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  1. Ischemic stroke causes a multitude of brain damage. Neurovascular injury and myelin sheath degradation are two manifestations of ischemic brain damage. Therapeutic strategies aiming only at repairing the neura...

    Authors: Yaning Li, Shuang Chang, Wanlu Li, Guanghui Tang, Yuanyuan Ma, Yanqun Liu, Fang Yuan, Zhijun Zhang, Guo-Yuan Yang and Yongting Wang
    Citation: Stem Cell Research & Therapy 2018 9:139
    Content type: Research Published on:

  2. Due to their extensive self-renewal and multilineage differentiation capacity, human embryonic stem cells (hESCs) have great potential for studying developmental biology, disease modeling, and developing cell ...

    Authors: Chuti Laowtammathron, Pimjai Chingsuwanrote, Roungsin Choavaratana, Suphadtra Phornwilardsiri, Ketsara Sitthirit, Chidchanok Kaewjunun, Orawan Makemaharn, Papussorn Terbto, Supaporn Waeteekul, Chanchao Lorthongpanich, Yaowalak U-pratya, Pimonwan Srisook, Pakpoom Kheolamai and Surapol Issaragrisil
    Citation: Stem Cell Research & Therapy 2018 9:138
    Content type: Research Published on:

  3. Peripheral nerve injury (PNI) is a worldwide issue associated with severe social and economic burden. Autologous nerve grafting, the gold standard treatment for peripheral nerve defects, still has a number of ...

    Authors: Xun Sun, Yun Zhu, He-yong Yin, Zhi-yuan Guo, Feng Xu, Bo Xiao, Wen-li Jiang, Wei-min Guo, Hao-ye Meng, Shi-bi Lu, Yu Wang and Jiang Peng
    Citation: Stem Cell Research & Therapy 2018 9:133
    Content type: Research Published on:

  4. Canine MuStem cells have demonstrated regenerative efficacy in a dog model of muscular dystrophy, and the recent characterization of human counterparts (hMuStem) has highlighted the therapeutic potential of th...

    Authors: Charlotte Saury, Aurélie Lardenois, Cindy Schleder, Isabelle Leroux, Blandine Lieubeau, Laurent David, Marine Charrier, Laëtitia Guével, Sabrina Viau, Bruno Delorme and Karl Rouger
    Citation: Stem Cell Research & Therapy 2018 9:128
    Content type: Research Published on:

  5. Adult bone marrow contains stem cells that replenish the myeloid and lymphoid lineages. A subset of human and mouse CD34+ bone marrow stem cells can be propagated in culture to autonomously express embryonic stem...

    Authors: Tapas Makar, Vamshi K. Nimmagadda, Poornachander R. Guda, Brian Hampton, Weiliang Huang, Maureen A. Kane, Paul S. Fishman, Bernard Pessac, Christopher T. Bever Jr. and David Trisler
    Citation: Stem Cell Research & Therapy 2018 9:127
    Content type: Research Published on:

  6. Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme ...

    Authors: Xuefeng Hu, Jyh-Wei Lee, Xi Zheng, Junhua Zhang, Xin Lin, Yingnan Song, Bingmei Wang, Xiaoxiao Hu, Hao-Hueng Chang, Yiping Chen, Chun-Pin Lin and Yanding Zhang
    Citation: Stem Cell Research & Therapy 2018 9:126
    Content type: Research Published on:

  7. Adipose-derived stem cells (ASCs) that show multidifferentiation and anti-immune rejection capacities have been widely used in plastic and reconstructive surgery. Previous studies have indicated that mechanica...

    Authors: Yiting Yang, Rongmei Qu, Tingyu Fan, Xi Zhu, Yanting Feng, Yuchao Yang, Ting Deng, Yan Peng, Wenhua Huang, Jun Ouyang and Jingxing Dai
    Citation: Stem Cell Research & Therapy 2018 9:125
    Content type: Research Published on:

  8. The use of platelet lysate (PL) for the ex-vivo expansion of mesenchymal stromal/stem cells (MSCs) was initially proposed by Doucet et al. in 2005, as an alternative to animal serum. Moreover, regulatory autho...

