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  1. Cardiac stem cells (CSCs) transplantation has been regarded as an optimal therapeutic approach for cardiovascular disease. However, inferior survival and low differentiation efficiency of these cells in the lo...

    Authors: Jingying Hou, Lei Wang, Huibao Long, Hao Wu, Quanhua Wu, Tingting Zhong, Xuxiang Chen, Changqing Zhou, Tianzhu Guo and Tong Wang
    Citation: Stem Cell Research & Therapy 2017 8:215
  2. Introduction of the transcription factors Oct4, Sox2, Klf4, and c-Myc (OSKM) is able to ‘reprogram’ somatic cells to become induced pluripotent stem cells (iPSCs). Several microRNAs (miRNAs) are known to enhan...

    Authors: Phan Nguyen Nhi Nguyen, Kong Bung Choo, Chiu-Jung Huang, Shigeki Sugii, Soon Keng Cheong and Tunku Kamarul
    Citation: Stem Cell Research & Therapy 2017 8:214
  3. The main goal of bone tissue engineering has been the generation of healthy bone in order to replace affected tissue. Therefore, optimized biomaterials are needed which allow the survival and growth of mesench...

    Authors: Anastasia Gabrielyan, Elena Neumann, Michael Gelinsky and Angela Rösen-Wolff
    Citation: Stem Cell Research & Therapy 2017 8:212
  4. Periodontitis is a widespread infectious disease ultimately resulting in tooth loss. The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired. Res...

    Authors: Nannan Han, Fengqiu Zhang, Guoqing Li, Xiuli Zhang, Xiao Lin, Haoqing Yang, Lijun Wang, Yangyang Cao, Juan Du and Zhipeng Fan
    Citation: Stem Cell Research & Therapy 2017 8:210
  5. Retinitis pigmentosa is a common genetic disease that causes retinal degeneration and blindness for which there is currently no curable treatment available. Vision preservation was observed in retinitis pigmen...

    Authors: Yong Liu, Shao Jun Chen, Shi Ying Li, Ling Hui Qu, Xiao Hong Meng, Yi Wang, Hai Wei Xu, Zhi Qing Liang and Zheng Qin Yin
    Citation: Stem Cell Research & Therapy 2017 8:209
  6. Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs. Hypo...

    Authors: Victor G. Martinez, Imelda Ontoria-Oviedo, Carolina P. Ricardo, Sian E. Harding, Rosa Sacedon, Alberto Varas, Agustin Zapata, Pilar Sepulveda and Angeles Vicente
    Citation: Stem Cell Research & Therapy 2017 8:208
  7. Human fibroblasts can be directly converted to several subtypes of neurons, but cortical projection neurons have not been generated.

    Authors: Giedre Miskinyte, Karthikeyan Devaraju, Marita Grønning Hansen, Emanuela Monni, Daniel Tornero, Niels Bjarne Woods, Johan Bengzon, Henrik Ahlenius, Olle Lindvall and Zaal Kokaia
    Citation: Stem Cell Research & Therapy 2017 8:207
  8. The injection of mesenchymal stem cells (MSCs) directly into the bone of osteoporotic (OP) patients for rapid recovery has been studied worldwide. Scaffolds associated with MSCs are used to maintain and avoid ...

    Authors: Patrícia Rodrigues Orsi, Fernanda Cruz Landim-Alvarenga, Luis Antônio Justulin Jr, Ramon Kaneno, Marjorie de Assis Golim, Daniela Carvalho dos Santos, Camila Fernanda Zorzella Creste, Eunice Oba, Leandro Maia, Benedito Barraviera and Rui Seabra Ferreira Jr
    Citation: Stem Cell Research & Therapy 2017 8:205
  9. Hepatitis B virus (HBV) carriers worldwide number approximately 240 million people and around 780,000 people die every year from HBV infection. HBV entry and uptake are functionally linked to the presence of t...

