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  1. The differentiation of corneal limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) has great power as a novel treatment for ocular surface reconstruction and for modeling corneal epithelial rene...

    Authors: Meri Vattulainen, Tanja Ilmarinen, Laura Koivusalo, Keijo Viiri, Heidi Hongisto and Heli Skottman
    Citation: Stem Cell Research & Therapy 2019 10:236
    Content type: Research Published on:

  2. Adipose tissue-derived mesenchymal stromal cells (ASCs) have been shown to exhibit some promising properties of their use in regenerative medicine as advanced therapy medicinal products (ATMP). However, differ...

    Authors: Justyna Czapla, Sybilla Matuszczak, Klaudia Kulik, Ewa Wiśniewska, Ewelina Pilny, Magdalena Jarosz-Biej, Ryszard Smolarczyk, Tomasz Sirek, Michał Oskar Zembala, Marian Zembala, Stanisław Szala and Tomasz Cichoń
    Citation: Stem Cell Research & Therapy 2019 10:235
    Content type: Research Published on:

  3. Neurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are invol...

    Authors: Ching-Wen Huang, Yuan-Yu Hsueh, Wen-Chin Huang, Shyam Patel and Song Li
    Citation: Stem Cell Research & Therapy 2019 10:234
    Content type: Research Published on:

  4. Cancer stem cells always express high levels of stemness-associated transcription factors to maintain their features. However, the regulatory mechanism of the stemness of cancer stem cells mediated by transcri...

    Authors: Fan Yang, Pei Cui, Yu Lu and Xiaobo Zhang
    Citation: Stem Cell Research & Therapy 2019 10:233
    Content type: Research Published on:

  5. Mesenchymal stem cells (MSCs) are multipotent cells with broad immunosuppressive capacities. Recently, it has been reported that MSCs can transfer mitochondria to various cell types, including fibroblast, canc...

    Authors: Patricia Luz-Crawford, Javier Hernandez, Farida Djouad, Noymar Luque-Campos, Andres Caicedo, Séverine Carrère-Kremer, Jean-Marc Brondello, Marie-Luce Vignais, Jérôme Pène and Christian Jorgensen
    Citation: Stem Cell Research & Therapy 2019 10:232
    Content type: Research Published on:

  6. Sepsis remains a source of high mortality in hospitalized patients despite proper antibiotic approaches. Encouragingly, mesenchymal stromal cells (MSCs) and their produced extracellular vesicles (EVs) have bee...

    Authors: Kyong-Su Park, Kristina Svennerholm, Ganesh V. Shelke, Elga Bandeira, Cecilia Lässer, Su Chul Jang, Rakesh Chandode, Inta Gribonika and Jan Lötvall
    Citation: Stem Cell Research & Therapy 2019 10:231
    Content type: Research Published on:

  7. The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effectiv...

    Authors: Ronghua Yang, Fengxia Liu, Jingru Wang, Xiaodong Chen, Julin Xie and Kun Xiong
    Citation: Stem Cell Research & Therapy 2019 10:229
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:447

  8. Human-induced pluripotent stem cells (hiPSCs) show a great promise as a renewable source of cells with broad biomedical applications. Since insulin has been used in the maintenance of hiPSCs, in this study we ...

    Authors: Mohammad Shahbazi, Paige Cundiff, Wenyu Zhou, Philip Lee, Achchhe Patel, Sunita L. D’Souza, Fahim Abbasi, Thomas Quertermous and Joshua W. Knowles
    Citation: Stem Cell Research & Therapy 2019 10:228
    Content type: Research Published on:

  9. High temperature has a very adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility through either apoptosis or DNA damage. However, the direct effects of heat stress on the dev...

    Authors: Jia Wang, Wei-Jun Gao, Shou-Long Deng, Xiang Liu, Hua Jia and Wen-Zhi Ma
    Citation: Stem Cell Research & Therapy 2019 10:227
    Content type: Research Published on:

  10. MicroRNAs (miRNAs) play a key role in regulating cell differentiation. In the present study, we aimed to explore the role of miR-140-5p in odontoblastic differentiation of dental pulp stem cells (DPSCs).

    Authors: Xiaohui Lu, Xi Chen, Jing Xing, Min Lian, Dan Huang, Yuanzhou Lu, Guijuan Feng and Xingmei Feng
    Citation: Stem Cell Research & Therapy 2019 10:226
    Content type: Research Published on:

  11. Intrauterine adhesion (IUA) is one of the most serious complications in patients with endometrial repair disorder after injury. Currently, there is no effective treatment for IUA. Stem cell is the main candida...

