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  1. Regenerative medicine potentially offers the opportunity for curing male infertility. Native extracellular matrix (ECM) creates a reconstruction platform to replace the organs. In this study, we aimed to evalu...

    Authors: Elias Kargar-Abarghouei, Zahra Vojdani, Ashraf Hassanpour, Sanaz Alaee and Tahereh Talaei-Khozani
    Citation: Stem Cell Research & Therapy 2018 9:324
  2. Amyotrophic lateral sclerosis (ALS) represents a devastating, progressive, heterogeneous, and the most common motor neuron (MN) disease. To date, no cure has been available for the condition. Studies with tran...

    Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen and Kun Qian
    Citation: Stem Cell Research & Therapy 2018 9:315

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:97

  3. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) exhibit strong and powerful potential in repairing different diseases. The expression profile of circular RNA (circRNA) provides valuable insight for re...

    Authors: Baolan Sun, Lei Shi, Qin Shi, Yao Jiang, Zhangyao Su, Xiaoqing Yang and Yuquan Zhang
    Citation: Stem Cell Research & Therapy 2018 9:314
  4. We have shown that the differentiation of human-induced pluripotent stem cells (hiPSCs) into endothelial cells (ECs) is more efficient when performed with a 3-dimensional (3D) scaffold of biomaterial than in m...

    Authors: Liping Su, Xiaocen Kong, Szeyun Lim, Szejie Loo, Shihua Tan, Kiankeong Poh, James Dutton, Colin Stewart, Stuart Cook, Xiaofei Su, Jianhua Ma, Jianyi Zhang and Lei Ye
    Citation: Stem Cell Research & Therapy 2018 9:313
  5. The aim of this study was to evaluate the safety of mesenchymal stem cell infusion in patients with autoimmune diseases.

    Authors: Jun Liang, Huayong Zhang, Wei Kong, Wei Deng, Dandan Wang, Xuebing Feng, Cheng Zhao, Bingzhu Hua, Hong Wang and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2018 9:312
  6. Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present. Previous studies have shown that early intervention with bone ...

    Authors: Enguo Zhang, Ye Yang, Shangya Chen, Cheng Peng, Martin F. Lavin, Abrey J. Yeo, Chao Li, Xiaoshan Liu, Yingjun Guan, Xinjing Du, Zhongjun Du and Hua Shao
    Citation: Stem Cell Research & Therapy 2018 9:311
  7. Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for delivery of therapeutic agents to disseminated gliobl...

    Authors: Lorena Favaro Pavon, Tatiana Tais Sibov, Andrea Vieira de Souza, Edgar Ferreira da Cruz, Suzana M. F. Malheiros, Francisco Romero Cabral, Jean Gabriel de Souza, Pamela Boufleur, Daniela Mara de Oliveira, Silvia Regina Caminada de Toledo, Luciana C. Marti, Jackeline Moraes Malheiros, Fernando F. Paiva, Alberto Tannús, Sérgio Mascarenhas de Oliveira, Ana Marisa Chudzinski-Tavassi…
    Citation: Stem Cell Research & Therapy 2018 9:310
  8. The positive effects of human bone marrow–derived mesenchymal stem cells (hBM-MSCs) and minocycline on ischemic stroke models have been well described through numerous studies. The aim of this study was to eva...

    Authors: Dong Young Cho and Sin-Soo Jeun
    Citation: Stem Cell Research & Therapy 2018 9:309
  9. Mesenchymal stem cells (MSCs) have been demonstrated to be effective in treating autoimmune diseases including Sjögren’s syndrome (SS). We aim to compare the effects of MSC transplantation (MSCT) and the role ...

    Authors: Bingyu Shi, Jingjing Qi, Genhong Yao, Ruihai Feng, Zhuoya Zhang, Dandan Wang, Chen Chen, Xiaojun Tang, Liwei Lu, Wanjun Chen and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2018 9:308
  10. In the context of regenerative medicine and cellular therapies, the treatment under study often targets a less common disease or condition for which recruitment of a large number of research participants at an...

    Authors: Erika Kleiderman, Audrey Boily, Craig Hasilo and Bartha Maria Knoppers
    Citation: Stem Cell Research & Therapy 2018 9:307
  11. Cardiovascular complications, especially myocardial infarctions (MIs), are the leading mortality cause in diabetic patients. The transplantation of stem cells into damaged hearts has had considerable success a...

    Authors: Xiao He, Meng-Wei Yao, Ming Zhu, Dong-Lan Liang, Wei Guo, Yi Yang, Rong-Seng Zhao, Ting-Ting Ren, Xiang Ao, Wei Wang, Chun-Yu Zeng, Hua-Ping Liang, Dong-po Jiang, Jian Yu and Xiang Xu
    Citation: Stem Cell Research & Therapy 2018 9:306
  12. Autophagy plays a critical role in the dynamic growth of each cell through different conditions. It seems that this intracellular mechanism acts as a two-edged sword against the numerous cell insults. Previous...

