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  1. Liver transplantation is a gold standard treatment for intractable liver diseases. Because of the shortage of donor organs, alternative therapies have been required. Due to their potential to differentiate int...

    Authors: Takayoshi Yamaza, Fatima Safira Alatas, Ratih Yuniartha, Haruyoshi Yamaza, Junko K. Fujiyoshi, Yusuke Yanagi, Koichiro Yoshimaru, Makoto Hayashida, Toshiharu Matsuura, Reona Aijima, Kenji Ihara, Shouichi Ohga, Songtao Shi, Kazuaki Nonaka and Tomoaki Taguchi
    Citation: Stem Cell Research & Therapy 2015 6:171
  2. Due to their immunomodulatory properties, mesenchymal stromal cells (MSCs) have been used for auto-immune disease treatment. Crohn disease (CD) and ulcerative colitis are two major inflammatory bowel diseases ...

    Authors: Dorian Forte, Marilena Ciciarello, Maria Chiara Valerii, Luigia De Fazio, Elena Cavazza, Rosaria Giordano, Valentina Parazzi, Lorenza Lazzari, Silvio Laureti, Fernando Rizzello, Michele Cavo, Antonio Curti, Roberto M. Lemoli, Enzo Spisni and Lucia Catani
    Citation: Stem Cell Research & Therapy 2015 6:170
  3. Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and multilineage differentiation. Their multipotential capacity and immunomodulatory properties have led to an increasing interest in...

    Authors: Carmen Muñiz, Cristina Teodosio, Andrea Mayado, Ana Teresa Amaral, Sergio Matarraz, Paloma Bárcena, Maria Luz Sanchez, Iván Alvarez-Twose, María Diez-Campelo, Andrés C. García-Montero, Juan F. Blanco, Maria Consuelo Del Cañizo, Javier del Pino Montes and Alberto Orfao
    Citation: Stem Cell Research & Therapy 2015 6:169
  4. We have recently found that miR-17 is necessary in the cell-extrinsic control of cord blood (CB) CD34+ cell function. Here, we demonstrated that the proper level of miR-17 is also necessary in the cell-intrinsic ...

    Authors: Yuxia Yang, Saifeng Wang, Zhenchuan Miao, Wei Ma, Yanju Zhang, Li Su, Mengyu Hu, Junhua Zou, Yuxin Yin and Jianyuan Luo
    Citation: Stem Cell Research & Therapy 2015 6:168
  5. Bone marrow-derived mesenchymal stromal cells (MSCs) have been intensely studied for the purpose of developing solutions for clinical tissue engineering. Autologous MSCs can potentially be used to replace tiss...

    Authors: Eeva Castrén, Tarvo Sillat, Sofia Oja, Ariel Noro, Anita Laitinen, Yrjö T Konttinen, Petri Lehenkari, Mika Hukkanen and Matti Korhonen
    Citation: Stem Cell Research & Therapy 2015 6:167
  6. Tumor necrosis factor alpha (TNFα) plays a physiological role in controlling synaptic transmission and plasticity in the healthy central nervous system by modulating glutamate receptor trafficking to the plasm...

    Authors: Raffaella Morini, Elsa Ghirardini, Erica Butti, Claudia Verderio, Gianvito Martino and Michela Matteoli
    Citation: Stem Cell Research & Therapy 2015 6:166
  7. Studies have proposed that mesenchymal stem cells (MSCs) improve the hematopoietic engraftment in allogeneic or xenogeneic transplants and this is probably due to the MSCs’ immunosuppressive properties. Our st...

    Authors: María Fernández-García, Rosa M. Yañez, Rebeca Sánchez-Domínguez, Miriam Hernando-Rodriguez, Miguel Peces-Barba, Guadalupe Herrera, Jose E. O’Connor, José C. Segovia, Juan A. Bueren and María L. Lamana
    Citation: Stem Cell Research & Therapy 2015 6:165
  8. The in vivo therapeutic effect of mesenchymal stromal cells (MSCs) is currently believed to be tightly linked to their paracrine secretion ability. However, insufficient or imprecise cell delivery, low cell su...