    Authors: Yuan Yao, Ran Chen, Guowu Wang, Yu Zhang and Fang Liu
    Citation: Stem Cell Research & Therapy 2019 10:225
    Content type: Research Published on:

  12. Interferon-β (IFN-β) is a cytokine with pleiotropic cellular functions, including antiviral, antiproliferative, and immunomodulatory activities. IFN-β inhibits multiple tumor cell growth in vitro. However, the...

    Authors: Lingqian Du, Qianyu Liang, Shaohua Ge, Chengzhe Yang and Pishan Yang
    Citation: Stem Cell Research & Therapy 2019 10:224
    Content type: Research Published on:

  13. The diabetic foot ulcer (DFU) is one of the most prevalent complications of diabetes mellitus and often develops severe effects that can lead to amputation. A non-healing “minor” amputation often precedes a ma...

    Authors: Roberto Lonardi, Nicola Leone, Stefano Gennai, Giulia Trevisi Borsari, Tea Covic and Roberto Silingardi
    Citation: Stem Cell Research & Therapy 2019 10:223
    Content type: Research Published on:

  14. iRoot BP Plus is a novel bioceramic endodontic material. Recently, it has been considered as an alternative to MTA which is the most popular scaffold cover during regenerative endodontic therapy. This study ai...

    Authors: Jiamin Lu, Zehan Li, Xiao Wu, Yan Chen, Ming Yan, Xingyun Ge and Jinhua Yu
    Citation: Stem Cell Research & Therapy 2019 10:222
    Content type: Research Published on:

  15. Familial hypercholesterolemia type IIA (FH) is due to mutations in the low-density lipoprotein receptor (LDLR) resulting in elevated levels of low-density lipoprotein cholesterol (LDL-c) in plasma and in prema...

    Authors: Jérôme Caron, Véronique Pène, Laia Tolosa, Maxime Villaret, Eléanor Luce, Angélique Fourrier, Jean-Marie Heslan, Samir Saheb, Eric Bruckert, María José Gómez-Lechón, Tuan Huy Nguyen, Arielle R. Rosenberg, Anne Weber and Anne Dubart-Kupperschmitt
    Citation: Stem Cell Research & Therapy 2019 10:221
    Content type: Research Published on:

  16. Human naïve pluripotency state cells can be derived from direct isolation of inner cell mass or primed-to-naïve resetting of human embryonic stem cells (hESCs) through different combinations of transcription f...

    Authors: Yingying Wang, Baosen Guo, Zengrong Xiao, Haijun Lin, Xi Zhang, Yueqiang Song, Yalei Li, Xuehu Gao, Jinjun Yu, Zhihua Shao, Xuekun Li, Yuping Luo and Siguang Li
    Citation: Stem Cell Research & Therapy 2019 10:220
    Content type: Research Published on:

  17. Cancer remains one of the leading lethal diseases worldwide. Identifying biomarkers of cancers might provide insights into the strategies for the development of novel targeted anti-cancer therapies. Leucine-ri...

    Authors: Liangliang Xu, Weiping Lin, Longping Wen and Gang Li
    Citation: Stem Cell Research & Therapy 2019 10:219
    Content type: Review Published on:

  18. Mesenchymal stem cells (MSCs) are attracting increasing interest for cell-based therapies, making use of both their immuno-modulating and regenerative potential. For such therapeutic applications, a massive in...

    Authors: Daniela Hladik, Ines Höfig, Ursula Oestreicher, Johannes Beckers, Martina Matjanovski, Xuanwen Bao, Harry Scherthan, Michael J. Atkinson and Michael Rosemann
    Citation: Stem Cell Research & Therapy 2019 10:218
    Content type: Research Published on:

  19. Both genetic and environmental factors are implicated in the pathogenesis of cleft palate. However, the molecular and cellular mechanisms that regulate the development of palatal shelves, which are composed of...

    Authors: Lungang Shi, Binchen Li, Binna Zhang, Congyuan Zhen, Jianda Zhou and Shijie Tang
    Citation: Stem Cell Research & Therapy 2019 10:217
    Content type: Research Published on:

  20. Temporomandibular joint osteoarthritis (TMJOA) is an inflammatory joint disease. This study investigated whether exosomes (Exos) of stem cells from human exfoliated deciduous teeth (SHEDs) have a therapeutic e...

