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  1. In light of pioneering findings in the 1980s and an estimation of more than 130 million global annual births, umbilical cord blood (UCB) is considered to be the most plentiful reservoir of cells and to have re...

    Authors: Santiago Roura, Josep-Maria Pujal, Carolina Gálvez-Montón and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2015 6:123
    Content type: Review Published on:

  2. Administration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological and degenerative disorders. Accumulating evidence indicates that the healing ef...

    Authors: Serena Rubina Baglio, Koos Rooijers, Danijela Koppers-Lalic, Frederik J. Verweij, M Pérez Lanzón, Nicoletta Zini, Benno Naaijkens, Francesca Perut, Hans W. M. Niessen, Nicola Baldini and D. Michiel Pegtel
    Citation: Stem Cell Research & Therapy 2015 6:127
    Content type: Research Published on:

  3. Autologous blood-derived biologicals, including autologous conditioned serum (ACS), are frequently used to treat tendinopathies in horses despite limited evidence for their efficacy. The purpose of this study ...

    Authors: Florian Geburek, Maren Lietzau, Andreas Beineke, Karl Rohn and Peter M. Stadler
    Citation: Stem Cell Research & Therapy 2015 6:126
    Content type: Research Published on:

  4. Induced pluripotent stem cells (iPSCs) have emerged as a promising cell source for immune-compatible cell therapy. Although a variety of somatic cells have been tried for iPSC generation, it is still of great ...

    Authors: Jinsoo Oh, Kang-In Lee, Hyeong-Taek Kim, Youngsang You, Do Heum Yoon, Ki Yeong Song, Eunji Cheong, Yoon Ha and Dong-Youn Hwang
    Citation: Stem Cell Research & Therapy 2015 6:125
    Content type: Research Published on:

  5. Chemotherapy has made an essential contribution to cancer treatment in recent decades despite its adverse effects. As cancer survivors have increased, concern about ex-patient lifespan has become more importan...

    Authors: Fernando Ezquer, Jaime Gutiérrez, Marcelo Ezquer, Christian Caglevic, Helio C Salgado and Sebastián D Calligaris
    Citation: Stem Cell Research & Therapy 2015 6:116
    Content type: Review Published on:

  6. Surface modification of titanium (Ti) implants promotes bone formation and shortens the osseointegration period. The aim of this study was to promote bone regeneration and stability around implants using atmos...

    Authors: Masahiro Omori, Shuhei Tsuchiya, Kenji Hara, Kensuke Kuroda, Hideharu Hibi, Masazumi Okido and Minoru Ueda
    Citation: Stem Cell Research & Therapy 2015 6:124
    Content type: Research Published on:

  7. The prospect of therapeutic applications of the induced pluripotent stem cells (iPSCs) is based on their ability to generate virtually any cell type present in human body. Generation of iPSCs from somatic cell...

    Authors: Anna M. Drozd, Maciej P. Walczak, Sylwester Piaskowski, Ewelina Stoczynska-Fidelus, Piotr Rieske and Dawid P. Grzela
    Citation: Stem Cell Research & Therapy 2015 6:122
    Content type: Research Published on:

  8. Despite its high incidence, nerve fiber (axon and myelin) damage after cerebral infarct has not yet been extensively investigated. The aim of this study was to investigate white matter repair after adipose-der...

    Authors: Laura Otero-Ortega, María Gutiérrez-Fernández, Jaime Ramos-Cejudo, Berta Rodríguez-Frutos, Blanca Fuentes, Tomás Sobrino, Teresa Navarro Hernanz, Francisco Campos, Juan Antonio López, Sebastián Cerdán, Jesús Vázquez and Exuperio Díez-Tejedor
    Citation: Stem Cell Research & Therapy 2015 6:121
    Content type: Research Published on:

  9. Wnt and Notch signaling pathways are critically involved in relative cell fate decisions within the development of cutaneous tissues. Moreover, several studies identified the above two pathways as having a sig...

    Authors: Yan Shi, Bin Shu, Ronghua Yang, Yingbin Xu, Bangrong Xing, Jian Liu, Lei Chen, Shaohai Qi, Xusheng Liu, Peng Wang, Jinming Tang and Julin Xie
    Citation: Stem Cell Research & Therapy 2015 6:120
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2015 6:254

  10. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging disease. One of...

