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  1. Mesenchymal stem cell (MSC) transplantation shows promise for treating transplant arteriosclerosis, at least partly via promoting endothelial regeneration. However, the efficacy and safety are still under inve...

    Authors: Xiaohu Meng, Min Chen, Wenjie Su, Xuan Tao, Mingyang Sun, Xiaoping Zou, Rongchao Ying, Wei Wei and Baolin Wang
    Citation: Stem Cell Research & Therapy 2018 9:85
    Content type: Research Published on:

  2. Latent microorganism infection is a safety concern for the clinical application of mesenchymal stem cells (MSCs). The aim of this study is to investigate the frequencies and sensitivities of the latent virus a...

    Authors: Ken Watanabe, Koji Otabe, Norio Shimizu, Keiichirou Komori, Mitsuru Mizuno, Hisako Katano, Hideyuki Koga and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2018 9:80
    Content type: Research Published on:

  3. In the bone tissue engineering domain, seed cells, scaffold and cell-scaffold composites are three focuses. In this study, the feasibility of using allogeneic adipose-derived stem cells(ADSCs) combined with he...

    Authors: Jia Liu, Peng Zhou, Yu Long, Chunxia Huang and Danna Chen
    Citation: Stem Cell Research & Therapy 2018 9:79
    Content type: Research Published on:

  5. The marrow microenvironment and vasculature plays a critical role in regulating hematopoietic cell recruitment, residence, and maturation. Extensive in vitro and in vivo studies have aimed to understand the marro...

    Authors: Surya S. Kotha, Brian J. Hayes, Kiet T. Phong, Meredith A. Redd, Karol Bomsztyk, Aravind Ramakrishnan, Beverly Torok-Storb and Ying Zheng
    Citation: Stem Cell Research & Therapy 2018 9:77
    Content type: Research Published on:

  6. The original article [1] contains an error whereby the corresponding authorship is mistakenly designated to the author Fengxia Ding.

    Authors: Bo Liu, Fengxia Ding, Dong Hu, Yu Zhou, Chunlan Long, Lianju Shen, Yuanyuan Zhang, Deying Zhang and Guanghui Wei
    Citation: Stem Cell Research & Therapy 2018 9:76
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:7

  7. Mesenchymal stem cells (MSCs) produced for clinical purposes rely on culture media containing fetal bovine serum (FBS) which is xenogeneic and has the potential to significantly alter the MSC phenotype, render...

    Authors: Maria C. Naskou, Scarlett M. Sumner, Anna Chocallo, Hannah Kemelmakher, Merrilee Thoresen, Ian Copland, Jacques Galipeau and John F. Peroni
    Citation: Stem Cell Research & Therapy 2018 9:75
    Content type: Research Published on:

  8. Three-dimensional (3D) cultures recapitulate the microenvironment of tissue-resident stem cells and enable them to modulate their properties. We determined whether salivary gland-resident stem cells (SGSCs) ar...

    Authors: Hyun-Soo Shin, Songyi Lee, Hye Jin Hong, Young Chang Lim, Won-Gun Koh and Jae-Yol Lim
    Citation: Stem Cell Research & Therapy 2018 9:74
    Content type: Research Published on:

  9. Three-dimensional (3D) cultured clumps of mesenchymal stem cell (MSC)/extracellular matrix (ECM) complexes (C-MSCs) consist of cells and self-produced ECM. C-MSCs can regulate cellular functions in vitro and c...

    Authors: Souta Motoike, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Susumu Horikoshi, Shinji Matsuda, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Tsuyoshi Fujita and Hidemi Kurihara
    Citation: Stem Cell Research & Therapy 2018 9:73
    Content type: Research Published on:

  12. Induced pluripotent stem-cell derived endothelial cells (iPSC-ECs) can be generated from any somatic cell and their iPSC sources possess unlimited self-renewal. Previous demonstration of their proangiogenic ac...

    Authors: Richard P. Tan, Alex H. P. Chan, Katarina Lennartsson, Maria M. Miravet, Bob S. L. Lee, Jelena Rnjak-Kovacina, Zoe E. Clayton, John P. Cooke, Martin K. C. Ng, Sanjay Patel and Steven G. Wise
    Citation: Stem Cell Research & Therapy 2018 9:70
    Content type: Research Published on:

  14. While a shift towards non-viral and animal component-free methods of generating induced pluripotent stem (iPS) cells is preferred for safer clinical applications, there is still a shortage of reliable cell sou...

