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  1. Content type: Research

    Irradiation-induced kidney damage is inevitable during radiotherapeutic practice, which limits effective radiotherapy doses on tumor treatment. In the present study, the role of mTOR complex 1 (mTORC1) signali...

    Authors: Lijian Shao, Wuping Yang, Rui Xu, Shuqin Zhu, Yanqiu Huang, Huan Li, Xincheng Wu, Mengzhen Yue, Xiaoliang Xiong, Xiaowen Chen, Bohai Kuang, Guangqin Fan, Qingxian Zhu and Huihong Zeng

    Citation: Stem Cell Research & Therapy 2018 9:219

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  2. Content type: Research

    Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to induce tissue regeneration. In search of the best cell...

    Authors: Cinzia Rota, Marina Morigi, Domenico Cerullo, Martino Introna, Ornella Colpani, Daniela Corna, Chiara Capelli, Ton J. Rabelink, Danielle G. Leuning, Daniela Rottoli, Ariela Benigni, Carlamaria Zoja and Giuseppe Remuzzi

    Citation: Stem Cell Research & Therapy 2018 9:220

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  3. Content type: Research

    Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing les...

    Authors: Yena Kim, Narae Park, Yeri Alice Rim, Yoojun Nam, Hyerin Jung, Kijun Lee and Ji Hyeon Ju

    Citation: Stem Cell Research & Therapy 2018 9:217

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  4. Content type: Research

    The effects of electromagnetic fields (EMF) on bone nonunion have been reported for many years. Many studies and randomized controlled trials have demonstrated that EMF exhibited benefits in curing delayed uni...

    Authors: Chang Tu, Yifan Xiao, Yongzhuang Ma, Hua Wu and Mingyu Song

    Citation: Stem Cell Research & Therapy 2018 9:215

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  5. Content type: Research

    The aim of this study was to investigate if epigenetically modified human mesenchymal stromal cells (hMSCs) can regulate the Th17-related immune responses.

    Authors: Kyoung-Woon Kim, Hye Joung Kim, Bo-Mi Kim, Yong-Rim Kwon, Hae-Rim Kim and Yoo-Jin Kim

    Citation: Stem Cell Research & Therapy 2018 9:208

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  6. Content type: Research

    Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly ...

    Authors: Zheying Min, Qian Gao, Xiumei Zhen, Yong Fan, Tao Tan, Rong Li, Yue Zhao and Yang Yu

    Citation: Stem Cell Research & Therapy 2018 9:210

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  7. Content type: Research

    Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone marro...

    Authors: Cecilie Gjerde, Kamal Mustafa, Sølve Hellem, Markus Rojewski, Harald Gjengedal, Mohammed Ahmed Yassin, Xin Feng, Siren Skaale, Trond Berge, Annika Rosen, Xie-Qi Shi, Aymen B. Ahmed, Bjørn Tore Gjertsen, Hubert Schrezenmeier and Pierre Layrolle

    Citation: Stem Cell Research & Therapy 2018 9:213

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  8. Content type: Research

    Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem ce...

    Authors: Barbara Bellei, Emilia Migliano, Marinella Tedesco, Silvia Caputo, Federica Papaccio, Gianluca Lopez and Mauro Picardo

    Citation: Stem Cell Research & Therapy 2018 9:207

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  9. Content type: Research

    Differentiation of human induced pluripotent stem cells (hiPSCs) into hepatocytes has important clinical significance in providing a new stem cell source for cell therapy of terminal liver disease. The differe...

    Authors: Ziran Xu, Xia He, Xu Shi, Yuhan Xia, Xiaomei Liu, Haitao Wu, Pengdong Li, Hongyu Zhang, Weisi Yin, Xiubo Du, Lisha Li and Yulin Li

    Citation: Stem Cell Research & Therapy 2018 9:211

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  10. Content type: Research

    Adipose-derived mesenchymal stem cells (ADSCs) have been extensively explored as a promising therapeutic agent due to their differentiation, proliferation and migration abilities. The epigenetic mechanisms tha...

    Authors: Chongyang Shen, Qingli Quan, Chuan Yang, Yueqiang Wen and Hong Li

    Citation: Stem Cell Research & Therapy 2018 9:212

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  11. Content type: Research

    Although many reports show that various kinds of stem cells have the ability to recover the function of premature ovarian insufficiency (POI), few studies are associated with the mechanism of stem cell treatme...