    Authors: Valentina Becherucci, Luisa Piccini, Serena Casamassima, Silvia Bisin, Valentina Gori, Francesca Gentile, Riccardo Ceccantini, Elena De Rienzo, Barbara Bindi, Paola Pavan, Vanessa Cunial, Elisa Allegro, Stefano Ermini, Francesca Brugnolo, Giuseppe Astori and Franco Bambi
    Citation: Stem Cell Research & Therapy 2018 9:124
    Content type: Research Published on:

  9. Synovial mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and meniscus regeneration. Synovial tissue can be histologically classified into three regions; surface, stromal and perivascu...

    Authors: Mitsuru Mizuno, Hisako Katano, Yo Mabuchi, Yusuke Ogata, Shizuko Ichinose, Shizuka Fujii, Koji Otabe, Keiichiro Komori, Nobutake Ozeki, Hideyuki Koga, Kunikazu Tsuji, Chihiro Akazawa, Takeshi Muneta and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2018 9:123
    Content type: Research Published on:

  10. α6-Integrin subunit (also known as CD49f) is a stemness signature that has been found on the plasma membrane of more than 30 stem cell populations. A growing body of studies have focused on the critical role o...

    Authors: Zijing Zhou, Jing Qu, Li He, Hong Peng, Ping Chen and Yong Zhou
    Citation: Stem Cell Research & Therapy 2018 9:122
    Content type: Review Published on:

  11. Bone marrow-derived allogeneic mesenchymal stem cells (MSCs) from young healthy donors are immunoprivileged and their clinical application for regenerative medicine is under evaluation. However, data from prec...

    Authors: Niketa Sareen, Glen Lester Sequiera, Rakesh Chaudhary, Ejlal Abu-El-Rub, Subir Roy Chowdhury, Vikram Sharma, Arun Surendran, Meenal Moudgil, Paul Fernyhough, Amir Ravandi and Sanjiv Dhingra
    Citation: Stem Cell Research & Therapy 2018 9:121
    Content type: Research Published on:

  12. We have previously demonstrated that acidic preconditioning of human endothelial colony-forming cells (ECFC) increased proliferation, migration, and tubulogenesis in vitro, and increased their regenerative pot...

    Authors: Hebe Agustina Mena, Paula Romina Zubiry, Blandine Dizier, Mirta Schattner, Catherine Boisson-Vidal and Soledad Negrotto
    Citation: Stem Cell Research & Therapy 2018 9:120
    Content type: Research Published on:

  13. Red blood cells are the most abundant cells in the blood that deliver oxygen to the whole body. Erythropoietin (EPO), a positive regulator of erythropoiesis, is currently the major treatment for chronic anemia...

    Authors: Tzu-Lin Chen, Ya-Wen Chiang, Guan-Ling Lin, Hsin-Hou Chang, Te-Sheng Lien, Min-Hua Sheh and Der-Shan Sun
    Citation: Stem Cell Research & Therapy 2018 9:119
    Content type: Research Published on:

  14. Critical tissues that undergo regeneration in periodontal tissue are of mesenchymal origin; thus, investigating the regulatory mechanisms underlying the fate of periodontal ligament stem cells could be benefic...

    Authors: Shan Yang, Lijia Guo, Yingying Su, Jing Wen, Juan Du, Xiaoyan Li, Yitong Liu, Jie Feng, Yongmei Xie, Yuxing Bai, Hao Wang and Yi Liu
    Citation: Stem Cell Research & Therapy 2018 9:118
    Content type: Research Published on:

  15. Employing growth factor-induced partial reprogramming in vitro, peripheral human blood monocytes can acquire a state of plasticity along with expression of various markers of pluripotency. These so-called prog...

