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  1. Implantation of mesenchymal stem cells (MSCs) has recently been reported to repair tissue injuries through anti-inflammatory and immunosuppressive effects. We established dedifferentiated fat (DFAT) cells that...

    Authors: Takashi Maruyama, Noboru Fukuda, Taro Matsumoto, Koichiro Kano, Morito Endo, Minako Kazama, Tomohiko Kazama, Jin Ikeda, Hiroyuki Matsuda, Takahiro Ueno, Masanori Abe, Kazuyoshi Okada, Masayoshi Soma, Koichi Matsumoto and Hiroshi Kawachi
    Citation: Stem Cell Research & Therapy 2015 6:80
    Content type: Research Published on:

  2. Inflammatory bowel diseases (IBD) are complex multi-factorial diseases with increasing incidence worldwide but their treatment is far from satisfactory. Unconventional strategies have consequently been investi...

    Authors: Antara Banerjee, Debora Bizzaro, Patrizia Burra, Rosa Di Liddo, Surajit Pathak, Diletta Arcidiacono, Andrea Cappon, Patrizio Bo, Maria Teresa Conconi, Marika Crescenzi, Claudia Maria Assunta Pinna, Pier Paolo Parnigotto, Malcolm R Alison, Giacomo Carlo Sturniolo, Renata D’Incà and Francesco Paolo Russo
    Citation: Stem Cell Research & Therapy 2015 6:79
    Content type: Research Published on:

  3. Macrophage-driven inflammation is a key feature of the early period following tendon repair, but excessive inflammation has been associated with poor clinical outcomes. Modulation of the inflammatory environme...

    Authors: Cionne N Manning, Catherine Martel, Shelly E Sakiyama-Elbert, Matthew J Silva, Shivam Shah, Richard H Gelberman and Stavros Thomopoulos
    Citation: Stem Cell Research & Therapy 2015 6:74
    Content type: Research Published on:

  4. Paracrine effects can be exploited in cell-based therapies that secrete factors, such as chemokines and cytokines, and can recruit inflammatory cells to transplants. In this study, mouse adipose tissue-derived...

    Authors: Hidemi Hattori and Masayuki Ishihara
    Citation: Stem Cell Research & Therapy 2015 6:70
    Content type: Research Published on:

  5. Recent studies in the literature have highlighted the critical role played by cell signalling in determining haemopoietic stem cell (HSC) fate within ex vivo culture systems. Stimulatory signals can enhance proli...

    Authors: Joseph D Berry, Pankaj Godara, Petar Liovic and David N Haylock
    Citation: Stem Cell Research & Therapy 2015 6:58
    Content type: Research Published on:

  7. Mesenchymal stem cells (MSCs) have the ability to proliferate in vivo with a large variety of differentiation potentials and therefore are widely used as an ideal material for cell therapy. MSCs derived from pig ...

    Authors: Lei Huang, Chenguang Niu, Belinda Willard, Weimin Zhao, Lan Liu, Wei He, Tianwen Wu, Shulin Yang, Shutang Feng, Yulian Mu, Lemin Zheng and Kui Li
    Citation: Stem Cell Research & Therapy 2015 6:77
    Content type: Research Published on:

  8. Intravenous (IV) injection of mesenchymal stem cells (MSCs) is used to treat systemic human diseases and disorders but is not routinely used in equine therapy. In horses, MSCs are isolated primarily from adipo...

    Authors: Amir Kol, Joshua A Wood, Danielle D Carrade Holt, Jessica A Gillette, Laurie K Bohannon-Worsley, Sarah M Puchalski, Naomi J Walker, Kaitlin C Clark, Johanna L Watson and Dori L Borjesson
    Citation: Stem Cell Research & Therapy 2015 6:73
    Content type: Research Published on:

  9. Healthy bone marrow cell (BMC) infusion improves renal function and limits renal injury in a model of chronic kidney disease (CKD) in rats. However, BMCs derived from rats with CKD fail to retain beneficial ef...

