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  1. Our previous works demonstrated that systemic orbital fat-derived stem cell (OFSC) transplantation was effective in ameliorating lipopolysaccharide (LPS)-induced extensive acute lung injury (ALI) in vivo mainly t...

    Authors: Gi-Shih Lien, Jen-Fang Liu, Ming-Hsien Chien, Wei-Tse Hsu, Tzu-Hao Chang, Chia-Chi Ku, Andrea Tung-Qian Ji, Peng Tan, Ting-Lieh Hsieh, Liang-Ming Lee and Jennifer H Ho
    Citation: Stem Cell Research & Therapy 2014 5:97
  2. Mesenchymal stromal cells (MSC) are an integral cellular component of the tumor microenvironment. Nevertheless, very little is known about MSC originating from human malignant tissue and modulation of these ce...

    Authors: Benjamin A Kansy, Philip A Dißmann, Hatim Hemeda, Kirsten Bruderek, Anna M Westerkamp, Vivien Jagalski, Patrick Schuler, Katinka Kansy, Stephan Lang, Claudia A Dumitru and Sven Brandau
    Citation: Stem Cell Research & Therapy 2014 5:95
  3. Autologous mesenchymal stem cell (MSC) injection into naturally-occurring equine tendon injuries has been shown to be safe and efficacious and protocols inform translation of the technique into humans. Efficie...

    Authors: Elaine R Garvican, Sandra Cree, Lydia Bull, Roger KW Smith and Jayesh Dudhia
    Citation: Stem Cell Research & Therapy 2014 5:1

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:161

  4. The optimal cell lineage for cardiac-regeneration approaches remains mysterious. Additionally, electrical stimulation promotes cardiomyogenic differentiation of stimulated cells. Therefore, we hypothesized tha...

    Authors: Aida Llucià-Valldeperas, Benjamin Sanchez, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Javier Rosell-Ferrer, Ramon Bragos and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2014 5:93
  5. Adipose tissue-derived stromal cells (ADSCs) are abundant and easy to obtain, but the diversity of differentiation potential from different locations may vary with the developmental origin of their mesenchymal...

    Authors: Xiaoming Wang, Hui Zhang, Liangming Nie, Linhai Xu, Min Chen and Zhaoping Ding
    Citation: Stem Cell Research & Therapy 2014 5:92
  6. Autologous mesenchymal stem cells (MSCs) are an attractive concept in regenerative medicine, but their mechanism of action remains poorly defined. No immune response is reported after in vivo injection of allogen...

    Authors: Yasmin Z Paterson, Nicola Rash, Elaine R Garvican, Romain Paillot and Deborah J Guest
    Citation: Stem Cell Research & Therapy 2014 5:90
  7. Mesenchymal stromal/stem cells (MSCs) for clinical use have largely been isolated from the bone marrow, although isolation of these cells from many different adult and fetal tissues has been reported as well. ...

    Authors: Priyanka Swamynathan, Parvathy Venugopal, Suresh Kannan, Charan Thej, Udaykumar Kolkundar, Swaroop Bhagwat, Malancha Ta, Anish Sen Majumdar and Sudha Balasubramanian
    Citation: Stem Cell Research & Therapy 2014 5:88
  8. New therapeutic options are necessary for patients with chronic Chagas disease, a leading cause of heart failure in Latin American countries. Stem cell therapy focused on improving cardiac function is a promis...

    Authors: Daniela Nascimento Silva, Bruno Solano de Freitas Souza, Carine Machado Azevedo, Juliana Fraga Vasconcelos, Rejane Hughes Carvalho, Milena Botelho Pereira Soares and Ricardo Ribeiro dos Santos
    Citation: Stem Cell Research & Therapy 2014 5:81
  9. The mortality of rhabdomyolysis-induced acute kidney injury (AKI) is still high, as there is no effective therapy. It has been shown that bone marrow-derived mesenchymal stem cells (MSCs) can induce M2 macroph...