    Authors: Jesús Mateos, Arancha Landeira-Abia, Juan Antonio Fafián-Labora, Pablo Fernández-Pernas, Iván Lesende-Rodríguez, Patricia Fernández-Puente, Mercedes Fernández-Moreno, Aitor Delmiro, Miguel A. Martín, Francisco J. Blanco and María C. Arufe
    Citation: Stem Cell Research & Therapy 2015 6:119
    Content type: Research Published on:

  11. The worldwide shortage of donor livers has prompted the search for alternative cell therapies. Previous data from our laboratory proved a supportive role for stem cell therapy in the treatment of end-stage liv...

    Authors: Abdel-Rahman N. Zekri, Hosny Salama, Eman Medhat, Sherief Musa, Hanan Abdel-Haleem, Ola S. Ahmed, Hanan Abdel Hafez Khedr, Mai M. Lotfy, Khaled S. Zachariah and Abeer A. Bahnassy
    Citation: Stem Cell Research & Therapy 2015 6:118
    Content type: Research Published on:

  13. The increasing interest in 99m-technetium (99mTc)-labeled stem cells encouraged us to study the 99mTc binding sites in stem cell compartments.

    Authors: Grazielle Dias Suhett, Sergio Augusto Lopes de Souza, Adriana Bastos Carvalho, Rachel de Pinho Rachid, Narcisa Leal da Cunha-E-Silva, Antonio Carlos Campos de Carvalho, Lea Mirian Barbosa da Fonseca, Regina Coeli dos Santos Goldenberg and Bianca Gutfilen
    Citation: Stem Cell Research & Therapy 2015 6:115
    Content type: Research Published on:

  14. The bursa subacromialis (BS) provides the gliding mechanism of the shoulder and regenerates itself after surgical removal. Therefore, we explored the presence of mesenchymal stem cells (MSCs) within the human ...

    Authors: Andre F. Steinert, Manuela Kunz, Patrick Prager, Sascha Göbel, Ludger Klein-Hitpass, Regina Ebert, Ulrich Nöth, Franz Jakob and Frank Gohlke
    Citation: Stem Cell Research & Therapy 2015 6:114
    Content type: Research Published on:

  16. Irreversible end-stage organ failure represents one of the leading causes of death, and organ transplantation is currently the only curative solution. Donor organ shortage and adverse effects of immunosuppress...

    Authors: Andrea Peloso, Abritee Dhal, Joao P Zambon, Peng Li, Giuseppe Orlando, Anthony Atala and Shay Soker
    Citation: Stem Cell Research & Therapy 2015 6:107
    Content type: Review Published on:

  17. Testicular torsion is a urological emergency and infertility is a common complication due to ischemic injury. Surgical reduction and orchiopexy is indicated, but to date there is no effective method for restor...

    Authors: Chi-Hao Hsiao, Andrea Tung-Qian Ji, Chih-Cheng Chang, Chien-Jui Cheng, Liang-Ming Lee and Jennifer Hui-Chun Ho
    Citation: Stem Cell Research & Therapy 2015 6:113
    Content type: Research Published on:

  18. Most studies on intracoronary bone marrow mononuclear cell transplantation for acute myocardial infarction involve treatment 3–7 days after primary percutaneous coronary intervention (PCI); however, the optima...

    Authors: Rongchong Huang, Kang Yao, Aijun Sun, Juying Qian, Lei Ge, Yiqi Zhang, Yuhong Niu, Keqiang Wang, Yunzeng Zou and Junbo Ge
    Citation: Stem Cell Research & Therapy 2015 6:112
    Content type: Research Published on:

  19. The release of trophic factors from mesenchymal stem cells (MSCs) is critical for tissue regeneration. A systematic investigation of the regenerative potential of trophic factors from different MSCs, however, ...

    Authors: Y Hayashi, M Murakami, R Kawamura, R Ishizaka, O Fukuta and M Nakashima
    Citation: Stem Cell Research & Therapy 2015 6:111
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:86

  20. Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an option for improving joint function in osteonecrosis of the femoral head (ONFH). Bone marrow-derived mesenchymal stromal cell (MSC) nu...

    Authors: Gildasio Cerqueira Daltro, Vitor Fortuna, Eliane Silva de Souza, Marcela Miranda Salles, Ana Claudia Carreira, Roberto Meyer, Songeli Menezes Freire and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2015 6:110
    Content type: Research Published on:

  22. Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovas...