    Authors: Srijaya Thekkeparambil Chandrabose, Sandhya Sriram, Subha Subramanian, Shanshan Cheng, Wee Kiat Ong, Steve Rozen, Noor Hayaty Abu Kasim and Shigeki Sugii
    Citation: Stem Cell Research & Therapy 2018 9:68
    Content type: Research Published on:

  15. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used to generate cellular models harboring specific disease-related genotypes. Of particular importance are ESC and iPSC ...

    Authors: Meixiang Zhang, Justine Ngo, Filomena Pirozzi, Ying-Pu Sun and Anthony Wynshaw-Boris
    Citation: Stem Cell Research & Therapy 2018 9:67
    Content type: Method Published on:

  16. Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and ot...

    Authors: Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang, Jiahui Wang, Caiyi Zhang, Wei Ge, Deqin Geng and Xiaotong Wang
    Citation: Stem Cell Research & Therapy 2018 9:66
    Content type: Review Published on:

  17. Mesenchymal stem cells (MSCs) are a reliable resource for bone regeneration and tissue engineering, but the molecular mechanisms of differentiation remain unclear. The tumor antigen 15-leucine-rich repeat cont...

    Authors: Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2018 9:65
    Content type: Research Published on:

  18. Scarring is the product of natural restoration, yet its treatment remains challenging. Both collagen and fibroblasts are abnormally abundant in scars, leading to scar hyperplasia or contracture. Several clinic...

    Authors: Xiao Xu, Linying Lai, Xuyi Zhang, Jinhong Chen, Junnan Chen, Fei Wang, Jingchen Zheng and Minliang Chen
    Citation: Stem Cell Research & Therapy 2018 9:64
    Content type: Research Published on:

  19. Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have...

    Authors: Somayeh Keshtkar, Negar Azarpira and Mohammad Hossein Ghahremani
    Citation: Stem Cell Research & Therapy 2018 9:63
    Content type: Review Published on:

  20. Mesenchymal stem cells derived from gingiva (GMSCs) display profound immunomodulation properties in addition to self-renewal and multilineage differentiation capacities. Hydrogen sulfide (H2S) is not only an envi...

    Authors: Ruili Yang, Tingting Yu, Dawei Liu, Songtao Shi and Yanheng Zhou
    Citation: Stem Cell Research & Therapy 2018 9:62
    Content type: Research Published on:

  21. Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive ...

    Authors: Ruhang Tang, Liufang Jing, Vincent P. Willard, Chia-lung Wu, Farshid Guilak, Jun Chen and Lori A. Setton
    Citation: Stem Cell Research & Therapy 2018 9:61
    Content type: Research Published on:

  22. Use of bioscaffolds to direct osteogenic differentiation of adult multipotent stromal cells (MSCs) without exogenous proteins is a contemporary approach to bone regeneration. Identification of in vivo osteogen...

    Authors: Wei Duan, Cong Chen, Masudul Haque, Daniel Hayes and Mandi J. Lopez
    Citation: Stem Cell Research & Therapy 2018 9:60
    Content type: Research Published on:

  24. The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes. Although previous efforts have succeeded in generating hepatocytes from human pluripotent ...

    Authors: Cong Du, Yuan Feng, Dongbo Qiu, Yan Xu, Mao Pang, Nan Cai, Andy Peng Xiang and Qi Zhang
    Citation: Stem Cell Research & Therapy 2018 9:58
    Content type: Research Published on:

  25. The reciprocal fate decision of mesenchymal stem cells (MSCs) to either bone or adipocytes is determined by Wnt-related signaling and the glucagon-like peptide-1 receptor (GLP-1R). Azoramide, an ER stress alle...

    Authors: Banjun Ruan, Zheng Zhu, Zhao Yan, Wei Yang, Dongsheng Zhai, Li Wang, Zichen Ye, Huanyu Lu, An Xiang, Jingwei Liang, Yinghao Jiang, Chengming Xu, Zhenyu Wang, Ming Wei, Xiaoying Lei, Xiaorui Cao…
    Citation: Stem Cell Research & Therapy 2018 9:57
    Content type: Research Published on:

  26. Circular RNAs (circRNAs) are regarded as a novel class of noncoding RNA regulators. Although a number of circRNAs have been identified by bioinformatics analysis of RNA-seq data, tissue and disease-specific ci...

