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  1. Biological pacemakers derived from pluripotent stem cell (PSC) have been considered as a potential therapeutic surrogate for sick sinus syndrome. So it is essential to develop highly efficient strategies for e...

    Authors: Feng Liu, Yibing Fang, Xiaojie Hou, Ying Yan, Haiying Xiao, Dongchuan Zuo, Jing Wen, Linli Wang, Zhichao Zhou, Xitong Dang, Rui Zhou and Bin Liao
    Citation: Stem Cell Research & Therapy 2020 11:284
    Content type: Research Published on:

  2. Human dental pulp stem cells (DPSCs) are a readily accessible and promising cell source for regenerative medicine. We recently reported that a xenogeneic serum-free culture medium (XFM) is preferable to fetal ...

    Authors: Mai Mochizuki, Hiroshi Sagara and Taka Nakahara
    Citation: Stem Cell Research & Therapy 2020 11:267
    Content type: Research Published on:

  3. Human umbilical cord mesenchymal stem cell (hUC-MSC) therapy is considered as a promising approach in the treatment of intrauterine adhesions (IUAs). Considerable researches have already detected hUC-MSCs by d...

    Authors: Jia-Hua Zheng, Jing-Kun Zhang, De-Sheng Kong, Yan-Biao Song, Shuang-Dan Zhao, Wen-Bo Qi, Ya-Nan Li, Ming-le Zhang and Xiang-Hua Huang
    Citation: Stem Cell Research & Therapy 2020 11:280
    Content type: Research Published on:

  4. Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been ch...

    Authors: Hailong Liu, Biao Huang, Shaolong Xue, Kin Pong U, Lai Ling Tsang, Xiaohu Zhang, Gang Li and Xiaohua Jiang
    Citation: Stem Cell Research & Therapy 2020 11:279
    Content type: Research Published on:

  5. Diabetic cystopathy (DCP) is a chronic complication of diabetes mainly within the submucosal and muscular layers of the bladder due to the hyperglycemia-induced ischemia. As no effective therapies are currentl...

    Authors: Yi Huang, Jie Gao, Yiduo Zhou, Shuo Wu, Yunpeng Shao, Haoliang Xue, Baixin Shen, Liucheng Ding and Zhongqing Wei
    Citation: Stem Cell Research & Therapy 2020 11:278
    Content type: Research Published on:

  6. Umbilical cord mesenchymal stem cells (UCMSCs) have been demonstrated to have good therapeutic effects in the treatment of HBV-related liver diseases. However, the therapeutic effect of UCMSCs on HBV-related l...

    Authors: Yifan Jia, Xin Shu, Xiaoan Yang, Haixia Sun, Huijuan Cao, Hong Cao, Ka Zhang, Qihuan Xu, Gang Li and Yang Yang
    Citation: Stem Cell Research & Therapy 2020 11:277
    Content type: Research Published on:

  7. This study aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro and in vivo models of osteoarthritis (OA).

    Authors: Lei He, Tianwei He, Jianghao Xing, Qing Zhou, Lei Fan, Can Liu, Yuyong Chen, Depeng Wu, Zhenming Tian, Bin Liu and Limin Rong
    Citation: Stem Cell Research & Therapy 2020 11:276
    Content type: Research Published on:

  9. Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular v...

    Authors: Yan Wang, Yi Fang Guo, Guang Ping Fu, Chang Guan, Xin Zhang, Dong Gang Yang and Yun Cong Shi
    Citation: Stem Cell Research & Therapy 2020 11:274
    Content type: Research Published on:

  10. Age and other cardiovascular risk factors have been reported to impair the activities of mesenchymal stem cells (MSCs), which will affect the efficacy of stem cell transplantation. The objective of the study i...

    Authors: Ning Zhang, Jinyun Zhu, Qunchao Ma, Yun Zhao, Yingchao Wang, Xinyang Hu, Jinghai Chen, Wei Zhu, Zhongchao Han and Hong Yu
    Citation: Stem Cell Research & Therapy 2020 11:273
    Content type: Research Published on:

  11. Adult clinical trials have reported safety and the therapeutic potential of stem cells for cardiac disease. These observations have now translated to the pediatric arena. We conducted a meta-analysis to assess...

