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  1. Infected bone defect poses a great challenge for orthopedists because it is difficult to cure. Tissue-engineered bone based on the human mesenchymal stem cells (hMSCs), has currently taken a promising treatmen...

    Authors: Hai Wang, Xiao-Qing He, Tao Jin, Yang Li, Xin-Yu Fan, Yi Wang and Yong-Qing Xu
    Citation: Stem Cell Research & Therapy 2016 7:18
    Content type: Research Published on:

  2. Human induced pluripotent stem (hiPS) cells have the ability to undergo self-renewal and differentiation similarly to human embryonic stem (hES) cells. We have recently shown that hES cells under replication s...

    Authors: Joelle A. Desmarais, Christian Unger, Ivan Damjanov, Mark Meuth and Peter Andrews
    Citation: Stem Cell Research & Therapy 2016 7:17
    Content type: Short report Published on:

  3. Bone formation and remodeling are influenced by the inflammatory state of the local microenvironment. In this regard, macrophages are postulated to play a crucial role in modulating osteogenesis. However, the ...

    Authors: Florence Loi, Luis A. Córdova, Ruth Zhang, Jukka Pajarinen, Tzu-hua Lin, Stuart B. Goodman and Zhenyu Yao
    Citation: Stem Cell Research & Therapy 2016 7:15
    Content type: Research Published on:

  4. Type 1 diabetes mellitus (T1D) is characterized by autoimmune responses resulting in destruction of insulin-producing pancreatic beta cells. Multipotent mesenchymal stromal cells (MSCs) exhibit immunomodulator...

    Authors: Juliana Navarro Ueda Yaochite, Kalil Willian Alves de Lima, Carolina Caliari-Oliveira, Patricia Vianna Bonini Palma, Carlos Eduardo Barra Couri, Belinda Pinto Simões, Dimas Tadeu Covas, Júlio César Voltarelli, Maria Carolina Oliveira, Eduardo Antônio Donadi and Kelen Cristina Ribeiro Malmegrim
    Citation: Stem Cell Research & Therapy 2016 7:14
    Content type: Research Published on:

  5. A dynamic vasculature is a prerequisite for bone formation where the interaction of bone cells and endothelial cells is essential for both the development and the healing process of bone. Enhanced understandin...

    Authors: Stefanie Inglis, David Christensen, David I. Wilson, Janos M. Kanczler and Richard O. C. Oreffo
    Citation: Stem Cell Research & Therapy 2016 7:13
    Content type: Research Published on:

  7. Neural stem cells for the treatment of spinal cord injury (SCI) are of particular interest for future therapeutic use. However, until now, stem cell therapies are often limited due to the inhibitory environmen...

    Authors: Jennifer Butenschön, Tina Zimmermann, Nikolai Schmarowski, Robert Nitsch, Barbara Fackelmeier, Kevin Friedemann, Konstantin Radyushkin, Jan Baumgart, Beat Lutz and Julia Leschik
    Citation: Stem Cell Research & Therapy 2016 7:11
    Content type: Research Published on:

  8. Amelogenin is an extracellular matrix protein well known for its role in the organization and mineralization of enamel. Clinically, it is used for periodontal regeneration and, due to its finding also in prede...

    Authors: Iris Frasheri, Christina Ern, Christian Diegritz, Reinhard Hickel, Michael Hristov and Matthias Folwaczny
    Citation: Stem Cell Research & Therapy 2016 7:10
    Content type: Research Published on:

  10. Amnion-derived stem cells have been proposed for cell replacement therapy and tissue regeneration. An easily accessible cell source, the placenta, allows us to potentially establish a bio-bank of cells for imm...

    Authors: Toshio Miki, Wisia Wong, Elton Zhou, Anthony Gonzalez, Irving Garcia and Brendan H. Grubbs
    Citation: Stem Cell Research & Therapy 2016 7:8
    Content type: Research Published on:

  12. Mesenchymal stromal cells (MSCs) are well known for their application potential in tissue engineering. We previously reported that MSCs are able to differentiate into hepatocytes in vitro. However, conventiona...

