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  1. One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage an...

    Authors: Haggai Kaspi, Jonathan Semo, Nathalie Abramov, Chen Dekel, Stacy Lindborg, Ralph Kern, Chaim Lebovits and Revital Aricha
    Citation: Stem Cell Research & Therapy 2021 12:72
  2. Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected ...

    Authors: Yaya Tang, Yan Zhou and Hong-Jun Li
    Citation: Stem Cell Research & Therapy 2021 12:71
  3. Age-related macular degeneration (AMD) is a result of degeneration/damage of the retinal pigment epithelium (RPE) while retinitis pigmentosa (RP), an inherited early-onset disease, results from premature loss ...

    Authors: Harshini Surendran, Swapna Nandakumar, Vijay Bhaskar Reddy K, Jonathan Stoddard, Varsha Mohan K, Pramod K. Upadhyay, Trevor J. McGill and Rajarshi Pal
    Citation: Stem Cell Research & Therapy 2021 12:70
  4. Optic-nerve injury results in impaired transmission of visual signals to central targets and leads to the death of retinal ganglion cells (RGCs) and irreversible vision loss. Therapies with mesenchymal stem ce...

    Authors: Almir Jordão da Silva-Junior, Louise Alessandra Mesentier-Louro, Gabriel Nascimento-dos-Santos, Leandro Coelho Teixeira-Pinheiro, Juliana F. Vasques, Luiza Chimeli-Ormonde, Victor Bodart-Santos, Luiza Rachel Pinheiro de Carvalho, Marcelo Felippe Santiago and Rosalia Mendez-Otero
    Citation: Stem Cell Research & Therapy 2021 12:69
  5. As the most important component of the vascular wall, vascular smooth muscle cells (VSMCs) participate in the pathological process by phenotype transformation or differentiation from stem/progenitor cells. The...

    Authors: Qing Zhang, Ting Chen, Yun Zhang, Lingxia Lyu, Bohuan Zhang, Chengchen Huang, Xuhao Zhou, Yutao Wu and Zhoubin Li
    Citation: Stem Cell Research & Therapy 2021 12:67
  6. Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The di...

    Authors: Boyan Wang, Yi Wang, Hainan Chen, Senyu Yao, Xiaofan Lai, Yuan Qiu, Jianye Cai, Yinong Huang, Xiaoyue Wei, Yuanjun Guan, Tao Wang, Jiancheng Wang and Andy Peng Xiang
    Citation: Stem Cell Research & Therapy 2021 12:65
  7. Human adipose-derived stem cells (hADSCs) are stem cells with the potential to differentiate in multiple directions. miR-204-5p is expressed at low levels during the osteogenic differentiation of hADSCs, and i...

    Authors: You Zhou, Siyu Liu, Wei Wang, Qiang Sun, Mengzhu Lv, Shude Yang, Shuang Tong and Shu Guo
    Citation: Stem Cell Research & Therapy 2021 12:64
  8. Radiation-induced rectal epithelial damage is a very common side effect of pelvic radiotherapy and often compromise the life quality and treatment outcome in patients with pelvic malignancies. Unlike small bow...

    Authors: Felipe Rodriguez Tirado, Payel Bhanja, Eduardo Castro-Nallar, Ximena Diaz Olea, Catalina Salamanca and Subhrajit Saha
    Citation: Stem Cell Research & Therapy 2021 12:63
  9. Hair follicle (HF) development and growth are dependent on epithelial-mesenchymal interactions (EMIs). Dermal papilla (DP) cells are recognized as the key inductive mesenchymal player, but the ideal source of ...

    Authors: Carla M. Abreu, Rogério P. Pirraco, Rui L. Reis, Mariana T. Cerqueira and Alexandra P. Marques
    Citation: Stem Cell Research & Therapy 2021 12:62

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:302

  10. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu
    Citation: Stem Cell Research & Therapy 2021 12:61

    The original article was published in Stem Cell Research & Therapy 2020 11:454

  11. Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types...

