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  1. With the development of regenerative medicine and tissue engineering technology, almost all stem cell therapy is efficacious for the treatment of premature ovarian failure (POF) or premature ovarian insufficie...

    Authors: Boxian Huang, Chunfeng Qian, Chenyue Ding, Qingxia Meng, Qinyan Zou and Hong Li
    Citation: Stem Cell Research & Therapy 2019 10:362
  2. Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulator...

    Authors: Guanguan Qiu, Guoping Zheng, Menghua Ge, Jiangmei Wang, Ruoqiong Huang, Qiang Shu and Jianguo Xu
    Citation: Stem Cell Research & Therapy 2019 10:359
  3. The therapeutic potential of mesenchymal stem cells (MSCs) may be attributed partly to the secreted paracrine factors, which comprise exosomes. Exosomes are small, saucer-shaped vesicles containing miRNAs, mRN...

    Authors: Kun Yang, Dong Li, Meitian Wang, Zhiliang Xu, Xiao Chen, Qiao Liu, Wenjie Sun, Jiangxia Li, Yaoqin Gong, Duo Liu, Changshun Shao, Qiji Liu and Xi Li
    Citation: Stem Cell Research & Therapy 2019 10:358
  4. The degenerative disc disease (DDD) is a major cause of low back pain. The physiological low-glucose microenvironment of the cartilage endplate (CEP) is disrupted in DDD. Glucose influences protein O-GlcNAcylatio...

    Authors: Chao Sun, Weiren Lan, Bin Li, Rui Zuo, Hui Xing, Minghan Liu, Jie Li, Yuan Yao, Junlong Wu, Yu Tang, Huan Liu and Yue Zhou
    Citation: Stem Cell Research & Therapy 2019 10:357
  5. Orthopaedic diseases are one of the major targets for regenerative medicine. In this context, Wharton’s jelly (WJ) is an alternative source to bone marrow (BM) for allogeneic transplantation since its isolatio...

    Authors: Raquel Cabrera-Pérez, Marta Monguió-Tortajada, Ana Gámez-Valero, Raquel Rojas-Márquez, Francesc Enric Borràs, Santiago Roura and Joaquim Vives
    Citation: Stem Cell Research & Therapy 2019 10:356
  6. White adipose tissue includes subcutaneous and visceral adipose tissue (SAT and VAT) with different metabolic features. SAT protects from metabolic disorders, while VAT promotes them. The proliferative and adi...

    Authors: Zhenzhen Pan, Zixin Zhou, Huiying Zhang, Hui Zhao, Peixuan Song, Di Wang, Jilong Yin, Wanyi Zhao, Zhaoxiang Xie, Fuwu Wang, Yan Li, Chun Guo, Faliang Zhu, Lining Zhang and Qun Wang
    Citation: Stem Cell Research & Therapy 2019 10:355
  7. Mesenchymal stem cells are heterogenous populations with hematopoietic supporting and immunomodulating capacities. Enormous studies have focused on their preclinical or clinical therapeutic effects, yet the sy...

    Authors: Qinjun Zhao, Leisheng Zhang, Yimeng Wei, Hao Yu, Linglin Zou, Jiali Huo, Hongju Yang, Baoquan Song, Teng Wei, Dan Wu, Wenxia Zhang, Lei Zhang, Dengke Liu, Zongjin Li, Ying Chi, Zhibo Han…
    Citation: Stem Cell Research & Therapy 2019 10:354
  8. In most stem cell therapy strategies reported to date, stem cells are introduced to damaged tissue sites to repair and regenerate the original tissue structure and function. MSC therapeutic efficacies are inco...

    Authors: Mitsuyoshi Nakao, Kyungsook Kim, Kenichi Nagase, David W. Grainger, Hideko Kanazawa and Teruo Okano
    Citation: Stem Cell Research & Therapy 2019 10:353
  9. Traumatic brain injury (TBI) is a common neurotrauma leading to brain dysfunction and death. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) hold promise in the treatment of TBI. However, their ...

    Authors: Fangxia Guan, Tuanjie Huang, Xinxin Wang, Qu Xing, Kristyn Gumpper, Peng Li, Jishi Song, Tao Tan, Greta Luyuan Yang, Xingxing Zang, Jiewen Zhang, Yuming Wang, Yunlei Yang, Yashi Liu, Yanting Zhang, Bo Yang…
    Citation: Stem Cell Research & Therapy 2019 10:352

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:522

  10. Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucid...