    Authors: Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Zhenya Shen, Wenbo Deng and Shijun Hu
    Citation: Stem Cell Research & Therapy 2018 9:56
    Content type: Research Published on:

  27. Although many reports show that various kinds of stem cells have the ability to recover function in premature ovarian aging, few studies have looked at stem cell treatment of natural ovarian aging (NOA). We de...

    Authors: Chenyue Ding, Qinyan Zou, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Mingfa Ling, Jian Sun, Wei Wang, Hong Li and Boxian Huang
    Citation: Stem Cell Research & Therapy 2018 9:55
    Content type: Research Published on:

  28. Shockwaves and mesenchymal stem cells (MSCs) have been widely accepted as useful tools for many orthopedic applications. However, the modulatory effects of shockwaves on MSCs remain controversial. In this stud...

    Authors: Hao Zhang, Zhong-Li Li, Fei Yang, Qiang Zhang, Xiang-Zheng Su, Ji Li, Ning Zhang, Chun-Hui Liu, Ning Mao and Heng Zhu
    Citation: Stem Cell Research & Therapy 2018 9:54
    Content type: Research Published on:

  29. Adipose-derived stem cells (ADSCs) are an attractive cell source for bone tissue engineering and have great potential for bone regeneration and defect repair. The transcriptional coactivator with PDZ-binding m...

    Authors: Yumin Zhu, Yaping Wu, Jie Cheng, Qiong Wang, Zhongwu Li, Yanling Wang, Dongmiao Wang, Hua Wang, Weibing Zhang, Jinhai Ye, Hongbing Jiang and Lin Wang
    Citation: Stem Cell Research & Therapy 2018 9:53
    Content type: Research Published on:

  30. Human mesenchymal stem cell (hMSC) differentiation into osteoblasts has important clinical significance in treating bone injury, and the stiffness of the extracellular matrix (ECM) has been shown to be an impo...

    Authors: Meiyu Sun, Guangfan Chi, Juanjuan Xu, Ye Tan, Jiayi Xu, Shuang Lv, Ziran Xu, Yuhan Xia, Lisha Li and Yulin Li
    Citation: Stem Cell Research & Therapy 2018 9:52
    Content type: Research Published on:

  31. The LIM-homeobox transcription factor islet-1 (ISL1) has been proposed as a marker for cardiovascular progenitor cells. This study investigated whether forced expression of ISL1 in human mesenchymal stem cells...

    Authors: Qiuling Xiang, Yan Liao, Hua Chao, Weijun Huang, Jia Liu, Haixuan Chen, Dongxi Hong, Zhengwei Zou, Andy Peng Xiang and Weiqiang Li
    Citation: Stem Cell Research & Therapy 2018 9:51
    Content type: Research Published on:

  32. Asherman’s syndrome (AS) is one of the gynecological disorders caused by the destruction of the endometrium. For some cases of AS available surgical methods and hormonal therapy are ineffective. Stem cell tran...

    Authors: Alisa Domnina, Polina Novikova, Julia Obidina, Irina Fridlyanskaya, Larisa Alekseenko, Irina Kozhukharova, Olga Lyublinskaya, Valeriy Zenin and Nikolay Nikolsky
    Citation: Stem Cell Research & Therapy 2018 9:50
    Content type: Research Published on:

  33. Induced pluripotent stem cells (iPS) represent an innovative source for the standardized in vitro generation of macrophages (Mφ). Mφ show great promise in disease pathogenesis, particularly tuberculosis. However,...

    Authors: Danping Hong, Jiongyan Ding, Ouyang Li, Quan He, Minxia Ke, Mengyi Zhu, Lili Liu, Wen-Bin Ou, Yulong He and Yuehong Wu
    Citation: Stem Cell Research & Therapy 2018 9:49
    Content type: Research Published on:

  34. Human menstrual blood-derived stromal cells (MenSCs) are highly proliferative and show multiple differentiation capacity. The convenience and non-invasiveness make MenSC a novel cell source for regenerative me...