    Authors: Rouven Berndt, Lars Hummitzsch, Katharina Heß, Martin Albrecht, Karina Zitta, Rene Rusch, Beke Sarras, Andreas Bayer, Jochen Cremer, Fred Faendrich and Justus Groß
    Citation: Stem Cell Research & Therapy 2018 9:117
    Content type: Research Published on:

  16. We recently demonstrated that autologous transplantation of mobilized dental pulp stem cells (MDPSCs) was a safe and efficacious potential therapy for total pulp regeneration in a clinical study. The autologou...

    Authors: Koichiro Iohara, Shinji Utsunomiya, Sakae Kohara and Misako Nakashima
    Citation: Stem Cell Research & Therapy 2018 9:116
    Content type: Research Published on:

  17. In the study by Sarveazad et al. adipose tissue-derived stem cells were injected to reinforce anal sphincter repair. The authors came to the conclusion that injection of stem cells during repair surgery for fe...

    Authors: Mohammed Mohammed El-Said and Sameh Hany Emile
    Citation: Stem Cell Research & Therapy 2018 9:115
    Content type: Commentary Published on:

    The original article was published in Stem Cell Research & Therapy 2017 8:40

  18. DNA topoisomerase IIβ (topo IIβ) is known to regulate neural differentiation by inducing the neuronal genes responsible for critical neural differentiation events such as neurite outgrowth and axon guidance. H...

    Authors: Merve Zaim and Sevim Isik
    Citation: Stem Cell Research & Therapy 2018 9:114
    Content type: Research Published on:

  19. Established therapies for managing kidney dysfunction such as kidney dialysis and transplantation are limited due to the shortage of compatible donated organs and high costs. Stem cell-based therapies are curr...

    Authors: Md Shaifur Rahman, Lucas-Sebastian Spitzhorn, Wasco Wruck, Carsten Hagenbeck, Percy Balan, Nina Graffmann, Martina Bohndorf, Audrey Ncube, Pascale V. Guillot, Tanja Fehm and James Adjaye
    Citation: Stem Cell Research & Therapy 2018 9:113
    Content type: Research Published on:

  20. The production of veritable in-vitro models of bone tissue is essential to understand the biology of bone and its surrounding environment, to analyze the pathogenesis of bone diseases (e.g., osteoporosis, oste...

    Authors: Alessandro Pirosa, Riccardo Gottardi, Peter G. Alexander and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2018 9:112
    Content type: Review Published on:

  21. The original article [1] mistakenly omitted a source of funding, and the authors would like to rectify this by acknowledging the additional support of the Natural Science Foundation in Jiangsu Province (BK2015...

    Authors: Zhaoyu Lin, Fei Liu, Peiliang Shi, Anying Song, Zan Huang, Dayuan Zou, Qin Chen, Jianxin Li and Xiang Gao
    Citation: Stem Cell Research & Therapy 2018 9:111
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:47

  22. Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances in stem cell research have made possible the treatment of var...

    Authors: Shangya Chen, Guanqun Cui, Cheng Peng, Martin F. Lavin, Xiaoying Sun, Enguo Zhang, Ye Yang, Yingjun Guan, Zhongjun Du and Hua Shao
    Citation: Stem Cell Research & Therapy 2018 9:110
    Content type: Research Published on:

  23. Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the ...

    Authors: Jingying Hou, Lingyun Wang, Quanhua Wu, Guanghui Zheng, Huibao Long, Hao Wu, Changqing Zhou, Tianzhu Guo, Tingting Zhong, Lei Wang, Xuxiang Chen and Tong Wang
    Citation: Stem Cell Research & Therapy 2018 9:109
    Content type: Research Published on:

  24. Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effect...

    Authors: Clara Grezella, Eduardo Fernandez-Rebollo, Julia Franzen, Mónica Sofia Ventura Ferreira, Fabian Beier and Wolfgang Wagner
    Citation: Stem Cell Research & Therapy 2018 9:108
    Content type: Short report Published on:

  25. Platelet-rich plasma (PRP) is an autologous blood product that contains a high concentration of several growth factors. Platelet-derived growth factor (PDGF)-BB is a potential mitogen for human adipose-derived...