    Authors: Camillo Sargiacomo, Hoda El-Kehdy, Kai Dallmeier, Joery de Kock, Clara Hernandez-Kelly, Vera Rogiers, Arturo Ortega, Johan Neyts, Etienne Sokal and Mustapha Najimi
    Citation: Stem Cell Research & Therapy 2017 8:204
  10. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSC) show remarkable therapeutic potential to repair tissue upon injury via paracrine signaling by secreting diverse trophic factors that promote angiogenesis...

    Authors: Gabriela Zavala, Catalina P. Prieto, Andrea A. Villanueva and Verónica Palma
    Citation: Stem Cell Research & Therapy 2017 8:203
  11. Mesenchymal stem cells (MSCs) are a mixture of progenitors that are heterogeneous in their regenerative potential. Development of MSC therapies with consistent efficacy is hindered by the absence of an immunop...

    Authors: Sean D. Madsen, Katie C. Russell, H. Alan Tucker, Julie Glowacki, Bruce A. Bunnell and Kim C. O’Connor
    Citation: Stem Cell Research & Therapy 2017 8:201
  12. Although tissue-resident mesenchymal stromal cells (MSCs) in the larynx have been described, their distinct characteristics and roles have not been thoroughly explored. Therefore, we investigated stem cell cha...

    Authors: Songyi Lee, Yeseulmi Kim, Hyun-Soo Shin and Jae-Yol Lim
    Citation: Stem Cell Research & Therapy 2017 8:200
  13. Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the func...

    Authors: Elisa Montanari, Raphael P. H. Meier, Redouan Mahou, Jörg D. Seebach, Christine Wandrey, Sandrine Gerber-Lemaire, Leo H. Buhler and Carmen Gonelle-Gispert
    Citation: Stem Cell Research & Therapy 2017 8:199
  14. Human induced pluripotent stem cells (iPSCs) have been verified as a powerful cell model for the study of pathogenesis in hereditary disease. Autosomal dominant polycystic kidney disease (ADPKD) is caused by m...

    Authors: Jiahui Huang, Shumin Zhou, Xin Niu, Bin Hu, Qing Li, Feng Zhang, Xue Zhang, Xiujuan Cai, Yuanlei Lou, Fen Liu, Chenming Xu and Yang Wang
    Citation: Stem Cell Research & Therapy 2017 8:196
  15. The paracrine effect is likely the major mechanism of the adipose-derived stem cell (ASC)-mediated cardioprotective effect. However, the exact composition and nature of ASC-released paracrine factors remain el...

    Authors: Jiyun Lee, Seahyung Lee, Chang Youn Lee, Hyang-Hee Seo, Sunhye Shin, Jung-Won Choi, Sang Woo Kim, Jong-Chul Park, Soyeon Lim and Ki-Chul Hwang
    Citation: Stem Cell Research & Therapy 2017 8:195
  16. Over the past years, vascular diseases have continued to threaten human health and increase financial burdens worldwide. Transplantation of allogeneic and autologous blood vessels is the most convenient treatm...

    Authors: Ying Wang, Pei Yin, Guang-Liang Bian, Hao-Yue Huang, Han Shen, Jun-Jie Yang, Zi-Ying Yang and Zhen-Ya Shen
    Citation: Stem Cell Research & Therapy 2017 8:194
  17. Transplantation of mesenchymal stem cells (MSC) has been proposed to improve wound healing. However, as these cells only transiently survive in the implantation site, the mechanisms underlying this beneficial ...

    Authors: Cecelia C. Yates, Melanie Rodrigues, Austin Nuschke, Zariel I Johnson, Diana Whaley, Donna Stolz, Joseph Newsome and Alan Wells
    Citation: Stem Cell Research & Therapy 2017 8:193
  18. Chronic pancreatitis has surgical options including total pancreatectomy to control pain. To avoid surgical diabetes, the explanted pancreas can have islets harvested and transplanted. Immediately following to...

    Authors: Lili Song, Zhen Sun, Do-sung Kim, Wenyu Gou, Charlie Strange, Huansheng Dong, Wanxing Cui, Gary Gilkeson, Katherine A. Morgan, David B. Adams and Hongjun Wang
    Citation: Stem Cell Research & Therapy 2017 8:192
  19. Stem cells have demonstrated encouraging potential as reparative therapy for patients suffering from post-stroke disability. Reperfusion interventions in the acute phase of stroke have shown significant benefi...