    Authors: John Martinez, Sarah Zoretic, Axel Moreira and Alvaro Moreira
    Citation: Stem Cell Research & Therapy 2020 11:272
    Content type: Review Published on:

  12. Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation. In the p...

    Authors: Haoqing Yang, Yangyang Cao, Jianpeng Zhang, Yuncun Liang, Xiaomin Su, Chen Zhang, Huina Liu, Xiao Han, Lihua Ge and Zhipeng Fan
    Citation: Stem Cell Research & Therapy 2020 11:271
    Content type: Research Published on:

  13. Prenatal dexamethasone exposure (PDE) induces low birth weight and retardation of fetal bone development which are associated with lower peak bone mass in adult offspring. Here we evaluated whether and how PDE...

    Authors: Jianwen Su, Yu Chai, Zhiguo Ji, Yongheng Xie, Bin Yu and Xianrong Zhang
    Citation: Stem Cell Research & Therapy 2020 11:270
    Content type: Research Published on:

  14. Bone mass loss in aging is linked with imbalanced lineage differentiation of bone marrow mesenchymal stem cells (BMMSCs). Recent studies have proved that histone deacetylases (HDACs) are regarded as key regula...

    Authors: Liqiang Zhang, Meng Qi, Ji Chen, Jiangdong Zhao, Liya Li, Jiachen Hu, Yan Jin and Wenjia Liu
    Citation: Stem Cell Research & Therapy 2020 11:269
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:360

  15. Previous studies of primary ovarian insufficiency (POI) have focused on granulosa cells (GCs) and ignored the role of theca-interstitial cells (TICs). This study aims to explore the mechanism of the protective...

    Authors: Xueyan Lu, Hongchu Bao, Linlu Cui, Wenqian Zhu, Lianshuang Zhang, Zheng Xu, Xuejing Man, Yongli Chu, Qiang Fu and Hongqin Zhang
    Citation: Stem Cell Research & Therapy 2020 11:268
    Content type: Research Published on:

  16. Mesenchymal stem cells (MSCs) can provide therapeutic benefits for myocardial infarction (MI) recovery; however, the molecular mechanism by which MSCs improve the heart function is unclear.

    Authors: Baoping Deng, Xianlan Zhang, Yi Liang, Haiming Jiang, Weizhao Huang, Yinmeng Wu and Weiping Deng
    Citation: Stem Cell Research & Therapy 2020 11:266
    Content type: Research Published on:

  17. Hemophagocytic lymphohistiocytosis (HLH) is a severe or even fatal inflammatory state. Epstein–Barr virus (EBV) infection-associated HLH (EBV-HLH) is one of the most common secondary HLH and suffers a very poo...

    Authors: Yue Song, Jingshi Wang, Yini Wang and Zhao Wang
    Citation: Stem Cell Research & Therapy 2020 11:265
    Content type: Research Published on:

  18. Large numbers of adipose-derived stem cells (ADSCs) are easily obtained and have been demonstrated to protect against ultraviolet B (UVB)-induced skin photoaging. Extracellular vesicles (EVs) exhibit some of t...

    Authors: Peng Xu, Yu Xin, Zheng Zhang, Xiangyu Zou, Ke Xue, Huizhong Zhang, Wenjie Zhang and Kai Liu
    Citation: Stem Cell Research & Therapy 2020 11:264
    Content type: Research Published on:

  19. Lamina-associated polypeptide 2α (LAP2α) is a nucleoplasmic protein that has been involved in the regulation of the cell cycle, gene transcription, and adult stem cell function. LAP2α down-regulation is linked...

    Authors: Yiman Tang, Xiao Zhang, Wenshu Ge and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2020 11:263
    Content type: Research Published on:

  20. Mesenchymal stem/stromal cells (MSC) are commonly used in regenerative medicine. Among different tissues, iliac crest bone marrow (BM) represents the most exploited source, but its disadvantages are a painful ...