    Authors: Fangyuan Lai, Natsuko Kakudo, Naoki Morimoto, Shigeru Taketani, Tomoya Hara, Takeshi Ogawa and Kenji Kusumoto
    Citation: Stem Cell Research & Therapy 2018 9:107
    Content type: Research Published on:

  26. Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective t...

    Authors: Jingyu Wang, Heyangzi Li, Ying Yao, Tengfei Zhao, Ying-ying Chen, Yue-liang Shen, Lin-lin Wang and Yongjian Zhu
    Citation: Stem Cell Research & Therapy 2018 9:106
    Content type: Review Published on:

  27. The fibrocyte, which was first described in 1994, is a type of circulating mesenchymal progenitor cell in the peripheral blood. Fibrocytes play important roles in chronic inflammation, wound healing, tissue re...

    Authors: Feng Zhang, Ke Liu, Han Zhao and Yan He
    Citation: Stem Cell Research & Therapy 2018 9:105
    Content type: Review Published on:

  28. The role of bone tissue engineering in the field of regenerative medicine has been a main research topic over the past few years. There has been much interest in the use of three-dimensional (3D) engineered sc...

    Authors: Francesca Diomede, Agnese Gugliandolo, Paolo Cardelli, Ilaria Merciaro, Valeria Ettorre, Tonino Traini, Rossella Bedini, Domenico Scionti, Alessia Bramanti, Antonio Nanci, Sergio Caputi, Antonella Fontana, Emanuela Mazzon and Oriana Trubiani
    Citation: Stem Cell Research & Therapy 2018 9:104
    Content type: Research Published on:

  29. Understanding stem cell behavior as a delivery tool in cancer therapy is essential for evaluating their future clinical potential. Previous in-vivo studies proved the use of mesenchymal stem cells (MSCs) for l...

    Authors: Hamideh Salehi, Siham Al-Arag, Elodie Middendorp, Csilla Gergely, Frederic Cuisinier and Valerie Orti
    Citation: Stem Cell Research & Therapy 2018 9:103
    Content type: Research Published on:

  30. Human decidua parietalis mesenchymal stem/multipotent stromal cells (DPMSCs) have unique phenotypic and functional properties that make them promising candidates for cell-based therapy. Here, we investigated DPMS...

    Authors: M. H. Abumaree, E. Bahattab, A. Alsadoun, A. Al Dosaimani, F. M. Abomaray, T. Khatlani, B. Kalionis, M. F. El-Muzaini, A. O. Alawad and A. S. AlAskar
    Citation: Stem Cell Research & Therapy 2018 9:102
    Content type: Research Published on:

  31. White smoke inhalation (WSI) is an uncommon but potentially deadly cause of acute lung injury and acute respiratory distress syndrome for which no effective pharmaceutical treatment has been developed. This st...

    Authors: Pei Cui, Haiming Xin, Yongming Yao, Shichu Xiao, Feng Zhu, Zhenyu Gong, Zhiping Tang, Qiu Zhan, Wei Qin, Yanhua Lai, Xiaohui Li, Yalin Tong and Zhaofan Xia
    Citation: Stem Cell Research & Therapy 2018 9:101
    Content type: Research Published on:

  32. With the development of osteoimmunology and bone tissue engineering (BTE), it has been recognized that the immunomodulatory properties of bone biomaterials have considerable impact in determining their fate af...

    Authors: Tao Li, Zhong Long Liu, Ming Xiao, Ze Zheng Yang, Ming Zheng Peng, Cui Di Li, Xiao Jun Zhou and Jin Wu Wang
    Citation: Stem Cell Research & Therapy 2018 9:100
    Content type: Research Published on:

  33. Bullosis diabeticorum is a rare presentation of cutaneous manifestation most commonly affecting the lower limbs in patients with diabetes. The appearance, often as insidious as its resolution, is characterized...