    Authors: Zheng Li, Shuhao Liu, Tengfei Fu, Yi Peng and Jian Zhang
    Citation: Stem Cell Research & Therapy 2019 10:351
  11. Human adipose-derived stem cells (hASCs) are a subset of mesenchymal stem cells (MSCs); it has been regarded as one of the most promising stem cells. We previously found that fibroblast growth factor-2 (FGF-2)...

    Authors: Yuanyuan Ma, Natsuko Kakudo, Naoki Morimoto, Fangyuan Lai, Shigeru Taketani and Kenji Kusumoto
    Citation: Stem Cell Research & Therapy 2019 10:350
  12. Distinct mechanical stimuli are known to manipulate the behaviors of embryonic stem cells (ESCs). Fundamental rationale of how ESCs respond to mechanical forces and the potential biological effects remain elus...

    Authors: Jiawen Wang, Yi Wu, Xiao Zhang, Fan Zhang, Dongyuan Lü, Bing Shangguan, Yuxin Gao and Mian Long
    Citation: Stem Cell Research & Therapy 2019 10:349
  13. Bone marrow mesenchymal stem cells (BMSCs) can partially repair chemotherapy-induced ovarian damage. However, low survival rate after transplantation hampers the therapeutic efficiency of BMSCs. Heat shock pre...

    Authors: Qing Wang, Xinran Li, Qingru Wang, Jiaxin Xie, Chuhai Xie and Xiafei Fu
    Citation: Stem Cell Research & Therapy 2019 10:348
  14. Extracellular vesicles (EVs) are cellular-derived versatile transporters with a specialized property for trafficking a variety of cargo, including metabolites, growth factors, cytokines, proteins, lipids, and ...

    Authors: Mujib Ullah, Yang Qiao, Waldo Concepcion and Avnesh S. Thakor
    Citation: Stem Cell Research & Therapy 2019 10:347
  15. Osteoarthritis and cartilage injury treatment is an unmet clinical need. Therefore, development of new approaches to treat these diseases is critically needed. Previous work in our laboratory has shown that mu...

    Authors: Xueqin Gao, Haizi Cheng, Hassan Awada, Ying Tang, Sarah Amra, Aiping Lu, Xuying Sun, Guijin Lv, Charles Huard, Bing Wang, Xiaohong Bi, Yadong Wang and Johnny Huard
    Citation: Stem Cell Research & Therapy 2019 10:346
  16. An uncontrolled inflammatory response is a critical pathophysiological feature of sepsis. Mesenchymal stem cells (MSCs) induce macrophage phenotype polarization and reduce inflammation in sepsis. MSC-secreted ...

    Authors: Feng Liu, Haibo Qiu, Ming Xue, Shi Zhang, Xiwen Zhang, Jingyuan Xu, Jianxiao Chen, Yi Yang and Jianfeng Xie
    Citation: Stem Cell Research & Therapy 2019 10:345
  17. With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced. Unfortunately, there i...

    Authors: Jian Zhu, Wei Yu, Yitian Wang, Kaishun Xia, Yuluan Huang, Ankai Xu, Qixin Chen, Bing Liu, Huimin Tao, Fangcai Li and Chengzhen Liang
    Citation: Stem Cell Research & Therapy 2019 10:344
  18. Satellite cells, a population of unipotent stem cells attached to muscle fibers, determine the excellent regenerative capability of injured skeletal muscles. Myogenic potential is also exhibited by other cell ...

    Authors: Paulina Kasprzycka, Karolina Archacka, Kamil Kowalski, Bartosz Mierzejewski, Małgorzata Zimowska, Iwona Grabowska, Mariusz Piotrowski, Milena Rafałko, Agata Ryżko, Aliksandra Irhashava, Kamil Senderowski, Magdalena Gołąbek, Władysława Stremińska, Katarzyna Jańczyk-Ilach, Marta Koblowska, Roksana Iwanicka-Nowicka…
    Citation: Stem Cell Research & Therapy 2019 10:343
  19. Injury of stem cell niches may disturb tissue homeostasis and regeneration coordinated by specific niche components. Yet, the mechanisms of stem cell niche restoration remain poorly understood. Herein, we exam...