    Authors: Arianne van Koppen, Diana A Papazova, Nynke R Oosterhuis, Hendrik Gremmels, Rachel H Giles, Joost O Fledderus, Jaap A Joles and Marianne C Verhaar
    Citation: Stem Cell Research & Therapy 2015 6:63
    Content type: Research Published on:

  10. The preliminary results of ovarian transplantation in clinical practice are encouraging. However, the follicular depletion caused by ischemic injury is a main concern and is directly related to short-term graf...

    Authors: Luciana Lamarão Damous, Juliana Sanajotti Nakamuta, Ana Elisa Teófilo Saturi de Carvalho, José Maria Soares-Jr, Manuel de Jesus Simões, José Eduardo Krieger and Edmund C Baracat
    Citation: Stem Cell Research & Therapy 2015 6:57
    Content type: Short report Published on:

  11. Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. Prior to their clinical application, hASCs must ...

    Authors: Ana CC Paula, Thaís MM Martins, Alessandra Zonari, Soraia PPJ Frade, Patrícia C Angelo, Dawidson A Gomes and Alfredo M Goes
    Citation: Stem Cell Research & Therapy 2015 6:76
    Content type: Research Published on:

  12. Growing recognition of paracrine mechanisms in stem cell plasticity has resulted in considerable interest in stem cell-derived secretome. The aim of this study was to investigate the effects of lipopolysacchar...

    Authors: Sang Chul Lee, Hye Jin Jeong, Sang Kuon Lee and Say-June Kim
    Citation: Stem Cell Research & Therapy 2015 6:75
    Content type: Research Published on:

  13. Subcutaneous adipose tissue is an interesting source of autologous stem cells with a fundamental role in the pathophysiology of obesity, metabolic syndromes and insulin resistance. We hypothesize that obesity ...

    Authors: Karina R Silva, Sally Liechocki, João R Carneiro, Cesar Claudio-da-Silva, Clarissa M Maya-Monteiro, Radovan Borojevic and Leandra S Baptista
    Citation: Stem Cell Research & Therapy 2015 6:72
    Content type: Research Published on:

  14. Human parthenogenetic embryonic stem cells (hpESCs) are generated from artificially activated oocytes, however, the issue of whether hpESCs have equivalent differentiation ability to human fertilized embryonic...

    Authors: Yang Yu, Qian Gao, Hong-cui Zhao, Rong Li, Jiang-man Gao, Ting Ding, Si-yu Bao, Yue Zhao, Xiao-fang Sun, Yong Fan and Jie Qiao
    Citation: Stem Cell Research & Therapy 2015 6:69
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2015 6:180

  15. Mesenchymal progenitor cells interact with immune cells and modulate inflammatory responses. The cellular characteristics required for this modulation are under fervent investigation. Upon interaction with mac...

    Authors: Jodi F Evans, Veronica Salvador, Sheela George, Cristina Trevino-Gutierrez and Catherine Nunez
    Citation: Stem Cell Research & Therapy 2015 6:56
    Content type: Research Published on:

  16. Previous studies have produced controversial results regarding whether mesenchymal stem cells (MSCs) promote or inhibit tumor development. Given the dual role of MSCs in inflammation and cancer, in this study ...

    Authors: Rui-jing Tang, Su-nan Shen, Xiao-yin Zhao, Yun-zhong Nie, Yu-jun Xu, Jing Ren, Ming-ming Lv, Ya-yi Hou and Ting-ting Wang
    Citation: Stem Cell Research & Therapy 2015 6:71
    Content type: Research Published on:

  17. Osteonecrosis of the femoral head (ONFH) is a degenerative disease progressing to a femoral head (FH) collapse. Injection of osteoprogenitor cells like bone marrow mesenchymal stromal cells (BMSCs) into the FH...