    Authors: Hao-Hsiang Wu, Jennifer H. Ho and Oscar K. Lee
    Citation: Stem Cell Research & Therapy 2016 7:6
    Content type: Research Published on:

  13. Adipose-derived mesenchymal stem cells (MSCs) have been gaining fame mainly due to their vast clinical potential, simple isolation methods and minimal donor site morbidity. Adipose-derived MSCs and microvascul...

    Authors: Alina Freiman, Yulia Shandalov, Dekel Rozenfeld, Erez Shor, Sofia Segal, Dror Ben-David, Shai Meretzki, Dana Egozi and Shulamit Levenberg
    Citation: Stem Cell Research & Therapy 2016 7:5
    Content type: Research Published on:

  14. Identification of surface markers for prospective isolation of functionally homogenous populations of human skeletal (stromal, mesenchymal) stem cells (hMSCs) is highly relevant for cell therapy protocols. Thu...

    Authors: Linda Harkness, Walid Zaher, Nicholas Ditzel, Adiba Isa and Moustapha Kassem
    Citation: Stem Cell Research & Therapy 2016 7:4
    Content type: Research Published on:

  15. Expansion protocols aim at both increasing the number of umbilical cord blood (UCB) hematopoietic stem cells and progenitor cells (HSPCs) and reducing the period of neutropenia in UCB HSPC graft. Because glyco...

    Authors: Lionel Faivre, Véronique Parietti, Fernando Siñeriz, Sandrine Chantepie, Marie Gilbert-Sirieix, Patricia Albanese, Jérôme Larghero and Valérie Vanneaux
    Citation: Stem Cell Research & Therapy 2016 7:3
    Content type: Research Published on:

  16. Many retinal degenerative diseases are caused by the loss of retinal ganglion cells (RGCs). Autosomal dominant optic atrophy is the most common hereditary optic atrophy disease and is characterized by central ...

    Authors: Jing Chen, Hamidreza Riazifar, Min-Xin Guan and Taosheng Huang
    Citation: Stem Cell Research & Therapy 2016 7:2
    Content type: Research Published on:

  17. Multiple sclerosis is a demyelinating disease mostly of autoimmune origin that affects and damages the central nervous system, leading to a disabling condition. The aim of the present study was to investigate ...

    Authors: Oriana Trubiani, Sabrina Giacoppo, Patrizia Ballerini, Francesca Diomede, Adriano Piattelli, Placido Bramanti and Emanuela Mazzon
    Citation: Stem Cell Research & Therapy 2016 7:1
    Content type: Research Published on:

  18. The use of mesenchymal stem cells (MSCs) to treat inflammatory bowel disease (IBD) is of great interest because of their immunomodulatory properties. Damage to the enteric nervous system (ENS) is implicated in...

    Authors: Rhian Stavely, Ainsley M. Robinson, Sarah Miller, Richard Boyd, Samy Sakkal and Kulmira Nurgali
    Citation: Stem Cell Research & Therapy 2015 6:263
    Content type: Research Published on:

  19. Although metformin, a first-line drug for treating diabetes, may play an important role in inhibition of epithelial ovarian cancer cell growth and cancer stem cells (CSCs), metformin at low dose showed less ef...

    Authors: Rongrong Zhang, Ping Zhang, Hong Wang, Dongming Hou, Wentao Li, Guishan Xiao and Chenwei Li
    Citation: Stem Cell Research & Therapy 2015 6:262
    Content type: Research Published on:

  20. Heterogeneity of endothelial cells (ECs) is a hallmark of the vascular system which may impact the development and management of vascular disorders. Despite the tremendous progress in differentiation of human ...