    Authors: Yan Chen, Yu Ma, Ning Li, Hongyan Wang, Bing Chen, Ziwen Liang, Rui Ren, Debin Lu, Johnson Boey, David G. Armstrong and Wuquan Deng
    Citation: Stem Cell Research & Therapy 2018 9:99
    Content type: Short report Published on:

  34. Nicotine has negative effects on tissue repair, little research concerns its effect on the cartilage repair of tissue engineering stem cells. The present study aimed to investigate the effects of nicotine on t...

    Authors: Kai Tie, Min Wu, Yu Deng, Yinxian Wen, Dan Xu, Liaobin Chen and Hui Wang
    Citation: Stem Cell Research & Therapy 2018 9:98
    Content type: Research Published on:

  35. Commitment of pluripotent stem cells into differentiated cells and associated gene expression necessitate specific epigenetic mechanisms that modify the DNA and corresponding histone proteins to render the chr...

    Authors: Varsha Pursani, Deepa Bhartiya, Vivek Tanavde, Mohsin Bashir and Prabha Sampath
    Citation: Stem Cell Research & Therapy 2018 9:97
    Content type: Research Published on:

  36. It is currently unknown if the intrathecal administration of a high dose of allogeneic mesenchymal stem cells (MSCs) is safe, how MSCs migrate throughout the vertebral canal after intrathecal administration, a...

    Authors: Danielle Jaqueta Barberini, Monica Aleman, Fabio Aristizabal, Mathieu Spriet, Kaitlin C. Clark, Naomi J. Walker, Larry D. Galuppo, Rogério Martins Amorim, Kevin D. Woolard and Dori L. Borjesson
    Citation: Stem Cell Research & Therapy 2018 9:96
    Content type: Research Published on:

  37. Mesenchymal stem cells have potential applications in inflammatory bowel disease due to their immunomodulatory properties. Our aim was to evaluate the feasibility, safety and efficacy of endoscopic administrat...

    Authors: Eduardo Martín Arranz, María Dolores Martín Arranz, Tomás Robredo, Pablo Mancheño-Corvo, Ramón Menta, Francisco Javier Alves, Jose Manuel Suárez de Parga, Pedro Mora Sanz, Olga de la Rosa, Dirk Büscher, Eleuterio Lombardo and Fernando de Miguel
    Citation: Stem Cell Research & Therapy 2018 9:95
    Content type: Research Published on:

  38. Upon orthognathic mandibular advancement surgery the adjacent soft tissues can displace the distal bone segment and increase the load on the temporomandibular joint causing loss of its integrity. Remodeling of...

    Authors: Ricardo de Souza Tesch, Esther Rieko Takamori, Karla Menezes, Rosana Bizon Vieira Carias, Cláudio Leonardo Milione Dutra, Marcelo de Freitas Aguiar, Tânia Salgado de Sousa Torraca, Alexandra Cristina Senegaglia, Cármen Lúcia Kuniyoshi Rebelatto, Debora Regina Daga, Paulo Roberto Slud Brofman and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2018 9:94
    Content type: Research Published on:

  39. Mesenchymal stem cells (MSCs) are multipotent cells holding much promise for applications in regenerative medicine. However, with problems such as aging, increases in heteroploid cells, genomic instability, an...

    Authors: Koichi Fujisawa, Kazusa Hara, Taro Takami, Sae Okada, Toshihiko Matsumoto, Naoki Yamamoto and Isao Sakaida
    Citation: Stem Cell Research & Therapy 2018 9:93
    Content type: Research Published on:

  40. Replacement therapy for hemophilia remains a lifelong treatment. Only gene therapy can cure hemophilia at a fundamental level. The clustered regularly interspaced short palindromic repeats–CRISPR associated nu...

