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  1. The blood-brain barrier (BBB) dynamically controls exchange between the brain and the body, but this interaction cannot be studied directly in the intact human brain or sufficiently represented by animal model...

    Authors: Donald J Alcendor, Frank E Block III, David E Cliffel, John Scott Daniels, Kate LJ Ellacott, Cody R Goodwin, Lucas H Hofmeister, Deyu Li, Dmitry A Markov, Jody C May, Lisa J McCawley, BethAnn McLaughlin, John A McLean, Kevin D Niswender, Virginia Pensabene, Kevin T Seale…

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S18

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  2. Kidney disease is a public health problem that affects more than 20 million people in the US adult population, yet little is understood about the impact of kidney disease on drug disposition. Consequently ther...

    Authors: Edward J Kelly, Zhican Wang, Jenna L Voellinger, Cathy K Yeung, Danny D Shen, Kenneth E Thummel, Ying Zheng, Giovanni Ligresti, David L Eaton, Kimberly A Muczynski, Jeremy S Duffield, Thomas Neumann, Anna Tourovskaia, Mark Fauver, Greg Kramer, Elizabeth Asp…

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S17

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  3. Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and ot...

    Authors: Abhinav Bhushan, Nina Senutovitch, Shyam S Bale, William J McCarty, Manjunath Hegde, Rohit Jindal, Inna Golberg, O Berk Usta, Martin L Yarmush, Lawrence Vernetti, Albert Gough, Ahmet Bakan, Tong Ying Shun, Richard Biasio and D Lansing Taylor

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S16

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  4. Cancer and cardiovascular disease remain the two leading causes of death in the United States. Progress in treatment to reduce morbidity and mortality will include the development of new drugs. Recent advances...

    Authors: Monica Moya, David Tran and Steven C George

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S15

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  5. Drug discovery and development to date has relied on animal models, which are useful but are often expensive, slow, and fail to mimic human physiology. The discovery of human induced pluripotent stem (iPS) cel...

    Authors: Anurag Mathur, Peter Loskill, SoonGweon Hong, Jae Young Lee, Sivan G Marcus, Laure Dumont, Bruce R Conklin, Holger Willenbring, Luke P Lee and Kevin E Healy

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S14

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  6. The female reproductive tract produces hormones for reproductive function and cardiovascular, bone and sexual health; the tract supplies a finite number of gametes, and it supports fetal development. Diseases ...

    Authors: Monica M Laronda, Joanna E Burdette, J Julie Kim and Teresa K Woodruff

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S13

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  7. A lack of affordable and effective testing and screening procedures mean surprisingly little is known about the health hazards of many of the tens of thousands of chemicals in use in the world today. The recen...

    Authors: Zhonggang Hou, Jue Zhang, Michael P Schwartz, Ron Stewart, C David Page, William L Murphy and James A Thomson

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S12

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  8. The vast majority of cancer mortalities result from distant metastases. The metastatic microenvironment provides unique protection to ectopic tumors as the primary tumors often respond to specific agents. Alth...

    Authors: Sarah E Wheeler, Jeffrey T Borenstein, Amanda M Clark, Mohammad R Ebrahimkhani, Ira J Fox, Linda Griffith, Walker Inman, Douglas Lauffenburger, Transon Nguyen, Venkateswaran C Pillai, Rachelle Prantil-Baun, Donna B Stolz, Donald Taylor, Theresa Ulrich, Raman Venkataramanan, Alan Wells…

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S11

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  9. Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable inte...

    Authors: George A Truskey, Hardean E Achneck, Nenad Bursac, Hon Fai Chan, Cindy S Cheng, Cristina Fernandez, Sungmin Hong, Youngmee Jung, Tim Koves, William E Kraus, Kam Leong, Lauran Madden, William M Reichert and Xuanhe Zhao

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S10

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  10. A multiorgan, functional, human in vitro assay system or 'Body-on-a-Chip' would be of tremendous benefit to the drug discovery and toxicology industries, as well as providing a more biologically accurate model fo...

    Authors: Alec ST Smith, Christopher J Long, Bonnie J Berry, Christopher McAleer, Maria Stancescu, Peter Molnar, Paula G Miller, Mandy B Esch, Jean-Matthieu Prot, James J Hickman and Michael L Shuler

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S9

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  11. Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The pla...

    Authors: Gordana Vunjak-Novakovic, Sangeeta Bhatia, Christopher Chen and Karen Hirschi

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S8

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  12. Detailed studies of lung pathology in patients during the course of development of acute lung injury or respiratory distress are limited, and in the past information related to lung-specific responses has been...