    Authors: Xin Lin, Mikella Robinson, Tye Petrie, Veronica Spandler, W. Douglas Boyd and Claus Svane Sondergaard
    Citation: Stem Cell Research & Therapy 2015 6:164
  9. In this study, we planned to assess if adult stem cell-based suicide gene therapy can efficiently eliminate glioblastoma cells in vivo. We investigated the therapeutic potential of mouse Oct4 bone marrow multipo...

    Authors: Cindy Leten, Jesse Trekker, Tom Struys, Tom Dresselaers, Rik Gijsbers, Greetje Vande Velde, Ivo Lambrichts, Annemie Van Der Linden, Catherine M. Verfaillie and Uwe Himmelreich
    Citation: Stem Cell Research & Therapy 2015 6:163
  10. Dental pulp stem cells (DPSCs) are mesenchymal stem cells located in dental pulp and are thought to be a potential source for cell therapy since DPSCs can be easily obtained from teeth extracted for orthodonti...

    Authors: Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Takahiro Tosaki, Megumi Miyabe, Norinaga Kojima, Katsutoshi Kubo, Shogo Ozawa, Hatsuhiko Maeda, Yoshinobu Tanaka, Tatsuaki Matsubara and Keiko Naruse
    Citation: Stem Cell Research & Therapy 2015 6:162
  11. Bone abnormalities, one of the primary manifestations of Menkes disease (MD), include a weakened bone matrix and low mineral density. However, the molecular and cellular mechanisms underlying these bone defect...

    Authors: Dongkyu Kim, Jieun Choi, Kyu-Min Han, Beom Hee Lee, Jin-Ho Choi, Han-Wook Yoo and Yong-Mahn Han
    Citation: Stem Cell Research & Therapy 2015 6:160
  12. Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. Membrane vesicles, actively released by cells, r...

    Authors: Peter J. Quesenberry, Jason Aliotta, Maria Chiara Deregibus and Giovanni Camussi
    Citation: Stem Cell Research & Therapy 2015 6:153
  13. Despite multimodal regimens and diverse treatment options alleviating disease symptoms, morbidity and mortality associated with advanced ischemic heart failure remain high. Recently, technological innovation h...

    Authors: Marko Banovic, Zlatibor Loncar, Atta Behfar, Marc Vanderheyden, Branko Beleslin, Andreas Zeiher, Marco Metra, Andre Terzic and Jozef Bartunek
    Citation: Stem Cell Research & Therapy 2015 6:159
  14. Zellweger spectrum disorder (PBD-ZSD) is a disease continuum caused by mutations in a subset of PEX genes required for normal peroxisome assembly and function. They highlight the importance of peroxisomes in the ...

    Authors: Xiao-Ming Wang, Wing Yan Yik, Peilin Zhang, Wange Lu, Ning Huang, Bo Ram Kim, Darryl Shibata, Madison Zitting, Robert H. Chow, Ann B. Moser, Steven J. Steinberg and Joseph G. Hacia
    Citation: Stem Cell Research & Therapy 2015 6:158
  15. Cancers are believed to adapt to continual changes in glucose and oxygen availability by relying almost exclusively on glycolytic metabolism for energy (i.e. the Warburg effect). The process by which breast ca...

    Authors: Nicole Gordon, Amy M. Skinner, Rodney F. Pommier, Robynn V. Schillace, Steven O’Neill, Jennifer L. Peckham, Patrick Muller, Mary E. Condron, Cory Donovan, Arpana Naik, Juliana Hansen and SuEllen J. Pommier
    Citation: Stem Cell Research & Therapy 2015 6:157
  16. Duchenne muscular dystrophy (DMD), caused by a lack of the functional structural protein dystrophin, leads to severe muscle degeneration where the patients are typically wheelchair-bound and die in their mid-t...

    Authors: Alessandra Pisciotta, Massimo Riccio, Gianluca Carnevale, Aiping Lu, Sara De Biasi, Lara Gibellini, Giovanni B. La Sala, Giacomo Bruzzesi, Adriano Ferrari, Johnny Huard and Anto De Pol
    Citation: Stem Cell Research & Therapy 2015 6:156
  17. In the context of drug delivery, mesenchymal stromal cells (MSCs) from bone marrow and adipose tissue have emerged as interesting candidates due to their homing abilities and capacity to carry toxic loads, whi...

