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  1. Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived...

    Authors: L. F. Mendes, H. Katagiri, W. L. Tam, Y. C. Chai, L. Geris, S. J. Roberts and F. P. Luyten
    Citation: Stem Cell Research & Therapy 2018 9:42
    Content type: Research Published on:

  2. C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that...

    Authors: Yuning Sun, Rongfeng Xu, Jia Huang, Yuyu Yao, Xiaodong Pan, Zhongpu Chen and Genshan Ma
    Citation: Stem Cell Research & Therapy 2018 9:41
    Content type: Research Published on:

  4. Numerous stem cell therapies use injection-based administration to deliver high-density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This stu...

    Authors: Mahetab H. Amer, Felicity R. A. J. Rose, Kevin M. Shakesheff and Lisa J. White
    Citation: Stem Cell Research & Therapy 2018 9:39
    Content type: Research Published on:

  5. Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeu...

    Authors: Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer and Duane L. Davis
    Citation: Stem Cell Research & Therapy 2018 9:38
    Content type: Research Published on:

  6. Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF)....

    Authors: Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan and Hongqin Zhang
    Citation: Stem Cell Research & Therapy 2018 9:37
    Content type: Research Published on:

  7. Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effect...

    Authors: Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma and Hong-Fei Xia
    Citation: Stem Cell Research & Therapy 2018 9:36
    Content type: Research Published on:

  8. Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering. Still, to tra...

    Authors: Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl and Wolfgang Holnthoner
    Citation: Stem Cell Research & Therapy 2018 9:35
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:261

  9. CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed...

    Authors: Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte and Sara Teresinha Olalla Saad
    Citation: Stem Cell Research & Therapy 2018 9:34
    Content type: Letter Published on:

  11. Several studies have focused on umbilical cord-derived mesenchymal stem cells (UC-MSCs) due to their potential therapeutic effects in a cluster of diseases. However, there has been no bibliometric analysis eva...

    Authors: Jian Zhao, Guanyu Yu, Mengxi Cai, Xiao Lei, Yanyong Yang, Qijin Wang and Xiao Zhai
    Citation: Stem Cell Research & Therapy 2018 9:32
    Content type: Review Published on:

  12. Mesenchymal stromal cells (MSCs) are an attractive therapeutic agent in regenerative medicine. Recently, there has been a paradigm shift from differentiation of MSCs to their paracrine effects at the injury si...

    Authors: Apeksha Damania, Deepika Jaiman, Arun Kumar Teotia and Ashok Kumar
    Citation: Stem Cell Research & Therapy 2018 9:31
    Content type: Research Published on:

  13. Doxorubicin (Dox) is a chemotherapy drug with limited application due to cardiotoxicity that may progress to heart failure. This study aims to evaluate the role of cardiomyocytes derived from mouse embryonic s...

    Authors: Danúbia Silva dos Santos, Guilherme Visconde Brasil, Isalira Peroba Rezende Ramos, Fernanda Cristina Paccola Mesquita, Tais Hanae Kasai-Brunswick, Michelle Lopes Araújo Christie, Gustavo Monnerat Cahli, Raiana Andrade Quintanilha Barbosa, Sandro Torrentes da Cunha, Jonathas Xavier Pereira, Emiliano Medei, Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho and Regina Coeli dos Santos Goldenberg
    Citation: Stem Cell Research & Therapy 2018 9:30
    Content type: Research Published on:

  14. Mature human hepatocytes are critical in preclinical research and therapy for liver disease, but are difficult to manipulate and expand in vitro. Hepatic stem cells (HpSCs) may be an alternative source of func...

    Authors: Ran-Ran Zhang, Yun-Wen Zheng, Bin Li, Yun-Zhong Nie, Yasuharu Ueno, Tomonori Tsuchida and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2018 9:29
    Content type: Research Published on:

  15. Studies in which mesenchymal stromal cells (MSC) from the placenta are compared with multiple MSC types from other sources are rare. The chorionic plate of the human placenta is mainly composed of fetal blood ...

    Authors: Mónica S. Ventura Ferreira, Michaela Bienert, Katrin Müller, Björn Rath, Tamme Goecke, Christian Opländer, Till Braunschweig, Petra Mela, Tim H. Brümmendorf, Fabian Beier and Sabine Neuss
    Citation: Stem Cell Research & Therapy 2018 9:28
    Content type: Research Published on:

  16. The study aimed to evaluate the efficacy and safety of gingival mesenchymal stem cells (GMSCs) from human fetal gingival tissue used for treating gingival defects in a rat model.