    Authors: Sara Galindo, Ana de la Mata, Marina López-Paniagua, Jose M. Herreras, Inmaculada Pérez, Margarita Calonge and Teresa Nieto-Miguel
    Citation: Stem Cell Research & Therapy 2021 12:60
  12. Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression whi...

    Authors: Nathalie Sumien, Matthew S. Wells, Akram Sidhu, Jessica M. Wong, Michael J. Forster, Qiao-Xi Zheng and Judith A. Kelleher-Andersson
    Citation: Stem Cell Research & Therapy 2021 12:59
  13. Critical limb ischemia (CLI) is the most advanced form of peripheral arterial disease (PAD) characterized by ischemic rest pain and non-healing ulcers. Currently, the standard therapy for CLI is the surgical r...

    Authors: Pegah Nammian, Seyedeh-Leili Asadi-Yousefabad, Sajad Daneshi, Mohammad Hasan Sheikhha, Seyed Mohammad Bagher Tabei and Vahid Razban
    Citation: Stem Cell Research & Therapy 2021 12:58
  14. Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear....

    Authors: Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga and Tomoaki Taguchi
    Citation: Stem Cell Research & Therapy 2021 12:57
  15. In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients’ survival rate. Bone marrow mesenchymal stem cells...

    Authors: Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu and Shaoyi Zheng
    Citation: Stem Cell Research & Therapy 2021 12:56
  16. Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potent...

    Authors: Breanna S. Borys, Tiffany Dang, Tania So, Leili Rohani, Tamas Revay, Tylor Walsh, Madalynn Thompson, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee and Michael S. Kallos
    Citation: Stem Cell Research & Therapy 2021 12:55
  17. Chronic obstructive pulmonary disease (COPD) is an incurable and debilitating chronic disease characterized by progressive airflow limitation associated with abnormal levels of tissue inflammation. Therefore, ...

    Authors: Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Seoparjoo Azmel Mohd Isa, Gurjeet Kaur Chatar Singh, Kong-Yong Then, Ghee-Chien Ooi and Badrul Hisham Yahaya
    Citation: Stem Cell Research & Therapy 2021 12:54
  18. Mesenchymal stromal cell (MSC)-based therapies are being actively investigated in various inflammatory disorders. However, functional variability among MSCs cultured in vitro will lead to distinct therapeutic ...

    Authors: Changbin Sun, Kehua Zhang, Jianhui Yue, Shufang Meng and Xi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:53
  19. Retinitis pigmentosa (RP) is a progressive inherited retinal disease with great interest for finding effective treatment modalities. Stem cell-based therapy is one of the promising candidates. We aimed to inve...

    Authors: Aekkachai Tuekprakhon, Siripakorn Sangkitporn, Adisak Trinavarat, Aulia Rahmi Pawestri, Visit Vamvanij, Monchai Ruangchainikom, Panya Luksanapruksa, Phitchapa Pongpaksupasin, Areerat Khorchai, Acharaporn Dambua, Patcharaporn Boonchu, Chonlada Yodtup, Mongkol Uiprasertkul, Somchai Sangkitporn and La-ongsri Atchaneeyasakul
    Citation: Stem Cell Research & Therapy 2021 12:52
  20. In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capac...

    Authors: Wen Li, Shanshan Wang, Hui He, Jianbing Qin, Xiang Cheng, Heyan Zhao, Meiling Tian, Xinhua Zhang and Guohua Jin
    Citation: Stem Cell Research & Therapy 2021 12:51
  21. Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue stem cells, especially mesenchymal stem cel...

    Authors: Shengchao Zhang, Jiankai Fang, Zhanhong Liu, Pengbo Hou, Lijuan Cao, Yuyan Zhang, Rui Liu, Yanan Li, Qianwen Shang, Yongjing Chen, Chao Feng, Guan Wang, Gerry Melino, Ying Wang, Changshun Shao and Yufang Shi
    Citation: Stem Cell Research & Therapy 2021 12:50
  22. Diabetic wounds remain a challenging clinical problem, which requires further treatment development. Published data showed that dermis-derived stem/progenitor cells (DSPCs) display superior wound healing in vi...