    Authors: Yanqiu Geng, Li Zhang, Bo Fu, Jianrong Zhang, Quan Hong, Jie Hu, Diangeng Li, Congjuan Luo, Shaoyuan Cui, Fei Zhu and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2014 5:80
  10. Pathophysiologic changes associated with diabetes impair new blood vessel formation and wound healing. Mesenchymal stem cells derived from adipose tissue (ASCs) have been used clinically to promote healing, al...

    Authors: Robert C Rennert, Michael Sorkin, Michael Januszyk, Dominik Duscher, Revanth Kosaraju, Michael T Chung, James Lennon, Anika Radiya-Dixit, Shubha Raghvendra, Zeshaan N Maan, Michael S Hu, Jayakumar Rajadas, Melanie Rodrigues and Geoffrey C Gurtner
    Citation: Stem Cell Research & Therapy 2014 5:79
  11. The optimization of an organic scaffold for specific types of applications and cells is vital to successful tissue engineering. In this study, we investigated the effects of a new fibrin sealant derived from s...

    Authors: Vinícius P O Gasparotto, Fernanda C Landim-Alvarenga, Alexandre L R Oliveira, Gustavo Ferreira Simões, João F Lima-Neto, Benedito Barraviera and Rui S Ferreira Jr
    Citation: Stem Cell Research & Therapy 2014 5:78
  12. In the present study, we established a novel in vitro coculture model to evaluate the influence of osteoarthritis (OA) cartilage explants on the composition of newly produced matrix and chondrogenic differentiati...

    Authors: Michaela Leyh, Andreas Seitz, Lutz Dürselen, Hans-Robert Springorum, Peter Angele, Anita Ignatius, Joachim Grifka and Susanne Grässel
    Citation: Stem Cell Research & Therapy 2014 5:77
  13. Mesenchymal stem cell-conditioned medium (MSC-CM) has been shown to have protective effects against various cellular-injury models. This mechanism of protection, however, has yet to be elucidated. Recently, ex...

    Authors: Cheau Yih Tan, Ruenn Chai Lai, Winnie Wong, Yock Young Dan, Sai-Kiang Lim and Han Kiat Ho
    Citation: Stem Cell Research & Therapy 2014 5:76
  14. Posttranscriptional control of mRNA by microRNA (miRNA) has been implicated in the regulation of diverse biologic processes from directed differentiation of stem cells through organism development. We describe...

    Authors: Vilas Wagh, Alexander Pomorski, Karlijn J Wilschut, Sebastian Piombo and Harold S Bernstein
    Citation: Stem Cell Research & Therapy 2014 5:75
  15. Mesenchymal stem cells (MSCs) reside in a variety of tissues and provide a stromal role in regulating progenitor cell function. Current studies focus on identifying the specific factors in the niche that can a...

    Authors: Michael De Lisio, Tor Jensen, Richard A Sukiennik, Heather D Huntsman and Marni D Boppart
    Citation: Stem Cell Research & Therapy 2014 5:74
  16. Insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs) and angiopoietin-like proteins (ANGPTLs) can enhance the ex vivo expansion of hematopoietic stem cells (HSCs) when used with a standard cytokine c...

    Authors: Xiubo Fan, Florence PH Gay, Francesca WI Lim, Justina ML Ang, Pat PY Chu, Sudipto Bari and William YK Hwang
    Citation: Stem Cell Research & Therapy 2014 5:71
  17. We have assessed the utility of autologous mesenchymal stem cell (MSC) peripheral vein infusion as a possible therapeutic modality for patients with end-stage liver diseases.

    Authors: Hosny Salama, Abdel-Rahman N Zekri, Eman Medhat, Shereen A Al Alim, Ola S Ahmed, Abeer A Bahnassy, Mai M Lotfy, Rasha Ahmed and Sherief Musa
    Citation: Stem Cell Research & Therapy 2014 5:70
  18. Periodontitis is initiated and sustained by bacteria. However, the mechanism of bacteria induced periodontitis is still unknown. We hypothesized that bacterial components can affect the functions of stem cells...