    Authors: Anjali Nagpal, Fong Chan Choy, Stuart Howell, Susan Hillier, Fiona Chan, Monica A. Hamilton-Bruce and Simon A. Koblar
    Citation: Stem Cell Research & Therapy 2017 8:191
  20. Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of th...

    Authors: Roksana Moraghebi, Agnete Kirkeby, Patricia Chaves, Roger E. Rönn, Ewa Sitnicka, Malin Parmar, Marcus Larsson, Andreas Herbst and Niels-Bjarne Woods
    Citation: Stem Cell Research & Therapy 2017 8:190
  21. Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have been implicated in many dis...

    Authors: Yafei Wang, Dongsheng Yu, Zhiming Liu, Fang Zhou, Jun Dai, Bingbing Wu, Jing Zhou, Boon Chin Heng, Xiao Hui Zou, Hongwei Ouyang and Hua Liu
    Citation: Stem Cell Research & Therapy 2017 8:189
  22. Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity ...

    Authors: Lingshu Wang, Li Qing, He Liu, Na Liu, Jingting Qiao, Chen Cui, Tianyi He, Ruxing Zhao, Fuqiang Liu, Fei Yan, Chuan Wang, Kai Liang, Xinghong Guo, Ying H. Shen, Xinguo Hou and Li Chen
    Citation: Stem Cell Research & Therapy 2017 8:188
  23. Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and funct...

    Authors: Xiafei Fu, Yuanli He, Xuefeng Wang, Dongxian Peng, Xiaoying Chen, Xinran Li and Qing Wang
    Citation: Stem Cell Research & Therapy 2017 8:187
  24. Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with self-renewal capabilities and multilineage differentiation potential, including osteogenesis. Although protein deubiquitinases hav...

    Authors: Yiman Tang, Longwei Lv, Wenyue Li, Xiao Zhang, Yong Jiang, Wenshu Ge and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2017 8:186
  25. Lineage commitment of mesenchymal stem cells (MSCs) to cardiac differentiation is controlled by transcription factors that are regulated by epigenetic events, mainly histone deacetylation and promoter DNA meth...

    Authors: G. Bhuvanalakshmi, Frank Arfuso, Alan Prem Kumar, Arun Dharmarajan and Sudha Warrier
    Citation: Stem Cell Research & Therapy 2017 8:185
  26. Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester h...

    Authors: Farwah Iqbal, Peter Szaraz, Matthew Librach, Andrée Gauthier-Fisher and Clifford L. Librach
    Citation: Stem Cell Research & Therapy 2017 8:184
  27. Although they are expandable in vitro, hepatic progenitors are immature cells and share many immunomarkers with hepatocellular carcinoma, raising potential concerns regarding maltransformation after transplant...

    Authors: Ping Wang, Min Cong, Tianhui Liu, Hufeng Xu, Lin Wang, Guangyong Sun, Aiting Yang, Dong Zhang, Jian Huang, Yameng Sun, Wenshan Zhao, Hong Ma, Jidong Jia and Hong You
    Citation: Stem Cell Research & Therapy 2017 8:183
  28. Neovascularization is impaired in diabetes mellitus, which leads to the development of peripheral arterial disease and is mainly attributed to the dysfunction of endothelial progenitor cells (EPCs). Previous s...

    Authors: Jinzhi You, Jiacheng Sun, Teng Ma, Ziying Yang, Xu Wang, Zhiwei Zhang, Jingjing Li, Longgang Wang, Masaaki Ii, Junjie Yang and Zhenya Shen
    Citation: Stem Cell Research & Therapy 2017 8:182
  29. A hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome. However, the optimum oxygen partial press...

    Authors: Sang Chul Lee, Kee-Hwan Kim, Ok-Hee Kim, Sang Kuon Lee, Ha-Eun Hong, Seong Su Won, Sang-Jin Jeon, Byung Jo Choi, Wonjun Jeong and Say-June Kim
    Citation: Stem Cell Research & Therapy 2017 8:181
  30. Surfactant therapy has become the standard of care for preterm infants with respiratory distress syndrome. Preclinical studies have reported the therapeutic benefits of mesenchymal stem cells (MSCs) in experim...