    Authors: Yu Xin, Peng Xu, Xiangsheng Wang, Yunsheng Chen, Zheng Zhang and Yixin Zhang
    Citation: Stem Cell Research & Therapy 2021 12:49
  23. Spinal cord injury (SCI) is a neurological, medically incurable disorder. Human pluripotent stem cells (hPSCs) have the potential to generate neural stem/progenitor cells (NS/PCs), which hold promise in the tr...

    Authors: Rui Bai, Yun Chang, Amina Saleem, Fujian Wu, Lei Tian, Siyao Zhang, Ya’nan Li, Shuhong Ma, Tao Dong, Tianwei Guo, Youxu Jiang, Yi You, Wen-Jing Lu, Hong Feng Jiang and Feng Lan
    Citation: Stem Cell Research & Therapy 2021 12:48
  24. Paracrine signaling from endothelial progenitor cells (EPCs) is beneficial for angiogenesis and thus promotes tissue regeneration. Microgravity (MG) environment is found to facilitate the functional potentials...

    Authors: Lingchi Kong, Yan Wang, Haixing Wang, Qi Pan, Rongtai Zuo, Shanshan Bai, Xiaoting Zhang, Wayne Yukwai Lee, Qinglin Kang and Gang Li
    Citation: Stem Cell Research & Therapy 2021 12:47
  25. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are regarded as promising cell type for cardiac cell replacement therapy, but it is not known whether the developmental stage influences their per...

    Authors: Gabriel Peinkofer, Martina Maass, Kurt Pfannkuche, Agapios Sachinidis, Stephan Baldus, Jürgen Hescheler, Tomo Saric and Marcel Halbach
    Citation: Stem Cell Research & Therapy 2021 12:46
  26. To investigate the in vitro and in vivo anti-inflammatory/anti-fibrotic capacity of IFP-MSC manufactured as 3D spheroids. Our hypothesis is that IFP-MSC do not require prior cell priming to acquire a robust im...

    Authors: Dimitrios Kouroupis, Melissa A. Willman, Thomas M. Best, Lee D. Kaplan and Diego Correa
    Citation: Stem Cell Research & Therapy 2021 12:44

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:282

  27. Epidermal stem cells (EpSCs) can self-renew, which are responsible for the long-term maintenance of the skin, and it also plays a critical role in wound re-epithelization, but the mechanism underlying EpSCs pr...

    Authors: Xiaohong Zhao, Ruyu Bian, Fan Wang, Ying Wang, Xue Li, Yicheng Guo, Xiaorong Zhang, Gaoxing Luo and Rixing Zhan
    Citation: Stem Cell Research & Therapy 2021 12:42
  28. Derivation of osteoblast-like cells from human pluripotent stem cells (hPSCs) is a popular topic in bone tissue engineering. Although many improvements have been achieved, the low induction efficiency because ...

    Authors: Ping Zhou, Jia-Min Shi, Jing-E Song, Yu Han, Hong-Jiao Li, Ya-Meng Song, Fang Feng, Jian-Lin Wang, Rui Zhang and Feng Lan
    Citation: Stem Cell Research & Therapy 2021 12:41
  29. Mesenchymal stem cell (MSC)-based therapy has the potential for immunomodulation and enhancement of tissue regeneration. Genetically modified MSCs that over-express specific cytokines, growth factors, or chemo...

    Authors: Ning Zhang, Chi-Wen Lo, Takeshi Utsunomiya, Masahiro Maruyama, Ejun Huang, Claire Rhee, Qi Gao, Zhenyu Yao and Stuart B. Goodman
    Citation: Stem Cell Research & Therapy 2021 12:40
  30. Precision or individualized medicine is increasingly pervasive across medical and surgical disciplines. However, the concept has not been introduced in regenerative medicine.