    Authors: Carolina Gálvez-Montón, M. Teresa Fernandez-Figueras, Mercè Martí, Carolina Soler-Botija, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Aida Llucià-Valldeperas, Ángel Raya and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2015 6:108
    Content type: Short report Published on:

  23. Severe spinal cord injury often causes temporary or permanent damages in strength, sensation, or autonomic functions below the site of the injury. So far, there is still no effective treatment for spinal cord ...

    Authors: Xue-Cheng Qiu, Hui Jin, Rong-Yi Zhang, Ying Ding, Xiang Zeng, Bi-Qin Lai, Eng-Ang Ling, Jin-Lang Wu and Yuan-Shan Zeng
    Citation: Stem Cell Research & Therapy 2015 6:105
    Content type: Research Published on:

  24. Secondary osteoporosis is common in systemic lupus erythematosus and leads to a reduction in quality of life due to fragility fractures, even in patients with improvement of the primary disorder. Systemic tran...

    Authors: Lan Ma, Reona Aijima, Yoshihiro Hoshino, Haruyoshi Yamaza, Erika Tomoda, Yosuke Tanaka, Soichiro Sonoda, Guangtai Song, Wei Zhao, Kazuaki Nonaka, Songtao Shi and Takayoshi Yamaza
    Citation: Stem Cell Research & Therapy 2015 6:104
    Content type: Research Published on:

  25. Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this...

    Authors: Hongwei Lv, Lisha Li, Meiyu Sun, Yin Zhang, Li Chen, Yue Rong and Yulin Li
    Citation: Stem Cell Research & Therapy 2015 6:103
    Content type: Review Published on:

  26. Malaria is the most relevant parasitic disease worldwide, and still accounts for 1 million deaths each year. Since current antimalarial drugs are unable to prevent death in severe cases, new therapeutic strate...

    Authors: Mariana C Souza, Johnatas D Silva, Tatiana A Pádua, Natália D Torres, Mariana A Antunes, Debora G Xisto, Thiago P Abreu, Vera L Capelozzi, Marcelo M Morales, Ana A. Sá Pinheiro, Celso Caruso-Neves, Maria G Henriques and Patricia RM Rocco
    Citation: Stem Cell Research & Therapy 2015 6:102
    Content type: Research Published on:

  27. The purpose of this study was to investigate the expression of Wnt and Notch signaling pathway-related genes in inflammatory bowel disease (IBD) treated with mesenchymal stem cell transplantation (MSCT).

    Authors: Yanfen Xing, Xiaojie Chen, Yanwen Cao, Jianyun Huang, Xuhong Xie and Yaming Wei
    Citation: Stem Cell Research & Therapy 2015 6:101
    Content type: Research Published on:

  28. Mesenchymal stem cells (MSCs) play a central role in the remediation of cell and tissue damage. Erythropoietin (EPO) may enhance the beneficial influence of MSCs during recovery from tissue and organ injuries....

    Authors: Yan Wang, Xingyan Lu, Juan He and Weihong Zhao
    Citation: Stem Cell Research & Therapy 2015 6:100
    Content type: Research Published on:

  29. Osteopontin (OPN) is a phosphoglycoprotein with important roles in tissue homeostasis, wound healing, immune regulation, and stress responses. It is expressed constitutively in the brain and upregulated during...

    Authors: Monika Rabenstein, Joerg Hucklenbroich, Antje Willuweit, Anne Ladwig, Gereon Rudolf Fink, Michael Schroeter, Karl-Josef Langen and Maria Adele Rueger
    Citation: Stem Cell Research & Therapy 2015 6:99
    Content type: Research Published on:

  30. Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired vi...

    Authors: Jiaojiao Wang, Yong Zhao, Xiaoyun Wu, Shande Yin, Yunhai Chuai and Aiming Wang
    Citation: Stem Cell Research & Therapy 2015 6:98
    Content type: Research Published on:

  31. Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with great therapeutic potential for the trea...

    Authors: Ying-Wei Lan, Kong-Bung Choo, Chuan-Mu Chen, Tsai-Hsien Hung, Young-Bin Chen, Chung-Hsing Hsieh, Han-Pin Kuo and Kowit-Yu Chong
    Citation: Stem Cell Research & Therapy 2015 6:97
    Content type: Research Published on:

  32. Mouse pancreas has a remarkable ability to regenerate after partial pancreatectomy, and several investigators have studied the underlying mechanisms involved in this regeneration process; however, the field re...

