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Stem Cell Research & Therapy


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  1. Content type: Research

    For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term resul...

    Authors: Jianming Guo, Lianrui Guo, Shijun Cui, Zhu Tong, Alan Dardik and Yongquan Gu

    Citation: Stem Cell Research & Therapy 2018 9:43

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  2. Content type: Research

    C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that...

    Authors: Yuning Sun, Rongfeng Xu, Jia Huang, Yuyu Yao, Xiaodong Pan, Zhongpu Chen and Genshan Ma

    Citation: Stem Cell Research & Therapy 2018 9:41

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  3. Content type: Research

    Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived...

    Authors: L. F. Mendes, H. Katagiri, W. L. Tam, Y. C. Chai, L. Geris, S. J. Roberts and F. P. Luyten

    Citation: Stem Cell Research & Therapy 2018 9:42

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  4. Content type: Research

    Numerous stem cell therapies use injection-based administration to deliver high-density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This stu...

    Authors: Mahetab H. Amer, Felicity R. A. J. Rose, Kevin M. Shakesheff and Lisa J. White

    Citation: Stem Cell Research & Therapy 2018 9:39

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  5. Content type: Research

    Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF)....

    Authors: Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan and Hongqin Zhang

    Citation: Stem Cell Research & Therapy 2018 9:37

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  6. Content type: Research

    Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeu...

    Authors: Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer and Duane L. Davis

    Citation: Stem Cell Research & Therapy 2018 9:38

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  7. Content type: Research

    Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effect...

    Authors: Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma and Hong-Fei Xia

    Citation: Stem Cell Research & Therapy 2018 9:36

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  8. Content type: Research

    Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering. Still, to tra...

    Authors: Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl and Wolfgang Holnthoner

    Citation: Stem Cell Research & Therapy 2018 9:35

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  9. Content type: Letter

    CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed...

    Authors: Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte and Sara Teresinha Olalla Saad

    Citation: Stem Cell Research & Therapy 2018 9:34

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  10. Content type: Review

    Several studies have focused on umbilical cord-derived mesenchymal stem cells (UC-MSCs) due to their potential therapeutic effects in a cluster of diseases. However, there has been no bibliometric analysis eva...

    Authors: Jian Zhao, Guanyu Yu, Mengxi Cai, Xiao Lei, Yanyong Yang, Qijin Wang and Xiao Zhai

    Citation: Stem Cell Research & Therapy 2018 9:32

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  11. Content type: Research

    Mesenchymal stromal cells (MSCs) are an attractive therapeutic agent in regenerative medicine. Recently, there has been a paradigm shift from differentiation of MSCs to their paracrine effects at the injury si...

    Authors: Apeksha Damania, Deepika Jaiman, Arun Kumar Teotia and Ashok Kumar

    Citation: Stem Cell Research & Therapy 2018 9:31

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  12. Content type: Research

    Doxorubicin (Dox) is a chemotherapy drug with limited application due to cardiotoxicity that may progress to heart failure. This study aims to evaluate the role of cardiomyocytes derived from mouse embryonic s...

    Authors: Danúbia Silva dos Santos, Guilherme Visconde Brasil, Isalira Peroba Rezende Ramos, Fernanda Cristina Paccola Mesquita, Tais Hanae Kasai-Brunswick, Michelle Lopes Araújo Christie, Gustavo Monnerat Cahli, Raiana Andrade Quintanilha Barbosa, Sandro Torrentes da Cunha, Jonathas Xavier Pereira, Emiliano Medei, Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho and Regina Coeli dos Santos Goldenberg

    Citation: Stem Cell Research & Therapy 2018 9:30

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  13. Content type: Research

    Studies in which mesenchymal stromal cells (MSC) from the placenta are compared with multiple MSC types from other sources are rare. The chorionic plate of the human placenta is mainly composed of fetal blood ...

    Authors: Mónica S. Ventura Ferreira, Michaela Bienert, Katrin Müller, Björn Rath, Tamme Goecke, Christian Opländer, Till Braunschweig, Petra Mela, Tim H. Brümmendorf, Fabian Beier and Sabine Neuss

    Citation: Stem Cell Research & Therapy 2018 9:28

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  14. Content type: Research

    Mature human hepatocytes are critical in preclinical research and therapy for liver disease, but are difficult to manipulate and expand in vitro. Hepatic stem cells (HpSCs) may be an alternative source of func...