    Authors: Amy L. Lightner and Timothy Chan
    Citation: Stem Cell Research & Therapy 2021 12:39
  31. Inflammatory bowel disease is a chronic and excessive inflammation of the colon and small intestine. We previously reported that priming of mesenchymal stromal cells (MSCs) with poly(I:C) induced them to expre...

    Authors: Ji-Young Lim, Byung-Su Kim, Da-Bin Ryu, Tae Woo Kim, Gyeongsin Park and Chang-Ki Min
    Citation: Stem Cell Research & Therapy 2021 12:37
  32. The spinal cord is part of the central nervous system (CNS) and serves to connect the brain to the peripheral nervous system and peripheral tissues. The cell types that primarily comprise the spinal cord are n...

    Authors: Bin Lv, Xing Zhang, Jishan Yuan, Yongxin Chen, Hua Ding, Xinbing Cao and Anquan Huang
    Citation: Stem Cell Research & Therapy 2021 12:36
  33. Lower back pain is often accredited to loss of intervertebral disc (IVD) height and compromised spine stability as a result of intervertebral disc degeneration (IVDD). We aim to locally use bleomycin to induce...

    Authors: Xiao Yang, Zhiqian Chen, Chen Chen, Chen Han, Yifan Zhou, Xunlin Li, Haijun Tian, Xiaofei Cheng, Kai Zhang, An Qin, Tangjun Zhou and Jie Zhao
    Citation: Stem Cell Research & Therapy 2021 12:34
  34. Fistulas have puzzled us all the time and stem cell therapy for it is still in its infancy. We conducted a meta-analysis and systematic review to evaluate the efficacy of stem cells and its potential mechanism...

    Authors: Yantian Cao, Qi Su, Bangjie Zhang, Fangfang Shen and Shaoshan Li
    Citation: Stem Cell Research & Therapy 2021 12:32
  35. Ulcerative colitis (UC) is a chronic and recurrent disease without satisfactory treatment strategies. Dental pulp stem cell (DPSC) transplantation has been proposed as a potential therapy for UC. This study ai...

    Authors: Ning Li, Yichi Zhang, Narayan Nepal, Guoqing Li, Ningning Yang, Haoyuan Chen, Qiuchi Lin, Xuechun Ji, Sijia Zhang and Shizhu Jin
    Citation: Stem Cell Research & Therapy 2021 12:30
  36. Extracellular vesicles (EVs) and their mimics from mesenchymal stem cells (MSCs) are promising drug carriers to improve cancer treatment, but their application is hindered by donor variations and expansion lim...

    Authors: Qingguo Zhao, Bo Hai, Jack Kelly, Samuel Wu and Fei Liu
    Citation: Stem Cell Research & Therapy 2021 12:29
  37. Bone marrow stromal cells (BMSC) show promise in cartilage repair, and sheep are the most common large animal pre-clinical model.

    Authors: K. Futrega, E. Music, P. G. Robey, S. Gronthos, R. Crawford, S. Saifzadeh, T. J. Klein and M. R. Doran
    Citation: Stem Cell Research & Therapy 2021 12:26
  38. Umbilical cord mesenchymal stem cells (UC-MSCs) have certain advantages over other MSCs and about 300 clinical trials have been registered using UC-MSCs to treat diseases such as osteoarthritis, autoimmune dis...

    Authors: Shaoyang Zhang, Jing Yi Wang, Baojie Li, Feng Yin and Huijuan Liu
    Citation: Stem Cell Research & Therapy 2021 12:25
  39. Subretinal fibrosis resulting from neovascular age-related macular degeneration (nAMD) is one of the major causes of serious and irreversible vision loss worldwide, and no definite and effective treatment exis...

    Authors: Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong and Zhi Zheng
    Citation: Stem Cell Research & Therapy 2021 12:24
  40. Mesenchymal stem cell-based acellular therapies have been widely exploited in managing hypertrophic scars. However, low maintenance dose and transitory therapeutic effects during topical medication remain a th...