    Authors: Chenghua Li, Bei Li, Zhiwei Dong, Li Gao, Xiaoning He, Li Liao, Chenghu Hu, Qintao Wang and Yan Jin
    Citation: Stem Cell Research & Therapy 2014 5:67
  19. Bone marrow mesenchymal stem cells (BMSCs) possess low immunogenicity and immunosuppression as an allograft, can differentiate into insulin-producing cells (IPCs) by in vitro induction, and may be a valuable cell...

    Authors: Yihua Zhang and Zhongying Dou
    Citation: Stem Cell Research & Therapy 2014 5:66
  20. This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative ...

    Authors: Eva Koellensperger, Felix Gramley, Fabian Preisner, Uwe Leimer, Guenter Germann and Verena Dexheimer
    Citation: Stem Cell Research & Therapy 2014 5:65
  21. Npas4 is a calcium-dependent transcription factor expressed within neurons of the brain where it regulates the expression of several genes that are important for neuronal survival and synaptic plasticity. It i...

    Authors: Thomas S Klaric, Paul Q Thomas, Mirella Dottori, Wai Khay Leong, Simon A Koblar and Martin D Lewis
    Citation: Stem Cell Research & Therapy 2014 5:64
  22. Human adipose-derived stromal cells (hASCs), due to their relative feasibility of isolation and ability to secrete large amounts of angiogenic factors, are being evaluated for regenerative medicine. However, t...

    Authors: Luigi Balducci, Antonella Blasi, Marilisa Saldarelli, Antonio Soleti, Augusto Pessina, Arianna Bonomi, Valentina Coccè, Marta Dossena, Valentina Tosetti, Valentina Ceserani, Stefania Elena Navone, Maria Laura Falchetti, Eugenio Agostino Parati and Giulio Alessandri
    Citation: Stem Cell Research & Therapy 2014 5:63
  23. We previously demonstrated that the lifespan of primary human keratinocytes could be extended indefinitely by culture in the presence of the Rho kinase (ROCK) inhibitor Y-27632. This technique has proven to be...

    Authors: Sandra Chapman, David H McDermott, Kui Shen, Moon Kyoo Jang and Alison A McBride
    Citation: Stem Cell Research & Therapy 2014 5:60
  24. Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue en...

    Authors: Ian H Bellayr, Jennifer G Catalano, Samir Lababidi, Amy X Yang, Jessica L Lo Surdo, Steven R Bauer and Raj K Puri
    Citation: Stem Cell Research & Therapy 2014 5:59
  25. Stem cell therapy has recently been introduced to treat patients with type 2 diabetes mellitus (T2DM). However, no data are available on the efficacy and safety of allogeneic Wharton’s Jelly-derived mesenchyma...

    Authors: Xuebin Liu, Pei Zheng, Xiaodong Wang, Guanghui Dai, Hongbin Cheng, Zan Zhang, Rongrong Hua, Xinxin Niu, Jing Shi and Yihua An
    Citation: Stem Cell Research & Therapy 2014 5:57
  26. The cancer stem cell model links neoplastic cells with normal stem cell biology, but little is known on how normal stem cells are transformed into cancer stem cells.

    Authors: Donatella Amendola, Marta Nardella, Loredana Guglielmi, Lidia Cerquetti, Elisabetta Carico, Viola Alesi, Manuela Porru, Carlo Leonetti, Claudia Bearzi, Roberto Rizzi, Igea D’Agnano, Antonio Stigliano, Giuseppe Novelli and Barbara Bucci
    Citation: Stem Cell Research & Therapy 2014 5:55
  27. Although mesenchymal stem cells (MSCs) have antitumor potential in hepatocellular carcinoma and breast cancer cells, the antitumor mechanism of human umbilical cord mesenchymal stem cells (hUCMSCs) in prostate...

