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  1. Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and s...

    Authors: Laura Tomasello, Rodolfo Mauceri, Antonina Coppola, Maria Pitrone, Giuseppe Pizzo, Giuseppina Campisi, Giuseppe Pizzolanti and Carla Giordano

    Citation: Stem Cell Research & Therapy 2017 8:179

    Content type: Research

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  2. Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) i...

    Authors: Shihong Lu, Meili Ge, Yizhou Zheng, Jianping Li, Xiaoming Feng, Sizhou Feng, Jinbo Huang, Ying Feng, Donglin Yang, Jun Shi, Fang Chen and Zhongchao Han

    Citation: Stem Cell Research & Therapy 2017 8:178

    Content type: Research

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  3. Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal ...

    Authors: Maria Beatriz Herrera Sanchez, Sara Previdi, Stefania Bruno, Valentina Fonsato, Maria Chiara Deregibus, Sharad Kholia, Sara Petrillo, Emanuela Tolosano, Rossana Critelli, Marco Spada, Renato Romagnoli, Mauro Salizzoni, Ciro Tetta and Giovanni Camussi

    Citation: Stem Cell Research & Therapy 2017 8:176

    Content type: Research

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  4. Dental pulp represents an easily accessible autologous source of adult stem cells. A subset of these cells, named dental pulp pluripotent-like stem cells (DPPSC), shows high plasticity and can undergo multiple...

    Authors: Ester Martínez-Sarrà, Sheyla Montori, Carlos Gil-Recio, Raquel Núñez-Toldrà, Domiziana Costamagna, Alessio Rotini, Maher Atari, Aernout Luttun and Maurilio Sampaolesi

    Citation: Stem Cell Research & Therapy 2017 8:175

    Content type: Research

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  5. Human adult stem cells hold the potential for the cure of numerous conditions and degenerative diseases. They possess major advantages over pluripotent stem cells as they can be derived from donors at any age,...

    Authors: Raju Khatri, Michal Arad, Timothy Ortlip, Benjamin A. Portney, W. Alex Meltzer, Silviu Diaconu, Lorna E. Silipino, Ying Wang, David M. Kaetzel, Rodney J. Taylor and Michal Zalzman

    Citation: Stem Cell Research & Therapy 2017 8:174

    Content type: Research

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  6. Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. Transplantation of human amniotic epithelial cells (hAECs) improves ovarian function...

    Authors: Chenyue Ding, Hong Li, Yun Wang, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Wei Wang and Boxian Huang

    Citation: Stem Cell Research & Therapy 2017 8:173

    Content type: Research

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  7. Transplantation of insulin-producing cells is considered an important diabetes therapy. Many research studies have shown that insulin-producing cells can be derived from the in-vitro cultured pancreatic coloni...

    Authors: Dongshen Ma, Shanshan Tang, Jing Song, Qiong Wu, Fangfang Zhang, Yun Xing, Yi Pan, Yanfeng Zhang, Jingwei Jiang, Yubin Zhang and Liang Jin

    Citation: Stem Cell Research & Therapy 2017 8:172

    Content type: Research

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  8. Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties. We have shown previously that minocycline enhances ...

    Authors: Alberto Daniel Guerra, Warren E. Rose, Peiman Hematti and W. John Kao

    Citation: Stem Cell Research & Therapy 2017 8:171

    Content type: Research

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  9. Keloid is one kind of benign skin disease caused by hyperplasia of fibroblasts and collagen fibrils. It is refractory due to the lack of an effective treatment at present, which puts pressure on seeking a new ...

    Authors: Ya Jiao, Xiao Wang, Jixun Zhang, Yongjun Qi, Hongmin Gong and Duyin Jiang

    Citation: Stem Cell Research & Therapy 2017 8:170

    Content type: Short report

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  10. Accumulated evidence supports the potent stimulating effects of multiple small molecules on the expansion of hematopoietic stem cells (HSCs) which are important for the therapy of various hematological disorde...

    Authors: Lan Wang, Xin Guan, Huihui Wang, Bin Shen, Yu Zhang, Zhihua Ren, Yupo Ma, Xinxin Ding and Yongping Jiang

    Citation: Stem Cell Research & Therapy 2017 8:169

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:458

  11. Mesenchymal stem cells (MSCs) represent an important source for cell therapy in regenerative medicine. MSCs have shown promising results for repair of damaged tissues in various degenerative diseases in animal...