    Authors: Jing Li, Shi-qing Xu, Kai Zhang, Wen-jian Zhang, Hong-lin Liu, Zhen Xu, Hong Li, Jin-ning Lou, Li-hong Ge and Bao-hua Xu
    Citation: Stem Cell Research & Therapy 2018 9:27
    Content type: Research Published on:

  17. Currently, ex-vivo handling of stem cells, including transport after harvest and therapeutic preparation, is generally done in culture media containing fetal bovine serum (FBS), which promotes cell attachment,...

    Authors: Mai Mochizuki and Taka Nakahara
    Citation: Stem Cell Research & Therapy 2018 9:25
    Content type: Research Published on:

  18. Radiation-induced gastrointestinal syndrome (RIGS) results from the acute loss of intestinal stem cells (ISC), impaired epithelial regeneration, and subsequent loss of the mucosal barrier, resulting in electro...

    Authors: Payel Bhanja, Andrew Norris, Pooja Gupta-Saraf, Andrew Hoover and Subhrajit Saha
    Citation: Stem Cell Research & Therapy 2018 9:26
    Content type: Research Published on:

  19. Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily from extracted teeth and are now considered to be ...

    Authors: Yasuyuki Fujii, Yoko Kawase-Koga, Hironori Hojo, Fumiko Yano, Marika Sato, Ung-il Chung, Shinsuke Ohba and Daichi Chikazu
    Citation: Stem Cell Research & Therapy 2018 9:24
    Content type: Research Published on:

  20. In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influ...

    Authors: Sunita Sharma, Dipak Sapkota, Ying Xue, Saroj Rajthala, Mohammed A. Yassin, Anna Finne-Wistrand and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2018 9:23
    Content type: Research Published on:

  21. During tumorigenesis and development, participation of the tumor microenvironment is not negligible. As an important component in the tumor microenvironment, mesenchymal stem cells (MSCs) have been corroborate...

    Authors: Ying Zheng, Gangyang Wang, Ruiling Chen, Yingqi Hua and Zhengdong Cai
    Citation: Stem Cell Research & Therapy 2018 9:22
    Content type: Review Published on:

  22. Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-me...

    Authors: Zhi Yang, Chengmin He, Jinyang He, Jing Chu, Hanping Liu and Xiaoyuan Deng
    Citation: Stem Cell Research & Therapy 2018 9:21
    Content type: Research Published on:

  23. This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone r...

    Authors: Hongqin Zhang, Qianqian Luo, Xueyan Lu, Na Yin, Dongli Zhou, Lianshuang Zhang, Wei Zhao, Dong Wang, Pengchao Du, Yun Hou, Yan Zhang and Wendan Yuan
    Citation: Stem Cell Research & Therapy 2018 9:20
    Content type: Research Published on:

  24. The underlying pathophysiology in intellectual disability (ID) involves abnormalities in dendritic branching and connectivity of the neuronal network. This limits the ability of the brain to process informatio...

    Authors: Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Suhasini Pai, Pooja Kulkarni, Vaishali Ganwir, Maitree Maheshwari, Ridhima Sharma, Meenakshi Raichur, Samson Nivins and Prerna Badhe
    Citation: Stem Cell Research & Therapy 2018 9:19
    Content type: Research Published on:

  25. Since radiotherapy is widely used in managing thoracic tumors, physicians have begun to realize that radiation-induced lung injury (RILI) seriously limits the effects of radiotherapy. Unfortunately, there are ...

    Authors: Tiankai Xu, Yuyu Zhang, Pengyu Chang, Shouliang Gong, Lihong Shao and Lihua Dong
    Citation: Stem Cell Research & Therapy 2018 9:18
    Content type: Review Published on:

  26. Mesenchymal stem (stromal) cells (MSCs) mediate their immunoregulatory and tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs). In several animal models of human dise...

    Authors: Mahesh Khatri, Levi Arthur Richardson and Tea Meulia
    Citation: Stem Cell Research & Therapy 2018 9:17
    Content type: Research Published on:

  27. Deciphering molecular mechanisms underlying the division of hematopoietic stem cells (HSCs) and malignant precursors would improve our understanding of the basis of stem cell-fate decisions and oncogenic trans...

    Authors: Yuchen Wang, Hong Tian, Wenzhi Cai, Zhaorui Lian, Dheeraj Bhavanasi, Chao Wu, Tomohiko Sato, Mineo Kurokawa, Depei Wu, Li Fu, Hong Wang, Hao Shen, Dong Liang and Jian Huang
    Citation: Stem Cell Research & Therapy 2018 9:16
    Content type: Research Published on:

  28. Pancreatic progenitors (PPs) co-expressing the two transcription factors (TFs) PDX1 and NKX6.1 are recognized as the indispensable precursors of functional pancreatic β cells. Here, we aimed to establish an ef...

