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  1. Content type: Research

    Although typically cultured at an atmospheric oxygen concentration (20–21%), adipose-derived stem cells (ASCs) reside under considerable low oxygen tension (physioxia) in vivo. In the present study, we explore...

    Authors: Chang Chen, Qi Tang, Yan Zhang, Mei Yu, Wei Jing and Weidong Tian

    Citation: Stem Cell Research & Therapy 2018 9:148

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  2. Content type: Research

    Human induced pluripotent stem cells-derived mesenchymal stem cells (iPSC-MSCs) have been shown to be effective in Type 2 helper T cells (Th2)-dominant eosinophilic allergic airway inflammation. However, the r...

    Authors: Shu-Bin Fang, Hong-Yu Zhang, Ai-Yun Jiang, Xing-Liang Fan, Yong-Dong Lin, Cheng-Lin Li, Cong Wang, Xiang-Ci Meng and Qing-Ling Fu

    Citation: Stem Cell Research & Therapy 2018 9:147

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  3. Content type: Research

    Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); howeve...

    Authors: Xiaoxi Xu, Yong Wang, Baoren Zhang, Xu Lan, Shanzheng Lu, Peng Sun, Xiang Li, Ganggang Shi, Yiming Zhao, Hongqiu Han, Caigan Du and Hao Wang

    Citation: Stem Cell Research & Therapy 2018 9:146

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  4. Content type: Research

    The ability of mesenchymal stem cells (MSCs) to migrate to the desired tissues or lesions is crucial for stem cell-based regenerative medicine and tissue engineering. Optimal therapeutics for promoting MSC mig...

    Authors: Yingchi Zhang, Jiyuan Yan, Haoran Xu, Yong Yang, Wenkai Li, Hua Wu and Chaoxu Liu

    Citation: Stem Cell Research & Therapy 2018 9:143

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  5. Content type: Research

    Multiple myeloma (MM) currently remains largely incurable. Cancer stem cells (CSCs) are believed to be responsible for drug resistance and eventual relapse. In this study, we exploited a novel agent to evaluat...

    Authors: Fangfang Shi, Miao Li, Jing Wang, Di Wu, Meng Pan, Mei Guo and Jun Dou

    Citation: Stem Cell Research & Therapy 2018 9:144

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  6. Content type: Research

    Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these process...

    Authors: Rami Anderi, Nehman Makdissy, Albert Azar, Francine Rizk and Aline Hamade

    Citation: Stem Cell Research & Therapy 2018 9:141

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  7. Content type: Research

    Due to their extensive self-renewal and multilineage differentiation capacity, human embryonic stem cells (hESCs) have great potential for studying developmental biology, disease modeling, and developing cell ...

    Authors: Chuti Laowtammathron, Pimjai Chingsuwanrote, Roungsin Choavaratana, Suphadtra Phornwilardsiri, Ketsara Sitthirit, Chidchanok Kaewjunun, Orawan Makemaharn, Papussorn Terbto, Supaporn Waeteekul, Chanchao Lorthongpanich, Yaowalak U-pratya, Pimonwan Srisook, Pakpoom Kheolamai and Surapol Issaragrisil

    Citation: Stem Cell Research & Therapy 2018 9:138

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  8. Content type: Research

    Peripheral nerve injury (PNI) is a worldwide issue associated with severe social and economic burden. Autologous nerve grafting, the gold standard treatment for peripheral nerve defects, still has a number of ...

    Authors: Xun Sun, Yun Zhu, He-yong Yin, Zhi-yuan Guo, Feng Xu, Bo Xiao, Wen-li Jiang, Wei-min Guo, Hao-ye Meng, Shi-bi Lu, Yu Wang and Jiang Peng

    Citation: Stem Cell Research & Therapy 2018 9:133

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  9. Content type: Research

    Ischemic stroke causes a multitude of brain damage. Neurovascular injury and myelin sheath degradation are two manifestations of ischemic brain damage. Therapeutic strategies aiming only at repairing the neura...

    Authors: Yaning Li, Shuang Chang, Wanlu Li, Guanghui Tang, Yuanyuan Ma, Yanqun Liu, Fang Yuan, Zhijun Zhang, Guo-Yuan Yang and Yongting Wang

    Citation: Stem Cell Research & Therapy 2018 9:139

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  10. Content type: Research

    A variety of neurological disorders including neurodegenerative diseases and infection by neurotropic viruses can cause structural and functional changes in the central nervous system (CNS), resulting in long-...

    Authors: Leonardo D’Aiuto, Jennifer Naciri, Nicholas Radio, Sesha Tekur, Dennis Clayton, Gerard Apodaca, Roberto Di Maio, Yun Zhi, Peter Dimitrion, Paolo Piazza, Matthew Demers, Joel Wood, Charleen Chu, Jason Callio, Lora McClain, Robert Yolken…

    Citation: Stem Cell Research & Therapy 2018 9:134

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  11. Content type: Research

    The subcellular distribution of prorenin receptor and adaptor protein ATP6AP2 may affect neurogenesis. In this study, we hypothesized that ATP6AP2 expression and subcellular relocalization from caveolae/lipid ...

    Authors: Nehman Makdissy, Katia Haddad, Jeanne D’arc AlBacha, Diana Chaker, Bassel Ismail, Albert Azar, Ghada Oreibi, David Ayoub, Ibrahim Achkar, Didier Quilliot and Ziad Fajloun

    Citation: Stem Cell Research & Therapy 2018 9:132

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  12. Content type: Method

    The stromal vascular fraction (SVF) derived from adipose tissue contains adipose-derived stromal/stem cells (ASC) and can be used for regenerative applications. Thus, a validated protocol for SVF isolation, fr...