    Authors: Joan E Nichols, Jean A Niles, Stephanie P Vega and Joaquin Cortiella

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S7

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  13. Osteoarthritis (OA), the most prevalent form of arthritis, affects up to 15% of the adult population and is principally characterized by degeneration of the articular cartilage component of the joint, often wi...

    Authors: Thomas P Lozito, Peter G Alexander, Hang Lin, Riccardo Gottardi, Anthony Wai-Ming Cheng and Rocky S Tuan

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S6

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  14. Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointesti...

    Authors: Kira G Hartman, James D Bortner Jr, Gary W Falk, Jian Yu, Martín G Martín, Anil K Rustgi and John P Lynch

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S5

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  15. This project aims to establish and characterize an in vitro model of the developing human brain for the purpose of testing drugs and chemicals. To accurately assess risk, a model needs to recapitulate the complex...

    Authors: Helena T Hogberg, Joseph Bressler, Kimberly M Christian, Georgina Harris, Georgia Makri, Cliona O'Driscoll, David Pamies, Lena Smirnova, Zhexing Wen and Thomas Hartung

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S4

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  16. Researchers need an available and easy-to-use model of the human intestine to better understand human intestinal physiology and pathophysiology of diseases, and to offer an enhanced platform for developing dru...

    Authors: Olga Kovbasnjuk, Nicholas C Zachos, Julie In, Jennifer Foulke-Abel, Khalil Ettayebi, Joseph M Hyser, James R Broughman, Xi-Lei Zeng, Sabine Middendorp, Hugo R de Jonge, Mary K Estes and Mark Donowitz

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S3

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  17. The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs has created the opportunity to model diseases in ...

    Authors: Zongyou Guo, Claire A Higgins, Brian M Gillette, Munenari Itoh, Noriko Umegaki, Karl Gledhill, Samuel K Sia and Angela M Christiano

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S2

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  18. Gastrointestinal (GI) disorders affect up to 25% of the US population. Common intestinal disorders include malabsorption, irritable bowel syndrome and fecal incontinence. Some GI disorders such as Hirschsprung...

    Authors: Samantha A Brugmann and James M Wells

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S1

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  19. The National Institutes of Health has partnered with the US Food and Drug Administration and the Defense Advanced Research Projects Agency to accelerate the development of human microphysiological systems (MPS...

    Authors: Margaret L Sutherland, Kristin M Fabre and Danilo A Tagle

    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):I1

    Content type: Introduction

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  20. Retrograde coronary venous infusion is a promising delivery method for cellular cardiomyoplasty. Poor cell retention is the major obstacle to the establishment of this method as the preferred route for cell de...

    Authors: Zheyong Huang, Yunli Shen, Aijun Sun, Gangyong Huang, Hongmin Zhu, Bingqing Huang, Jianfeng Xu, Yanan Song, Ning Pei, Jing Ma, Xiangdong Yang, Yunzeng Zou, Juying Qian and Junbo Ge

    Citation: Stem Cell Research & Therapy 2013 4:149

    Content type: Research

    Published on:

  21. Adipose-derived stem cells (ASCs) are progenitor cells used in bone tissue engineering and regenerative medicine. Despite subcutaneous adipose tissue being more abundant, the buccal fat pad (BFP) is easily acc...

    Authors: Stefania Niada, Lorena Maria Ferreira, Elena Arrigoni, Alessandro Addis, Marino Campagnol, Eugenio Broccaioli and Anna Teresa Brini

    Citation: Stem Cell Research & Therapy 2013 4:148

    Content type: Research

    Published on:

  22. Human amniotic fluid stem (hAFS) cells have been shown to differentiate into multiple lineages, including myoblasts. However, molecular mechanisms underlying the myogenic differentiation of hAFS cells and thei...

    Authors: Ju Ang Kim, Yun Hee Shon, Jeong Ok Lim, James J Yoo, Hong-In Shin and Eui Kyun Park

    Citation: Stem Cell Research & Therapy 2013 4:147

    Content type: Research

    Published on:

  23. The existence of breast cancer stem-like cells (BCSCs) has profound implications for cancer prevention. Genistein, a predominant isoflavone found in soy products, has multiple robust anti-tumor effects in vari...

    Authors: Panhong Fan, Shujun Fan, Huan Wang, Jun Mao, Yu Shi, Mohammed M Ibrahim, Wei Ma, Xiaotang Yu, Zhenhuan Hou, Bo Wang and Lianhong Li

    Citation: Stem Cell Research & Therapy 2013 4:146

    Content type: Research

    Published on:

  24. Embryonic stem (ES) cells are considered a potentially advantageous source of hepatocytes for both transplantation and the development of bioartificial livers. However, the efficient large-scale generation of ...

