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  1. Radiation myelitis is a rather rare but devastating complication following therapeutic irradiation to neoplasms when the spinal cord is included within the radiation field. Symptoms of radiation myelitis with ...

    Authors: Jun Liang, Fan Wang, Dandan Wang, Huayong Zhang, Cheng Zhao, Shiying Wang and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2015 6:213
  2. Stem cells from adult tissues were considered for a long time as promising tools for regenerative therapy of neurological diseases, including spinal cord injuries (SCI). Indeed, mesenchymal (MSCs) and neural c...

    Authors: Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion, Bernard Rogister, Rachelle Franzen and Sabine Wislet
    Citation: Stem Cell Research & Therapy 2015 6:211

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:509

    The Editor's Note to this article has been published in Stem Cell Research & Therapy 2021 12:135

  3. Stem cells have great therapeutic potential due to their capacity for self-renewal and their potential for differentiating into multiple cell lineages. It has been recently shown that the host immune system ha...

    Authors: Yu Cao, Jimin Xiong, Shenghui Mei, Fu Wang, Zhigang Zhao, Songlin Wang and Yi Liu
    Citation: Stem Cell Research & Therapy 2015 6:210
  4. Endothelial dysfunction is found in different pathologies such as diabetes and renal and heart diseases, representing one of the major health problems. The reduced vasodilation of impaired endothelium starts a...

    Authors: Andrea Alex Schiavo, Chiara Franzin, Mattia Albiero, Martina Piccoli, Giovanna Spiro, Enrica Bertin, Luca Urbani, Silvia Visentin, Erich Cosmi, Gian Paolo Fadini, Paolo De Coppi and Michela Pozzobon
    Citation: Stem Cell Research & Therapy 2015 6:209
  5. Effective therapies for obesity and diabetes are still lacking. The aim of this study was to evaluate whether a single intravenous infusion of syngeneic adipose-derived mesenchymal stem cells (ASCs) can reduce...

    Authors: Mingjun Cao, Qingjie Pan, Huansheng Dong, Xinxu Yuan, Yang Li, Zhen Sun, Xiao Dong and Hongjun Wang
    Citation: Stem Cell Research & Therapy 2015 6:208
  6. Despite the strong appeal of ferritin as a magnetic resonance imaging (MRI) reporter for stem cell research, no attempts have been made to apply this genetic imaging reporter in stem cells in an inducible mann...

    Authors: Xiaoya He, Jinhua Cai, Bo Liu, Yi Zhong and Yong Qin
    Citation: Stem Cell Research & Therapy 2015 6:207
  7. The fate and whereabouts of the allogenic mesenchymal stem cells (MSCs) following their transplantation are not well understood. The present study investigated the fate of systemically administrated allogeneic...

    Authors: Shuo Huang, Liangliang Xu, Yuxin Sun, Yifeng Zhang and Gang Li
    Citation: Stem Cell Research & Therapy 2015 6:206
  8. The mammalian adult heart maintains a continuous, low cardiomyocyte turnover rate throughout life. Although many cardiac stem cell populations have been studied, the natural source for homeostatic repair has n...

    Authors: Iñigo Valiente-Alandi, Carmen Albo-Castellanos, Diego Herrero, Elvira Arza, Maria Garcia-Gomez, José C. Segovia, Mario Capecchi and Antonio Bernad
    Citation: Stem Cell Research & Therapy 2015 6:205
  9. Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. Administration technique is crucial and among others minimal constructs -...

    Authors: Pavel I. Makarevich, Maria A. Boldyreva, Evgeny V. Gluhanyuk, Anastasia Yu Efimenko, Konstantin V. Dergilev, Evgeny K. Shevchenko, Georgy V. Sharonov, Julia O. Gallinger, Polina A. Rodina, Stepan S. Sarkisyan, Yu-Chen Hu and Yelena V. Parfyonova
    Citation: Stem Cell Research & Therapy 2015 6:204
  10. Mesenchymal stem cells (MSCs) hold great promise for regenerative therapies in the musculoskeletal system. Although MSCs from bone marrow (BM-MSCs) and adipose tissue (AD-MSCs) have been extensively characteri...