    Authors: Ran-Ran Zhang, Yun-Wen Zheng, Bin Li, Yun-Zhong Nie, Yasuharu Ueno, Tomonori Tsuchida and Hideki Taniguchi

    Citation: Stem Cell Research & Therapy 2018 9:29

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  15. Content type: Research

    The study aimed to evaluate the efficacy and safety of gingival mesenchymal stem cells (GMSCs) from human fetal gingival tissue used for treating gingival defects in a rat model.

    Authors: Jing Li, Shi-qing Xu, Kai Zhang, Wen-jian Zhang, Hong-lin Liu, Zhen Xu, Hong Li, Jin-ning Lou, Li-hong Ge and Bao-hua Xu

    Citation: Stem Cell Research & Therapy 2018 9:27

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  16. Content type: Research

    Currently, ex-vivo handling of stem cells, including transport after harvest and therapeutic preparation, is generally done in culture media containing fetal bovine serum (FBS), which promotes cell attachment,...

    Authors: Mai Mochizuki and Taka Nakahara

    Citation: Stem Cell Research & Therapy 2018 9:25

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  17. Content type: Research

    Radiation-induced gastrointestinal syndrome (RIGS) results from the acute loss of intestinal stem cells (ISC), impaired epithelial regeneration, and subsequent loss of the mucosal barrier, resulting in electro...

    Authors: Payel Bhanja, Andrew Norris, Pooja Gupta-Saraf, Andrew Hoover and Subhrajit Saha

    Citation: Stem Cell Research & Therapy 2018 9:26

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  18. Content type: Research

    Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily from extracted teeth and are now considered to be ...

    Authors: Yasuyuki Fujii, Yoko Kawase-Koga, Hironori Hojo, Fumiko Yano, Marika Sato, Ung-il Chung, Shinsuke Ohba and Daichi Chikazu

    Citation: Stem Cell Research & Therapy 2018 9:24

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  19. Content type: Research

    The underlying pathophysiology in intellectual disability (ID) involves abnormalities in dendritic branching and connectivity of the neuronal network. This limits the ability of the brain to process informatio...

    Authors: Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Suhasini Pai, Pooja Kulkarni, Vaishali Ganwir, Maitree Maheshwari, Ridhima Sharma, Meenakshi Raichur, Samson Nivins and Prerna Badhe

    Citation: Stem Cell Research & Therapy 2018 9:19

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  20. Content type: Research

    Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-me...

    Authors: Zhi Yang, Chengmin He, Jinyang He, Jing Chu, Hanping Liu and Xiaoyuan Deng

    Citation: Stem Cell Research & Therapy 2018 9:21

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  21. Content type: Research

    This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone r...

    Authors: Hongqin Zhang, Qianqian Luo, Xueyan Lu, Na Yin, Dongli Zhou, Lianshuang Zhang, Wei Zhao, Dong Wang, Pengchao Du, Yun Hou, Yan Zhang and Wendan Yuan

    Citation: Stem Cell Research & Therapy 2018 9:20

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  22. Content type: Review

    During tumorigenesis and development, participation of the tumor microenvironment is not negligible. As an important component in the tumor microenvironment, mesenchymal stem cells (MSCs) have been corroborate...

    Authors: Ying Zheng, Gangyang Wang, Ruiling Chen, Yingqi Hua and Zhengdong Cai

    Citation: Stem Cell Research & Therapy 2018 9:22

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  23. Content type: Review

    Since radiotherapy is widely used in managing thoracic tumors, physicians have begun to realize that radiation-induced lung injury (RILI) seriously limits the effects of radiotherapy. Unfortunately, there are ...

    Authors: Tiankai Xu, Yuyu Zhang, Pengyu Chang, Shouliang Gong, Lihong Shao and Lihua Dong

    Citation: Stem Cell Research & Therapy 2018 9:18

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