    Authors: Gopu Sriram, Jia Yong Tan, Intekhab Islam, Abdul Jalil Rufaihah and Tong Cao
    Citation: Stem Cell Research & Therapy 2015 6:261
    Content type: Research Published on:

  21. Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bon...

    Authors: Loïc Reppel, Jessica Schiavi, Naceur Charif, Léonore Leger, Hao Yu, Astrid Pinzano, Christel Henrionnet, Jean-François Stoltz, Danièle Bensoussan and Céline Huselstein
    Citation: Stem Cell Research & Therapy 2015 6:260
    Content type: Research Published on:

  22. Recent evidence has demonstrated that cardiac progenitor cells play an essential role in the induction of angiomyogenesis in infarcted myocardium. We and others have shown that engraftment of c-kit+ cardiac stem ...

    Authors: Yu Tina Zhao, Jianfeng Du, Youfang Chen, Yaoliang Tang, Gangjian Qin, Guorong Lv, Shougang Zhuang and Ting C. Zhao
    Citation: Stem Cell Research & Therapy 2015 6:259
    Content type: Research Published on:

  23. Adult mesenchymal stem cells (MSCs) are considered promising candidates for cell-based therapies. Their potential utility derives primarily from their immunomodulatory activity, multi-lineage differentiation p...

    Authors: Catherine M. Kolf, Lin Song, Jeannine Helm and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2015 6:258
    Content type: Research Published on:

  24. Stem cell treatment provides a promising therapy for patients with spinal cord injury (SCI). However, the applied stem cells exert their effects in different manners that are dependent on the route used for ad...

    Authors: Takashi Amemori, Jiri Ruzicka, Nataliya Romanyuk, Meena Jhanwar-Uniyal, Eva Sykova and Pavla Jendelova
    Citation: Stem Cell Research & Therapy 2015 6:257
    Content type: Research Published on:

  25. Promotion of bone regeneration is important for successful repair of bony defects. This study aimed to investigate whether combining bone marrow-derived mesenchymal stem cell (BMSC) sheets with platelet-rich p...

    Authors: Yiying Qi, Lie Niu, Tengfei Zhao, Zhongli Shi, Tuoyu Di, Gang Feng, Junhua Li and Zhongming Huang
    Citation: Stem Cell Research & Therapy 2015 6:256
    Content type: Research Published on:

  28. Mesenchymal stem cells (MSCs) harvested from cadaveric tissues represent a promising approach for regenerative medicine. To date, no study has investigated whether viable MSCs could survive in cadaveric tissue...

    Authors: Mohamad Khir Shikh Alsook, Annick Gabriel, Joëlle Piret, Olivier Waroux, Céline Tonus, Delphine Connan, Etienne Baise and Nadine Antoine
    Citation: Stem Cell Research & Therapy 2015 6:253
    Content type: Research Published on:

  29. Molecular imaging is one of the methods to follow-up stem cell therapy by visualization in the brain. In a recent article in Stem Cell Research & Therapy, Micci et al. offer a thorough discussion of the advantage...

    Authors: Nora Sandu, Tumul Chowdhury and Bernhard Schaller
    Citation: Stem Cell Research & Therapy 2015 6:252
    Content type: Commentary Published on:

  30. Adult skeletal stem cells (SSCs) often exhibit limited in vitro expansion with undesirable phenotypic changes and loss of differentiation capacity. Foetal tissues offer an alternative cell source, providing SSCs ...

    Authors: David Gothard, Kelvin Cheung, Janos M. Kanczler, David I. Wilson and Richard O. C. Oreffo
    Citation: Stem Cell Research & Therapy 2015 6:251
    Content type: Research Published on:

  31. Mesenchymal stem cells (MSCs) stabilise endothelial barrier function in acute lung injury via paracrine hepatocyte growth factor (HGF). Vascular endothelial growth factor (VEGF), which is secreted by MSCs, is ...