    Authors: Boxian Huang, Jiafeng Lu, Chenyue Ding, Qinyan Zou, Wei Wang and Hong Li

    Citation: Stem Cell Research & Therapy 2018 9:216

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  12. Content type: Short report

    Human endometrial epithelia undergo injury repair and regeneration with the menstrual cycle; however, mechanisms underpinning the roles of endometrial epithelial cells in endometrial lesions and regeneration r...

    Authors: Dandan Li, Hui Li, Ying Wang, Ahmed Eldomany, Jing Wu, Chao Yuan, Jing Xue, Juan Shi, Yuanyuan Jia, Chunfang Ha, Shuxia Han, Xiaoming Liu, Jiali Yang and Dan Liu

    Citation: Stem Cell Research & Therapy 2018 9:209

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  13. Content type: Research

    Several studies have confirmed that gold nanoparticles (AuNPs) of specific concentration and size exert a boosting effect on cell proliferation; however, the mechanism through which this effect occurs remains ...

    Authors: Chen Li, Zhuoquan Li, Yan Zhang, Abdel Hamid Fathy and Min Zhou

    Citation: Stem Cell Research & Therapy 2018 9:214

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  14. Content type: Research

    Deletions and mutations in the SHANK3 gene are strongly associated with autism spectrum disorder and underlie the autism-associated disorder Phelan–McDermid syndrome. SHANK3 is a scaffolding protein found at the ...

    Authors: Samuel E. Taylor, Ruth D. Taylor, Jack Price and Laura C. Andreae

    Citation: Stem Cell Research & Therapy 2018 9:206

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  15. Content type: Research

    Differentiation of mesenchymal stem cells to osteoblasts is widely performed in research laboratories. Classical tests to prove this differentiation employ procedures such as cell fixation, cell lysis or cell ...

    Authors: Hanna Hanna, Lluis M. Mir and Franck M. Andre

    Citation: Stem Cell Research & Therapy 2018 9:203

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  16. Content type: Research

    Hematopoietic lineage cells derived from human pluripotent stem cells (hPSCs) hold great promise for the treatment of hematological diseases and providing sufficient cells for immune therapy. However, a simple...

    Authors: Fuyu Duan, Rujin Huang, Fengzhi Zhang, Yonglin Zhu, Lin Wang, Xia Chen, Lufeng Bai, Wei Guo, Sophia Chia-Ning Chang, Xiaoyu Hu and Jie Na

    Citation: Stem Cell Research & Therapy 2018 9:205

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  17. Content type: Review

    Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past d...

    Authors: Haissam Abou-Saleh, Fouad A. Zouein, Ahmed El-Yazbi, Despina Sanoudou, Christophe Raynaud, Christopher Rao, Gianfranco Pintus, Hassan Dehaini and Ali H. Eid

    Citation: Stem Cell Research & Therapy 2018 9:201

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  18. Content type: Research

    As the prevalence of therapeutic approaches involving transplanted cells increases, so does the need to noninvasively track the cells to determine their homing patterns. Of particular interest is the fate of t...

    Authors: Sean K. Sweeney, Gohar S. Manzar, Nicholas Zavazava and Jose G. Assouline

    Citation: Stem Cell Research & Therapy 2018 9:204

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  19. Content type: Short report

    Patients with scarred vocal folds (congenitally or following phonosurgery) are currently difficult to treat and present a dysphonia, often disabling in daily life. Several therapies are available on the market...

    Authors: Alexia Mattei, Jérémy Magalon, Baptiste Bertrand, Fanny Grimaud, Joana Revis, Mélanie Velier, Julie Veran, Patrick Dessi, Florence Sabatier and Antoine Giovanni

    Citation: Stem Cell Research & Therapy 2018 9:202

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  20. Content type: Research

    Endothelial cells have been shown to mediate angiogenesis in ischemic injury sites and contribute to the repair of damaged tissues. However, the treatment of ischemic disease requires a significant number of e...

    Authors: Jae Kyung Park, Tae Wook Lee, Eun Kyoung Do, Hye Ji Moon and Jae Ho Kim

    Citation: Stem Cell Research & Therapy 2018 9:197

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  21. Content type: Research

    Platelet-rich plasma (PRP) is becoming a promising strategy to treat early intervertebral disc degeneration (IDD) in clinics. Pure PRP without leukocytes (P-PRP) may decrease the catabolic and inflammatory cha...