    Authors: Bushra Memon, Manale Karam, Sara Al-Khawaga and Essam M. Abdelalim
    Citation: Stem Cell Research & Therapy 2018 9:15
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:262

  29. Autologous transplantation of endothelial progenitor cells (EPCs) is a promising therapeutic approach in the treatment of various vascular diseases. We previously reported a two-step culture system for scalabl...

    Authors: Meng Qin, Xin Guan, Yu Zhang, Bin Shen, Fang Liu, Qingyu Zhang, Yupo Ma and Yongping Jiang
    Citation: Stem Cell Research & Therapy 2018 9:14
    Content type: Research Published on:

  30. Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived mesenchymal stem cells (BM-MSCs) are multipotent stro...

    Authors: Zhongyu Xie, Su’an Tang, Guiwen Ye, Peng Wang, Jinteng Li, Wenjie Liu, Ming Li, Shan Wang, Xiaohua Wu, Shuizhong Cen, Guan Zheng, Mengjun Ma, Yanfeng Wu and Huiyong Shen
    Citation: Stem Cell Research & Therapy 2018 9:13
    Content type: Research Published on:

  31. Runt-related transcription factor 2 (RUNX2) haploinsufficiency causes cleidocranial dysplasia (CCD) which is characterized by supernumerary teeth, short stature, clavicular dysplasia, and osteoporosis. At pres...

    Authors: Akiko Saito, Akio Ooki, Takashi Nakamura, Shoko Onodera, Kamichika Hayashi, Daigo Hasegawa, Takahito Okudaira, Katsuhito Watanabe, Hiroshi Kato, Takeshi Onda, Akira Watanabe, Kenjiro Kosaki, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Teruo Sakamoto…
    Citation: Stem Cell Research & Therapy 2018 9:12
    Content type: Research Published on:

  32. Mesenchymal stem cells (MSCs) are one of the most promising candidates for the treatment of major neurological disorders. Desirable therapeutic properties of MSCs include reparative and regenerative potential ...

    Authors: Elena Redondo-Castro, Catriona J. Cunningham, Jonjo Miller, Helena Brown, Stuart M. Allan and Emmanuel Pinteaux
    Citation: Stem Cell Research & Therapy 2018 9:11
    Content type: Research Published on:

  33. Mesenchymal stromal cells (MSC) are a heterogeneous population of multipotent progenitors used in the clinic because of their immunomodulatory properties and their ability to differentiate into multiple mesode...

    Authors: Eliana Amati, Omar Perbellini, Gianluca Rotta, Martina Bernardi, Katia Chieregato, Sabrina Sella, Francesco Rodeghiero, Marco Ruggeri and Giuseppe Astori
    Citation: Stem Cell Research & Therapy 2018 9:10
    Content type: Research Published on:

  34. Recent studies have shown that autophagy plays a central role in mesenchymal stem cells (MSCs), and many studies have shown that human umbilical cord MSCs (huMSCs) can treat Alzheimer’s disease (AD) through a ...

    Authors: Wen Li, Kai Li, Jing Gao and Zhuo Yang
    Citation: Stem Cell Research & Therapy 2018 9:9
    Content type: Research Published on:

  35. Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicit...

    Authors: Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun and Xiaobing Fu
    Citation: Stem Cell Research & Therapy 2018 9:8
    Content type: Research Published on:

  36. Renal fibrosis is characterized by infiltration of interstitial inflammatory cells and release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition of excessive extracellular ...

    Authors: Bo Liu, Fengxia Ding, Dong Hu, Yu Zhou, Chunlan Long, Lianju Shen, Yuanyuan Zhang, Deying Zhang and Guanghui Wei
    Citation: Stem Cell Research & Therapy 2018 9:7
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:76

  37. Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal st...

    Authors: S. Oja, P. Komulainen, A. Penttilä, J. Nystedt and M. Korhonen
    Citation: Stem Cell Research & Therapy 2018 9:6
    Content type: Research Published on:

  38. Acute liver failure (ALF) is a life-threatening disease with a high mortality rate. However, there are limited treatments or devices available for ALF therapy. Here, we aimed to develop a new strategy for ALF ...

    Authors: Yun-Zhong Nie, Yun-Wen Zheng, Miyuki Ogawa, Etsuko Miyagi and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2018 9:5
    Content type: Research Published on:

  39. Mesenchymal stem cell therapy is a promising treatment for perianal Crohn’s fistulas refractory to conventional therapy, which are an extremely morbid complication and a true therapeutic challenge. Autologous ...