    Authors: Chung-Ming Chen, Hsiu-Chu Chou, Willie Lin and Chris Tseng
    Citation: Stem Cell Research & Therapy 2017 8:180
  31. Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and s...

    Authors: Laura Tomasello, Rodolfo Mauceri, Antonina Coppola, Maria Pitrone, Giuseppe Pizzo, Giuseppina Campisi, Giuseppe Pizzolanti and Carla Giordano
    Citation: Stem Cell Research & Therapy 2017 8:179
  32. Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) i...

    Authors: Shihong Lu, Meili Ge, Yizhou Zheng, Jianping Li, Xiaoming Feng, Sizhou Feng, Jinbo Huang, Ying Feng, Donglin Yang, Jun Shi, Fang Chen and Zhongchao Han
    Citation: Stem Cell Research & Therapy 2017 8:178
  33. Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal ...

    Authors: Maria Beatriz Herrera Sanchez, Sara Previdi, Stefania Bruno, Valentina Fonsato, Maria Chiara Deregibus, Sharad Kholia, Sara Petrillo, Emanuela Tolosano, Rossana Critelli, Marco Spada, Renato Romagnoli, Mauro Salizzoni, Ciro Tetta and Giovanni Camussi
    Citation: Stem Cell Research & Therapy 2017 8:176
  34. Dental pulp represents an easily accessible autologous source of adult stem cells. A subset of these cells, named dental pulp pluripotent-like stem cells (DPPSC), shows high plasticity and can undergo multiple...

    Authors: Ester Martínez-Sarrà, Sheyla Montori, Carlos Gil-Recio, Raquel Núñez-Toldrà, Domiziana Costamagna, Alessio Rotini, Maher Atari, Aernout Luttun and Maurilio Sampaolesi
    Citation: Stem Cell Research & Therapy 2017 8:175
  35. Human adult stem cells hold the potential for the cure of numerous conditions and degenerative diseases. They possess major advantages over pluripotent stem cells as they can be derived from donors at any age,...

    Authors: Raju Khatri, Michal Arad, Timothy Ortlip, Benjamin A. Portney, W. Alex Meltzer, Silviu Diaconu, Lorna E. Silipino, Ying Wang, David M. Kaetzel, Rodney J. Taylor and Michal Zalzman
    Citation: Stem Cell Research & Therapy 2017 8:174
  36. Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. Transplantation of human amniotic epithelial cells (hAECs) improves ovarian function...

    Authors: Chenyue Ding, Hong Li, Yun Wang, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Wei Wang and Boxian Huang
    Citation: Stem Cell Research & Therapy 2017 8:173
  37. Transplantation of insulin-producing cells is considered an important diabetes therapy. Many research studies have shown that insulin-producing cells can be derived from the in-vitro cultured pancreatic coloni...

    Authors: Dongshen Ma, Shanshan Tang, Jing Song, Qiong Wu, Fangfang Zhang, Yun Xing, Yi Pan, Yanfeng Zhang, Jingwei Jiang, Yubin Zhang and Liang Jin
    Citation: Stem Cell Research & Therapy 2017 8:172
  38. Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties. We have shown previously that minocycline enhances ...

    Authors: Alberto Daniel Guerra, Warren E. Rose, Peiman Hematti and W. John Kao
    Citation: Stem Cell Research & Therapy 2017 8:171
  39. Keloid is one kind of benign skin disease caused by hyperplasia of fibroblasts and collagen fibrils. It is refractory due to the lack of an effective treatment at present, which puts pressure on seeking a new ...

    Authors: Ya Jiao, Xiao Wang, Jixun Zhang, Yongjun Qi, Hongmin Gong and Duyin Jiang
    Citation: Stem Cell Research & Therapy 2017 8:170
  40. Accumulated evidence supports the potent stimulating effects of multiple small molecules on the expansion of hematopoietic stem cells (HSCs) which are important for the therapy of various hematological disorde...