    Authors: Amruta Barhanpurkar-Naik, Suhas T. Mhaske, Satish T. Pote, Kanupriya Singh and Mohan R. Wani

    Citation: Stem Cell Research & Therapy 2017 8:168

    Content type: Research

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  12. Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where pancreatic beta cells are lost before the clinical manifestations of the disease. Administration of mesenchymal stem cells (MSCs) or MSCs dif...

    Authors: Anshu Sharma and Rajni Rani

    Citation: Stem Cell Research & Therapy 2017 8:167

    Content type: Research

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  13. Equine mesenchymal stromal/stem cells (MSCs) are most commonly harvested from bone marrow (BM) or adipose tissue, requiring the use of surgical procedures. By contrast, the uterus can be accessed nonsurgically...

    Authors: B. Elisabeth Rink, Karin R. Amilon, Cristina L. Esteves, Hilari M. French, Elaine Watson, Christine Aurich and F. Xavier Donadeu

    Citation: Stem Cell Research & Therapy 2017 8:166

    Content type: Research

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  14. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, acts as an inhibitor of angiogenesis and is associated with an increased risk of cardiovascular mortality. Administration o...

    Authors: Juraj Madaric, Martina Valachovicova, Ludovit Paulis, Jana Pribojova, Renata Mateova, Katarina Sebekova, Luba Postulkova, Terezia Madaricova, Maria Bucova, Martin Mistrik and Ivan Vulev

    Citation: Stem Cell Research & Therapy 2017 8:165

    Content type: Research

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  15. Mesenchymal stem cells (MSCs) migrate via the bloodstream to sites of injury and are possibly attracted by inflammatory factors. As a proinflammatory mediator, angiotensin II (Ang II) reportedly enhances the m...

    Authors: Xiu-ping Xu, Hong-li He, Shu-ling Hu, Ji-bin Han, Li-li Huang, Jing-yuan Xu, Jian-feng Xie, Ai-ran Liu, Yi Yang and Hai-bo Qiu

    Citation: Stem Cell Research & Therapy 2017 8:164

    Content type: Research

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  16. Blood-brain barrier impairment is a major indicator of endothelial dysfunction in diabetes. Studies showed that endothelial progenitor cell (EPC) transplantation promoted angiogenesis and improved function rec...

    Authors: Jieli Geng, Liping Wang, Meijie Qu, Yaying Song, Xiaojie Lin, Yajing Chen, Muyassar Mamtilahun, Shengdi Chen, Zhijun Zhang, Yongting Wang and Guo-Yuan Yang

    Citation: Stem Cell Research & Therapy 2017 8:163

    Content type: Research

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  17. Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has emerged as a novel therapy for acute liver failure (ALF). However, the homing efficiency of BMSCs to the injured liver sites appears to...

    Authors: Kun Wang, Yuwen Li, Tiantian Zhu, Yongting Zhang, Wenting Li, Wenyu Lin, Jun Li and Chuanlong Zhu

    Citation: Stem Cell Research & Therapy 2017 8:162

    Content type: Research

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  18. The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available ...

    Authors: Léonore Avercenc-Léger, Philippe Guerci, Jean-Marc Virion, Ghislaine Cauchois, Sébastien Hupont, Rachid Rahouadj, Jacques Magdalou, Jean-François Stoltz, Danièle Bensoussan, Céline Huselstein and Loïc Reppel

    Citation: Stem Cell Research & Therapy 2017 8:161

    Content type: Research

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  19. Human embryonic stem cells (hESCs) potentially offer new routes to study, on the basis of the Developmental Origins of Health and Disease (DOHaD) concept, how the maternal environment during pregnancy influenc...

    Authors: Maria Barandalla, Hui Shi, Hui Xiao, Silvia Colleoni, Cesare Galli, Pietro Lio, Matthew Trotter and Giovanna Lazzari

    Citation: Stem Cell Research & Therapy 2017 8:160

    Content type: Research

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  20. Primary graft dysfunction (PGD) is considered to be the end result of an inflammatory response targeting the new lung allograft after transplant. Previous research has indicated that MAPC cell therapy might at...