    Authors: Mehdi Hassanpour, Aysa Rezabakhsh, Masoud Pezeshkian, Reza Rahbarghazi and Mohammad Nouri
    Citation: Stem Cell Research & Therapy 2018 9:305
  13. Autologous urothelial cells are often obtained via bladder biopsy to generate the bio-engineered urethra or bladder, while urine-derived stem cells (USC) can be obtained by a non-invasive approach. The objecti...

    Authors: Qian Wan, Geng Xiong, Guihua Liu, Thomas D. Shupe, Guanghui Wei, Deying Zhang, Dan Liang, Xiongbing Lu, Anthony Atala and Yuanyuan Zhang
    Citation: Stem Cell Research & Therapy 2018 9:304
  14. Hyperbilirubinemia that occurs in pediatric liver diseases such as biliary atresia can result in the development of not only jaundice in the brain, eyes, and skin, but also tooth abnormalities including green ...

    Authors: Haruyoshi Yamaza, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita and Takayoshi Yamaza
    Citation: Stem Cell Research & Therapy 2018 9:303
  15. The generation of hematopoietic stem cells (HSCs) and blood cells from human embryonic stem cells (hESCs) is a major goal for regenerative medicine; however, the differentiation mechanisms are largely undefine...

    Authors: Pengfei Li, Mengyao Wu, Qiwang Lin, Shu Wang, Tong Chen and Hua Jiang
    Citation: Stem Cell Research & Therapy 2018 9:301
  16. Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal...

    Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda and Roberta Tasso
    Citation: Stem Cell Research & Therapy 2018 9:300
  17. Medical management of the severe musculocutaneous radiation syndrome involves surgical intervention with debridement of necrotic tissue. Even when skin excision is replaced by specific plastic surgery, treatme...

    Authors: Christine Linard, Michel Brachet, Bruno L’homme, Carine Strup-Perrot, Elodie Busson, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey and Marc Benderitter
    Citation: Stem Cell Research & Therapy 2018 9:299
  18. Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue s...

    Authors: Swati Paliwal, Rituparna Chaudhuri, Anurag Agrawal and Sujata Mohanty
    Citation: Stem Cell Research & Therapy 2018 9:298

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:215

  19. A single administration of mesenchymal stromal cells (MSCs) has been shown to reduce lung inflammation in experimental elastase-induced emphysema; however, effects were limited in terms of lung-tissue repair a...

    Authors: Hananda A. Poggio, Mariana A. Antunes, Nazareth N. Rocha, Jamil Z. Kitoko, Marcelo M. Morales, Priscilla C. Olsen, Miquéias Lopes-Pacheco, Fernanda F. Cruz and Patricia R. M. Rocco
    Citation: Stem Cell Research & Therapy 2018 9:296
  20. We recently demonstrated that intracellular xenogen-contaminated autologous MSCs (FBS) and non-xenogen-contaminated allogeneic (ALLO) MSCs caused an adverse clinical response after repeated intra-articular inj...

    Authors: Aileen L. Rowland, Jiajie Jessica Xu, Amanda Jo Joswig, Carl A. Gregory, Douglas F. Antczak, Kevin J. Cummings and Ashlee E. Watts
    Citation: Stem Cell Research & Therapy 2018 9:295
  21. The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the re...

    Authors: Ziyou Yu, Yizuo Cai, Mingwu Deng, Dong Li, Xiangsheng Wang, Hongjie Zheng, Yuda Xu, Wei Li and Wenjie Zhang
    Citation: Stem Cell Research & Therapy 2018 9:294
  22. Mesenchymal stem cell-derived conditioned medium (MSC-CM) has emerged as a promising cell-free tool for restoring degenerative diseases and treating traumatic injuries. The present study describes the effect o...

    Authors: Junghyun Park, Jung Han Lee, Byung Sun Yoon, Eun Kyoung Jun, Gilju Lee, In Yong Kim and Seungkwon You
    Citation: Stem Cell Research & Therapy 2018 9:293
  23. Deer antlers are bony structures that re-grow at very high rates, making them an attractive model for studying rapid bone regeneration.

    Authors: Dai Fei Elmer Ker, Dan Wang, Rashmi Sharma, Bin Zhang, Ben Passarelli, Norma Neff, Chunyi Li, William Maloney, Stephen Quake and Yunzhi Peter Yang
    Citation: Stem Cell Research & Therapy 2018 9:292
  24. Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased ...