    Authors: Yi Yang, Qi-hong Chen, Ai-ran Liu, Xiu-ping Xu, Ji-bin Han and Hai-bo Qiu
    Citation: Stem Cell Research & Therapy 2015 6:250
    Content type: Research Published on:

  32. Periodontitis is one of the most widespread infectious diseases in humans. We previously promoted significant periodontal tissue regeneration in swine models with the transplantation of autologous periodontal ...

    Authors: Yu Cao, Zhenhai Liu, Yilin Xie, Jingchao Hu, Hua Wang, Zhipeng Fan, Chunmei Zhang, Jingsong Wang, Chu-Tse Wu and Songlin Wang
    Citation: Stem Cell Research & Therapy 2015 6:249
    Content type: Research Published on:

  33. Mesenchymal stem cells (MSCs) have been widely applied to treat various inflammatory diseases. Inflammatory cytokines can induce both apoptosis and autophagy in MSCs. However, whether autophagy plays a pro- or...

    Authors: Shipeng Dang, Zhi-ming Yu, Chang-ying Zhang, Jie Zheng, Ku-lin Li, Ying Wu, Ling-ling Qian, Zhen-yu Yang, Xiao-rong Li, Yanyun Zhang and Ru-xing Wang
    Citation: Stem Cell Research & Therapy 2015 6:247
    Content type: Research Published on:

  34. Huntington’s disease (HD) is an inherited disease that causes progressive nerve cell degeneration. It is triggered by a mutation in the HTT gene that strongly influences functional abilities and usually results i...

    Authors: Irina Kerkis, Monica Santoro Haddad, Cristiane Wenceslau Valverde and Sabina Glosman
    Citation: Stem Cell Research & Therapy 2015 6:232
    Content type: Review Published on:

  35. Hepatic cell therapy has become a viable alternative to liver transplantation for life-threatening liver diseases. However, the supply of human hepatocytes is limited due to the shortage of suitable donor orga...

    Authors: Laia Tolosa, Jérôme Caron, Zara Hannoun, Marc Antoni, Silvia López, Deborah Burks, Jose Vicente Castell, Anne Weber, Maria-Jose Gomez-Lechon and Anne Dubart-Kupperschmitt
    Citation: Stem Cell Research & Therapy 2015 6:246
    Content type: Research Published on:

  36. Systemic delivery of bone marrow-derived mesenchymal stem cells (MSC) seems to be of benefit in the treatment of multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) sustained by ...

    Authors: Federica Benvenuto, Adriana Voci, Enrico Carminati, Francesca Gualandi, Gianluigi Mancardi, Antonio Uccelli and Laura Vergani
    Citation: Stem Cell Research & Therapy 2015 6:245
    Content type: Research Published on:

  37. Mesenchymal stem cells (MSCs) have been identified as a viable treatment for inflammatory bowel disease (IBD). MSCs derived from bone marrow (BM-MSCs) have predominated in experimental models whereas the major...

    Authors: Rhian Stavely, Ainsley M. Robinson, Sarah Miller, Richard Boyd, Samy Sakkal and Kulmira Nurgali
    Citation: Stem Cell Research & Therapy 2015 6:244
    Content type: Research Published on:

  38. For expansion of human mesenchymal stem cells (MSCs), autologous human serum is safer than fetal bovine serum in clinical situations. One of the problems with the use of autologous human serum is that its prol...

    Authors: Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yukie Matsumoto, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Akifumi Matsuyama and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2015 6:243
    Content type: Research Published on:

  39. Human mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into fat, muscle, bone and cartilage cells. Exposure of subcutaneous abdominal adipose tissue derived AD-MSCs to high glucose (H...

    Authors: Sabyasachi Sen, Cleyton C. Domingues, Carol Rouphael, Cyril Chou, Chul Kim and Nagendra Yadava
    Citation: Stem Cell Research & Therapy 2015 6:242
    Content type: Research Published on:

  40. The use of stem cells from adipose tissue or adipose-derived stem cells (ASCs) in regenerative medicine could be an interesting alternative to bone marrow stem cells because they are easily accessible and avai...

