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  1. Primordial germ cells (PGCs) are the major population of cells in the developing bilateral embryonic gonads. Little is known about the cellular responses of PGCs after treatment with toxic chemicals such as bu...

    Authors: Hyung Chul Lee, Sung Kyu Kim, Tae Sub Park, Deivendran Rengaraj, Kyung Je Park, Hong Jo Lee, Soo Bong Park, Sung Woo Kim, Seong Bok Choi and Jae Yong Han
    Citation: Stem Cell Research & Therapy 2013 4:136
  2. Advanced atherosclerotic lesions are characterized by lipid accumulation, inflammation, and defective efferocytosis. An ideal therapy should address all aspects of this multifactorial disease. Ixmyelocel-T the...

    Authors: Kelly J Ledford, Nikki Murphy, Frank Zeigler and Ronnda L Bartel
    Citation: Stem Cell Research & Therapy 2013 4:135
  3. M2 macrophages promote tissue repair and regeneration through various mechanisms including immunomodulation and scavenging of tissue debris. Delivering increased numbers of these cells to ischemic tissues may ...

    Authors: Kelly J Ledford, Frank Zeigler and Ronnda L Bartel
    Citation: Stem Cell Research & Therapy 2013 4:134
  4. While amniotic mesenchymal cells have been isolated and characterized in different species, amniotic epithelial cells (AECs) have been found only in humans and horses and are recently considered valid candidat...

    Authors: Lucia Rutigliano, Bruna Corradetti, Luisa Valentini, Davide Bizzaro, Aurora Meucci, Fausto Cremonesi and Anna Lange-Consiglio
    Citation: Stem Cell Research & Therapy 2013 4:133
  5. High expression of aldehyde dehydrogenase1A1 (ALDH1A1) is observed in many organs and tumors and may identify benign and cancer stem cell populations.

    Authors: Kalyan J Gangavarapu, Gissou Azabdaftari, Carl D Morrison, Austin Miller, Barbara A Foster and Wendy J Huss
    Citation: Stem Cell Research & Therapy 2013 4:132
  6. Murine models of hind-limb ischemia are frequently used to assess interventions aimed at improving therapeutic angiogenesis in critical limb ischemia. Much of the current focus of angiogenesis lies with mesenc...

    Authors: Garry P Duffy and Caroline C Herron
    Citation: Stem Cell Research & Therapy 2013 4:131
  7. Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat on the short arm of chromosome 4 resulting in cognitive decline, motor dysfunction, and death, typically occurring 1...

    Authors: Kyle D Fink, Julien Rossignol, Andrew T Crane, Kendra K Davis, Matthew C Bombard, Angela M Bavar, Steven Clerc, Steven A Lowrance, Cheng Song, Laurent Lescaudron and Gary L Dunbar
    Citation: Stem Cell Research & Therapy 2013 4:130
  8. Mesenchymal stem cells (MSCs) have immunosuppressive activity. They do not induce allospecific T cell responses, making them promising tools for reducing the severity of graft versus host disease (GVHD) as wel...

    Authors: Cristina Nazarov, Jessica Lo Surdo, Steven R Bauer and Cheng-Hong Wei
    Citation: Stem Cell Research & Therapy 2013 4:128
  9. The development of an appropriate procedure for lentiviral gene transduction into keratinocyte stem cells is crucial for stem cell biology and regenerative medicine for genetic disorders of the skin. However, ...

    Authors: Daisuke Nanba, Natsuki Matsushita, Fujio Toki and Shigeki Higashiyama
    Citation: Stem Cell Research & Therapy 2013 4:127
  10. The application of mesenchymal stem cells (MSCs) in treating rheumatoid arthritis (RA) has been made possible by the immunosuppressive and differentiation abilities of these cells. A non-invasive means of asse...

    Authors: Hareklea Markides, Oksana Kehoe, Robert H Morris and Alicia J El Haj
    Citation: Stem Cell Research & Therapy 2013 4:126
  11. The ability to self-renew, be easily expanded in vitro and differentiate into different mesenchymal tissues, render mesenchymal stem cells (MSCs) an attractive therapeutic method for degenerative diseases. The su...