    Authors: Katarzyna Drela, Luiza Stanaszek, Konrad Snioch, Zuzanna Kuczynska, Mikolaj Wrobel, Sylwia Sarzynska, Pawel Legosz, Pawel Maldyk and Barbara Lukomska
    Citation: Stem Cell Research & Therapy 2020 11:262
    Content type: Research Published on:

  21. Wound healing is a complex biological process comprised of a series of sequential events aiming to repair injured tissue. Adult mesenchymal stem cells (MSCs) have been used in cellular therapy in preclinical a...

    Authors: Nathaly Enciso, Luis Avedillo, María Luisa Fermín, Cristina Fragío and Concepción Tejero
    Citation: Stem Cell Research & Therapy 2020 11:261
    Content type: Research Published on:

  22. Mesenchymal stromal cell-derived exosomes (MSC-EXs) could exert protective effects on recipient cells by transferring the contained microRNAs (miRs), and miR-132-3p is one of angiogenic miRs. However, whether ...

    Authors: Qunwen Pan, Xiaoli Kuang, Shuyun Cai, Xiang Wang, Donghui Du, Jinju Wang, Yan Wang, Yanyu Chen, Ji Bihl, Yanfang Chen, Bin Zhao and Xiaotang Ma
    Citation: Stem Cell Research & Therapy 2020 11:260
    Content type: Research Published on:

  23. After surgery, wound recovery in diabetic patients may be disrupted due to delayed inflammation, which can lead to undesired consequences, and there is currently a lack of effective measures to address this is...

    Authors: Wei Liu, Muyu Yu, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Fang Liu and Lili Yang
    Citation: Stem Cell Research & Therapy 2020 11:259
    Content type: Research Published on:

  24. Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance of the stemness in P...

    Authors: Lei Wang, Hao Zi, Yi Luo, Tongzu Liu, Hang Zheng, Conghua Xie, Xinghuan Wang and Xing Huang
    Citation: Stem Cell Research & Therapy 2020 11:258
    Content type: Research Published on:

  25. Schwann cells (SCs) are primarily responsible for regeneration and repair of the peripheral nervous system (PNS). Renewable and lineage-restricted SC precursors (SCPs) are considered highly desirable and promi...

    Authors: Han-Seop Kim, Jae Yun Kim, Cho Lok Song, Ji Eun Jeong and Yee Sook Cho
    Citation: Stem Cell Research & Therapy 2020 11:257
    Content type: Research Published on:

  26. MSCTRAIL is a cell-based therapy consisting of human allogeneic umbilical cord-derived MSCs genetically modified to express the anti-cancer protein TRAIL. Though cell-based therapies are typically designed wit...

    Authors: P. Stephen Patrick, Krishna K. Kolluri, May Zaw Thin, Adam Edwards, Elizabeth K. Sage, Tom Sanderson, Benjamin D. Weil, John C. Dickson, Mark F. Lythgoe, Mark Lowdell, Sam M. Janes and Tammy L. Kalber
    Citation: Stem Cell Research & Therapy 2020 11:256
    Content type: Research Published on:

  27. Clinical use of mesenchymal stem cells (MSCs) requires a uniform cell population, and their harvesting is invasive and produces a limited number of cells. Human embryonic stem cell-derived MSCs (hESC-MSCs) can...

    Authors: Sook Young Yoon, Jung Ah Yoon, Mira Park, Eun-Young Shin, Sookyung Jung, Jeoung Eun Lee, Jin Hee Eum, Haengseok Song, Dong Ryul Lee, Woo Sik Lee and Sang Woo Lyu
    Citation: Stem Cell Research & Therapy 2020 11:255
    Content type: Research Published on:

  28. Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD, B10.D2 → BALB/c) model that is characterized by skin and lung fibrosis. In this stu...

    Authors: Ji-Young Lim, Da-Bin Ryu, Tae Woo Kim, Sung-Eun Lee, Gyeongsin Park, Hyoung Kyu Yoon and Chang-Ki Min
    Citation: Stem Cell Research & Therapy 2020 11:254
    Content type: Research Published on:

  29. Extracellular vesicles produced by bone marrow mesenchymal stem cells (BMSC-EVs) can play important roles in the repair of injured tissues. Though numerous studies have reported the effect of EVs on renal fibr...