    Authors: Angélique Lebouvier, Alexandre Poignard, Madeleine Cavet, Jérôme Amiaud, Julie Leotot, Philippe Hernigou, Alain Rahmouni, Philippe Bierling, Pierre Layrolle, Hélène Rouard and Nathalie Chevallier
    Citation: Stem Cell Research & Therapy 2015 6:68
    Content type: Research Published on:

  18. Stimulation of mesenchymal stromal cells and adipose tissue-derived stromal cells (ASCs) with vascular endothelial growth factor (VEGF) has been used in multiple animal studies and clinical trials for regenera...

    Authors: Josefine Tratwal, Anders Bruun Mathiasen, Morten Juhl, Sonja Kim Brorsen, Jens Kastrup and Annette Ekblond
    Citation: Stem Cell Research & Therapy 2015 6:62
    Content type: Research Published on:

  19. Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapies. Human platelet lysate represents an efficient alternative to fetal bovine serum for clinical-scale expansion of MSCs. Different ...

    Authors: Chun-yu Li, Xiao-yun Wu, Jia-bei Tong, Xin-xin Yang, Jing-li Zhao, Quan-fu Zheng, Guo-bin Zhao and Zhi-jie Ma
    Citation: Stem Cell Research & Therapy 2015 6:55
    Content type: Research Published on:

  20. Following injury such as stroke, adult mammalian subependymal neural precursor cells (NPCs) are induced to proliferate and migrate toward the lesion site where they differentiate into neural cells, albeit with...

    Authors: Robart Babona-Pilipos, Alex Pritchard-Oh, Milos R Popovic and Cindi M Morshead
    Citation: Stem Cell Research & Therapy 2015 6:67
    Content type: Research Published on:

  21. Diabetes is associated with reduced expression of heme oxygenase-1 (HO-1), a heme-degrading enzyme with cytoprotective and proangiogenic properties. In myoblasts and muscle satellite cells HO-1 improves surviv...

    Authors: Magdalena Kozakowska, Jerzy Kotlinowski, Anna Grochot-Przeczek, Maciej Ciesla, Bartosz Pilecki, Rafal Derlacz, Jozef Dulak and Alicja Jozkowicz
    Citation: Stem Cell Research & Therapy 2015 6:61
    Content type: Research Published on:

  22. This study tested the hypothesis that Major Histocompatibility Complex (MHC) incompatible equine mesenchymal stromal cells (MSCs) would induce cytotoxic antibodies to donor MHC antigens in recipient horses aft...

    Authors: Lynn M Pezzanite, Lisa A Fortier, Douglas F Antczak, Jennifer M Cassano, Margaret M Brosnahan, Donald Miller and Lauren V Schnabel
    Citation: Stem Cell Research & Therapy 2015 6:54
    Content type: Research Published on:

  23. The prevalence of impaired cutaneous wound healing is high and treatment is difficult and often ineffective, leading to negative social and economic impacts for our society. Innovative treatments to improve cu...

    Authors: Leen Bussche, Rebecca M Harman, Bethany A Syracuse, Eric L Plante, Yen-Chun Lu, Theresa M Curtis, Minglin Ma and Gerlinde R Van de Walle
    Citation: Stem Cell Research & Therapy 2015 6:66
    Content type: Research Published on:

  24. Mesenchymal stem cells (MSCs) have potential for re-epithelization and recovery in acute respiratory distress syndrome (ARDS). In a previous in vitro study, the results showed that the canonical Wnt/β-catenin pat...

    Authors: Shi-xia Cai, Ai-ran Liu, Song Chen, Hong-li He, Qi-hong Chen, Jing-yuan Xu, Chun Pan, Yi Yang, Feng-mei Guo, Ying-zi Huang, Ling Liu and Hai-bo Qiu
    Citation: Stem Cell Research & Therapy 2015 6:65
    Content type: Research Published on:

  25. The beta-amyloid (Aβ) peptide and the Aβ-oligomer receptor, prion protein (PrP), both influence neurogenesis. Using in vitro murine neural stem cells (NSCs), we investigated whether Aβ and PrP interact to modify ...