    Authors: Andreia Ribeiro, Paula Laranjeira, Sandrine Mendes, Isabel Velada, Cristiana Leite, Pedro Andrade, Francisco Santos, Ana Henriques, Mário Grãos, Carla M P Cardoso, António Martinho, M Luísa Pais, Cláudia Lobato da Silva, Joaquim Cabral, Hélder Trindade and Artur Paiva
    Citation: Stem Cell Research & Therapy 2013 4:125
  12. Ovarian dysfunction frequently occurs in female cancer patients after chemotherapy, but human amniotic epithelial cells (hAECs) that can differentiate into cell types that arise from all three germ layers may ...

    Authors: Fangyuan Wang, Li Wang, Xiaofen Yao, Dongmei Lai and Lihe Guo
    Citation: Stem Cell Research & Therapy 2013 4:124
  13. Administration of bone marrow-derived cells produces beneficial effects in experimental extrapulmonary acute respiratory distress syndrome (ARDS). However, there are controversies regarding the effects of timi...

    Authors: Tatiana Maron-Gutierrez, Johnatas Dutra Silva, Fernanda Ferreira Cruz, Samantha Alegria, Debora Gonçalves Xisto, Edson Fernandes Assis, Hugo Caire Castro-Faria-Neto, Claudia Chimisso Dos Santos, Marcelo Marcos Morales and Patricia Rieken Macedo Rocco
    Citation: Stem Cell Research & Therapy 2013 4:123
  14. On 23 May 2013, the Italian health minister decided to endorse a law regarding controversial stem cell-based therapies in 32 young terminally ill patients, shocking many scientists. According to the internatio...

    Authors: Paola Frati, Giacomo Frati, Matteo Gulino, Gianluca Montanari Vergallo, Alessandro Di Luca and Vittorio Fineschi
    Citation: Stem Cell Research & Therapy 2013 4:122
  15. Tissue factor (TF) is expressed in various types of cells. TF expression is essential for many biological processes, such as blood coagulation and embryonic development, while its high expression in stem cells...

    Authors: Yan-Hui Yu, Deng-Shu Wu, Fang-Fang Huang, Zheng Zhang, Lin-Xin Liu, Jian Zhang, Hui-En Zhan, Min-Yuan Peng, Hui Zeng and Fang-Ping Chen
    Citation: Stem Cell Research & Therapy 2013 4:121
  16. Cell supplementation to the herniated or degenerated intervertebral disc (IVD) is a potential strategy to promote tissue regeneration and slow disc pathology. Human umbilical cord mesenchymal stromal cells (HU...

    Authors: Brian H Chon, Esther J Lee, Liufang Jing, Lori A Setton and Jun Chen
    Citation: Stem Cell Research & Therapy 2013 4:120
  17. The standard procedure for the osteogenic differentiation of multipotent stem cells is treatment of a confluent monolayer with a cocktail of dexamethasone (Dex), ascorbic acid (Asc) and β-glycerophosphate (β-G...

    Authors: Fabian Langenbach and Jörg Handschel
    Citation: Stem Cell Research & Therapy 2013 4:117
  18. Rat middle cerebral artery occlusion (MCAO) model is the most commonly used animal model in ischemic stroke studies. In the model, to increase the amount of stem cells or drugs to enter the brain after deliver...

    Authors: Ling Guo, Jianfeng Ge, Shan Wang, Ying Zhou, Xiaoxiao Wang and Yaojiong Wu
    Citation: Stem Cell Research & Therapy 2013 4:116
  19. Studying cancer tumors’ microenvironment may reveal a novel role in driving cancer progression and metastasis. The biological interaction between stromal (mesenchymal) stem cells (MSCs) and cancer cells remain...

    Authors: Mashael Al-toub, Abdulaziz Almusa, Mohammed Almajed, May Al-Nbaheen, Moustapha Kassem, Abdullah Aldahmash and Nehad M Alajez
    Citation: Stem Cell Research & Therapy 2013 4:114
  20. Treatment of chronic skin wounds is difficult and largely ineffective. Little improvement has been shown in promoting the healing of these wounds in the past few decades. Innovative treatments to enhance chron...