    Authors: Shan-zheng Wang, Wei-min Fan, Jun Jia, Liang-yu Ma, Jia-bin Yu and Chen Wang

    Citation: Stem Cell Research & Therapy 2018 9:199

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  22. Content type: Research

    Male germline stem cells (mGSCs) offer great promise in regenerative medicine and animal breeding due to their capacity to maintain self-renewal and to transmit genetic information to the next generation follo...

    Authors: Yinshan Bai, Cui Zhu, Meiying Feng, Hengxi Wei, Li Li, Xiuchun Tian, Zhihong Zhao, Shanshan Liu, Ningfang Ma, Xianwei Zhang, Ruyi Shi, Chao Fu, Zhenfang Wu and Shouquan Zhang

    Citation: Stem Cell Research & Therapy 2018 9:200

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  23. Content type: Research

    Familial hemophagocytic lymphohistiocytosis 2 (FHL2) is the most common familial type of hemophagocytic lymphohistiocytosis with immune dysregulation. FHL2 patients have mutations in the perforin gene which ca...

    Authors: Handan Sevim, Yusuf Çetin Kocaefe, Mehmet Ali Onur, Duygu Uçkan-Çetinkaya and Özer Aylin Gürpınar

    Citation: Stem Cell Research & Therapy 2018 9:198

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  24. Content type: Research

    Refinement of therapeutic-scale platelet production in vitro will provide a new source for transfusion in patients undergoing chemotherapy or radiotherapy. However, procedures for cost-effective and scalable p...

    Authors: Leisheng Zhang, Cuicui Liu, Hongtao Wang, Dan Wu, Pei Su, Mengge Wang, Jiaojiao Guo, Shixuan Zhao, Shuxu Dong, Wen Zhou, Cameron Arakaki, Xiaobing Zhang and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2018 9:194

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  25. Content type: Research

    Skeletal muscle has a remarkable regenerative capacity. However, extensive damage that exceeds the self-regenerative ability of the muscle can lead to irreversible fibrosis, scarring, and significant loss of f...

    Authors: Agata Gorecka, Souzan Salemi, Deana Haralampieva, Federica Moalli, Deborah Stroka, Daniel Candinas, Daniel Eberli and Lukas Brügger

    Citation: Stem Cell Research & Therapy 2018 9:195

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  26. Content type: Research

    Compromised wound healing has become a global public health challenge which presents a significant psychological, financial, and emotional burden on patients and physicians. We recently reported that acellular...

    Authors: Nazihah Bakhtyar, Marc G. Jeschke, Elaine Herer, Mohammadali Sheikholeslam and Saeid Amini-Nik

    Citation: Stem Cell Research & Therapy 2018 9:193

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  27. Content type: Research

    The fully developed adult skeleton adapts to mechanical forces by generating more bone, usually at the periosteal surface. Progenitor cells in the periosteum are believed to differentiate into bone-forming ost...

    Authors: Emily R. Moore, Ya Xing Zhu, Han Seul Ryu and Christopher R. Jacobs

    Citation: Stem Cell Research & Therapy 2018 9:190

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  28. Content type: Review

    Desirable cells for human cell therapy would be ones that can be generated by simple isolation and culture techniques using a donor sample obtained by non-invasive methods. To date, the different donor-specifi...

    Authors: Nimshitha Pavathuparambil Abdul Manaph, Mohammed Al-Hawwas, Larisa Bobrovskaya, Patrick T. Coates and Xin-Fu Zhou

    Citation: Stem Cell Research & Therapy 2018 9:189

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  29. Content type: Research

    Intrauterine adhesions (IUA) are the most common cause of uterine infertility and are caused by endometrium fibrotic regeneration following severe damage to the endometrium. Although current stem cell treatmen...

    Authors: Yun Cao, Haixiang Sun, Hui Zhu, Xianghong Zhu, Xiaoqiu Tang, Guijun Yan, Jingmei Wang, Donghui Bai, Juan Wang, Liu Wang, Qi Zhou, Huiyan Wang, Chengyan Dai, Lijun Ding, Biyun Xu, Yan Zhou…

    Citation: Stem Cell Research & Therapy 2018 9:192

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  30. Content type: Research

    Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU oc...