    Authors: Steven J Collins, Carolin Tumpach, Qiao-Xin Li, Victoria Lewis, Timothy M Ryan, Blaine Roberts, Simon C Drew, Victoria A Lawson and Cathryn L Haigh
    Citation: Stem Cell Research & Therapy 2015 6:60
    Content type: Short report Published on:

  26. Chemokine-directed migration is crucial for homing of regenerative cells to the infarcted heart and correlates with outcomes of cell therapy trials. Hence, transplantation of chemokine-responsive bone marrow c...

    Authors: Raimondo Ascione, Jonathan Rowlinson, Elisa Avolio, Rajesh Katare, Marco Meloni, Helen L Spencer, Giuseppe Mangialardi, Caroline Norris, Nicolle Kränkel, Gaia Spinetti, Costanza Emanueli and Paolo Madeddu
    Citation: Stem Cell Research & Therapy 2015 6:53
    Content type: Research Published on:

  27. The study of hematopoiesis has been a focus for developmental biologists for over 100 years. What started as a series of microscopic observations in different animal model systems has since evolved into studie...

    Authors: Haydn C-Y Liang and Juan Carlos Zúñiga-Pflücker
    Citation: Stem Cell Research & Therapy 2015 6:52
    Content type: Review Published on:

  28. ‘Patient-specific’ induced pluripotent stem cells (iPSCs) are attractive because they can generate abundant cells without the risk of immune rejection for cell therapy. Studies have shown that iPSC-derived mes...

    Authors: Guo-wen Hu, Qing Li, Xin Niu, Bin Hu, Juan Liu, Shu-min Zhou, Shang-chun Guo, Hai-li Lang, Chang-qing Zhang, Yang Wang and Zhi-feng Deng
    Citation: Stem Cell Research & Therapy 2015 6:10
    Content type: Research Published on:

  29. The therapeutic potential of acyclic retinoid (ACR), a synthetic retinoid, has been confirmed in experimental and clinical studies. Therapeutic targets include precancerous and cancer stem cells. As ACR is als...

    Authors: Hong-Bin Guan, Yun-Zhong Nie, Yun-Wen Zheng, Kazuya Takiguchi, Hong-Wei Yu, Ran-Ran Zhang, Bin Li, Tomonori Tsuchida and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2015 6:51
    Content type: Research Published on:

  30. Stem cell therapy has emerged as potential therapeutic strategy for damaged heart muscles. Umbilical cord blood (UCB) cells are the most prevalent stem cell source available, yet have not been fully tested in ...

    Authors: Saji Oommen, Satsuki Yamada, Susana Cantero Peral, Katherine A Campbell, Elizabeth S Bruinsma, Andre Terzic and Timothy J Nelson
    Citation: Stem Cell Research & Therapy 2015 6:50
    Content type: Research Published on:

  31. Chimeric mice with humanized livers were recently established by transplanting human hepatocytes. This mouse model that is repopulated with functional human hepatocytes could be a useful tool for investigating...

    Authors: Ran-Ran Zhang, Yun-Wen Zheng, Bin Li, Tomonori Tsuchida, Yasuharu Ueno, Yun-Zhong Nie and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2015 6:49
    Content type: Research Published on:

  32. Advances in the field of stem cells have led to novel avenues for generating induced pluripotent stem cells (iPSCs) from differentiated somatic cells. iPSCs are typically obtained by the introduction of four f...

    Authors: Christopher B Driscoll, Jason M Tonne, Moustafa El Khatib, Roberto Cattaneo, Yasuhiro Ikeda and Patricia Devaux
    Citation: Stem Cell Research & Therapy 2015 6:48
    Content type: Research Published on:

  33. The therapeutic potential of mesenchymal stem cells (MSCs) for traumatic brain injury (TBI) is attractive. Conducting systematic review and meta-analyses based on data from animal studies can be used to inform...

    Authors: Weijun Peng, Jing Sun, Chenxia Sheng, Zhe Wang, Yang Wang, Chunhu Zhang and Rong Fan
    Citation: Stem Cell Research & Therapy 2015 6:47
    Content type: Research Published on:

  34. Understanding the mechanism of stem cell mobilization into injured skeletal muscles is a prerequisite step for the development of muscle disease therapies. Many of the currently studied stem cell types present...