    Authors: Rui Li, Qiu-Xia Lin, Xue-Zhen Liang, Guang-Bo Liu, He Tang, Yu Wang, Shi-Bi Lu and Jiang Peng
    Citation: Stem Cell Research & Therapy 2018 9:291
  25. Transplantation of allogeneic human cardiac/stem progenitor cells (hCSCs) is currently being tested in several phase I/II clinical trials as a novel and promising therapy for restoration of myocardial tissue f...

    Authors: Maria J Sebastião, Ramón Menta, Margarida Serra, Itziar Palacios, Paula M Alves, Belén Sanchez, Olga DelaRosa, Wilfried Dalemans, Eleuterio Lombardo and Patrícia Gomes-Alves
    Citation: Stem Cell Research & Therapy 2018 9:290
  26. Stem cells have great potential for tissue regeneration, but before stem cell populations can be used in the clinic, it is crucial that the stem cells have been definitely characterized by a set of specific ma...

    Authors: Louise Bundgaard, Allan Stensballe, Kirstine Juul Elbæk and Lise Charlotte Berg
    Citation: Stem Cell Research & Therapy 2018 9:288
  27. Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study conditions and diseases including those of the eye that lack appropriate animal models to facilitate the development of no...

    Authors: Koushik Chakrabarty, Rohit Shetty and Arkasubhra Ghosh
    Citation: Stem Cell Research & Therapy 2018 9:287
  28. During the last decade, mesenchymal stem cells (MSCs) have gained much attention in the field of regenerative medicine due to their capacity to differentiate into different cell types and to promote immunosupp...

    Authors: Denise Philipp, Laura Suhr, Thorsten Wahlers, Yeong-Hoon Choi and Adnana Paunel-Görgülü
    Citation: Stem Cell Research & Therapy 2018 9:286
  29. Diabetic peripheral neurovascular diseases (DPNVs) are complex, lacking effective treatment. Autologous/allogeneic transplantation of adipose-derived stem cells (ADSCs) is a promising strategy for DPNVs. Nonet...

    Authors: Xing Zhang, Jinbao Qin, Xin Wang, Xin Guo, Junchao Liu, Xuhui Wang, Xiaoyu Wu, Xinwu Lu, Weimin Li and Xiaobing Liu
    Citation: Stem Cell Research & Therapy 2018 9:285
  30. Treatment with bone marrow mesenchymal stem cells (BM-MSCs) has been demonstrated to be an excellent cellular-based therapeutic strategy for treating myocardial infarction (MI). However, most of the patients s...

    Authors: Ming Yang, Tong Wen, Haixu Chen, Jingyu Deng, Chao Yang and Zheng Zhang
    Citation: Stem Cell Research & Therapy 2018 9:284
  31. Conventional cell-based bone regeneration suffers from the major disadvantage of limited cell supply, time-consuming in vitro expansion cultures, and limited patient-friendliness related to cell isolation and ...

    Authors: Yang Zhang, Eline C Grosfeld, Winston A Camargo, Hongbo Tang, Angela M P Magri and Jeroen J J P van den Beucken
    Citation: Stem Cell Research & Therapy 2018 9:283
  32. Severe acute pancreatitis (SAP) is an acute abdominal disease characterized by pancreatic necrosis and systemic disease. In a previous study, we showed that bone marrow-derived mesenchymal stem cells (BMSCs) c...

    Authors: Daohai Qian, Guodong Song, Zhilong Ma, Guannan Wang, Lei Jin, Minghua Hu, Zhenshun Song and Xiaoming Wang
    Citation: Stem Cell Research & Therapy 2018 9:282
  33. Mesenchymal stem cells (MSCs) are known to home to injured and inflamed regions via the bloodstream to assist in tissue regeneration in response to signals of cellular damage. However, the factors and mechanis...

    Authors: Yu-Chien Guo, Yun-Hsuan Chiu, Chie-Pein Chen and Hwai-Shi Wang
    Citation: Stem Cell Research & Therapy 2018 9:281
  34. Mesenchymal stem cells (MSCs) derived from bone marrow have potent stabilizing effects for the treatment of acute respiratory distress syndrome (ARDS). However, low efficiency and survival in MSC homing to inj...

    Authors: Shan-Shan Meng, Xiu-Ping Xu, Wei Chang, Zhong-Hua Lu, Li-Li Huang, Jing-Yuan Xu, Ling Liu, Hai-Bo Qiu, Yi Yang and Feng-Mei Guo
    Citation: Stem Cell Research & Therapy 2018 9:280
  35. Generation of induced photoreceptors holds promise for in vitro modeling of intractable retinal diseases. Retinitis pigmentosa is an inherited retinal dystrophy that leads to visual impairment. The EYS gene was r...