    Authors: Georgy Sagaradze, Nataliya Basalova, Vladimir Kirpatovsky, Dmitry Ohobotov, Peter Nimiritsky, Olga Grigorieva, Vladimir Popov, Armais Kamalov, Vsevolod Tkachuk and Anastasia Efimenko
    Citation: Stem Cell Research & Therapy 2019 10:342
  20. Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate into all specialized cell types including gametes. iPSCs do not exist naturally and are instead generated (“induc...

    Authors: Sharif Moradi, Hamid Mahdizadeh, Tomo Šarić, Johnny Kim, Javad Harati, Hosein Shahsavarani, Boris Greber and Joseph B. Moore IV
    Citation: Stem Cell Research & Therapy 2019 10:341
  21. Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not yet been fully explai...

    Authors: Elaheh Mianehsaz, Hamid Reza Mirzaei, Maryam Mahjoubin-Tehran, Alireza Rezaee, Roxana Sahebnasagh, Mohammad Hossein Pourhanifeh, Hamed Mirzaei and Michael R. Hamblin
    Citation: Stem Cell Research & Therapy 2019 10:340
  22. The Wnt/β-catenin pathway is involved in the osteogenic differentiation of human adipose-derived stem cells (hASCs) under cyclic strain. Very little is known about the role of microRNAs in these events.

    Authors: Yadong Luo, Ran Ge, Heming Wu, Xu Ding, Haiyang Song, Huan Ji, Meng Li, Yunan Ma, Sheng Li, Chenxing Wang and Hongming Du
    Citation: Stem Cell Research & Therapy 2019 10:339
  23. During joint replacement, surgical vacuum suction guarantees a sufficient overview on the situs. We assume high concentrations of mesenchymal stromal cells (MSCs) on surgical vacuum filters.

    Authors: Katharina Henze, Monika Herten, Marcel Haversath, André Busch, Sven Brandau, Alexander Hackel, Stefanie B. Flohé and Marcus Jäger
    Citation: Stem Cell Research & Therapy 2019 10:338
  24. The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This r...

    Authors: Marc G. Jeschke, Sarah Rehou, Matthew R. McCann and Shahriar Shahrokhi
    Citation: Stem Cell Research & Therapy 2019 10:337
  25. Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidate agents for treating critical-sized bone defects; they promote angiogenesis and may be an alternative to cell therapy. In this ...

    Authors: Bo Liang, Jia-Ming Liang, Jia-Ning Ding, Jia Xu, Jian-Guang Xu and Yi-Min Chai
    Citation: Stem Cell Research & Therapy 2019 10:335
  26. Acute graft-versus-host disease (aGvHD), post-allogeneic hematopoietic stem cell transplantation, is associated with high mortality rates in patients not responding to standard line care with steroids. Adoptiv...

    Authors: Caroline Gavin, Erik Boberg, Lena Von Bahr, Matteo Bottai, Anton Törnqvist Andrén, Annika Wernerson, Lindsay C. Davies, Rachael V. Sugars and Katarina Le Blanc
    Citation: Stem Cell Research & Therapy 2019 10:334
  27. Long-term diabetes-associated complications are the major causes of morbidity and mortality in individuals with diabetes. These diabetic complications are closely linked to immune system activation along with ...

    Authors: Songyan Yu, Yu Cheng, Linxi Zhang, Yaqi Yin, Jing Xue, Bing Li, Zhengyuan Gong, Jieqing Gao and Yiming Mu
    Citation: Stem Cell Research & Therapy 2019 10:333
  28. Mesenchymal stem cells (MSCs) have been explored as promising tools for treatment of several neurological and neurodegenerative diseases. MSCs release abundant extracellular vesicles (EVs) containing a variety...

    Authors: Victor Bodart-Santos, Luiza R. P. de Carvalho, Mariana A. de Godoy, André F. Batista, Leonardo M. Saraiva, Luize G. Lima, Carla Andreia Abreu, Fernanda G. De Felice, Antonio Galina, Rosalia Mendez-Otero and Sergio T. Ferreira
    Citation: Stem Cell Research & Therapy 2019 10:332
  29. Experimental and clinical trials have demonstrated the efficiency of bone marrow-derived mesenchymal stromal/stem cells (bMSCs) in the treatment of myocardial infarction. However, after intravenous injection, ...

    Authors: Dong-Mei Xie, Yuan-Long Li, Jie Li, Qinglang Li, Guihua Lu, Yuansheng Zhai, Juhong Zhang, Zhibin Huang and Xiuren Gao
    Citation: Stem Cell Research & Therapy 2019 10:331
  30. The existing cell surface markers used for sorting glioma stem cells (GSCs) have obvious limitations, such as vulnerability to the enzymatic digestion and time-consuming labeling procedure. Reduced nicotinamid...