    Authors: Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen and Xiaosong Chen
    Citation: Stem Cell Research & Therapy 2021 12:23
  41. Previous studies have suggested that promoting endogenous neurogenesis has great significance for the recovery of cognitive dysfunction caused by cerebral ischemia (CI). Pharmacological inhibition of GABAB recept...

    Authors: Dan Song, Yaohua Chen, Cheng Chen, Lili Chen and Oumei Cheng
    Citation: Stem Cell Research & Therapy 2021 12:22
  42. Retinal degenerative diseases remain the dominant causes of blindness worldwide, and cell replacement is viewed as a promising therapeutic direction. However, the resources of seed cells are hard to obtain. To...

    Authors: Yifeng Ke, Xiaoe Fan, Rui Hao, Lijie Dong, Min Xue, Liangzhang Tan, Chunbo Yang, Xiaorong Li and Xinjun Ren
    Citation: Stem Cell Research & Therapy 2021 12:21

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:134

  43. Spinal cord injury is a devastating clinical condition for which there are currently no effective therapeutic options. In the present study, we aim to investigate if the effect of an administered injection of ...

    Authors: Yong Cao, Yan Xu, Chunyuan Chen, Hui Xie, Hongbin Lu and Jianzhong Hu
    Citation: Stem Cell Research & Therapy 2021 12:20
  44. Radial extracorporeal shockwave (r-ESW), an innovative and noninvasive technique, is gaining increasing attention in regenerative medicine due to its mechanobiological effects. Subchondral bone stem/progenitor...

    Authors: Zhidong Zhao, Yuxing Wang, Qian Wang, Jiawu Liang, Wei Hu, Sen Zhao, Peilin Li, Heng Zhu and Zhongli Li
    Citation: Stem Cell Research & Therapy 2021 12:19
  45. Steroid-induced osteonecrosis of the femoral head (SONFH) is a devastating orthopedic disease, which seriously affects the quality of life of patients. The study aims to investigate the effects of LncRNA NORAD...

    Authors: Dapeng Fu, Sheng Yang, Jianmin Lu, Haoyi Lian and Kairong Qin
    Citation: Stem Cell Research & Therapy 2021 12:18
  46. Hematopoietic stem cell (HSC) transplantation is an effective treatment strategy for many types of diseases. Peripheral blood (PB) is the most commonly used source of bone marrow (BM)-derived stem cells for cu...

    Authors: Xiao Fang, Xiong Fang, Yujia Mao, Aaron Ciechanover, Yan Xu, Jing An and Ziwei Huang
    Citation: Stem Cell Research & Therapy 2021 12:17
  47. Our previous studies have proved the efficient exogenous repairing responses via bone marrow stem and progenitor cells (BMSPCs). However, the trafficking of endogenous bone marrow stem and progenitor cells to ...

    Authors: Wenting Gao, Xuetao Yang, Juan Du, Haiyan Wang, Hejiang Zhong, Jianxin Jiang and Ce Yang
    Citation: Stem Cell Research & Therapy 2021 12:16
  48. The creation of a bioengineered cardiac patch (BCP) is a potential novel strategy for myocardial repair. Nevertheless, the ideal scaffold for BCP is unknown.

    Authors: Yu Jiang, Si-Jia Sun, Zhe Zhen, Rui Wei, Nannan Zhang, Song-Yan Liao and Hung-Fat Tse
    Citation: Stem Cell Research & Therapy 2021 12:13
  49. Mesenchymal stromal cells (MSCs) have been introduced as promising cell source for regenerative medicine. Besides their multilineage differentiation capacity, MSCs release a wide spectrum of bioactive factors....

    Authors: Sebastian Wangler, Amir Kamali, Christina Wapp, Karin Wuertz-Kozak, Sonja Häckel, Claudia Fortes, Lorin M. Benneker, Lisbet Haglund, R. Geoff Richards, Mauro Alini, Marianna Peroglio and Sibylle Grad
    Citation: Stem Cell Research & Therapy 2021 12:11

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