    Authors: Edyta Brzoska, Kamil Kowalski, Agnieszka Markowska-Zagrajek, Magdalena Kowalewska, Rafał Archacki, Izabela Plaskota, Władysława Stremińska, Katarzyna Jańczyk-Ilach and Maria A Ciemerych
    Citation: Stem Cell Research & Therapy 2015 6:46
    Content type: Research Published on:

  35. Bone marrow mesenchymal stem cells (BMSCs) have been studied extensively because of their potential use in clinical therapy, regenerative medicine, and tissue engineering. However, their application in tumor t...

    Authors: Lei Zhang, Xiao San Su, Jun Song Ye, Yi Yin Wang, Zheng Guan and Yan Feng Yin
    Citation: Stem Cell Research & Therapy 2015 6:45
    Content type: Research Published on:

  36. Mesenchymal stem cells (MSCs) have potent stabilising effects on vascular endothelium injury, inhibiting endothelial permeability in lung injury via paracrine hepatocyte growth factor (HGF). Recently, it has b...

    Authors: Qi-Hong Chen, Ai-Ran Liu, Hai-Bo Qiu and Yi Yang
    Citation: Stem Cell Research & Therapy 2015 6:44
    Content type: Research Published on:

  37. There is a practical need for the identification of robust cell-surface markers that can be used to enrich for living keratinocyte progenitor cells. Breast cancer resistance protein (ABCG2), a member of the AT...

    Authors: Dongrui Ma, Alvin Wen Choong Chua, Ennan Yang, Peiyun Teo, Yixin Ting, Colin Song, Ellen Birgitte Lane and Seng Teik Lee
    Citation: Stem Cell Research & Therapy 2015 6:43
    Content type: Research Published on:

  38. Mouse fibroblasts could be directly converted into induced neural stem cells (iNSCs), by introducing a set of known transcription factors (TFs). This process, known as direct reprogramming, is an alternative s...

    Authors: Moein Yaqubi, Abdulshakour Mohammadnia and Hossein Fallahi
    Citation: Stem Cell Research & Therapy 2015 6:42
    Content type: Research Published on:

  39. The loss of oligodendrocytes in a lesion of the central nervous system causes demyelination and therefore impairs axon function and survival. Transplantation of neural stem cell-derived oligodendrocyte precurs...

    Authors: Yongchao Li, Pei-Shan Wang, George Lucas, Rong Li and Li Yao
    Citation: Stem Cell Research & Therapy 2015 6:41
    Content type: Research Published on:

  40. Acute liver failure (ALF) is a highly lethal disease, for which effective therapeutic methods are limited. Although allogeneic liver transplantation is a viable treatment method for ALF, there is a serious sho...

    Authors: Guangfeng Chen, Yinpeng Jin, Xiujuan Shi, Yu Qiu, Yushan Zhang, Mingliang Cheng, Xiaojin Wang, Chengwei Chen, Yinxia Wu, Fuzhu Jiang, Li Li, Heng Zhou, Qingchun Fu and Xiaoqing Liu
    Citation: Stem Cell Research & Therapy 2015 6:40
    Content type: Research Published on:

  41. Type 1 long QT syndrome (LQT1) is a common type of cardiac channelopathy associated with loss-of-function mutations of KCNQ1. Currently there is a lack of drugs that target the defected slowly activating delayed ...

    Authors: Dongrui Ma, Heming Wei, Jun Lu, Dou Huang, Zhenfeng Liu, Li Jun Loh, Omedul Islam, Reginald Liew, Winston Shim and Stuart A Cook
    Citation: Stem Cell Research & Therapy 2015 6:39
    Content type: Research Published on:

  42. Successful stem cell therapy relies on large-scale generation of stem cells and their maintenance in a proliferative multipotent state. This study aimed to establish a three-dimension culture system for large-...