    Authors: Deepa Bhartiya and Hiren Patel
    Citation: Stem Cell Research & Therapy 2015 6:96
    Content type: Review Published on:

  33. Adipose-derived stem cells (ADSC) are non-hematopoietic mesenchymal stem cells that have shown great promise in their ability to differentiate into multiple cell lineages. Their ubiquitous nature and the ease ...

    Authors: Haitao Shen, Enchen Zhou, Xiujing Wei, Zhiwei Fu, Chenguang Niu, Yang Li, Bing Pan, Anna V Mathew, Xu Wang, Subramaniam Pennathur, Lemin Zheng and Yongyu Wang
    Citation: Stem Cell Research & Therapy 2015 6:95
    Content type: Research Published on:

  34. The evolution of articular cartilage repair procedures has resulted in a variety of cell-based therapies that use both autologous and allogeneic mesenchymal stromal cells (MSCs). As these cells are increasingl...

    Authors: Lucienne A. Vonk, Tommy S. de Windt, Ineke C. M. Slaper-Cortenbach and Daniël B. F. Saris
    Citation: Stem Cell Research & Therapy 2015 6:94
    Content type: Review Published on:

  35. Diffuse axonal injury is an extremely common type of traumatic brain injury encountered in motor vehicle crashes, sports injuries, and in combat. Although many cases of diffuse axonal injury result in chronic ...

    Authors: Leyan Xu, Jiwon Ryu, Hakim Hiel, Adarsh Menon, Ayushi Aggarwal, Elizabeth Rha, Vasiliki Mahairaki, Brian J Cummings and Vassilis E Koliatsos
    Citation: Stem Cell Research & Therapy 2015 6:93
    Content type: Research Published on:

  36. Growing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of...

    Authors: Fei Zhou, Shane Gao, Lin Wang, Chenxi Sun, Lu Chen, Ping Yuan, Haiyang Zhao, Yi Yi, Ying Qin, Zhiqiang Dong, Limei Cao, Haiyan Ren, Liang Zhu, Qiang Li, Bing Lu, Aibin Liang…
    Citation: Stem Cell Research & Therapy 2015 6:92
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:76

  37. Transplantation of bone marrow mesenchymal stem cells (BMSCs) can repair injured hearts. However, whether BMSC populations contain cells with cardiac stem cell characteristics is ill-defined. We report here th...

    Authors: Ranran Ding, Xiaofan Jiang, Yanping Ha, Zhenliang Wang, Junli Guo, Hanguo Jiang, Shaojiang Zheng, Zhihua Shen and Wei Jie
    Citation: Stem Cell Research & Therapy 2015 6:91
    Content type: Research Published on:

  38. The secretion of trophic factors by mesenchymal stromal cells has gained increased interest given the benefits it may bring to the treatment of a variety of traumatic injuries such as skin wounds. Herein, we r...

    Authors: Jorge M Santos, Sérgio P Camões, Elysse Filipe, Madalena Cipriano, Rita N Barcia, Mariana Filipe, Mariana Teixeira, Sandra Simões, Manuela Gaspar, Diogo Mosqueira, Diana S Nascimento, Perpétua Pinto-do-Ó, Pedro Cruz, Helder Cruz, Matilde Castro and Joana P Miranda
    Citation: Stem Cell Research & Therapy 2015 6:90
    Content type: Research Published on:

  39. Advances in tendon engineering with mesenchymal stem cells (MSCs) are hindered by a need for cues to direct tenogenesis, and markers to assess tenogenic state. We examined the effects of factors involved in em...

    Authors: Jeffrey P Brown, Thomas V Galassi, Matteo Stoppato, Nathan R Schiele and Catherine K Kuo
    Citation: Stem Cell Research & Therapy 2015 6:89
    Content type: Research Published on:

  40. Human mesenchymal stem cells (hMSCs) reside in a perivascular niche of the body, suggesting that they interact closely with vascular endothelial cells (ECs) through cell-cell interaction or paracrine signaling...

    Authors: Tsung-Lin Tsai, Bowen Wang, Matthew W Squire, Lian-Wang Guo and Wan-Ju Li
    Citation: Stem Cell Research & Therapy 2015 6:88
    Content type: Research Published on:

  41. Breast cancer progression is promoted by stromal cells that populate the tumors, including cancer-associated fibroblasts (CAFs) and mesenchymal stem/stromal cells (MSCs). The activities of CAFs and MSCs in bre...