    Authors: Zhengzhou Shi, Qi Wang, Youbo Zhang and Dapeng Jiang
    Citation: Stem Cell Research & Therapy 2020 11:253
    Content type: Research Published on:

  30. Recently, extensive researches about stem cell-based therapies for ischemic stroke have been published; our review evaluated the efficacy and safety of stem cell-based therapies for ischemic stroke. Our review...

    Authors: Zhonghao Li, Xiaoke Dong, Min Tian, Chongchong Liu, Kaiyue Wang, Lili Li, Zunjing Liu and Jinmin Liu
    Citation: Stem Cell Research & Therapy 2020 11:252
    Content type: Review Published on:

  31. GATA4 is an early cardiac-specific transcription factor, and endogenous GATA4-positive cells play a critical role in cardioprotection after myocardial injury. As functional paracrine units of therapeutic cells...

    Authors: Chunshu Hao, Zhengri Lu, Yuanyuan Zhao, Zhong Chen, Chengxing Shen, Genshan Ma and Lijuan Chen
    Citation: Stem Cell Research & Therapy 2020 11:251
    Content type: Research Published on:

  32. Consumption of non-nutritive sweeteners (NNS) has been consistently associated with obesity and cardiometabolic disease in epidemiologic studies. Herein, we investigated effects of sucralose, a widely used NNS...

    Authors: Nabanita Kundu, Cleyton C. Domingues, Jay Patel, Mohammed Aljishi, Neeki Ahmadi, Mona Fakhri, Allison C. Sylvetsky and Sabyasachi Sen
    Citation: Stem Cell Research & Therapy 2020 11:250
    Content type: Research Published on:

  33. The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectat...

    Authors: Dongwei Liu, Fei Cheng, Shaokang Pan and Zhangsuo Liu
    Citation: Stem Cell Research & Therapy 2020 11:249
    Content type: Review Published on:

  34. Melanoma is a type of aggressive skin cancer with a poor survival rate. The resistance to conventional therapy of this disease is, at least in part, attributed to its cancer stem cell population. However, the ...

    Authors: Wenlin Wu, Chenxi Xu, Xiaobo Zhang, An Yu and Le Shu
    Citation: Stem Cell Research & Therapy 2020 11:248
    Content type: Research Published on:

  35. Induced pluripotent stem cells (iPSCs) have enormous potential in developmental biology studies and in cellular therapies. Although extensively studied and characterized in human and murine models, iPSCs from ...

    Authors: Fabiana Fernandes Bressan, Vinícius Bassanezze, Laís Vicari de Figueiredo Pessôa, Chester Bittencourt Sacramento, Tathiane Maistro Malta, Simone Kashima, Paulo Fantinato Neto, Ricardo De Francisco Strefezzi, Naira Caroline Godoy Pieri, José Eduardo Krieger, Dimas Tadeu Covas and Flávio Vieira Meirelles
    Citation: Stem Cell Research & Therapy 2020 11:247
    Content type: Research Published on:

  36. Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury i...

    Authors: Haibin Sun, Xiaoqing Zhao, Qihang Tai, Guangxiao Xu, Yingnan Ju and Wei Gao
    Citation: Stem Cell Research & Therapy 2020 11:246
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:491

  37. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is considered a promising therapeutic approach for bone defect repair. However, during the transplantation procedure, the functions and viabilit...

    Authors: Yusi Guo, Xiaopei Chi, Yifan Wang, Boon Chin Heng, Yan Wei, Xuehui Zhang, Han Zhao, Ying Yin and Xuliang Deng
    Citation: Stem Cell Research & Therapy 2020 11:245
    Content type: Research Published on:

  38. Pathological skin scars, caused by cesarean section, affected younger mothers esthetically and psychosocially and to some extent frustrated obstetricians and dermatologists. Umbilical cord mesenchymal stem cel...

    Authors: Dazhi Fan, Meng Zeng, Qing Xia, Shuzhen Wu, Shaoxin Ye, Jiaming Rao, Dongxin Lin, Huishan Zhang, Huiting Ma, Zhongchao Han, Xiaoling Guo and Zhengping Liu
    Citation: Stem Cell Research & Therapy 2020 11:244
    Content type: Research Published on:

  39. In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we expl...

    Authors: Rui Ma, Zhili Ren, Bin Li, Shirley W. I. Siu, Guokai Chen and Hang Fai Kwok
    Citation: Stem Cell Research & Therapy 2020 11:243
    Content type: Research Published on:

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hongtao Wang, Mengge Wang, Yu Wang, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2020 11:242
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:147

  41. Mesenchymal stem cells (MSCs) have become a promising candidate for cell-based immune therapy for acute rejection (AR) after heart transplantation due to possessing immunomodulatory properties. In this study, ...