    Authors: Joseph S. Fernandez-Moure, Bruna Corradetti, Paige Chan, Jeffrey L. Van Eps, Trevor Janecek, Pranela Rameshwar, Bradley K. Weiner and Ennio Tasciotti
    Citation: Stem Cell Research & Therapy 2015 6:203
  11. Mesenchymal stem cells (MSCs) can protect bone marrow transplantation (BMT) recipients from the lethal acute graft-versus-host disease (aGVHD) development. However, the mechanisms underlying the anti-inflammat...

    Authors: Kyoung-Woon Kim, Su-Jin Moon, Min-Jung Park, Bo-Mi Kim, Eun-Kyung Kim, Sung-Hee Lee, Eun-Jung Lee, Byung-Ha Chung, Chul-Woo Yang and Mi-La Cho
    Citation: Stem Cell Research & Therapy 2015 6:202

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:80

  12. Ex vivo expansion of umbilical cord blood (UCB) is attempted to increase cell numbers to overcome the limitation of cell dose. Presently, suspension cultures or feeder mediated co-cult...

    Authors: Darshana Kadekar, Vaijayanti Kale and Lalita Limaye
    Citation: Stem Cell Research & Therapy 2015 6:201
  13. Osteoporosis is a syndrome of excessive skeletal fragility characterized by the loss of mass and deterioration of microarchitecture in bone. Single use of aspirin or adipose-derived stromal cells (ASCs) has be...

    Authors: Hao Liu, Wei Li, Yunsong Liu, Xiao Zhang and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2015 6:200
  14. Sepsis is a clinical syndrome associated with a severe systemic inflammation induced by infection. Although different anti-microbial drugs have been used as treatments, morbidity and mortality rates remain hig...

    Authors: Francisca Alcayaga-Miranda, Jimena Cuenca, Aldo Martin, Luis Contreras, Fernando E. Figueroa and Maroun Khoury
    Citation: Stem Cell Research & Therapy 2015 6:199
  15. Cancer stem cells (CSCs) possess characteristics associated with normal stem cells, specifically the abilities to renew themselves and to give rise to all cell types (differentiation). It is assumed that induc...

    Authors: Shuqiang Yuan, Yunxin Lu, Jing Yang, Gang Chen, Sangbae Kim, Li Feng, Marcia Ogasawara, Naima Hammoudi, Weiqin Lu, Hui Zhang, Jinyun Liu, Howard Colman, Ju-Seog Lee, Xiao-Nan Li, Rui-hua Xu, Peng Huang…
    Citation: Stem Cell Research & Therapy 2015 6:198
  16. There is a clinical need for developing systemic transplantation protocols for use of human skeletal stem cells (also known bone marrow stromal stem cells) (hBMSC) in tissue regeneration. In systemic transplan...

    Authors: Rikke K. Andersen, Walid Zaher, Kenneth H. Larsen, Nicholas Ditzel, Katharina Drews, Wasco Wruck, James Adjaye, Basem M. Abdallah and Moustapha Kassem
    Citation: Stem Cell Research & Therapy 2015 6:196
  17. Mesenchymal stem cell (MSC)-based therapies have had positive outcomes both in animal models of cardiovascular diseases and in clinical patients. However, the number and function of MSCs decline during hypoxia...

    Authors: Fengyun Zhang, Jinjin Cui, Xiaojing Liu, Bo Lv, Xinxin Liu, Zulong Xie and Bo Yu
    Citation: Stem Cell Research & Therapy 2015 6:195

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:331

  18. Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases because of their immunosuppressive capacities. However, few clinical trials of MSCs have yielded satisfacto...

    Authors: Myoung Woo Lee, Somi Ryu, Dae Seong Kim, Ki Woong Sung, Hong Hoe Koo and Keon Hee Yoo
    Citation: Stem Cell Research & Therapy 2015 6:179
  19. The goal of cancer chemotherapy is targeting tumor cells and/or tumor-associated microvessels with the lowest systemic toxicity. Mesenchymal stromal cells (MSCs) are promising vehicles for selective drug deliv...