    Authors: Yunling Li, Lei Zheng, Xia Xu, Lili Song, Yin Li, Wei Li, Suhan Zhang, Feng Zhang and Haiyan Jin
    Citation: Stem Cell Research & Therapy 2013 4:113
  21. Knowing the repertoire of cell signaling receptors would provide pivotal insight into the developmental and regenerative capabilities of bone marrow cell (BMC)-derived hematopoietic stem/progenitor cells (HSPC...

    Authors: Khairul Anam and Thomas A Davis
    Citation: Stem Cell Research & Therapy 2013 4:112
  22. Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue ...

    Authors: Ikiru Atsuta, Shiyu Liu, Yasuo Miura, Kentaro Akiyama, Chider Chen, Ying An, Songtao Shi and Fa-Ming Chen
    Citation: Stem Cell Research & Therapy 2013 4:111
  23. MicroRNA-21 (miR-21) functions have been linked to cancer progression and chemo- or radiotherapy resistance. While an increasing number of studies have reported a potential role of miR-21 expression in promoti...

    Authors: Hong-Yo Kang
    Citation: Stem Cell Research & Therapy 2013 4:110
  24. Microspheres fabricated from natural materials serve as a promising biodegradable and biocompatible carrier in a small volume for efficient cell delivery to the lesion of the injured neural tissue to generate ...

    Authors: Li Yao, Francis Phan and Yongchao Li
    Citation: Stem Cell Research & Therapy 2013 4:109
  25. Bones adapt to accommodate the physical forces they experience through changes in architecture and mass. Stem cells differentiate into bone-forming osteoblasts, and mechanical stimulation is involved in this p...

    Authors: Julia C Chen and Christopher R Jacobs
    Citation: Stem Cell Research & Therapy 2013 4:107
  26. Advances in the fields of stem cell biology, biomaterials, and tissue engineering over the last decades have brought the possibility of constructing tissue substitutes with a broad range of applications in reg...

    Authors: Giuseppe Maria de Peppo and Darja Marolt
    Citation: Stem Cell Research & Therapy 2013 4:106
  27. To stimulate healing of large bone defects research has concentrated on the application of mesenchymal stem cells (MSCs).

    Authors: Johannes C Reichert, Jonas Schmalzl, Patrick Prager, Fabian Gilbert, Verena MC Quent, Andre F Steinert, Maximilian Rudert and Ulrich Nöth
    Citation: Stem Cell Research & Therapy 2013 4:105
  28. Potential stem cell niches (SNs) were recently reported in intervertebral discs (IVDs) and knee joints (KJs) in different mammals (located adjacent to the epiphyseal plate; EP). The aim here was to examine fur...

    Authors: Helena Barreto Henriksson, Anders Lindahl, Eva Skioldebrand, Katarina Junevik, Carolina Tängemo, Johan Mattsson and Helena Brisby
    Citation: Stem Cell Research & Therapy 2013 4:104
  29. The apoptosis and subsequent injury of podocytes plays a pathogenic role in diabetic nephropathy (DN). Mesenchymal stem cells (MSCs) are promising therapeutic cells for preventing apoptosis and reducing cellul...

    Authors: Diangeng Li, Nan Wang, Li Zhang, Zhu Hanyu, Bai Xueyuan, Bo Fu, Cui Shaoyuan, Weiguang Zhang, Sun Xuefeng, Rongshan Li and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2013 4:103
  30. Human neural stem cell transplants have potential as therapeutic candidates to treat a vast number of disorders of the central nervous system (CNS). StemCells, Inc. has purified human neural stem cells and dev...

    Authors: Ann Tsukamoto, Nobuko Uchida, Alexandra Capela, Thorsten Gorba and Stephen Huhn
    Citation: Stem Cell Research & Therapy 2013 4:102
  31. Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in d...

    Authors: Nathalie De Vocht, Jelle Praet, Kristien Reekmans, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Zwi Berneman, Annemie Van der Linden and Peter Ponsaerts
    Citation: Stem Cell Research & Therapy 2013 4:101
  32. Twenty years ago glial cells were shown to contribute to neuronal information processing, instead of merely supporting neuronal function, thus challenging the century old neuron doctrine. Due to the lack of ap...