    Authors: Jonathan Rodriguez, Fabien Boucher, Charlotte Lequeux, Audrey Josset-Lamaugarny, Ondine Rouyer, Orianne Ardisson, Héléna Rutschi, Dominique Sigaudo-Roussel, Odile Damour and Ali Mojallal
    Citation: Stem Cell Research & Therapy 2015 6:241
    Content type: Research Published on:

  42. Treating a myocardial infarction (MI), the most frequent cause of death worldwide, remains one of the most exciting medical challenges in the 21st century. Cardiac tissue engineering, a novel emerging treatmen...

    Authors: Isaac Perea-Gil, Cristina Prat-Vidal and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2015 6:248
    Content type: Review Published on:

  43. Pathophysiological changes associated with chronic kidney disease impair angiogenic processes and increase renal fibrosis. Progenitor-like cells derived from adult kidney have been previously used to promote r...

    Authors: CL Chen, KJ Chou, HC Fang, CY Hsu, WC Huang, CW Huang, CK Huang, HY Chen and PT Lee
    Citation: Stem Cell Research & Therapy 2015 6:239
    Content type: Research Published on:

  44. Extracellular vesicles (EVs) are a heterogeneous population of naturally occurring secreted small vesicles, with distinct biophysical properties and different functions both in physiology and under pathologica...

    Authors: Almudena Fuster-Matanzo, Florian Gessler, Tommaso Leonardi, Nunzio Iraci and Stefano Pluchino
    Citation: Stem Cell Research & Therapy 2015 6:227
    Content type: Review Published on:

  45. Stem cells are considered an important resource for tissue repair and regeneration. Their utilization in regenerative medicine will be aided by mechanistic insight into their responsiveness to external stimuli...

    Authors: Natasha Baker, Jihee Sohn and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2015 6:238
    Content type: Research Published on:

  46. Mesenchymal stem/stromal cells (MSCs) improve the metabolic function of co-cultured hepatocytes. The present study aimed to further enhance the trophic effects of co-culture with hepatocytes using hypoxic prec...

    Authors: Harry H. Qin, Céline Filippi, Song Sun, Sharon Lehec, Anil Dhawan and Robin D. Hughes
    Citation: Stem Cell Research & Therapy 2015 6:237
    Content type: Research Published on:

  47. The inherent immunomodulatory capacity of mesenchymal stem/progenitor cells (MSPCs) encouraged initiation of multiple clinical trials. Release criteria for therapeutic MSPCs cover identity, purity and safety b...

    Authors: Nina Ketterl, Gabriele Brachtl, Cornelia Schuh, Karen Bieback, Katharina Schallmoser, Andreas Reinisch and Dirk Strunk
    Citation: Stem Cell Research & Therapy 2015 6:236
    Content type: Method Published on:

  48. Bone marrow-derived mesenchymal stem cells (BM-MSCs) for clinical use should not be grown in media containing fetal bovine serum (FBS), because of serum-related concerns over biosafety and batch-to-batch varia...

    Authors: Rubie Rakian, Travis J. Block, Shannan M. Johnson, Milos Marinkovic, Junjie Wu, Qiuxia Dai, David D. Dean and Xiao-Dong Chen
    Citation: Stem Cell Research & Therapy 2015 6:235
    Content type: Research Published on:

  49. Mesenchymal stem cells (MSCs) are ideal for cell-based therapy in various inflammatory diseases because of their immunosuppressive and tissue repair properties. Moreover, their immunosuppressive properties and...

    Authors: Jun Zhang, Xiaowen Huang, Haijun Wang, Xiaoyan Liu, Tao Zhang, Yunchuan Wang and Dahai Hu
    Citation: Stem Cell Research & Therapy 2015 6:234
    Content type: Review Published on:
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