    Authors: An Martens, Sofie Ordies, Bart M. Vanaudenaerde, Stijn E. Verleden, Robin Vos, Dirk E. Van Raemdonck, Geert M. Verleden, Valerie D. Roobrouck, Sandra Claes, Dominique Schols, Eric Verbeken, Catherine M. Verfaillie and Arne P. Neyrinck

    Citation: Stem Cell Research & Therapy 2017 8:159

    Content type: Research

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  21. The development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration...

    Authors: Beverley J. Cottle, Fiona C. Lewis, Victoria Shone and Georgina M. Ellison-Hughes

    Citation: Stem Cell Research & Therapy 2017 8:158

    Content type: Research

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  22. The prevalence of chronic skin wounds in humans is high, and treatment is often complicated by the presence of pathogenic bacteria. Therefore, safe and innovative treatments to reduce the bacterial load in cut...

    Authors: Rebecca M. Harman, Steven Yang, Megan K. He and Gerlinde R. Van de Walle

    Citation: Stem Cell Research & Therapy 2017 8:157

    Content type: Research

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  23. Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem cells (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth muscle pathologies. However,...

    Authors: Yanhui Li, Yan Wen, Morgaine Green, Elise K. Cabral, Prachi Wani, Fan Zhang, Yi Wei, Thomas M. Baer and Bertha Chen

    Citation: Stem Cell Research & Therapy 2017 8:156

    Content type: Research

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  24. Transplantation of cultured epidermal cell sheets (CES) has long been used to treat patients with burns, chronic wounds, and stable vitiligo. In patients with large area burns this can be a life-saving procedu...

    Authors: Catherine J. Jackson, Kim Alexander Tønseth and Tor Paaske Utheim

    Citation: Stem Cell Research & Therapy 2017 8:155

    Content type: Review

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  25. Due to their “natural immune privilege” and immunoregulatory properties human fibroblast-like limbal stem cells (f-LSCs) have acquired great interest as a potential tool for achieving immunotolerance. Hashimot...

    Authors: Antonina Coppola, Laura Tomasello, Maria Pitrone, Salvatore Cillino, Pierina Richiusa, Giuseppe Pizzolanti and Carla Giordano

    Citation: Stem Cell Research & Therapy 2017 8:154

    Content type: Research

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  26. Mesenchymal stem cells (MSCs) have been widely used in cytotherapy and tissue engineering due to their immunosuppressive ability and regenerative potential. Recently, the immunomodulatory influence of MSCs has...

    Authors: Yuan Yin, Rui-Xin Wu, Xiao-Tao He, Xin-Yue Xu, Jia Wang and Fa-Ming Chen

    Citation: Stem Cell Research & Therapy 2017 8:153

    Content type: Research

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  27. To reduce young female fertility loss, the in-vitro culture of cryopreserved ovarian cortical tissues (OCTs) is considered an effective approach without delaying treatment and undergoing stimulation medicine. ...

    Authors: Yingxian Jia, Xiaohan Shi, Yidong Xie, Xiaochuan Xie, Yan Wang and Shangwei Li

    Citation: Stem Cell Research & Therapy 2017 8:152

    Content type: Research

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  28. Asthma is a chronic inflammatory disease that can be difficult to treat due to its complex pathophysiology. Most current drugs focus on controlling the inflammatory process, but are unable to revert the change...

    Authors: Ligia Lins de Castro, Debora Gonçalves Xisto, Jamil Zola Kitoko, Fernanda Ferreira Cruz, Priscilla Christina Olsen, Patricia Albuquerque Garcia Redondo, Tatiana Paula Teixeira Ferreira, Daniel Jay Weiss, Marco Aurélio Martins, Marcelo Marcos Morales and Patricia Rieken Macedo Rocco

    Citation: Stem Cell Research & Therapy 2017 8:151

    Content type: Research

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  29. Disorders of the oxidative phosphorylation (OXPHOS) system represent a large group among the inborn errors of metabolism. The most frequently observed biochemical defect is isolated deficiency of mitochondrial...

    Authors: Marlen Melcher, Katharina Danhauser, Annette Seibt, Özer Degistirici, Fabian Baertling, Arun Kumar Kondadi, Andreas S. Reichert, Werner J. H. Koopman, Peter H. G. M. Willems, Richard J. Rodenburg, Ertan Mayatepek, Roland Meisel and Felix Distelmaier

    Citation: Stem Cell Research & Therapy 2017 8:150

    Content type: Research

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  30. Due to the multilineage differentiation ability and paracrine role of adipose-derived stem cells (ASCs) for bladder defect repair, various scaffolds have been applied in combination with ASCs to promote bladde...