    Authors: Sonia Spitzer, Sylvia Agathou and Ragnhildur Thora Karadottir
    Citation: Stem Cell Research & Therapy 2013 4:100
  33. Guided migration of chondrogenically differentiated cells has not been well studied, even though it may be critical for growth, repair, and regenerative processes. The chemokine CCL25 is believed to play a cri...

    Authors: Mujib Ullah, Jan Eucker, Michael Sittinger and Jochen Ringe
    Citation: Stem Cell Research & Therapy 2013 4:99
  34. Heart diseases remain a major cause of mortality and morbidity worldwide. However, terminally differentiated human adult cardiomyocytes (CMs) possess a very limited innate ability to regenerate. Directed diffe...

    Authors: Maggie Zi Chow, Kenneth R Boheler and Ronald A Li
    Citation: Stem Cell Research & Therapy 2013 4:97
  35. Vascularization remains one of the primary obstacles in the repair of bone defects. In the previous issue of Stem Cell Research & Therapy, Pedersen and colleagues show that co-immobilization of endothelial cells ...

    Authors: Meadhbh Aín Brennan, Jean-Michel Davaine and Pierre Layrolle
    Citation: Stem Cell Research & Therapy 2013 4:96
  36. Retinal Müller cells exhibit the characteristics of retinal progenitor cells, and differentiate into ganglion cells under certain conditions. However, the number of ganglion cells differentiated from retinal M...

    Authors: Wei-tao Song, Xue-yong Zhang and Xiao-bo Xia
    Citation: Stem Cell Research & Therapy 2013 4:94
  37. Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous hea...

    Authors: Danielle Drury-Stewart, Mingke Song, Osama Mohamad, Ying Guo, Xiaohuan Gu, Dongdong Chen and Ling Wei
    Citation: Stem Cell Research & Therapy 2013 4:93
  38. Multipotent mesenchymal stromal cells (MSCs) have gained considerable interest because of their potential use in the treatment of a variety of diseases and injuries. Although remarkable advancements have been ...

    Authors: Carolina Soares Barros Melo, Jerusa Araújo Quintão Arantes Faria, Natássia Caroline Resende Corrêa, Carolina de Andrade, Juliana Lott Carvalho, Alfredo M Goes, Michele A Rodrigues and Dawidson Assis Gomes
    Citation: Stem Cell Research & Therapy 2013 4:92
  39. Adipose-derived stem cells (ADSCs) have been isolated, expanded, and applied in the treatment of many diseases. ADSCs have also been used to treat injured articular cartilage. However, there is controversy reg...

    Authors: Phuc Van Pham, Khanh Hong-Thien Bui, Dat Quoc Ngo, Ngoc Bich Vu, Nhung Hai Truong, Nhan Lu-Chinh Phan, Dung Minh Le, Triet Dinh Duong, Thanh Duc Nguyen, Vien Tuong Le and Ngoc Kim Phan
    Citation: Stem Cell Research & Therapy 2013 4:91
  40. Experimental evidence has indicated a role of adult renal progenitor cells in kidney regeneration and a protective role of the kidney by erythropoietin (EPO) and suramin in animal models and in humans after ac...

    Authors: Pei-Rong Wang
    Citation: Stem Cell Research & Therapy 2013 4:89
  41. Resistance of cancer stem/progenitor cells (CSPCs) to chemotherapy can lead to cancer relapse. Ovarian teratocarcinoma (OVTC) arises from germ cells and comprises pluripotent cells that can be used to study ca...

    Authors: Wei-Min Chung, Wei-Chun Chang, Lumin Chen, Ying-Yi Chang, Chih-Rong Shyr, Yao-Ching Hung and Wen-Lung Ma
    Citation: Stem Cell Research & Therapy 2013 4:88
  42. BALB/c mice and C57/BL6 mice have different abilities to recover from ischemia. C57/BL6 mice display increased vessel collateralization and vascular endothelial growth factor expression with a consequent rapid...

    Authors: Flavia Franco Cunha, Leonardo Martins, Priscila Keiko Matsumoto Martin, Roberta Sessa Stilhano and Sang Won Han
    Citation: Stem Cell Research & Therapy 2013 4:86

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