easily isolated and expanded, and can differentiate into several mesenchymal tissues. Notochor...

    Authors: Casey L Korecki, Juan M Taboas, Rocky S Tuan and James C Iatridis

    Citation: Stem Cell Research & Therapy 2010 1:18

    Content type: Research

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  28. This study aimed to determine the homing potential and fate of epidermal neural crest stem cells (eNCSCs) derived from hair follicles, and bone marrow-derived stem cells (BMSCs) of mesenchymal origin, in a lip...

    Authors: Johanna S Jackson, Jon P Golding, Catherine Chapon, William A Jones and Kishore K Bhakoo

    Citation: Stem Cell Research & Therapy 2010 1:17

    Content type: Research

    Published on:

  29. Hematopoietic stem cells (HSCs) follow a genetically programmed pattern of migration during development. Extracellular matrix and adhesion molecules, as well as chemokines and their receptors, are important in...

    Authors: Jesús Ciriza and Marcos E García-Ojeda

    Citation: Stem Cell Research & Therapy 2010 1:14

    Content type: Research

    Published on:

  30. Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wi...

    Authors: Farida Djouad, Wesley M Jackson, Brent E Bobick, Sasa Janjanin, Yingjie Song, George TJ Huang and Rocky S Tuan

    Citation: Stem Cell Research & Therapy 2010 1:11

    Content type: Research

    Published on:

  31. Treatment of extensive bone defects requires autologous bone grafting or implantation of bone substitute materials. An attractive alternative has been to engineer fully viable, biological bone grafts in vitro by ...

    Authors: Darja Marolt, Miomir Knezevic and Gordana Vunjak-Novakovic

    Citation: Stem Cell Research & Therapy 2010 1:10

    Content type: Review

    Published on:

  32. Human multipotent mesenchymal stem cell (MSC) therapies are being tested clinically for a variety of disorders, including Crohn's disease, multiple sclerosis, graft-versus-host disease, type 1 diabetes, bone frac...

    Authors: Lucas G Chase, Uma Lakshmipathy, Luis A Solchaga, Mahendra S Rao and Mohan C Vemuri

    Citation: Stem Cell Research & Therapy 2010 1:8

    Content type: Research

    Published on:

  33. The objective of this study was to find highly reliable internal-control genes (ICGs) for normalization of qPCR data from porcine adult mesenchymal stem cells induced to differentiate toward adipogenic and ost...

    Authors: Elisa Monaco, Massimo Bionaz, Alecsandra Sobreira de Lima, Walter L Hurley, Juan J Loor and Matthew B Wheeler

    Citation: Stem Cell Research & Therapy 2010 1:7

    Content type: Research

    Published on:

  34. Stem cells from human exfoliated deciduous teeth (SHED) have been identified as a population of postnatal stem cells capable of differentiating into osteogenic and odontogenic cells, adipogenic cells, and neur...

    Authors: Takayoshi Yamaza, Akiyama Kentaro, Chider Chen, Yi Liu, Yufang Shi, Stan Gronthos, Songlin Wang and Songtao Shi

    Citation: Stem Cell Research & Therapy 2010 1:5

    Content type: Research

    Published on:

  35. Induction of pluripotency from somatic cells by exogenous transcription factors is made possible by a variety of epigenetic changes that take place during the reprogramming process. The derivation of fully rep...

    Authors: Ugljesa Djuric and James Ellis

    Citation: Stem Cell Research & Therapy 2010 1:3

    Content type: Review

    Published on:

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