    Authors: Ping Luo, Chao Jiang, Ping Ji, Menghong Wang and Jie Xu
    Citation: Stem Cell Research & Therapy 2019 10:216
    Content type: Research Published on:

  21. The original article [1] contains errors in Fig. 1. The authors noticed a potentially misleading aspect of the original article Fig. 1 where representative flow cytometry data for different panels were from di...

    Authors: Swati Paliwal, Rituparna Chaudhuri, Anurag Agrawal and Sujata Mohanty
    Citation: Stem Cell Research & Therapy 2019 10:215
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:298

  22. To explore the mechanism of human umbilical cord-derived mesenchymal stem cell (hUMSC) transplantation to improve ovarian function and the endometrial receptivity in autoimmune premature ovarian failure (POF) ...

    Authors: Xueyan Lu, Jingjing Cui, Linlu Cui, Qianqian Luo, Qizhi Cao, Wendan Yuan and Hongqin Zhang
    Citation: Stem Cell Research & Therapy 2019 10:214
    Content type: Research Published on:

  23. As the representative of fenamic acids, an important group of NSAIDs, flufenamic acid (FFA) has been used for anti-inflammation and analgesia in the clinic. Recently, researches have focused on the role of som...

    Authors: Xuenan Liu, Zheng Li, Hao Liu, Yuan Zhu, Dandan Xia, Siyi Wang, Ranli Gu, Weiliang Wu, Ping Zhang, Yunsong Liu and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2019 10:213
    Content type: Research Published on:

  24. Over 50% of acute stroke patients have hyperglycemia, which is associated with a poorer prognosis and outcome. Our aim was to investigate the impact of hyperglycemia on behavioral recovery and brain repair of ...

    Authors: Mari Carmen Gómez-de Frutos, Fernando Laso-García, Luke Diekhorst, Laura Otero-Ortega, Blanca Fuentes, Jukka Jolkkonen, Olivier Detante, Anaick Moisan, Arturo Martínez-Arroyo, Exuperio Díez-Tejedor and María Gutiérrez-Fernández
    Citation: Stem Cell Research & Therapy 2019 10:212
    Content type: Research Published on:

  25. Autosomal recessive osteopetrosis is a genetically and phenotypically heterogeneous disease, caused by defects in osteoclast formation and function. The only available treatment is allogeneic stem cell transpl...

    Authors: Fatma Visal Okur, İnci Cevher, Cansu Özdemir, Çetin Kocaefe and Duygu Uçkan Çetinkaya
    Citation: Stem Cell Research & Therapy 2019 10:211
    Content type: Research Published on:

  26. The paradigm of hematopoietic stem and progenitor cells (HSPCs) has become accepted ever since the discovery of adult mouse liver hematopoietic stem cells and their multipotent characteristics that give rise t...

    Authors: Yuhong Qin, Keke Fang, Nan Lu, Yuan Hu, Zhigang Tian and Cai Zhang
    Citation: Stem Cell Research & Therapy 2019 10:210
    Content type: Research Published on:

  27. Definitive treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) have not been developed. Cell-based therapy is an attractive treatment method for intractable diseases in the medical...

    Authors: Shinichiro Kuroshima, Kazunori Nakajima, Muneteru Sasaki, Takashi I, Yoshinori Sumita, Takayuki Asahara, Izumi Asahina and Takashi Sawase
    Citation: Stem Cell Research & Therapy 2019 10:209
    Content type: Research Published on:

  28. Stem cell therapy has revealed a promising future for treating erectile dysfunction (ED), but the fate and curative mechanism of intracavernosal transplanted stem cells are under further exploration. This stud...

    Authors: Hai-Bo Zhang, Feng-Zhi Chen, Shu-Hua He, Yan-Bing Liang, Zhi-Qiang Wang, Li Wang, Ze-Rong Chen, Wei Ding, Shan-Chao Zhao and An-Yang Wei
    Citation: Stem Cell Research & Therapy 2019 10:208
    Content type: Research Published on:

  29. The goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mesenchymal stromal cells (MSCs) involved in regulating t...