    Authors: Simone Pacioni, Quintino Giorgio D’Alessandris, Stefano Giannetti, Liliana Morgante, Ivana De Pascalis, Valentina Coccè, Arianna Bonomi, Luisa Pascucci, Giulio Alessandri, Augusto Pessina, Maria Laura Falchetti and Roberto Pallini
    Citation: Stem Cell Research & Therapy 2015 6:194
  20. The generation of functional hepatocytes is a major challenge for regenerative medicine and drug discovery. Here we show a method that facilitates generation of induced functional hepatocytes (iHeps) from adip...

    Authors: Fen Xu, Junli Liu, Jie Deng, Xiaolei Chen, Yuan Wang, Pengchao Xu, Lin Cheng, Yanli Fu, Fuyi Cheng, Yunqi Yao, Yujing Zhang, Meijuan Huang, Dechao Yu, Yuquan Wei and Hongxin Deng
    Citation: Stem Cell Research & Therapy 2015 6:193
  21. Regenerative medicine studies using autologous bone marrow mononuclear cells (BM-MNCs) have shown improved clinical outcomes that correlate to in vitro BM-MNC invasive capacity. The current Boyden-chamber assay f...

    Authors: Michael J. Rutten, Bryan Laraway, Cynthia R. Gregory, Hua Xie, Christian Renken, Charles Keese and Kenton W. Gregory
    Citation: Stem Cell Research & Therapy 2015 6:192
  22. Mesenchymal stem cells (MSCs) are widely considered to hold promise for the treatment of intervertebral disc (IVD) degeneration. However, variation in the therapeutic efficacy of MSCs is a major problem and th...

    Authors: Jongchan Ahn, Eun-mi Park, Byeong Ju Kim, Jin-Soo Kim, Bogyu Choi, Soo-Hong Lee and Inbo Han
    Citation: Stem Cell Research & Therapy 2015 6:190
  23. Mesenchymal stem cells (MSC) are well described for their role in tissue regeneration following injury. Migratory properties of endogenous or administrated MSC are critical for tissue repair processes. Platele...

    Authors: Valérie Chabot, Cécile Dromard, Angélique Rico, Alain Langonné, Julien Gaillard, Fabien Guilloton, Louis Casteilla and Luc Sensebé
    Citation: Stem Cell Research & Therapy 2015 6:188
  24. The blood–brain barrier (BBB) protects the brain against potentially neurotoxic molecules in the circulation, and loss of its integrity may contribute to disease progression in neurodegenerative conditions. Re...

    Authors: Hyun Jung Park, Jin Young Shin, Ha Na Kim, Se Hee Oh, Sook K. Song and Phil Hyu Lee
    Citation: Stem Cell Research & Therapy 2015 6:187
  25. Despite attempts to prevent brain injury during the hyperacute phase of stroke, most sufferers end up with significant neuronal loss and functional deficits. The use of cell-based therapies to recover the inju...

    Authors: Hima C. S. Abeysinghe, Laita Bokhari, Anita Quigley, Mahesh Choolani, Jerry Chan, Gregory J. Dusting, Jeremy M. Crook, Nao R. Kobayashi and Carli L. Roulston
    Citation: Stem Cell Research & Therapy 2015 6:186
  26. The prevalence of renal fibrosis is higher in older than in younger individuals. Through paracrine activity, bone marrow mesenchymal stem cell-derived microvesicles (BM-MSC-MVs) influence the process of renal ...

    Authors: Yan Wang, Bo Fu, Xuefeng Sun, Diangeng Li, Qi Huang, Weihong Zhao and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2015 6:185
  27. Allogenic dendritic cells (DCs) generated from healthy donors, who are complete or partially HLA-matched, have been used for clinical trials. One of the sources for allogenic DCs is umbilical cord blood (UCB) ...

    Authors: Jeetendra Kumar, Vaijayanti Kale and Lalita Limaye
    Citation: Stem Cell Research & Therapy 2015 6:184
  28. Therapy-associated onset of stemness-maintenance in surviving tumor-cells dictates tumor relapse/recurrence. Recently, we recognized the anti-pancreatic cancer (PC) potential of seaweed polyphenol manifolds an...