    Authors: Ihn Han, Miyong Yun, Eun-Ok Kim, Bonglee Kim, Min-Hyung Jung and Sung-Hoon Kim
    Citation: Stem Cell Research & Therapy 2014 5:54

    The Retraction Note to this article has been published in Stem Cell Research & Therapy 2018 9:354

  28. Different mesenchymal stromal cells (MSC) have been successfully isolated and expanded in vitro and nowadays they are tested in clinical trials for a wide variety of diseases. Whether all MSC express the same cel...

    Authors: Paola Romina Amable, Marcus Vinicius Telles Teixeira, Rosana Bizon Vieira Carias, José Mauro Granjeiro and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2014 5:53
  29. Gingiva-derived mesenchymal stem cells (GMSCs) have recently been harvested and applied for rebuilding lost periodontal tissue. Enamel matrix derivative (EMD) has been used for periodontal regeneration and the...

    Authors: Shu-Man Wu, Hsien-Chung Chiu, Yu-Tang Chin, Heng-Yi Lin, Cheng-Yang Chiang, Hsiao-Pei Tu, Martin MJ Fu and Earl Fu
    Citation: Stem Cell Research & Therapy 2014 5:52
  30. Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer’s disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the under...

    Authors: Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A Castello, Andranik A Agazaryan, Joy L Davis, Franz-Josef Müller, Jeanne F Loring, Eliezer Masliah and Frank M LaFerla
    Citation: Stem Cell Research & Therapy 2014 5:46

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:88

  31. Adipose tissue has the unique property of expanding throughout adult life, and angiogenesis is required for its growth. However, endothelial progenitor cells contribute minimally to neovascularization. Because...

    Authors: Amparo Navarro, Severiano Marín, Nicasia Riol, Francisco Carbonell-Uberos and María Dolores Miñana
    Citation: Stem Cell Research & Therapy 2014 5:50
  32. Therapeutic potentials of mesenchymal stem cells (MSCs) from different sources have been evaluated in pre-clinical and clinical settings. Although MSCs from different sources share MSC-specific characteristics...

    Authors: Yongzhao Zhu, Yinxue Yang, Yaolin Zhang, Guiliang Hao, Ting Liu, Libin Wang, Tingting Yang, Qiong Wang, Guangyi Zhang, Jun Wei and Yukui Li
    Citation: Stem Cell Research & Therapy 2014 5:48
  33. Integrating viruses represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertiona...

    Authors: Asifiqbal Kadari, Min Lu, Ming Li, Thileepan Sekaran, Rajkumar P Thummer, Naomi Guyette, Vi Chu and Frank Edenhofer
    Citation: Stem Cell Research & Therapy 2014 5:47
  34. Stroke is the second leading cause of death worldwide, claims six lives every 60 seconds, and is a leading cause of adult disability across the globe. Tissue plasminogen activator, the only United States Food ...

    Authors: Neha Karlupia, Nathan C Manley, Kameshwar Prasad, Richard Schäfer and Gary K Steinberg
    Citation: Stem Cell Research & Therapy 2014 5:45
  35. Acute respiratory distress syndrome (ARDS) is the most common cause of respiratory failure among critically ill subjects, sepsis and severe bacterial pneumonia being its most common causes. The only interventi...

    Authors: Mauricio Rojas, Nayra Cárdenes, Ergin Kocyildirim, John R Tedrow, Eder Cáceres, Robert Deans, Anthony Ting and Christian Bermúdez
    Citation: Stem Cell Research & Therapy 2014 5:42
  36. Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been proposed as an ideal autologous stem cell source for cell-based therapy for myocardial infarction (MI). However, decreased viability and impaired ...

    Authors: Zheng Zhang, Chuanxu Zhao, Bing Liu, Dong Liang, Xing Qin, Xiujuan Li, Rongqing Zhang, Congye Li, Haichang Wang, Dongdong Sun and Feng Cao
    Citation: Stem Cell Research & Therapy 2014 5:33
  37. A mouse model of progeria derived by insertion of the human mutant LMNA gene (mLMNA), producing mutant lamin A, shows loss of smooth muscle cells in the media of the ascending aorta. We hypothesized that high she...