    Authors: Chao Gao, Xiaodong Wang, Jian Lu, Zhilin Li, Haowen Jia, Minghao Chen, Yuchen Chang, Yanhong Liu, Peiyuan Li, Baotong Zhang, Xuezhi Du and Feng Qi
    Citation: Stem Cell Research & Therapy 2020 11:241
    Content type: Research Published on:

  42. Many studies have shown that long noncoding RNAs (lncRNAs) are closely related to the stimulation of osteogenic differentiation of adipose-derived stem cells (ADSCs) and the prevention of osteoporosis. Current...

    Authors: Zheng-liang Shi, Hua Zhang, Zhi-yong Fan, Wei Ma, Yong-zhou Song, Ming Li, Tong-qiu Li, Shu-xing Cao and Guo-jun Feng
    Citation: Stem Cell Research & Therapy 2020 11:240
    Content type: Research Published on:

  43. The identification of endometrial stem/progenitor cells in a high turnover rate tissue suggests that a well-orchestrated underlying network controls the behaviour of these stem cells. The thickness of the endo...

    Authors: Shan Xu, Rachel W. S. Chan, Tianqi Li, Ernest H. Y. Ng and William S. B. Yeung
    Citation: Stem Cell Research & Therapy 2020 11:239
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:199

  44. Pluripotent stem cells present the ability to self-renew and undergo differentiation into any cell type building an organism. Importantly, a lot of evidence on embryonic stem cell (ESC) differentiation comes f...

    Authors: Anita Florkowska, Igor Meszka, Magdalena Zawada, Diana Legutko, Tomasz J. Proszynski, Katarzyna Janczyk-Ilach, Wladyslawa Streminska, Maria A. Ciemerych and Iwona Grabowska
    Citation: Stem Cell Research & Therapy 2020 11:238
    Content type: Research Published on:

  45. Although it has been preclinically suggested that adipose tissue-derived mesenchymal stem cell (ADSC)-based therapy could effectively treat chronic liver diseases, the hepatic engraftment of ADSCs is still ext...

    Authors: Naishun Liao, Yingjun Shi, Yingchao Wang, Fangyu Liao, Bixing Zhao, Youshi Zheng, Yongyi Zeng, Xiaolong Liu and Jingfeng Liu
    Citation: Stem Cell Research & Therapy 2020 11:237
    Content type: Research Published on:

  46. Dental pulp stem cells (DPSCs) have high proliferation and multi-differentiation capabilities that maintain their functionality after cryopreservation. In our previous study, we demonstrated that cryopreserved...

    Authors: Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Eriko Makino, Saki Kanada, Tomokazu Saiki, Tasuku Ohno, Yuka Imanishi, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Shogo Ozawa, Ken Miyazawa…
    Citation: Stem Cell Research & Therapy 2020 11:236
    Content type: Research Published on:

  47. We would like to thank for the interest for the article and comments in the response. We believe that cell therapy may offer a treatment for severe voice problems in patients with vocal fold scarring and MSC t...

    Authors: Stellan Hertegård and Katarina LeBlanc
    Citation: Stem Cell Research & Therapy 2020 11:235
    Content type: Commentary Published on:

    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:173

  48. Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies usi...

    Authors: Keerthana Shankar, Christian M. Capitini and Krishanu Saha
    Citation: Stem Cell Research & Therapy 2020 11:234
    Content type: Review Published on:

  49. Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal...

    Authors: Marco Thurner, Martin Deutsch, Katrin Janke, Franka Messner, Christina Kreutzer, Stanislav Beyl, Sébastien Couillard-Després, Steffen Hering, Jakob Troppmair and Rainer Marksteiner
    Citation: Stem Cell Research & Therapy 2020 11:233
    Content type: Research Published on:
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