    Authors: Sheeja Aravindan, Satish Kumar Ramraj, Somasundaram T. Somasundaram, Terence S. Herman and Natarajan Aravindan
    Citation: Stem Cell Research & Therapy 2015 6:182
  29. Mesenchymal stem cells (MSCs) are adult multipotent stem cells that possess regenerative and immunomodulatory properties. They have been widely investigated as therapeutic agents for a variety of disease condi...

    Authors: Linan Liu, Shirley X. Zhang, Rangoli Aeran, Wenbin Liao, Mengrou Lu, George Polovin, Egest J. Pone and Weian Zhao
    Citation: Stem Cell Research & Therapy 2015 6:181
  30. Authors: Yang Yu, Qian Gao, Hong-cui Zhao, Rong Li, Jiang-man Gao, Ting Ding, Si-yu Bao, Yue Zhao, Xiao-fang Sun, Yong Fan and Jie Qiao
    Citation: Stem Cell Research & Therapy 2015 6:180

    The original article was published in Stem Cell Research & Therapy 2015 6:69

  31. In recent years, cancer stem cells (CSCs)/tumor initiating cells (TICs) have been identified inside different tumors. However, currently used anti-cancer therapies are mostly directed against somatic tumor cel...

    Authors: Mohammed I. Khan, Anna M. Czarnecka, Igor Helbrecht, Ewa Bartnik, Fei Lian and Cezary Szczylik
    Citation: Stem Cell Research & Therapy 2015 6:178
  32. Glaucoma is a sight-threatening retinal neuropathy associated with elevated intraocular pressure (IOP) due to degeneration and fibrosis of the trabecular meshwork (TM). Glaucoma medications aim to reduce IOP w...

    Authors: Christophe Roubeix, David Godefroy, Céline Mias, Anaïs Sapienza, Luisa Riancho, Julie Degardin, Valérie Fradot, Ivana Ivkovic, Serge Picaud, Florian Sennlaub, Alexandre Denoyer, William Rostene, José Alain Sahel, Stéphane Melik Parsadaniantz, Françoise Brignole-Baudouin and Christophe Baudouin
    Citation: Stem Cell Research & Therapy 2015 6:177
  33. Stem cell-based therapies are currently widely explored as a tool to treat neuroimmune diseases. Multipotent adult progenitor cells (MAPC) have been suggested to have strong immunomodulatory and neuroprotectiv...

    Authors: Stylianos Ravanidis, Jeroen F. J. Bogie, Raf Donders, David Craeye, Robert W. Mays, Robert Deans, Kristel Gijbels, Annelies Bronckaers, Piet Stinissen, Jef Pinxteren and Niels Hellings
    Citation: Stem Cell Research & Therapy 2015 6:176
  34. Hematopoietic stem/progenitor cells (HSPCs) reside in a tightly controlled local microenvironment called bone marrow niche. The specialized microenvironment or niche not only provides a favorable habitat for H...

    Authors: Sidan Li, Dehui Zou, Changhong Li, Hengxing Meng, Weiwei Sui, Sizhou Feng, Tao Cheng, Qiongli Zhai and Lugui Qiu
    Citation: Stem Cell Research & Therapy 2015 6:175
  35. Despite the success of interventional processes such as drug-eluting stents, complete prevention of restenosis is still hindered by impaired or delayed endothelialization or both. Here, we report that 1H-pyrrole-...

    Authors: Byeong-Wook Song, Il-Kwon Kim, Seahyoung Lee, Eunhyun Choi, Onju Ham, Se-Yeon Lee, Chang Yeon Lee, Jun-Hee Park, Jiyun Lee, Hyang-Hee Seo, Woochul Chang, Cheesoon Yoon and Ki-Chul Hwang
    Citation: Stem Cell Research & Therapy 2015 6:174
  36. Platelet-rich plasma (PRP) is widely used to treat tendon injuries in clinics. These PRP preparations often contain white blood cells or leukocytes, and the precise cellular effects of leukocyte-rich PRP (L-PR...

    Authors: Yiqin Zhou, Jianying Zhang, Haishan Wu, MaCalus V. Hogan and James H-C. Wang
    Citation: Stem Cell Research & Therapy 2015 6:173
  37. Activation of endogenous stem cell mobilization can contribute to myocardial regeneration after ischemic injury. This study aimed to evaluate the possible role of Avemar or Echinacea extracts in inducing mobiliza...