    Authors: Arianna Bonomi, Antonietta Silini, Elsa Vertua, Patrizia Bonassi Signoroni, Valentina Coccè, Loredana Cavicchini, Francesca Sisto, Giulio Alessandri, Augusto Pessina and Ornella Parolini
    Citation: Stem Cell Research & Therapy 2015 6:155
  18. Cell-based therapy was a promising treatment method for disc degenerative diseases. Wharton’s jelly cell (WJC) has been explored to cure various human diseases, while it still remains unknown about this MSC fo...

    Authors: Yan Zhang, Hui Tao, Tao Gu, Mingyue Zhou, Zhiwei Jia, Gangqiang Jiang, Chun Chen, Zhihua Han, Cheng Xu, Deli Wang, Qing He and Dike Ruan
    Citation: Stem Cell Research & Therapy 2015 6:154
  19. Premature ovarian failure and insufficiency are significant long-term side-effects of chemotherapy for female cancer patients. Recently, stem cell transplantation has been identified as a promising treatment f...

    Authors: Qiuwan Zhang, Minhua Xu, Xiaofen Yao, Ting Li, Qian Wang and Dongmei Lai
    Citation: Stem Cell Research & Therapy 2015 6:152
  20. Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, c...

    Authors: Claas Baustian, Shirley Hanley and Rhodri Ceredig
    Citation: Stem Cell Research & Therapy 2015 6:151
  21. Multipotent stromal cells (MSCs) are among the key candidates in regenerative medicine. However variety of MSC sources and general heterogeneity lead to controversial data in functional characterization. Furth...

    Authors: Olena Pogozhykh, Denys Pogozhykh, Anna-Lena Neehus, Andrea Hoffmann, Rainer Blasczyk and Thomas Müller
    Citation: Stem Cell Research & Therapy 2015 6:150
  22. Conditionally immortalised human neural progenitor cells (hNPCs) represent a robust source of native neural cells to investigate physiological mechanisms in both health and disease. However, in order to recogn...

    Authors: Greg W. Anderson, P. J. Michael Deans, Ruth D T Taylor, Pooja Raval, Ding Chen, Harrison Lowder, Srishti Murkerji, Laura C. Andreae, Brenda P. Williams and Deepak P. Srivastava
    Citation: Stem Cell Research & Therapy 2015 6:149
  23. Doxorubicin (DOX) is a well-known anticancer drug. However its clinical use has been limited due to cardiotoxic effects. One of the major concerns with DOX therapy is its toxicity in patients who are frail, pa...

    Authors: Hania Ibrahim Ammar, Glen Lester Sequiera, Mira B. Nashed, Rasha I. Ammar, Hala M. Gabr, Hany E. Elsayed, Niketa Sareen, Ejlal Abu-El Rub, Maha B. Zickri and Sanjiv Dhingra
    Citation: Stem Cell Research & Therapy 2015 6:148
  24. Mesenchymal stem cells (MSCs) have therapeutic potential for the repair of myocardial injury. The efficacy of MSC therapy for myocardial regeneration mainly depends on the survival of cells after transplantati...

    Authors: Onju Ham, Se-Yeon Lee, Chang Youn Lee, Jun-Hee Park, Jiyun Lee, Hyang-Hee Seo, Min-Ji Cha, Eunhyun Choi, Soonhag Kim and Ki-Chul Hwang
    Citation: Stem Cell Research & Therapy 2015 6:147
  25. Over the last two decades, a new therapeutic paradigm has emerged which has changed the way debilitating diseases may be treated in the future. Instead of using small-molecule drugs and devices to ameliorate t...

    Authors: Timothy O’Brien, Michael Creane, Anthony J. Windebank, Andre Terzic and Allan B. Dietz
    Citation: Stem Cell Research & Therapy 2015 6:146
  26. Redundant collagen deposition at sites of healing dermal wounds results in hypertrophic scars. Adipose-derived stem cells (ADSCs) exhibit promise in a variety of anti-fibrosis applications by attenuating colla...

    Authors: Qi Zhang, Li-Na Liu, Qi Yong, Jing-Cheng Deng and Wei-Gang Cao
    Citation: Stem Cell Research & Therapy 2015 6:145
  27. Previously, we established a simple method for deriving mesenchymal stem cells (MSCs) from human induced pluripotent stem cells (iPSC-MSCs). These iPSC-MSCs were capable of forming osteogenic structures in sca...