    Authors: Ye Yuan, Zexuan Yan, Jingya Miao, Ruili Cai, Mengsi Zhang, Yanxia Wang, Lihong Wang, Weiqi Dang, Di Wang, Dongfang Xiang, Yan Wang, Peng Zhang, Youhong Cui, Xiuwu Bian and Qinghua Ma
    Citation: Stem Cell Research & Therapy 2019 10:330
  31. Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study...

    Authors: Md Nahidul Islam, Tomás P. Griffin, Elizabeth Sander, Stephanie Rocks, Junaid Qazi, Joana Cabral, Jasmin McCaul, Tara McMorrow and Matthew D. Griffin
    Citation: Stem Cell Research & Therapy 2019 10:329
  32. Previous studies including ours have demonstrated a critical function of the transcription factor ETV2 (ets variant 2; also known as ER71) in determining the fate of cardiovascular lineage development. However...

    Authors: Ju Young Kim, Dong Hun Lee, Joo Kyung Kim, Hong Seo Choi, Bhakti Dwivedi, Manali Rupji, Jeanne Kowalski, Stefan J. Green, Heesang Song, Won Jong Park, Ji Young Chang, Tae Min Kim and Changwon Park
    Citation: Stem Cell Research & Therapy 2019 10:328
  33. Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell microenvironment provides factors and elements that play significant roles in controlling the cell fate direction. The b...

    Authors: Pan Zhang, Chen Zhang, Jing Li, Jiyang Han, Xiru Liu and Hui Yang
    Citation: Stem Cell Research & Therapy 2019 10:327
  34. When the deer antler is cast, it leaves a cutaneous wound that can achieve scarless healing due to the presence of antler stem cells (ASCs). This provides an opportunity to study regenerative wound healing.

    Authors: Xiaoli Rong, Wenhui Chu, Haiying Zhang, Yusu Wang, Xiaoyan Qi, Guokun Zhang, Yimin Wang and Chunyi Li
    Citation: Stem Cell Research & Therapy 2019 10:326
  35. Multiple sclerosis (MS) is one of the most common autoimmune diseases of the central nervous system (CNS). CNS has its own unique structural and functional features, while the lack of precision regulatory elem...

    Authors: Xi Wang, Wantong Zhai, Jiahui Zhu, Wei Zhao, Xiaoyi Zou, Siying Qu, Shenyue Wang, Zhongze He, Zhaoying Li, Lingyang Wang, Bo Sun and Hulun Li
    Citation: Stem Cell Research & Therapy 2019 10:325
  36. As the precursors of sperm and eggs, human primordial germ cells (hPGCs) emerge as early as weeks 2 to 3 of post-implantation development. Recently, robust hPGC induction models have been established in vitro ...

    Authors: Zili Li, Fang Fang, Qian Zhao, Honggang Li and Chengliang Xiong
    Citation: Stem Cell Research & Therapy 2019 10:324
  37. Our study sought to investigate the therapeutic effects and mechanisms of miR-326-5p-overexpressing endothelial progenitor cells (EPCs) on acute myocardial infarction (AMI).

    Authors: Xiaoting Li, Xiang Xue, Yuejun Sun, Lei Chen, Ting Zhao, Wentao Yang, Yongbing Chen and Zhiwei Zhang
    Citation: Stem Cell Research & Therapy 2019 10:323
  38. Human pancreata contain many types of cells, such as endocrine islets, acinar, ductal, fat, and mesenchymal stromal cells (MSCs). MSCs are important and shown to have a promising therapeutic potential to treat...

    Authors: Bashar Khiatah, Meirigeng Qi, Weiting Du, Kuan T-Chen, Kayleigh M. van Megen, Rachel G. Perez, Jeffrey S. Isenberg, Fouad Kandeel, Bart O. Roep, Hsun Teresa Ku and Ismail H. Al-Abdullah
    Citation: Stem Cell Research & Therapy 2019 10:322
  39. Damaged endothelial cells and downregulated osteogenic ability are two key pathogenic mechanisms of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies suggested that transplan...