    Authors: Maha Abdelmonem, Samar H. Kassem, Hala Gabr, Amira A. Shaheen and Tarek Aboushousha
    Citation: Stem Cell Research & Therapy 2015 6:172
  38. Liver transplantation is a gold standard treatment for intractable liver diseases. Because of the shortage of donor organs, alternative therapies have been required. Due to their potential to differentiate int...

    Authors: Takayoshi Yamaza, Fatima Safira Alatas, Ratih Yuniartha, Haruyoshi Yamaza, Junko K. Fujiyoshi, Yusuke Yanagi, Koichiro Yoshimaru, Makoto Hayashida, Toshiharu Matsuura, Reona Aijima, Kenji Ihara, Shouichi Ohga, Songtao Shi, Kazuaki Nonaka and Tomoaki Taguchi
    Citation: Stem Cell Research & Therapy 2015 6:171
  39. Due to their immunomodulatory properties, mesenchymal stromal cells (MSCs) have been used for auto-immune disease treatment. Crohn disease (CD) and ulcerative colitis are two major inflammatory bowel diseases ...

    Authors: Dorian Forte, Marilena Ciciarello, Maria Chiara Valerii, Luigia De Fazio, Elena Cavazza, Rosaria Giordano, Valentina Parazzi, Lorenza Lazzari, Silvio Laureti, Fernando Rizzello, Michele Cavo, Antonio Curti, Roberto M. Lemoli, Enzo Spisni and Lucia Catani
    Citation: Stem Cell Research & Therapy 2015 6:170
  40. Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and multilineage differentiation. Their multipotential capacity and immunomodulatory properties have led to an increasing interest in...

    Authors: Carmen Muñiz, Cristina Teodosio, Andrea Mayado, Ana Teresa Amaral, Sergio Matarraz, Paloma Bárcena, Maria Luz Sanchez, Iván Alvarez-Twose, María Diez-Campelo, Andrés C. García-Montero, Juan F. Blanco, Maria Consuelo Del Cañizo, Javier del Pino Montes and Alberto Orfao
    Citation: Stem Cell Research & Therapy 2015 6:169
  41. Bone marrow-derived mesenchymal stromal cells (MSCs) have been intensely studied for the purpose of developing solutions for clinical tissue engineering. Autologous MSCs can potentially be used to replace tiss...

    Authors: Eeva Castrén, Tarvo Sillat, Sofia Oja, Ariel Noro, Anita Laitinen, Yrjö T Konttinen, Petri Lehenkari, Mika Hukkanen and Matti Korhonen
    Citation: Stem Cell Research & Therapy 2015 6:167
  42. Tumor necrosis factor alpha (TNFα) plays a physiological role in controlling synaptic transmission and plasticity in the healthy central nervous system by modulating glutamate receptor trafficking to the plasm...

    Authors: Raffaella Morini, Elsa Ghirardini, Erica Butti, Claudia Verderio, Gianvito Martino and Michela Matteoli
    Citation: Stem Cell Research & Therapy 2015 6:166
  43. Studies have proposed that mesenchymal stem cells (MSCs) improve the hematopoietic engraftment in allogeneic or xenogeneic transplants and this is probably due to the MSCs’ immunosuppressive properties. Our st...

    Authors: María Fernández-García, Rosa M. Yañez, Rebeca Sánchez-Domínguez, Miriam Hernando-Rodriguez, Miguel Peces-Barba, Guadalupe Herrera, Jose E. O’Connor, José C. Segovia, Juan A. Bueren and María L. Lamana
    Citation: Stem Cell Research & Therapy 2015 6:165
  44. In this study, we planned to assess if adult stem cell-based suicide gene therapy can efficiently eliminate glioblastoma cells in vivo. We investigated the therapeutic potential of mouse Oct4− bone marrow multipo...

    Authors: Cindy Leten, Jesse Trekker, Tom Struys, Tom Dresselaers, Rik Gijsbers, Greetje Vande Velde, Ivo Lambrichts, Annemie Van Der Linden, Catherine M. Verfaillie and Uwe Himmelreich
    Citation: Stem Cell Research & Therapy 2015 6:163

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