    Authors: Qiong Wang, Dong-dong Xiao, Hao Yan, Yang Zhao, Shi Fu, Juan Zhou, Zhong Wang, Zhe Zhou, Ming Zhang and Mu-Jun Lu

    Citation: Stem Cell Research & Therapy 2017 8:149

    Content type: Research

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  31. Polycaprolactone (PCL) has been regarded as a promising synthetic material for bone tissue engineering application. Owing to its unique biochemical properties and great compatibility, PCL fibers have come to b...

    Authors: Ruyue Xue, Yuna Qian, Linhao Li, Guidong Yao, Li Yang and Yingpu Sun

    Citation: Stem Cell Research & Therapy 2017 8:148

    Content type: Research

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  32. Craniofacial mesenchymal stem cells (MSCs), isolated from an abundant and accessible source of craniofacial tissues, possess self-renewal and multilineage differentiation potential. It has been reported that c...

    Authors: Ruili Yang, Tingting Yu and Yanheng Zhou

    Citation: Stem Cell Research & Therapy 2017 8:147

    Content type: Review

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  33. Recent studies have indicated that microRNA-223 (miR-223) plays a role in the tissue-protective effect of mesenchymal stem cells (MSCs). NLR family-pyrin domain containing 3 (NLRP3) was reported to affect a re...

    Authors: Xiaopeng Yuan, Xiaoping Wang, Chuanbao Chen, Jian Zhou and Ming Han

    Citation: Stem Cell Research & Therapy 2017 8:146

    Content type: Research

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  34. In our clinical practice, we perform transplantations of autologous synovial mesenchymal stem cells (MSCs) for cartilage and meniscus regenerative medicine. One of the most important issues to ensuring clinica...

    Authors: Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta and Ichiro Sekiya

    Citation: Stem Cell Research & Therapy 2017 8:144

    Content type: Research

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  35. Mesenchymal stromal cells (MSCs) from various tissues have shown moderate therapeutic efficacy in reversing liver fibrosis in preclinical models. Here, we compared the relative therapeutic potential of pooled,...

    Authors: Mathiyazhagan Rengasamy, Gurbind Singh, Noor Atiqah Fakharuzi, Siddikuzzaman, Sudha Balasubramanian, Priyanka Swamynathan, Charan Thej, Gopinath Sasidharan, Pawan Kumar Gupta, Anjan Kumar Das, Ahmad Zuhairi Abd Rahman, Kamal Shaik Fakiruddin, Lim Moon Nian, Zubaidah Zakaria and Anish S. Majumdar

    Citation: Stem Cell Research & Therapy 2017 8:143

    Content type: Research

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  36. The delivery of alternative myogenic cell sources to enhance the efficacy of minced muscle grafts (MG) for the treatment of volumetric muscle loss (VML) injuries is a promising strategy to overcome the demand ...

    Authors: Stephen M. Goldman, Beth E. P. Henderson and Benjamin T. Corona

    Citation: Stem Cell Research & Therapy 2017 8:142

    Content type: Short report

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  37. A number of studies have shown that tooth-like structures can be regenerated using induced pluripotent stem cells and mouse embryonic stem (mES) cells. However, few studies have reported the regeneration of to...

    Authors: Yancong Zhang, Yongliang Li, Ruirui Shi, Siqi Zhang, Hao Liu, Yunfei Zheng, Yan Li, Jinglei Cai, Duanqing Pei and Shicheng Wei

    Citation: Stem Cell Research & Therapy 2017 8:141

    Content type: Research

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  38. Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in cl...

    Authors: Samantha F. H. de Witte, Ana M. Merino, Marcella Franquesa, Tanja Strini, Johanna A. A. van Zoggel, Sander S. Korevaar, Franka Luk, Madhu Gargesha, Lisa O’Flynn, Debashish Roy, Steve J. Elliman, Philip N. Newsome, Carla C. Baan and Martin J. Hoogduijn

    Citation: Stem Cell Research & Therapy 2017 8:140

    Content type: Research

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  39. Mechanical stimuli play important roles in the proliferation and differentiation of adult stem cells. However, few studies on their effects on induced pluripotent stem cells (iPSCs) have been published.