    Authors: Guifang Zhao, Feilin Liu, Shaowei Lan, Pengdong Li, Li Wang, Junna Kou, Xiaojuan Qi, Ruirui Fan, Deshun Hao, Chunling Wu, Tingting Bai, Yulin Li and Jin Yu Liu
    Citation: Stem Cell Research & Therapy 2015 6:38
    Content type: Research Published on:

  43. Unstable atherosclerotic plaques are prone to rupture, which leads to atherothrombosis. Endothelial progenitor cells (EPCs) are bone marrow-derived precursor cells that may repair vascular injury in atheroscle...

    Authors: Zhongwen Zhang, Jianjun Dong, Corrinne G Lobe, Peiyun Gong, Ju Liu and Lin Liao
    Citation: Stem Cell Research & Therapy 2015 6:36
    Content type: Research Published on:

  45. Local delivery of mesenchymal stem cells (MSCs) to the acutely injured or osteoarthritic joint retards cartilage destruction. However, in the absence of assistive materials the efficiency of engraftment of MSC...

    Authors: Sarah E Bulman, Cynthia M Coleman, J Mary Murphy, Nicholas Medcalf, Aideen E Ryan and Frank Barry
    Citation: Stem Cell Research & Therapy 2015 6:34
    Content type: Research Published on:

  46. Stem cells isolated from menstrual fluid (MenSCs) exhibit mesenchymal stem cell (MSCs)-like properties including multi-lineage differentiation capacity. Besides, menstrual fluid has important advantages over o...

    Authors: Francisca Alcayaga-Miranda, Jimena Cuenca, Patricia Luz-Crawford, Carolina Aguila-Díaz, Ainoa Fernandez, Fernando E Figueroa and Maroun Khoury
    Citation: Stem Cell Research & Therapy 2015 6:32
    Content type: Research Published on:

  47. Mesenchymal stromal/stem cells (MSCs) are multipotent cells that have the ability to express and secrete a wide range of immunomodulatory molecules, cytokines, growth factors and antiapoptotic proteins. MSCs m...

    Authors: Juliana Navarro Ueda Yaochite, Carolina Caliari-Oliveira, Lucas Eduardo Botelho de Souza, Lourenço Sbragia Neto, Patrícia Vianna Bonini Palma, Dimas Tadeu Covas, Kelen Cristina Ribeiro Malmegrim, Julio César Voltarelli and Eduardo Antônio Donadi
    Citation: Stem Cell Research & Therapy 2015 6:31
    Content type: Research Published on:

  48. Globoid cell leukodystrophy (GLD) is a severe disorder of the central and peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity. Cell-based therapies are highly promising stra...

    Authors: Xiao Ling Kuai, Run Zhou Ni, Guo Xiong Zhou, Zheng Biao Mao, Jian Feng Zhang, Nan Yi, Zhao Xiu Liu, Nan Shao, Wen Kai Ni and Zhi Wei Wang
    Citation: Stem Cell Research & Therapy 2015 6:30
    Content type: Research Published on:

  49. Retinitis pigmentosa (RP) is a severe neurodegenerative disease of the retina that can lead to blindness. Even without treatment, a clinical study with the use of stem cells is currently underway and the resul...

    Authors: Rubens C Siqueira, Andre Messias, Katharina Messias, Rafael S Arcieri, Milton A Ruiz, Neiglene F Souza, Lia C Martins and Rodrigo Jorge
    Citation: Stem Cell Research & Therapy 2015 6:29
    Content type: Research Published on:

  50. Although there is an increase in clinical trials assessing the efficacy of cell therapy in structural and functional regeneration after stroke, there are not enough data in the literature describing the best c...

    Authors: Leopoldo P Nucci, Helio R Silva, Viviana Giampaoli, Javier B Mamani, Mariana P Nucci and Lionel F Gamarra
    Citation: Stem Cell Research & Therapy 2015 6:27
    Content type: Research Published on:
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ISSN: 1757-6512