    Authors: Ming Li, Zhongyu Xie, Zhaopeng Cai, Fang Su, Guan Zheng, Jinteng Li, Shan Wang, Shuizhong Cen, Wenjie Liu, Su’an Tang, Guiwen Ye, Zhaofeng Li, Rujia Mi, Yiqian Pan, Peng Wang, Yanfeng Wu…
    Citation: Stem Cell Research & Therapy 2019 10:207
    Content type: Research Published on:

  30. The original article [1] displayed a co-author, Junbo Ge who has since stated that he should not have been a co-author in the article; the article has now been amended to remove Junbo Ge accordingly. All autho...

    Authors: Mengkang Fan, Yin Huang, Zhangwei Chen, Yan Xia, Ao Chen, Danbo Lu, Yuan Wu, Ning Zhang and Juying Qian
    Citation: Stem Cell Research & Therapy 2019 10:206
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2019 10:150

  31. Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake. The present study aimed at i...

    Authors: María Elena Quintanilla, Fernando Ezquer, Paola Morales, Daniela Santapau, Pablo Berríos-Cárcamo, Marcelo Ezquer, Mario Herrera-Marschitz and Yedy Israel
    Citation: Stem Cell Research & Therapy 2019 10:205
    Content type: Research Published on:

  32. Endometrial regenerative cells (ERCs) are a new type of mesenchymal-like stromal cells, and their therapeutic potential has been tested in a variety of disease models. SDF-1/CXCR4 axis plays a chemotaxis role ...

    Authors: Xiang Li, Xu Lan, Yiming Zhao, Grace Wang, Ganggang Shi, Hongyue Li, Yonghao Hu, Xiaoxi Xu, Baoren Zhang, Kui Ye, Xiangying Gu, Caigan Du and Hao Wang
    Citation: Stem Cell Research & Therapy 2019 10:204
    Content type: Research Published on:

  33. Friedreich’s ataxia (FRDA) is an autosomal recessive disease caused by a non-coding mutation in the first intron of the frataxin (FXN) gene that suppresses its expression. Compensatory hypertrophic cardiomyopathy...

    Authors: Andy On-Tik Wong, Gabriel Wong, Michael Shen, Maggie Zi-Ying Chow, Wan Wai Tse, Bimal Gurung, Suet Yee Mak, Deborah K. Lieu, Kevin D. Costa, Camie W. Chan, Alain Martelli, Joseph F. Nabhan and Ronald A. Li
    Citation: Stem Cell Research & Therapy 2019 10:203
    Content type: Research Published on:

  34. By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma cells (ECCs) are...

    Authors: Ildercílio Mota de Souza Lima, Josiane Lilian dos Santos Schiavinato, Sarah Blima Paulino Leite, Danuta Sastre, Hudson Lenormando de Oliveira Bezerra, Bruno Sangiorgi, Amanda Cristina Corveloni, Carolina Hassibe Thomé, Vitor Marcel Faça, Dimas Tadeu Covas, Marco Antônio Zago, Mauro Giacca, Miguel Mano and Rodrigo Alexandre Panepucci
    Citation: Stem Cell Research & Therapy 2019 10:202
    Content type: Research Published on:

  35. The meniscus tear is one of the most common knee injuries particularly seen in athletes and aging populations. Subchondral bone sclerosis, irreparable joint damage, and the early onset of osteoarthritis make t...

    Authors: Feng Liu, Hongyao Xu and He Huang
    Citation: Stem Cell Research & Therapy 2019 10:201
    Content type: Research Published on:

  38. Follicle depletion is one of the causes of premature ovarian failure (POF) and primary ovarian insufficiency (POI). Hence, maintenance of a certain number of female germline stem cells (FGSCs) is optimal to pr...

    Authors: Yu Jiang, Dantian Zhu, Wenfeng Liu, Qiushi Qin, Zhi Fang and Zezheng Pan
    Citation: Stem Cell Research & Therapy 2019 10:198
    Content type: Research Published on:

  40. Adipose-derived stem cells (ASCs) are promising therapeutic cells for ischemic heart diseases, due to the ease and efficiency of acquisition, the potential of myocardial lineage differentiation, and the paracr...

    Authors: Xiaoting Li, Teng Ma, Jiacheng Sun, Mingjing Shen, Xiang Xue, Yongbing Chen and Zhiwei Zhang
    Citation: Stem Cell Research & Therapy 2019 10:196
    Content type: Review Published on:

  41. Recent progress in the induced generation of dopaminergic (DA) neurons from different types of stem cells or reprogrammed somatic cells holds tremendous potential for the treatment of Parkinson’s disease (PD)....