    Authors: Rongtai Zuo, Lingchi Kong, Mengwei Wang, Wenbo Wang, Jia Xu, Yimin Chai, Junjie Guan and Qinglin Kang
    Citation: Stem Cell Research & Therapy 2019 10:321
  40. The inflammation and regeneration process may be accompanied by the shift in the M1/M2 polarization of macrophages to adapt to extracellular signals. How the macrophages responded to the altered immunological ...

    Authors: Jiaying Liu, Bin Chen, Jun Bao, Yangheng Zhang, Lang Lei and Fuhua Yan
    Citation: Stem Cell Research & Therapy 2019 10:320
  41. Metabolomics is the systemic study of the unique fingerprints of metabolites involved in cellular processes and biochemical reactions. The metabolomic approach is useful in diagnosing and predicting the develo...

    Authors: Juryun Kim, Sunyoung Christina Kang, Na Eun Yoon, Yena Kim, Jinhyeok Choi, Narae Park, Hyerin Jung, Byung Hwa Jung and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2019 10:319
  42. Retinal inflammation affecting the neurovascular unit may play a role in the development of visual deficits following mild traumatic brain injury (mTBI). We have shown that concentrated conditioned media from ...

    Authors: Kumar Abhiram Jha, Mickey Pentecost, Raji Lenin, Jordy Gentry, Lada Klaic, Nobel Del Mar, Anton Reiner, Chuan He Yang, Lawrence M. Pfeffer, Nicolas Sohl and Rajashekhar Gangaraju
    Citation: Stem Cell Research & Therapy 2019 10:318
  43. Human fibroblasts can be reprogrammed into induced hepatocyte-like cells through the expression of a set of transcription factors. Although the generation of induced hepatocyte-like cells by HNF4A, HNF1A, and ...

    Authors: Maria Ballester, Miguel Bolonio, Ramon Santamaria, José V. Castell, Carmen Ribes-Koninckx and Roque Bort
    Citation: Stem Cell Research & Therapy 2019 10:317
  44. Serum-free xenogen-free defined media and continuous controlled physiological cell culture conditions have been developed for stem cell therapeutics, but the effect of these conditions on the relative potency ...

    Authors: Seth Mount, Pushpinder Kanda, Sandrine Parent, Saad Khan, Connor Michie, Liliana Davila, Vincent Chan, Ross A. Davies, Haissam Haddad, David Courtman, Duncan J. Stewart and Darryl R. Davis
    Citation: Stem Cell Research & Therapy 2019 10:316
  45. Hepatocyte nuclear factor-1 alpha (HNF-1α) is a transcription factor expressed predominantly in the liver among other organs. Structurally, it contains POU-homeodomain that binds to DNA and form proteins that ...

    Authors: Xue Wang, Waseem Hassan, Jing Zhao, Sahar Bakht, Yunjuan Nie, Ying Wang, Qingfeng Pang and Zhaohui Huang
    Citation: Stem Cell Research & Therapy 2019 10:315
  46. Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery syst...

    Authors: Hargita Hegyesi, Nikolett Sándor, Géza Sáfrány, Virág Lovas, Árpád Kovács, Angéla Takács, László Kőhidai, Lilla Turiák, Ágnes Kittel, Krisztina Pálóczi, Lóránd Bertók and Edit Irén Buzás
    Citation: Stem Cell Research & Therapy 2019 10:313
  47. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is one of the new therapeutic strategies for treating ischemic brain and heart tissues. However, the poor survival rate of transplanted BMSCs in...

    Authors: Jiankang Fang, Xia Zhao, Shuai Li, Xingan Xing, Haitao Wang, Philip Lazarovici and Wenhua Zheng
    Citation: Stem Cell Research & Therapy 2019 10:312
  48. The attainment of extensive neurological function recovery remains the key challenge for the treatment of traumatic brain injury (TBI). Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has...

    Authors: Ke Wu, Dongdong Huang, Can Zhu, Ella A. Kasanga, Ying Zhang, Enxing Yu, Hengli Zhang, Zhihui Ni, Sheng Ye, Chunli Zhang, Jiangnan Hu, Qichuan Zhuge and Jianjing Yang
    Citation: Stem Cell Research & Therapy 2019 10:311
  49. Spermatogonial stem cell transplantation (SSCT) is a promising therapy in restoring the fertility of childhood cancer survivors. However, the low efficiency of SSCT is a significant concern. SSCT could be impr...

    Authors: Prashant Kadam, Elissavet Ntemou, Jaime Onofre, Dorien Van Saen and Ellen Goossens
    Citation: Stem Cell Research & Therapy 2019 10:310

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