    Authors: Ran Kang, Yan Zhou, Shuang Tan, Guangqian Zhou, Lars Aagaard, Lin Xie, Cody Bünger, Lars Bolund and Yonglun Luo
    Citation: Stem Cell Research & Therapy 2015 6:144
  28. An effective immune response to severe bacterial infections requires a robust production of the innate immunity cells from hematopoietic stem and progenitor cells (HSPCs) in a process called emergency myelopoi...

    Authors: Tomasz Skirecki, Jerzy Kawiak, Eugeniusz Machaj, Zygmunt Pojda, Danuta Wasilewska, Jarosław Czubak and Grażyna Hoser
    Citation: Stem Cell Research & Therapy 2015 6:142
  29. To this end human MSCs were isolated from adipose tissue and the MSC:CD4+ T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 ...

    Authors: Ozge Kizilay Mancini, Dominique Shum-Tim, Ursula Stochaj, José A. Correa and Inés Colmegna
    Citation: Stem Cell Research & Therapy 2015 6:140

    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:35

  30. Endothelial colony-forming cells (ECFCs) significantly improve tissue repair by providing regeneration potential within injured cardiovascular tissue. However, ECFC transplantation into ischemic tissue exhibit...

    Authors: Sang Hun Lee, Jun Hee Lee, Yong-Seok Han, Jung Min Ryu, Yeo Min Yoon and Ho Jae Han
    Citation: Stem Cell Research & Therapy 2015 6:139
  31. Therapeutic angiogenesis by transplantation of autologous/allogeneic adipose-derived stem cells (ADSCs) is a potential approach for severe ischemic diseases. However, poor viability, adhesion, migration and di...

    Authors: Jinbao Qin, Fukang Yuan, Zhiyou Peng, Kaichuang Ye, Xinrui Yang, Lijia Huang, Mier Jiang and Xinwu Lu
    Citation: Stem Cell Research & Therapy 2015 6:138
  32. Crohn’s disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subjects. Growing evidence highlights the safety ...

    Authors: Rachele Ciccocioppo, Giuseppina C. Cangemi, Peter Kruzliak, Alessandra Gallia, Elena Betti, Carla Badulli, Miryam Martinetti, Marila Cervio, Alessandro Pecci, Valeria Bozzi, Paolo Dionigi, Livia Visai, Antonella Gurrado, Costanza Alvisi, Cristina Picone, Manuela Monti…
    Citation: Stem Cell Research & Therapy 2015 6:137
  33. Bone marrow-derived stromal cells (BMSCs), also known as mesenchymal stem cells, are the focus of intensive efforts worldwide to elucidate their function and biology. Despite the importance of BMSC migration f...

    Authors: Caroline M. Ryan, James A. L. Brown, Emer Bourke, Áine M. Prendergast, Claire Kavanagh, Zhonglin Liu, Peter Owens, Georgina Shaw, Walter Kolch, Timothy O’Brien and Frank P. Barry
    Citation: Stem Cell Research & Therapy 2015 6:136
  34. Tumor microenvironment conferred by stromal (mesenchymal) stem cells (MSCs) plays a key role in tumor development, progression, and response to therapy. Defining the role of MSCs in tumorigenesis is crucial fo...

    Authors: Mashael Al-toub, Radhakrishnan Vishnubalaji, Rimi Hamam, Moustapha Kassem, Abdullah Aldahmash and Nehad M. Alajez
    Citation: Stem Cell Research & Therapy 2015 6:135
  35. The aim of our study is to identify the contribution of hematopoietic-derived cells to burn-wound healing in a non-severe injury. There are many conflicting reports of the contribution of bone marrow-derived c...

    Authors: Suzanne Rea, Andrew Stevenson, Natalie L. Giles, Fiona M. Wood and Mark W. Fear
    Citation: Stem Cell Research & Therapy 2015 6:134
  36. The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application...

    Authors: Fábio G. Teixeira, Krishna M. Panchalingam, Sandra Isabel Anjo, Bruno Manadas, Ricardo Pereira, Nuno Sousa, António J. Salgado and Leo A. Behie
    Citation: Stem Cell Research & Therapy 2015 6:133
  37. Histone H3 lysine 27 trimethylation (H3K27me3) and H3 lysine 36 trimethylation (H3K36me3) are important epigenetic modifications correlated with transcription repression and activation, respectively. These two...