    Authors: Hao Yang, Dingjun Hao, Cheng Liu, Dageng Huang, Bo Chen, Hong Fan, Cuicui Liu, Lingling Zhang, Qian Zhang, Jing An and Jingjing Zhao
    Citation: Stem Cell Research & Therapy 2019 10:195
    Content type: Research Published on:

  42. Exosomes are bilayer membrane vesicles with cargos that contain a variety of surface proteins, markers, lipids, nucleic acids, and noncoding RNAs. Exosomes from different cardiac cells participate in the proce...

    Authors: Ming-yue Xu, Zhi-shuai Ye, Xian-tao Song and Rong-chong Huang
    Citation: Stem Cell Research & Therapy 2019 10:194
    Content type: Review Published on:

  43. Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent models. In addition, transplantation studies using pi...

    Authors: Junjun Xu, Leqian Yu, Jianxiong Guo, Jinzhu Xiang, Zheng Zheng, Dengfeng Gao, Bingbo Shi, Haiyang Hao, Deling Jiao, Liang Zhong, Yu Wang, Jun Wu, Hongjiang Wei and Jianyong Han
    Citation: Stem Cell Research & Therapy 2019 10:193
    Content type: Research Published on:

  44. The use of mesenchymal stem cells (MSCs) is being extensively studied in clinical trials in the setting of various diseases including diabetes, stroke, and progressive multiple sclerosis. The unique immunomodu...

    Authors: Caroline Laroye, Amir Boufenzer, Lucie Jolly, Lisiane Cunat, Corentine Alauzet, Jean-Louis Merlin, Clémence Yguel, Danièle Bensoussan, Loïc Reppel and Sébastien Gibot
    Citation: Stem Cell Research & Therapy 2019 10:192
    Content type: Research Published on:

  45. WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. ...

    Authors: Maryam Kay, Bahram Mohammad Soltani, Fahimeh Hosseini Aghdaei, Hassan Ansari and Hossein Baharvand
    Citation: Stem Cell Research & Therapy 2019 10:191
    Content type: Research Published on:

  46. There is an urgent need for targeted biological therapies for prostate cancer with greater efficacy and less toxicity, particularly for metastatic disease, where current therapies are not curative. Therapeutic...

    Authors: Tahir Muhammad, Ali Sakhawat, Aamir Ali Khan, Ling Ma, Ruth A. Gjerset and Yinghui Huang
    Citation: Stem Cell Research & Therapy 2019 10:190
    Content type: Research Published on:

  47. Management of fracture healing with a large bone defect remains a tricky subject in orthopedic trauma. Enhancing osteogenesis of human bone marrow-derived mesenchymal stem cells (hBMSCs) is one of the useful t...

    Authors: Kai Hang, Chenyi Ye, Jianxiang Xu, Erman Chen, Cong Wang, Wei Zhang, Lic Ni, Zhih Kuang, Li Ying, Deting Xue and Zhijun Pan
    Citation: Stem Cell Research & Therapy 2019 10:189
    Content type: Research Published on:

  48. Feline adipose-derived mesenchymal stem cells (ASCs) have been successfully used in clinical trials for the treatment of immune-mediated diseases with T cell dysregulation. However, the immunomodulatory pathwa...

    Authors: Nopmanee Taechangam, Smita S. Iyer, Naomi J. Walker, Boaz Arzi and Dori L. Borjesson
    Citation: Stem Cell Research & Therapy 2019 10:188
    Content type: Research Published on:

  49. Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissues. However, in order to evaluate the therapeutic activity of MSC, cell tracking techniques are r...

    Authors: Anna Andrzejewska, Anna Jablonska, Martyna Seta, Sylwia Dabrowska, Piotr Walczak, Miroslaw Janowski and Barbara Lukomska
    Citation: Stem Cell Research & Therapy 2019 10:187
    Content type: Research Published on:

  50. Evidence has suggested that human adipose-derived stem cells (hADSCs) and low-level laser has neuroprotective effects on spinal cord injury (SCI). Therefore, the combined effect of the hADSCs and laser on neur...

    Authors: Arash Sarveazad, Atousa Janzadeh, Gholamreza Taheripak, Sima Dameni, Mahmoud Yousefifard and Farinaz Nasirinezhad
    Citation: Stem Cell Research & Therapy 2019 10:183
    Content type: Research Published on:
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