    Authors: Lara Lopes, Ocean Setia, Afsha Aurshina, Shirley Liu, Haidi Hu, Toshihiko Isaji, Haiyang Liu, Tun Wang, Shun Ono, Xiangjiang Guo, Bogdan Yatsula, Jianming Guo, Yongquan Gu, Tulio Navarro and Alan Dardik

    Citation: Stem Cell Research & Therapy 2018 9:188

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  31. Content type: Research

    The concept of establishing a dental stem cell (DSC) bank for oral and maxillofacial regeneration has become of great interest but it remains at a primitive stage. The routine application of serum-containing c...

    Authors: Jingyi Xiao, Dawei Yang, Qiwen Li, Weidong Tian and Weihua Guo

    Citation: Stem Cell Research & Therapy 2018 9:191

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  32. Content type: Letter

    Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids...

    Authors: Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon Yi

    Citation: Stem Cell Research & Therapy 2018 9:187

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  33. Content type: Short report

    Organoids from human pluripotent stem cells are becoming suitable models for studies of organ development, drug screening, regenerative medicine, and disease modeling. Three-dimensional minilungs in Matrigel c...

    Authors: Esmeralda Magro-Lopez, Charlotte Palmer, Joana Manso, Isabel Liste and Alberto Zambrano

    Citation: Stem Cell Research & Therapy 2018 9:186

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  34. Content type: Research

    Osteopontin (OPN), an acidic phosphoglycoprotein, is upregulated in the brain after cerebral ischemia. We previously reported that OPN supports migration, survival, and proliferation of neural stem cells (NSC)...

    Authors: Rebecca Rogall, Monika Rabenstein, Sabine Vay, Annika Bach, Anton Pikhovych, Johannes Baermann, Mathias Hoehn, Sébastien Couillard-Despres, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger

    Citation: Stem Cell Research & Therapy 2018 9:182

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  35. Content type: Research

    Mesenchymal stromal cells (MSCs) are promising cell therapy candidates. Clinical application is considered safe. However, minor side effects have included thromboembolism and instant blood-mediated inflammator...

    Authors: P. Netsch, S. Elvers-Hornung, S. Uhlig, H. Klüter, V. Huck, F. Kirschhöfer, G. Brenner-Weiß, K. Janetzko, H. Solz, P. Wuchter, P. Bugert and K. Bieback

    Citation: Stem Cell Research & Therapy 2018 9:184

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  36. Content type: Method

    Exosomes are nanovesicles (30–120 nm) of endosomal origin. These exosomes contain various functional proteins and RNAs that could be used for therapeutic purposes. Currently, having a standard method for exoso...

    Authors: Suchi Gupta, Sonali Rawat, Vivek Arora, Sarat Kumar Kottarath, Amit Kumar Dinda, Pradeep Kumar Vaishnav, Baibaswata Nayak and Sujata Mohanty

    Citation: Stem Cell Research & Therapy 2018 9:180

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  37. Content type: Research

    Vascularization is one of the most important processes in tissue-engineered bone graft (TEBG)-mediated regeneration of large segmental bone defects. We previously showed that prevascularization of TEBGs promot...

    Authors: Pengzhen Cheng, Donglin Li, Yi Gao, Tianqing Cao, Huijie Jiang, Jimeng Wang, Junqin Li, Shuaishuai Zhang, Yue Song, Bin Liu, Chunmei Wang, Liu Yang and Guoxian Pei

    Citation: Stem Cell Research & Therapy 2018 9:176

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  38. Content type: Research

    In cell-based therapy, the transmission of communicable diseases imposes a substantial threat to recipients. In this study, we investigated whether cell-based screening could detect hepatitis B virus (HBV) in ...

    Authors: Wei Liu, Yuanyuan Xie, Tianyun Gao, Feifei Huang, Liudi Wang, Lijun Ding, Wenqing Wang, Shuo Liu, Jianwu Dai and Bin Wang

    Citation: Stem Cell Research & Therapy 2018 9:177

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  39. Content type: Research

    Skin injuries in horses frequently lead to chronic wounds that lack a keratinocyte cover essential for healing. The limited proliferation of equine keratinocytes using current protocols has limited their use f...