    Authors: Minjung Song, Hong San, Stasia A Anderson, Richard O Cannon III and Donald Orlic
    Citation: Stem Cell Research & Therapy 2014 5:41
  38. Studies have demonstrated that mesenchymal stromal cells (MSCs) could reverse acute and chronic kidney injury by a paracrine or endocrine mechanism, and microvesicles (MVs) have been regarded as a crucial mean...

    Authors: Xiangyu Zou, Guangyuan Zhang, Zhongliang Cheng, Deming Yin, Tao Du, Guanqun Ju, Shuai Miao, Guohua Liu, Mujun Lu and Yingjian Zhu
    Citation: Stem Cell Research & Therapy 2014 5:40
  39. The present work was designed to explore the feasibility and efficacy of articular cartilage repair using composites of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) and four different ...

    Authors: Jun Young Chung, Minjung Song, Chul-Won Ha, Jin-A Kim, Choong-Hee Lee and Yong-Beom Park
    Citation: Stem Cell Research & Therapy 2014 5:39
  40. Elevated midkine (MK) expression may contribute to ventricular remodeling and ameliorate cardiac dysfunction after myocardial infarction (MI). Ex vivo modification of signaling mechanisms in mesenchymal stem cell...

    Authors: Shu-Li Zhao, Yao-Jun Zhang, Ming-Hui Li, Xin-Lei Zhang and Shao-Liang Chen
    Citation: Stem Cell Research & Therapy 2014 5:37
  41. Fibronectin (FN) is commonly used in the development of serum-free media for the expansion of mesenchymal stem cells (MSCs). This study was aimed to observe if thrombin could stimulate FN secretion by human bo...

    Authors: Jin Chen, Yujie Ma, Zi Wang, Hengxiang Wang, Lisheng Wang, Fengjun Xiao, Hua Wang, Jianming Tan and Zikuan Guo
    Citation: Stem Cell Research & Therapy 2014 5:36
  42. Human induced pluripotent stem cells (hiPSCs) offer great promise for regenerative therapies or in vitro modelling of neurodegenerative disorders like Parkinson’s disease. Currently, widely used cell sources for ...

    Authors: Nancy Stanslowsky, Alexandra Haase, Ulrich Martin, Maximilian Naujock, Andreas Leffler, Reinhard Dengler and Florian Wegner
    Citation: Stem Cell Research & Therapy 2014 5:35
  43. Facing the challenging treatment of neurodegenerative diseases as well as complex craniofacial injuries such as those common after cancer therapy, the field of regenerative medicine increasingly relies on stem...

    Authors: Johannes FW Greiner, Lena-Marie Grunwald, Janine Müller, Holger Sudhoff, Darius Widera, Christian Kaltschmidt and Barbara Kaltschmidt
    Citation: Stem Cell Research & Therapy 2014 5:34
  44. During normal pulp tissue healing, inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) or interleukins, act in the initial 48 hours (inflammatory phase) and play important roles not only as che...

    Authors: Mayu Ueda, Takuo Fujisawa, Mitsuaki Ono, Emilio Satoshi Hara, Hai Thanh Pham, Ryu Nakajima, Wataru Sonoyama and Takuo Kuboki
    Citation: Stem Cell Research & Therapy 2014 5:31
  45. Interest in the use of dental pulp stem cells (DPSC) to enhance neurological recovery following stroke and traumatic injury is increasing following successful pre-clinical studies. A murine model of autologous...

    Authors: Kylie M Ellis, David C O’Carroll, Martin D Lewis, Grigori Y Rychkov and Simon A Koblar
    Citation: Stem Cell Research & Therapy 2014 5:30
  46. Transplanting mesenchymal stromal cells (MSCs) or their derivatives into a neurodegenerative environment is believed to be beneficial because of the trophic support, migratory guidance, immunosuppression, and ...

    Authors: Irina Aizman, Brenna J Tirumalashetty, Michael McGrogan and Casey C Case
    Citation: Stem Cell Research & Therapy 2014 5:29

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