    Authors: Christina Katanov, Shalom Lerrer, Yulia Liubomirski, Leonor Leider-Trejo, Tsipi Meshel, Jair Bar, Rotem Feniger-Barish, Iris Kamer, Gali Soria-Artzi, Hadar Kahani, Debabrata Banerjee and Adit Ben-Baruch
    Citation: Stem Cell Research & Therapy 2015 6:87
    Content type: Research Published on:

  43. Skin as the largest and easily accessible organ of the body represents an abundant source of adult stem cells. Among them, dermal stem cells hold great promise in tissue repair and the skin granulation tissue ...

    Authors: Zelin Chen, Tingyu Dai, Xia Chen, Li Tan and Chunmeng Shi
    Citation: Stem Cell Research & Therapy 2015 6:85
    Content type: Research Published on:

  44. The quality of cartilaginous tissue derived from bone marrow mesenchymal stromal stem cell (BMSC) transplantation has been correlated with clinical outcome. Therefore, culture conditions capable of modulating ...

    Authors: Troy D Bornes, Nadr M Jomha, Aillette Mulet-Sierra and Adetola B Adesida
    Citation: Stem Cell Research & Therapy 2015 6:84
    Content type: Research Published on:

  45. Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) may be suitable for myocardial repair. While their functional and structural properties have been extensively investigated, their response to isch...

    Authors: Andreja Brodarac, Tomo Šarić, Barbara Oberwallner, Shokoufeh Mahmoodzadeh, Klaus Neef, Julie Albrecht, Karsten Burkert, Matteo Oliverio, Filomain Nguemo, Yeong-Hoon Choi, Wolfram F Neiss, Ingo Morano, Jürgen Hescheler and Christof Stamm
    Citation: Stem Cell Research & Therapy 2015 6:83
    Content type: Research Published on:

  46. Mesenchymal stem cells (MSCs)-based therapies have had positive outcomes in animal models of cardiovascular diseases. However, the number and function of MSCs decline with age, reducing their ability to contri...

    Authors: Wenzheng Xia, Fengyun Zhang, Congying Xie, Miaomiao Jiang and Meng Hou
    Citation: Stem Cell Research & Therapy 2015 6:82
    Content type: Research Published on:

  47. Osteosarcoma is the most common primary malignant bone tumor, and the grading of osteosarcoma cells relies on traditional histopathology and molecular biology methods, which require RNA extraction, protein iso...

    Authors: Yi-Hung Chiang, Stewart H Wu, Yi-Chun Kuo, How-Foo Chen, Arthur Chiou and Oscar K Lee
    Citation: Stem Cell Research & Therapy 2015 6:81
    Content type: Research Published on:

  48. Deciduous and permanent human teeth represent an excellent model system to study aging of stromal populations. Aging is tightly connected to self-renewal and proliferation and thus, mapping potential molecular...

    Authors: Nina Kaukua, Mo Chen, Paolo Guarnieri, Markus Dahl, Mei Ling Lim, Tülay Yucel-Lindberg, Erik Sundström, Igor Adameyko, Jeremy J Mao and Kaj Fried
    Citation: Stem Cell Research & Therapy 2015 6:59
    Content type: Research Published on:

  49. A still not well defined proportion of patients with multiple myeloma (MM) and eligible for autologous stem cell transplantation (AuSCT) fails to mobilize CD34+ peripheral blood stem cells (PBSC) at all or to ...

    Authors: Pellegrino Musto, Vittorio Simeon, Alberto Grossi, Francesca Gay, Sara Bringhen, Alessandra Larocca, Roberto Guariglia, Giuseppe Pietrantuono, Oreste Villani, Giovanni D’Arena, Carmela Cuomo, Clelia Musto, Fortunato Morabito, Maria Teresa Petrucci, Massimo Offidani, Elena Zamagni…
    Citation: Stem Cell Research & Therapy 2015 6:64
    Content type: Research Published on:

  50. Transplantation of endothelial progenitor cells (EPCs) restores endothelial function in patients with endothelial dysfunction and initial denudation. The goal of the present study was to determine the effect o...

    Authors: Yangguang Yin, Huanyun Liu, Fangjuan Wang, Lufeng Li, Mengyang Deng, Lan Huang and Xiaohui Zhao
    Citation: Stem Cell Research & Therapy 2015 6:37
    Content type: Research Published on:
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