    Authors: Yuko Seko, Masaki Iwanami, Kiyoko Miyamoto-Matsui, Shimpei Takita, Noriyuki Aoi, Akihiro Umezawa and Seishi Kato
    Citation: Stem Cell Research & Therapy 2018 9:279
  36. Mesenchymal stem cells (MSCs) isolated from adult tissues (Ad-MSCs) have shown great promise for use in regenerative medicine. However, their poor in vitro expansion capacity and tissue scarcity have been majo...

    Authors: William D’Angelo, Bohan Chen, Chandan Gurung and Yan-Lin Guo
    Citation: Stem Cell Research & Therapy 2018 9:278
  37. Transplantation of pancreatic β cells generated in vitro from pluripotent stem cells (hPSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been proposed as an alternative th...

    Authors: Hideomi Ida, Tomohiko Akiyama, Keiichiro Ishiguro, Sravan K. Goparaju, Yuhki Nakatake, Nana Chikazawa-Nohtomi, Saeko Sato, Hiromi Kimura, Yukihiro Yokoyama, Masato Nagino, Minoru S. H. Ko and Shigeru B. H. Ko
    Citation: Stem Cell Research & Therapy 2018 9:277
  38. Physical loading is necessary to maintain bone tissue integrity. Loading-induced fluid shear is recognised as one of the most potent bone micromechanical cues and has been shown to direct stem cell osteogenesi...

    Authors: Elena Stavenschi, Michele A. Corrigan, Gillian P. Johnson, Mathieu Riffault and David A. Hoey
    Citation: Stem Cell Research & Therapy 2018 9:276
  39. Human decidua basalis mesenchymal stem/multipotent stromal cells (DBMSCs) inhibit endothelial cell activation by inflammation induced by monocytes. This property makes them a promising candidate for cell-based th...

    Authors: M. A. Alshabibi, T. Khatlani, F. M. Abomaray, A. S. AlAskar, B. Kalionis, S. A. Messaoudi, R. Khanabdali, A. O. Alawad and M. H. Abumaree
    Citation: Stem Cell Research & Therapy 2018 9:275
  40. To date, several trials have reported the use of mesenchymal stem cell (MSC) implantation for osteonecrosis of the femoral head (ONFH). However, the clinical outcomes have not been conclusive. This study compa...

    Authors: Joon Soon Kang, Young Ju Suh, Kyoung Ho Moon, Jun Sung Park, Tae Hoon Roh, Myung Hoon Park and Dong Jin Ryu
    Citation: Stem Cell Research & Therapy 2018 9:274
  41. Mesenchymal stem cells (MSCs) are known for their ability to induce the conversion of conventional T cells (Tconvs) into induced regulatory T cells (iTregs) in specific inflammatory contexts. Stable Foxp3 expr...

    Authors: Maryam Khosravi, Ali Bidmeshkipour, José L. Cohen, Ali Moravej, Suzzan Hojjat-Assari, Sina Naserian and Mohammad Hossein Karimi
    Citation: Stem Cell Research & Therapy 2018 9:273
  42. Mesenchymal stromal cells (MSCs) are an essential element of the bone marrow (BM) microenvironment, playing a crucial function in regulating hematopoietic stem cell proliferation and differentiation. Recent fi...

    Authors: Giulia Corradi, Carmen Baldazzi, Darina Očadlíková, Giovanni Marconi, Sarah Parisi, Nicoletta Testoni, Carlo Finelli, Michele Cavo, Antonio Curti and Marilena Ciciarello
    Citation: Stem Cell Research & Therapy 2018 9:271
  43. The original article [1] contains an error in Fig. 5e whereby the immunofluorescence of ΔNp63α in the ME group is incorrectly presented; thus, the corrected figure is shown ahead.

    Authors: X. Y. Zhao, H. T. Xie, C. Y. Duan, J. Li and M. C. Zhang
    Citation: Stem Cell Research & Therapy 2018 9:270

    The original article was published in Stem Cell Research & Therapy 2018 9:256

  44. The original article [1] contains an error regarding the erroneous inclusion of 3 μl as a parameter in the x-axis of Fig. 2c; the correct version of Fig. 2c can instead be seen below.

    Authors: Siyuan Zha, Zhen Li, Qing Cao, Fei Wang and Fang Liu
    Citation: Stem Cell Research & Therapy 2018 9:269

    The original article was published in Stem Cell Research & Therapy 2018 9:224

  45. Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs)....

    Authors: Frances D. Liu, Kimberley Tam, Novalia Pishesha, Zhiyong Poon and Krystyn J. Van Vliet
    Citation: Stem Cell Research & Therapy 2018 9:268

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