    Authors: Siwen Zhang, Pingping Li, Zhengwei Yuan and Jichun Tan
    Citation: Stem Cell Research & Therapy 2018 9:48
    Content type: Research Published on:

  35. Changes in metabolic pathway preferences are key events in the reprogramming process of somatic cells to induced pluripotent stem cells (iPSCs). The optimization of metabolic conditions can enhance reprogrammi...

    Authors: Zhaoyu Lin, Fei Liu, Peiliang Shi, Anying Song, Zan Huang, Dayuan Zou, Qin Chen, Jianxin Li and Xiang Gao
    Citation: Stem Cell Research & Therapy 2018 9:47
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:111

  36. Thalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy. The definitive cure for thalassemia is allogeneic hematopoieti...

    Authors: Methichit Wattanapanitch, Nattaya Damkham, Ponthip Potirat, Kongtana Trakarnsanga, Montira Janan, Yaowalak U-pratya, Pakpoom Kheolamai, Nuttha Klincumhom and Surapol Issaragrisil
    Citation: Stem Cell Research & Therapy 2018 9:46
    Content type: Research Published on:

  37. Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. N...

    Authors: Luisa H. A. Silva, Mariana A. Antunes, Claudia C. Dos Santos, Daniel J. Weiss, Fernanda F. Cruz and Patricia R. M. Rocco
    Citation: Stem Cell Research & Therapy 2018 9:45
    Content type: Review Published on:

  38. In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a p...

    Authors: Xiaofei Guo, Yan Bai, Li Zhang, Bo Zhang, Naufal Zagidullin, Katherine Carvalho, Zhimin Du and Benzhi Cai
    Citation: Stem Cell Research & Therapy 2018 9:44
    Content type: Review Published on:

  39. For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term resul...

    Authors: Jianming Guo, Lianrui Guo, Shijun Cui, Zhu Tong, Alan Dardik and Yongquan Gu
    Citation: Stem Cell Research & Therapy 2018 9:43
    Content type: Research Published on:

  40. Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived...

    Authors: L. F. Mendes, H. Katagiri, W. L. Tam, Y. C. Chai, L. Geris, S. J. Roberts and F. P. Luyten
    Citation: Stem Cell Research & Therapy 2018 9:42
    Content type: Research Published on:

  41. C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that...

    Authors: Yuning Sun, Rongfeng Xu, Jia Huang, Yuyu Yao, Xiaodong Pan, Zhongpu Chen and Genshan Ma
    Citation: Stem Cell Research & Therapy 2018 9:41
    Content type: Research Published on:

  43. Numerous stem cell therapies use injection-based administration to deliver high-density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This stu...

    Authors: Mahetab H. Amer, Felicity R. A. J. Rose, Kevin M. Shakesheff and Lisa J. White
    Citation: Stem Cell Research & Therapy 2018 9:39
    Content type: Research Published on:

  44. Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeu...

    Authors: Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer and Duane L. Davis
    Citation: Stem Cell Research & Therapy 2018 9:38
    Content type: Research Published on:

  45. Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF)....

    Authors: Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan and Hongqin Zhang
    Citation: Stem Cell Research & Therapy 2018 9:37
    Content type: Research Published on:

  46. Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effect...

    Authors: Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma and Hong-Fei Xia
    Citation: Stem Cell Research & Therapy 2018 9:36
    Content type: Research Published on:

  47. Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering. Still, to tra...

    Authors: Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl and Wolfgang Holnthoner
    Citation: Stem Cell Research & Therapy 2018 9:35
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:261

  48. CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed...

    Authors: Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte and Sara Teresinha Olalla Saad
    Citation: Stem Cell Research & Therapy 2018 9:34
    Content type: Letter Published on:

  50. Several studies have focused on umbilical cord-derived mesenchymal stem cells (UC-MSCs) due to their potential therapeutic effects in a cluster of diseases. However, there has been no bibliometric analysis eva...

    Authors: Jian Zhao, Guanyu Yu, Mengxi Cai, Xiao Lei, Yanyong Yang, Qijin Wang and Xiao Zhai
    Citation: Stem Cell Research & Therapy 2018 9:32
    Content type: Review Published on:
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