    Authors: Faris Alkhilaiwi, Liqing Wang, Dan Zhou, Terje Raudsepp, Sharmila Ghosh, Siddartha Paul, Nancy Palechor-Ceron, Sabine Brandt, Jennifer Luff, Xuefeng Liu, Richard Schlegel and Hang Yuan

    Citation: Stem Cell Research & Therapy 2018 9:181

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  40. Content type: Research

    The mammalian target of rapamycin (mTOR) pathway plays a significant role in osteogenic differentiation and bone maintenance. As the only known endogenous inhibitor of mTOR function, DEP domain containing mTOR...

    Authors: Si Chen, Lingfei Jia, Shan Zhang, Yunfei Zheng and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2018 9:185

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  41. Content type: Research

    Diabetes is a proinflammatory state. Fibrosis of the renal glomerulus is the most common cause of end-stage renal disease. Glomerulosclerosis is caused by the accumulation of extracellular matrix (ECM) protein...

    Authors: Ching-Chuan Hsieh, Chun-Liang Lin, Jie-Teng He, Meihua Chiang, Yuhsiu Wang, Yu-Chin Tsai, Chien-Hui Hung and Pey-Jium Chang

    Citation: Stem Cell Research & Therapy 2018 9:183

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  42. Content type: Research

    Recently, the capacity of mesenchymal stem/stromal cells (MSCs) to migrate into damaged tissues has been reported. For MSCs to be a promising tool for tissue engineering and cell and gene therapy, it is essent...

    Authors: Alexandra Calle, Clara Barrajón-Masa, Ernesto Gómez-Fidalgo, Mercedes Martín-Lluch, Paloma Cruz-Vigo, Raúl Sánchez-Sánchez and Miguel Ángel Ramírez

    Citation: Stem Cell Research & Therapy 2018 9:178

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  43. Content type: Research

    Damaged or malfunctioning sweat glands (SGs) after a burn injury would cause significant hyperthermia and even death, and there is an unmet need for effective treatment. Genetically reprogrammed stem cells sho...

    Authors: Bin Yao, Wei Song, Zhao Li, Tian Hu, Rui Wang, Yihui Wang, Sha Huang and Xiaobing Fu

    Citation: Stem Cell Research & Therapy 2018 9:179

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  44. Content type: Research

    Mesenchymal stem cells (MSCs) have diverse functions in regulating injury and inflammation through the secretion of extracellular vesicles (EVs).

    Authors: Nesrine Ebrahim, Ola Mostafa, Rania Ebrahim El Dosoky, Inas A. Ahmed, Ahmed S. Saad, Abeer Mostafa, Dina Sabry, Khalid Abdelaziz Ibrahim and Ayman Samir Farid

    Citation: Stem Cell Research & Therapy 2018 9:175

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  45. Content type: Research

    Direct intra-articular injection (DIAI) of mesenchymal stem cells (MSCs) is a promising technique for cartilage repair. However, the repair process was hindered by the absence of scaffold and poor cell–matrix ...

    Authors: Hansong Xia, Chi Liang, Pan Luo, Junjie Huang, Jinshen He, Zili Wang, Xu Cao, Cheng Peng and Song Wu

    Citation: Stem Cell Research & Therapy 2018 9:174

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  46. Content type: Research

    Cell therapy for the treatment of intervertebral disc degeneration (IDD) faces serious barriers since tissue-specific adult cells such as nucleus pulposus cells (NPCs) have limited proliferative ability and po...

    Authors: Xiao-Chuan Li, Mao-Sheng Wang, Wei Liu, Cheng-Fan Zhong, Gui-Bin Deng, Shao-Jian Luo and Chun-Ming Huang

    Citation: Stem Cell Research & Therapy 2018 9:171

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  47. Content type: Research

    Mesenchymal stem cells (MSCs) are promising tools for the treatment of human lung disease and other pathologies relevant to newborn medicine. Recent studies have established MSC exosomes (EXO), as one of the m...

    Authors: Sushma Chaubey, Sam Thueson, Devasena Ponnalagu, Mohammad Afaque Alam, Ciprian P. Gheorghe, Zubair Aghai, Harpreet Singh and Vineet Bhandari

    Citation: Stem Cell Research & Therapy 2018 9:173

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  48. Content type: Research

    Mesenchymal stromal cells (MSC) are components of connective tissues and, in vitro, cell entities characterized by cell adhesion and immunophenotyping, although specific markers for their identification are la...

    Authors: David Alfaro and Agustín G. Zapata

    Citation: Stem Cell Research & Therapy 2018 9:172

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