    Authors: Shichang Zhang, Yunping Zhang, Li Chen, Tao Liu, Yangxin Li, Yingjie Wang and Yongjian Geng

    Citation: Stem Cell Research & Therapy 2013 4:145

    Content type: Research

    Published on:

  25. Multiple myeloma is a common hematological malignancy that leads to the occurrence of bone lesions. The combination of traditional cytotoxic and novel agents is usually taken to treat multiple myeloma-related ...

    Authors: Jinhua Yu and Yao Li

    Citation: Stem Cell Research & Therapy 2013 4:144

    Content type: Commentary

    Published on:

  26. Acute respiratory distress syndrome (ARDS) is one of the devastating sequelae of sepsis, and so far no specific promising pharmacotherapies have been proven to decrease mortality from it. Stem cell therapy is ...

    Authors: Paolo Pelosi and Yuda Sutherasan

    Citation: Stem Cell Research & Therapy 2013 4:143

    Content type: Commentary

    Published on:

  27. With the shortage of donor organs for islet transplantation, insulin-producing cells have been generated from different types of stem cell. Human fetal pancreatic stem cells have a better self-renewal capacity...

    Authors: Wen-Jian Zhang, Shi-Qing Xu, Han-Qing Cai, Xiu-Li Men, Zai Wang, Hua Lin, Li Chen, Yong-Wei Jiang, Hong-Lin Liu, Cheng-Hui Li, Wei-Guo Sui, Hong-Kui Deng and Jin-Ning Lou

    Citation: Stem Cell Research & Therapy 2013 4:141

    Content type: Research

    Published on:

  28. Cell therapy using mesenchymal stromal cells (MSCs) is a promising new avenue of treatment for critical limb ischemia (CLI). Preclinical studies have suggested that MSCs enhance neovascularization in ischemic ...

    Authors: Hendrik Gremmels, Joost O Fledderus, Martin Teraa and Marianne C Verhaar

    Citation: Stem Cell Research & Therapy 2013 4:140

    Content type: Commentary

    Published on:

  29. Impaction allograft with cement is a common technique used in revision hip surgeries for the last 20 years. However, its clinical results are inconsistent. Recent studies have shown that mesenchymal stem cells...

    Authors: Yannis Reissis, Elena García-Gareta, Michelle Korda, Gordon W Blunn and Jia Hua

    Citation: Stem Cell Research & Therapy 2013 4:139

    Content type: Research

    Published on:

  30. Primordial germ cells (PGCs) are the major population of cells in the developing bilateral embryonic gonads. Little is known about the cellular responses of PGCs after treatment with toxic chemicals such as bu...

    Authors: Hyung Chul Lee, Sung Kyu Kim, Tae Sub Park, Deivendran Rengaraj, Kyung Je Park, Hong Jo Lee, Soo Bong Park, Sung Woo Kim, Seong Bok Choi and Jae Yong Han

    Citation: Stem Cell Research & Therapy 2013 4:136

    Content type: Research

    Published on:

  31. Advanced atherosclerotic lesions are characterized by lipid accumulation, inflammation, and defective efferocytosis. An ideal therapy should address all aspects of this multifactorial disease. Ixmyelocel-T the...

    Authors: Kelly J Ledford, Nikki Murphy, Frank Zeigler and Ronnda L Bartel

    Citation: Stem Cell Research & Therapy 2013 4:135

    Content type: Research

    Published on:

  32. M2 macrophages promote tissue repair and regeneration through various mechanisms including immunomodulation and scavenging of tissue debris. Delivering increased numbers of these cells to ischemic tissues may ...

    Authors: Kelly J Ledford, Frank Zeigler and Ronnda L Bartel

    Citation: Stem Cell Research & Therapy 2013 4:134

    Content type: Research

    Published on:

  33. While amniotic mesenchymal cells have been isolated and characterized in different species, amniotic epithelial cells (AECs) have been found only in humans and horses and are recently considered valid candidat...

    Authors: Lucia Rutigliano, Bruna Corradetti, Luisa Valentini, Davide Bizzaro, Aurora Meucci, Fausto Cremonesi and Anna Lange-Consiglio

    Citation: Stem Cell Research & Therapy 2013 4:133

    Content type: Research

    Published on:

  34. High expression of aldehyde dehydrogenase1A1 (ALDH1A1) is observed in many organs and tumors and may identify benign and cancer stem cell populations.

    Authors: Kalyan J Gangavarapu, Gissou Azabdaftari, Carl D Morrison, Austin Miller, Barbara A Foster and Wendy J Huss

    Citation: Stem Cell Research & Therapy 2013 4:132

    Content type: Research

    Published on:

  35. Murine models of hind-limb ischemia are frequently used to assess interventions aimed at improving therapeutic angiogenesis in critical limb ischemia. Much of the current focus of angiogenesis lies with mesenc...