    Authors: Francesco Agostini, Francesca Maria Rossi, Donatella Aldinucci, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Samuele Massarut, Pier Camillo Parodi, Alessandro Da Ponte, Giovanni Tessitori, Barbara Pivetta, Cristina Durante and Mario Mazzucato

    Citation: Stem Cell Research & Therapy 2018 9:130

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  13. Content type: Research

    Differentiation of human induced pluripotent stem cells (hiPSCs) into retinal lineages offers great potential for medical application. Therefore, it is of crucial importance to know the key intrinsic regulator...

    Authors: Jen-Hua Chuang, Aliaksandr A. Yarmishyn, De-Kuang Hwang, Chih-Chien Hsu, Mong-Lien Wang, Yi-Ping Yang, Ke-Hung Chien, Shih-Hwa Chiou, Chi-Hsien Peng and Shih-Jen Chen

    Citation: Stem Cell Research & Therapy 2018 9:140

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  14. Content type: Research

    Spinal cord injuries (SCIs) are sustained by an increasing number of patients each year worldwide. The treatment of SCIs has long been a hard nut to crack for doctors around the world. Mesenchymal stem cells (...

    Authors: Chaohua Yang, Gaoju Wang, Fenfen Ma, Baoqing Yu, Fancheng Chen, Jin Yang, Jianjun Feng and Qing Wang

    Citation: Stem Cell Research & Therapy 2018 9:136

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  15. Content type: Research

    Multipotent mesenchymal stromal cell (MSC) therapy has been widely recognized as a feasible strategy for regenerating injured myocardial tissue. However, little is known about the efficacy of intravenous injec...

    Authors: Meikuang Lim, Weiqiang Wang, Lu Liang, Zhi-bo Han, Zongjin Li, Jie Geng, Meng Zhao, Honghong Jia, Jie Feng, Zhe Wei, Baoquan Song, Jiemin Zhang, Jun Li, Tianwen Liu, Fan Wang, Ting Li…

    Citation: Stem Cell Research & Therapy 2018 9:129

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  16. Content type: Research

    Adult mesenchymal stem cells (MSCs) hold great promise for regenerative medicine because of their self-renewal, multipotency, and trophic and immunosuppressive effects. Due to the rareness and high heterogenei...

    Authors: Yueh-Hsun Kevin Yang, Courtney R. Ogando, Carmine Wang See, Tsui-Yun Chang and Gilda A. Barabino

    Citation: Stem Cell Research & Therapy 2018 9:131

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  17. Content type: Research

    Adult mesenchymal stem cells (MSCs) play a crucial role in the maintenance of tissue homeostasis and in regenerative processes. Among the different MSC types, the gingiva-derived mesenchymal stem cells (GMSCs)...

    Authors: Chiara Giacomelli, Letizia Natali, Marco Nisi, Marinella De Leo, Simona Daniele, Barbara Costa, Filippo Graziani, Mario Gabriele, Alessandra Braca, M. Letizia Trincavelli and Claudia Martini

    Citation: Stem Cell Research & Therapy 2018 9:135

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  18. Content type: Research

    Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and t...

    Authors: Flavia Bruna, Anita Plaza, Martha Arango, Iris Espinoza and Paulette Conget

    Citation: Stem Cell Research & Therapy 2018 9:137

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  19. Content type: Research

    Bone marrow-derived allogeneic mesenchymal stem cells (MSCs) from young healthy donors are immunoprivileged and their clinical application for regenerative medicine is under evaluation. However, data from prec...

    Authors: Niketa Sareen, Glen Lester Sequiera, Rakesh Chaudhary, Ejlal Abu-El-Rub, Subir Roy Chowdhury, Vikram Sharma, Arun Surendran, Meenal Moudgil, Paul Fernyhough, Amir Ravandi and Sanjiv Dhingra

    Citation: Stem Cell Research & Therapy 2018 9:121

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  20. Content type: Research

    Critical tissues that undergo regeneration in periodontal tissue are of mesenchymal origin; thus, investigating the regulatory mechanisms underlying the fate of periodontal ligament stem cells could be benefic...

    Authors: Shan Yang, Lijia Guo, Yingying Su, Jing Wen, Juan Du, Xiaoyan Li, Yitong Liu, Jie Feng, Yongmei Xie, Yuxing Bai, Hao Wang and Yi Liu

    Citation: Stem Cell Research & Therapy 2018 9:118

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  21. Content type: Review

    α6-Integrin subunit (also known as CD49f) is a stemness signature that has been found on the plasma membrane of more than 30 stem cell populations. A growing body of studies have focused on the critical role o...

    Authors: Zijing Zhou, Jing Qu, Li He, Hong Peng, Ping Chen and Yong Zhou

    Citation: Stem Cell Research & Therapy 2018 9:122

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  22. Content type: Research

    Red blood cells are the most abundant cells in the blood that deliver oxygen to the whole body. Erythropoietin (EPO), a positive regulator of erythropoiesis, is currently the major treatment for chronic anemia...

    Authors: Tzu-Lin Chen, Ya-Wen Chiang, Guan-Ling Lin, Hsin-Hou Chang, Te-Sheng Lien, Min-Hua Sheh and Der-Shan Sun

    Citation: Stem Cell Research & Therapy 2018 9:119

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