    Authors: Young Mi Kim, Yun Gyeong Kang, So Hee Park, Myung-Kwan Han, Jae Ho Kim, Ji Won Shin and Jung-Woog Shin

    Citation: Stem Cell Research & Therapy 2017 8:139

    Content type: Research

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  40. Pathways directing endogenous stem/progenitor cells to restore normal architecture and function of damaged/diseased lungs remain underexplored. Published data have revealed that alveolar progenitor type II cel...

    Authors: Yuan Quan, Zhaohua Wang, Ling Gong, Xinmiao Peng, Melissa A. Richard, Junlan Zhang, Myriam Fornage, Joseph L. Alcorn and Dachun Wang

    Citation: Stem Cell Research & Therapy 2017 8:138

    Content type: Research

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  41. Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that ...

    Authors: Jie Wang, Panpan Cen, Jiajia Chen, Linxiao Fan, Jun Li, Hongcui Cao and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2017 8:137

    Content type: Review

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  42. Stem cell therapy (SCT) for the treatment of Crohn’s disease (CD) is still in its infancy, and whether SCT is associated with improved outcomes is unclear. We performed a meta-analysis to evaluate the efficacy...

    Authors: Yun Qiu, Man-ying Li, Ting Feng, Rui Feng, Ren Mao, Bai-li Chen, Yao He, Zhi-rong Zeng, Sheng-hong Zhang and Min-hu Chen

    Citation: Stem Cell Research & Therapy 2017 8:136

    Content type: Review

    Published on:

  43. Age-related macular degeneration (AMD) is a major cause of blindness in older adults in developed countries. It is a multifactorial disease triggered by both environmental and genetic factors. High-temperature...

    Authors: Shuo Sun, ZhiQing Li, Patrick Glencer, BinCui Cai, XiaoMin Zhang, Jin Yang and XiaoRong Li

    Citation: Stem Cell Research & Therapy 2017 8:135

    Content type: Review

    Published on:

  44. Non-integrating episomal vectors have become an important tool for induced pluripotent stem cell reprogramming. The episomal vectors carrying the “Yamanaka reprogramming factors” (Oct4, Klf, Sox2, and L-Myc + ...

    Authors: Christopher E. Schmitt, Blanca M. Morales, Ellen M. H. Schmitz, John S. Hawkins, Carlos O. Lizama, Joan P. Zape, Edward C. Hsiao and Ann C. Zovein

    Citation: Stem Cell Research & Therapy 2017 8:132

    Content type: Method

    Published on:

  45. Progressive liver fibrosis leads to cirrhosis and end-stage liver disease. This disease is a consequence of strong interactions between matrix-producing hepatic stellate cells (HSCs) and resident and infiltrat...

    Authors: Mustapha Najimi, Silvia Berardis, Hoda El-Kehdy, Valérie Rosseels, Jonathan Evraerts, Catherine Lombard, Adil El Taghdouini, Patrick Henriet, Leo van Grunsven and Etienne Marc Sokal

    Citation: Stem Cell Research & Therapy 2017 8:131

    Content type: Research

    Published on:

  46. MicroRNAs (miRNAs) have emerged as crucial factors that regulate proliferation and apoptosis of cardiac c-kit+ cells. Although much is known about their role in maintaining cardiac c-kit+ cell pluripotency, the m...

    Authors: Jingjin Liu, Yongshun Wang, Jinjin Cui, Meng Sun, Zhongyue Pu, Chao Wang, Wenjuan Du, Xinxin Liu, Jian Wu, Jingbo Hou, Shuo Zhang and Bo Yu

    Citation: Stem Cell Research & Therapy 2017 8:127

    Content type: Research

    Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:404

  47. Autoimmune dacryoadenitis, such as Sjögren syndrome, comprises multifactorial and complex diseases. Inflammation of the lacrimal gland plays a key role in the pathogenesis of diseases. Unfortunately, current t...

    Authors: Xiaoxiao Lu, Xilian Wang, Hong Nian, Dan Yang and Ruihua Wei

    Citation: Stem Cell Research & Therapy 2017 8:126

    Content type: Review

    Published on:

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