    Authors: Garry P Duffy and Caroline C Herron

    Citation: Stem Cell Research & Therapy 2013 4:131

    Content type: Commentary

    Published on:

  36. Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat on the short arm of chromosome 4 resulting in cognitive decline, motor dysfunction, and death, typically occurring 1...

    Authors: Kyle D Fink, Julien Rossignol, Andrew T Crane, Kendra K Davis, Matthew C Bombard, Angela M Bavar, Steven Clerc, Steven A Lowrance, Cheng Song, Laurent Lescaudron and Gary L Dunbar

    Citation: Stem Cell Research & Therapy 2013 4:130

    Content type: Research

    Published on:

  37. Mesenchymal stem cells (MSCs) have immunosuppressive activity. They do not induce allospecific T cell responses, making them promising tools for reducing the severity of graft versus host disease (GVHD) as wel...

    Authors: Cristina Nazarov, Jessica Lo Surdo, Steven R Bauer and Cheng-Hong Wei

    Citation: Stem Cell Research & Therapy 2013 4:128

    Content type: Research

    Published on:

  38. The development of an appropriate procedure for lentiviral gene transduction into keratinocyte stem cells is crucial for stem cell biology and regenerative medicine for genetic disorders of the skin. However, ...

    Authors: Daisuke Nanba, Natsuki Matsushita, Fujio Toki and Shigeki Higashiyama

    Citation: Stem Cell Research & Therapy 2013 4:127

    Content type: Research

    Published on:

  39. The application of mesenchymal stem cells (MSCs) in treating rheumatoid arthritis (RA) has been made possible by the immunosuppressive and differentiation abilities of these cells. A non-invasive means of asse...

    Authors: Hareklea Markides, Oksana Kehoe, Robert H Morris and Alicia J El Haj

    Citation: Stem Cell Research & Therapy 2013 4:126

    Content type: Research

    Published on:

  40. The ability to self-renew, be easily expanded in vitro and differentiate into different mesenchymal tissues, render mesenchymal stem cells (MSCs) an attractive therapeutic method for degenerative diseases. The su...

    Authors: Andreia Ribeiro, Paula Laranjeira, Sandrine Mendes, Isabel Velada, Cristiana Leite, Pedro Andrade, Francisco Santos, Ana Henriques, Mário Grãos, Carla M P Cardoso, António Martinho, M Luísa Pais, Cláudia Lobato da Silva, Joaquim Cabral, Hélder Trindade and Artur Paiva

    Citation: Stem Cell Research & Therapy 2013 4:125

    Content type: Research

    Published on:

  41. Ovarian dysfunction frequently occurs in female cancer patients after chemotherapy, but human amniotic epithelial cells (hAECs) that can differentiate into cell types that arise from all three germ layers may ...

    Authors: Fangyuan Wang, Li Wang, Xiaofen Yao, Dongmei Lai and Lihe Guo

    Citation: Stem Cell Research & Therapy 2013 4:124

    Content type: Research

    Published on:

  42. Administration of bone marrow-derived cells produces beneficial effects in experimental extrapulmonary acute respiratory distress syndrome (ARDS). However, there are controversies regarding the effects of timi...

    Authors: Tatiana Maron-Gutierrez, Johnatas Dutra Silva, Fernanda Ferreira Cruz, Samantha Alegria, Debora Gonçalves Xisto, Edson Fernandes Assis, Hugo Caire Castro-Faria-Neto, Claudia Chimisso Dos Santos, Marcelo Marcos Morales and Patricia Rieken Macedo Rocco

    Citation: Stem Cell Research & Therapy 2013 4:123

    Content type: Research

    Published on:

  43. On 23 May 2013, the Italian health minister decided to endorse a law regarding controversial stem cell-based therapies in 32 young terminally ill patients, shocking many scientists. According to the internatio...

    Authors: Paola Frati, Giacomo Frati, Matteo Gulino, Gianluca Montanari Vergallo, Alessandro Di Luca and Vittorio Fineschi

    Citation: Stem Cell Research & Therapy 2013 4:122

    Content type: Review

    Published on:

  44. Tissue factor (TF) is expressed in various types of cells. TF expression is essential for many biological processes, such as blood coagulation and embryonic development, while its high expression in stem cells...

    Authors: Yan-Hui Yu, Deng-Shu Wu, Fang-Fang Huang, Zheng Zhang, Lin-Xin Liu, Jian Zhang, Hui-En Zhan, Min-Yuan Peng, Hui Zeng and Fang-Ping Chen

    Citation: Stem Cell Research & Therapy 2013 4:121

    Content type: Research

    Published on:

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