    Authors: Cécile Philandrianos, Mélanie Serrero, Fanny Grimaud, Jérémy Magalon, Carine Visée, Mélanie Velier, Pauline Francois, Pierre Orsoni, Guy Magalon, Jean-Charles Grimaud, Ariadne Desjeux, Julie Véran and Florence Sabatier
    Citation: Stem Cell Research & Therapy 2018 9:4
    Content type: Short report Published on:

  41. Pluripotent stem cells hold great promise for regenerative medicine. However, before clinical application, reproducible protocols for pluripotent stem cell differentiation should be established. Extracellular ...

    Authors: Yang Yu, Xiaoxiao Wang, Xiaoxin Zhang, Yanhua Zhai, Xukun Lu, Haixia Ma, Kai Zhu, Tongbiao Zhao, Jianwei Jiao, Zhen-Ao Zhao and Lei Li
    Citation: Stem Cell Research & Therapy 2018 9:2
    Content type: Research Published on:

  42. The history of stem cell therapies is one of a limited number of clinical applications despite a vast therapeutic potential. Major breakthroughs in stem cell research have not yet enjoyed clinical success—all ...

    Authors: Jordan Poulos
    Citation: Stem Cell Research & Therapy 2018 9:1
    Content type: Review Published on:

  43. Bone marrow mesenchymal stem cells (MSCs) are promising candidates for the treatment of various inflammatory disorders due to their profound immunomodulatory properties. However, the immunosuppressive capacity...

    Authors: Binsheng Wang, Yu Lin, Yongxian Hu, Wei Shan, Senquan Liu, Yulin Xu, Hao Zhang, Shuyang Cai, Xiaohong Yu, Zhen Cai and He Huang
    Citation: Stem Cell Research & Therapy 2017 8:292
    Content type: Research Published on:

  44. Human pluripotent stem cells (hPSCs) provide a promising cell source for ocular cell replacement therapy, but often lack standardized and xenogeneic-free culture and differentiation protocols. We aimed to deve...

    Authors: Heidi Hongisto, Tanja Ilmarinen, Meri Vattulainen, Alexandra Mikhailova and Heli Skottman
    Citation: Stem Cell Research & Therapy 2017 8:291
    Content type: Research Published on:

  45. Retinal degeneration (RD) is a leading cause of irreversible blindness, affecting millions of people worldwide. Stem cell transplantation has been considered a promising therapy for retinal degenerative diseas...

    Authors: Li Huang, Zongyi Li, Haibin Tian, Weiguo Wang, Dawei Cui, Zhe Zhou, Xiao Chen, Herman S. Cheung, Guo-tong Xu and Yu Chen
    Citation: Stem Cell Research & Therapy 2017 8:290
    Content type: Research Published on:

  46. Sepsis is a severe medical condition that ranks among the top 10 causes of death worldwide and which has permanently high incidence rates. Mesenchymal stem cells (MSCs) have been found to be potent modulators ...

    Authors: Leonardo Pedrazza, Monica Cubillos-Rojas, Fernanda Cristina de Mesquita, Carolina Luft, Aline Andrea Cunha, Jose Luis Rosa and Jarbas Rodrigues de Oliveira
    Citation: Stem Cell Research & Therapy 2017 8:289
    Content type: Research Published on:

  47. Autologous and allogeneic adult mesenchymal stem/stromal cells (MSCs) are increasingly being investigated for treating a wide range of clinical diseases. Allogeneic MSCs are especially attractive due to their ...

    Authors: Alix K. Berglund, Lisa A. Fortier, Douglas F. Antczak and Lauren V. Schnabel
    Citation: Stem Cell Research & Therapy 2017 8:288
    Content type: Review Published on:

  48. Corneal endothelial dysfunction causes severe impairment of vision. The only solution is corneal transplantation. However, this treatment is hampered by a worldwide shortage of donor corneas. New therapies may...

    Authors: Peng Sun, Lin Shen, Canwei Zhang, Liqun Du and Xinyi Wu
    Citation: Stem Cell Research & Therapy 2017 8:287
    Content type: Research Published on:

  49. Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of the graft would be the major unmet deal in order ...

    Authors: Sophie Domingues, Yolande Masson, Aurore Marteyn, Jennifer Allouche, Anselme L. Perrier, Marc Peschanski, Cecile Martinat, Christine Baldeschi and Gilles Lemaître
    Citation: Stem Cell Research & Therapy 2017 8:285
    Content type: Short report Published on:

  50. Mesenchymal stem cells (MSCs) hold great promise for cartilage repair given their relative abundance, ease of isolation, and chondrogenic potential. To enhance MSC chondrogenesis, extracellular matrix componen...

    Authors: Tianyi Wang and Fan Yang
    Citation: Stem Cell Research & Therapy 2017 8:284
    Content type: Research Published on:
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