    Authors: Hailei Mao, Gang Han, Longyong Xu, Duming Zhu, Hanqing Lin, Xiongwen Cao, Yi Yu and Charlie Degui Chen
    Citation: Stem Cell Research & Therapy 2015 6:132
  38. Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Current...

    Authors: Maria-Adelaide Micci, Debbie R. Boone, Margaret A. Parsley, Jingna Wei, Igor Patrikeev, Massoud Motamedi and Helen L. Hellmich
    Citation: Stem Cell Research & Therapy 2015 6:131
  39. Cell replacement therapy may be considered as an alternate approach to provide therapeutic dose of plasma factor VIII (FVIII) in patients with hemophilia A (HA). However, immune rejection limits the use of all...

    Authors: Veena Kochat, Sumod Kanjirakkuzhiyil, Prakash Baligar, Perumal Nagarajan and Asok Mukhopadhyay
    Citation: Stem Cell Research & Therapy 2015 6:129
  40. Peripheral nerves may fail to regenerate across tube implants because these lack the microarchitecture of native nerves. Bone marrow mesenchymal stem cells (MSC) secrete soluble factors that improve the regene...

    Authors: A. Carrier-Ruiz, F. Evaristo-Mendonça, R. Mendez-Otero and V. T. Ribeiro-Resende
    Citation: Stem Cell Research & Therapy 2015 6:128
  41. In light of pioneering findings in the 1980s and an estimation of more than 130 million global annual births, umbilical cord blood (UCB) is considered to be the most plentiful reservoir of cells and to have re...

    Authors: Santiago Roura, Josep-Maria Pujal, Carolina Gálvez-Montón and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2015 6:123
  42. Administration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological and degenerative disorders. Accumulating evidence indicates that the healing ef...

    Authors: Serena Rubina Baglio, Koos Rooijers, Danijela Koppers-Lalic, Frederik J. Verweij, M Pérez Lanzón, Nicoletta Zini, Benno Naaijkens, Francesca Perut, Hans W. M. Niessen, Nicola Baldini and D. Michiel Pegtel
    Citation: Stem Cell Research & Therapy 2015 6:127
  43. Autologous blood-derived biologicals, including autologous conditioned serum (ACS), are frequently used to treat tendinopathies in horses despite limited evidence for their efficacy. The purpose of this study ...

    Authors: Florian Geburek, Maren Lietzau, Andreas Beineke, Karl Rohn and Peter M. Stadler
    Citation: Stem Cell Research & Therapy 2015 6:126
  44. Induced pluripotent stem cells (iPSCs) have emerged as a promising cell source for immune-compatible cell therapy. Although a variety of somatic cells have been tried for iPSC generation, it is still of great ...

    Authors: Jinsoo Oh, Kang-In Lee, Hyeong-Taek Kim, Youngsang You, Do Heum Yoon, Ki Yeong Song, Eunji Cheong, Yoon Ha and Dong-Youn Hwang
    Citation: Stem Cell Research & Therapy 2015 6:125
  45. Chemotherapy has made an essential contribution to cancer treatment in recent decades despite its adverse effects. As cancer survivors have increased, concern about ex-patient lifespan has become more importan...

    Authors: Fernando Ezquer, Jaime Gutiérrez, Marcelo Ezquer, Christian Caglevic, Helio C Salgado and Sebastián D Calligaris
    Citation: Stem Cell Research & Therapy 2015 6:116
  46. Despite its high incidence, nerve fiber (axon and myelin) damage after cerebral infarct has not yet been extensively investigated. The aim of this study was to investigate white matter repair after adipose-der...

    Authors: Laura Otero-Ortega, María Gutiérrez-Fernández, Jaime Ramos-Cejudo, Berta Rodríguez-Frutos, Blanca Fuentes, Tomás Sobrino, Teresa Navarro Hernanz, Francisco Campos, Juan Antonio López, Sebastián Cerdán, Jesús Vázquez and Exuperio Díez-Tejedor
    Citation: Stem Cell Research & Therapy 2015 6:121

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