    Authors: Cuicui Lyu, Jun Shen, Rui Wang, Haihui Gu, Jianping Zhang, Feng Xue, Xiaofan Liu, Wei Liu, Rongfeng Fu, Liyan Zhang, Huiyuan Li, Xiaobing Zhang, Tao Cheng, Renchi Yang and Lei Zhang
    Citation: Stem Cell Research & Therapy 2018 9:92
    Content type: Research Published on:

  41. Inflammatory bowel disease (IBD) is an intractable autoimmune disorder that markedly deteriorates one’s quality of life. Mesenchymal stem cells (MSCs) alleviate inflammation by modulating inflammatory cytokine...

    Authors: Woo-Jin Song, Qiang Li, Min-Ok Ryu, Jin-Ok Ahn, Dong Ha Bhang, Yun Chan Jung and Hwa-Young Youn
    Citation: Stem Cell Research & Therapy 2018 9:91
    Content type: Research Published on:

  42. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis and death. There is no effective treatment for ALS and stem cell therapy has arisen a...

    Authors: Amaya Rando, Diego Pastor, Mari Carmen Viso-León, Anna Martínez, Raquel Manzano, Xavier Navarro, Rosario Osta and Salvador Martínez
    Citation: Stem Cell Research & Therapy 2018 9:90
    Content type: Research Published on:

  43. The Th1 cell-specific transcription factor TBX21 functions as a regulator of expression of a Th1 cytokine, interferon gamma (IFN-γ). However, the specific function of TBX21 correlated with cancer stemness rema...

    Authors: Shuangtao Zhao, Wenzhi Shen, Jiangyong Yu and Luhua Wang
    Citation: Stem Cell Research & Therapy 2018 9:89
    Content type: Research Published on:

  44. Skeletal muscle plays an important role in the body’s physiology but there are still no effective treatments for volumetric muscle loss (VML) resulting from severe traumatic injury or tumor excision. Recent st...

    Authors: Xinyu Qiu, Shiyu Liu, Hao Zhang, Bin Zhu, Yuting Su, Chenxi Zheng, Rong Tian, Miao Wang, Huijuan Kuang, Xinyi Zhao and Yan Jin
    Citation: Stem Cell Research & Therapy 2018 9:88
    Content type: Research Published on:

  46. Adult mesenchymal stem cells (MSCs) are an important resource for tissue growth, repair, and regeneration. To utilize MSCs more effectively, a clear understanding of how they react to environmental cues is ess...

    Authors: Jihee Sohn, Hang Lin, Madalyn Rose Fritch and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2018 9:86
    Content type: Research Published on:

  47. Despite the significant progress in the development of skin equivalents (SEs), the problem of noninvasively assessing the quality of the cell components and the collagen structure of living SEs both before and...

    Authors: Aleksandra V. Meleshina, Olga S. Rogovaya, Varvara V. Dudenkova, Marina A. Sirotkina, Maria M. Lukina, Alena S. Bystrova, Victoria G. Krut, Daria S. Kuznetsova, Ekaterina P. Kalabusheva, Andrey V. Vasiliev, Ekaterina A. Vorotelyak and Elena V. Zagaynova
    Citation: Stem Cell Research & Therapy 2018 9:84
    Content type: Research Published on:

  48. The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1+ MPCs is required for...

    Authors: Idil I. Aigha, Bushra Memon, Ahmed K. Elsayed and Essam M. Abdelalim
    Citation: Stem Cell Research & Therapy 2018 9:83
    Content type: Research Published on:

  49. Inflammatory licensed mesenchymal stem cells (MSCs) have the ability to promote functional tissue repair. This study specifically sought to understand how the recipient tissue environment reciprocally affects ...

    Authors: Jennifer M. Cassano, Lauren V. Schnabel, Margaret B. Goodale and Lisa A. Fortier
    Citation: Stem Cell Research & Therapy 2018 9:82
    Content type: Research Published on:

  50. Previous studies have reported that transplantation of mesenchymal stem cells (MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study has revealed the therapeutic efficiency of M...

    Authors: Jun Li, Qingtong Yu, Haisen Huang, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu and Ximing Xu
    Citation: Stem Cell Research & Therapy 2018 9:81
    Content type: Research Published on:
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