    Authors: Lan Wang, Xin Guan, Huihui Wang, Bin Shen, Yu Zhang, Zhihua Ren, Yupo Ma, Xinxin Ding and Yongping Jiang
    Citation: Stem Cell Research & Therapy 2017 8:169

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:458

  41. Mesenchymal stem cells (MSCs) represent an important source for cell therapy in regenerative medicine. MSCs have shown promising results for repair of damaged tissues in various degenerative diseases in animal...

    Authors: Amruta Barhanpurkar-Naik, Suhas T. Mhaske, Satish T. Pote, Kanupriya Singh and Mohan R. Wani
    Citation: Stem Cell Research & Therapy 2017 8:168
  42. Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where pancreatic beta cells are lost before the clinical manifestations of the disease. Administration of mesenchymal stem cells (MSCs) or MSCs dif...

    Authors: Anshu Sharma and Rajni Rani
    Citation: Stem Cell Research & Therapy 2017 8:167
  43. Equine mesenchymal stromal/stem cells (MSCs) are most commonly harvested from bone marrow (BM) or adipose tissue, requiring the use of surgical procedures. By contrast, the uterus can be accessed nonsurgically...

    Authors: B. Elisabeth Rink, Karin R. Amilon, Cristina L. Esteves, Hilari M. French, Elaine Watson, Christine Aurich and F. Xavier Donadeu
    Citation: Stem Cell Research & Therapy 2017 8:166
  44. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, acts as an inhibitor of angiogenesis and is associated with an increased risk of cardiovascular mortality. Administration o...

    Authors: Juraj Madaric, Martina Valachovicova, Ludovit Paulis, Jana Pribojova, Renata Mateova, Katarina Sebekova, Luba Postulkova, Terezia Madaricova, Maria Bucova, Martin Mistrik and Ivan Vulev
    Citation: Stem Cell Research & Therapy 2017 8:165
  45. Mesenchymal stem cells (MSCs) migrate via the bloodstream to sites of injury and are possibly attracted by inflammatory factors. As a proinflammatory mediator, angiotensin II (Ang II) reportedly enhances the m...

    Authors: Xiu-ping Xu, Hong-li He, Shu-ling Hu, Ji-bin Han, Li-li Huang, Jing-yuan Xu, Jian-feng Xie, Ai-ran Liu, Yi Yang and Hai-bo Qiu
    Citation: Stem Cell Research & Therapy 2017 8:164
  46. Blood-brain barrier impairment is a major indicator of endothelial dysfunction in diabetes. Studies showed that endothelial progenitor cell (EPC) transplantation promoted angiogenesis and improved function rec...

    Authors: Jieli Geng, Liping Wang, Meijie Qu, Yaying Song, Xiaojie Lin, Yajing Chen, Muyassar Mamtilahun, Shengdi Chen, Zhijun Zhang, Yongting Wang and Guo-Yuan Yang
    Citation: Stem Cell Research & Therapy 2017 8:163
  47. Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has emerged as a novel therapy for acute liver failure (ALF). However, the homing efficiency of BMSCs to the injured liver sites appears to...

    Authors: Kun Wang, Yuwen Li, Tiantian Zhu, Yongting Zhang, Wenting Li, Wenyu Lin, Jun Li and Chuanlong Zhu
    Citation: Stem Cell Research & Therapy 2017 8:162
  48. The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available ...

    Authors: Léonore Avercenc-Léger, Philippe Guerci, Jean-Marc Virion, Ghislaine Cauchois, Sébastien Hupont, Rachid Rahouadj, Jacques Magdalou, Jean-François Stoltz, Danièle Bensoussan, Céline Huselstein and Loïc Reppel
    Citation: Stem Cell Research & Therapy 2017 8:161
  49. Human embryonic stem cells (hESCs) potentially offer new routes to study, on the basis of the Developmental Origins of Health and Disease (DOHaD) concept, how the maternal environment during pregnancy influenc...

    Authors: Maria Barandalla, Hui Shi, Hui Xiao, Silvia Colleoni, Cesare Galli, Pietro Lio, Matthew Trotter and Giovanna Lazzari
    Citation: Stem Cell Research & Therapy 2017 8:160

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