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  1. Preeclampsia (PE) is a frequently occurring pregnancy disorder in the placenta, which results in various maternal and fetal complications. The current study aims to evaluate the role of extracellular vesicles ...

    Authors: Jinhui Cui, Xinjuan Chen, Shuo Lin, Ling Li, Jianhui Fan, Hongying Hou and Ping Li
    Citation: Stem Cell Research & Therapy 2020 11:231
    Content type: Research Published on:

  2. Proliferation and transdifferentiation of lung stem cells (LSCs) could promote lung injury repair. The distal airways of the lung are innervated by the vagus nerve. Vagal-alpha7 nicotinic acetylcholine recepto...

    Authors: Xiaoyan Chen, Caiqi Zhao, Cuiping Zhang, Qingmei Li, Jie Chen, Lianping Cheng, Jian Zhou, Xiao Su and Yuanlin Song
    Citation: Stem Cell Research & Therapy 2020 11:230
    Content type: Research Published on:

  3. To investigate the therapeutic effect of human dental pulp stem cells (DPSCs) transfected with adenovirus expressing hepatocyte growth factor (HGF) in a mouse model of collagen-induced arthritis (CIA).

    Authors: Xiwen Dong, Fanxuan Kong, Chao Liu, Shiyun Dai, Yuning Zhang, Fengjun Xiao, Huan Zhang, Chu-Tse Wu and Hua Wang
    Citation: Stem Cell Research & Therapy 2020 11:229
    Content type: Research Published on:

  4. The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI). Irisin, a novel myokine which ...

    Authors: Jingyu Deng, Ning Zhang, Yong Wang, Chao Yang, Yabin Wang, Chao Xin, Jinming Zhao, Zhitao Jin, Feng Cao and Zheng Zhang
    Citation: Stem Cell Research & Therapy 2020 11:228
    Content type: Research Published on:

  5. Bone marrow mesenchymal stem cells (BMSCs) exhibit the capacity to self-renew and differentiate into multi-lineage cell types, including osteoblasts, which are crucial regulators of fracture healing. Thus, thi...

    Authors: Xueliang Zhang, Yongping Wang, Haiyan Zhao, Xingwen Han, Tong Zhao, Peng Qu, Guangjie Li and Wenji Wang
    Citation: Stem Cell Research & Therapy 2020 11:227
    Content type: Research Published on:

  6. Adipose-derived mesenchymal stem cells (ADMSCs) have attracted widespread interest as cell-based tissue repair systems. To obtain adequate quantities of ADMSCs for therapeutic applications, extensive in vitro ...

    Authors: Qiliang Yin, Na Xu, Dongsheng Xu, Mingxin Dong, Xiumin Shi, Yan Wang, Zhuo Hao, Shuangshuang Zhu, Donghai Zhao, Haofan Jin and Wensen Liu
    Citation: Stem Cell Research & Therapy 2020 11:226
    Content type: Research Published on:

  7. Acetaminophen (APAP) overdose is the common cause of acute liver failure (ALF) due to the oxidative damage of multiple cellular components. This study aimed to investigate whether plasma membrane vesicles (PMV...

    Authors: Mei-jia Lin, Shuang Li, Lu-jun Yang, Dan-yan Ye, Li-qun Xu, Xin Zhang, Ping-nan Sun and Chi-ju Wei
    Citation: Stem Cell Research & Therapy 2020 11:225
    Content type: Research Published on:

  8. Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiom...

    Authors: Hao Cheng, Shufu Chang, Rende Xu, Lu Chen, Xiaoyue Song, Jian Wu, Juying Qian, Yunzeng Zou and Jianying Ma
    Citation: Stem Cell Research & Therapy 2020 11:224
    Content type: Research Published on:

  9. Mesenchymal stem cell (MSC)-based therapy is currently considered to be an effective treatment strategy for diabetes and hepatic disorders, such as liver cirrhosis and non-alcoholic fatty liver disease. Exosom...

    Authors: Qin He, Lingshu Wang, Ruxing Zhao, Fei Yan, Sha Sha, Chen Cui, Jia Song, Huiqing Hu, Xinghong Guo, Mengmeng Yang, Yixin Cui, Yujing Sun, Zheng Sun, Fuqiang Liu, Ming Dong, Xinguo Hou…
    Citation: Stem Cell Research & Therapy 2020 11:223
    Content type: Research Published on:

  10. Machado-Joseph disease is the most common autosomal dominant hereditary ataxia worldwide without effective treatment. Mesenchymal stem cells (MSCs) could slow the disease progression, but side effects limited ...

    Authors: Hua-Jing You, Shu-Bin Fang, Teng-Teng Wu, Hongyu Zhang, Yu-Kun Feng, Xue-Jiao Li, Hui-Hua Yang, Ge Li, Xun-Hua Li, Chao Wu, Qing-Ling Fu and Zhong Pei
    Citation: Stem Cell Research & Therapy 2020 11:222
    Content type: Research Published on:

  11. Mesenchymal stem cells (MSCs) can improve limb perfusion and increase vessel density in a murine model of hindlimb ischemia. But low engraftment rate of those cells limited their therapeutic effect. Endothelia...

    Authors: Ziping Yao, Huihui Liu, Min Yang, Yun Bai, Bihui Zhang, Chengen Wang, Ziguang Yan, Guochen Niu, Yinghua Zou and Yuan Li
    Citation: Stem Cell Research & Therapy 2020 11:221
    Content type: Research Published on:

  12. Restenosis is a serious problem in patients who have undergone percutaneous transluminal angioplasty. Endothelial injury resulting from surgery can lead to endothelial dysfunction and neointimal formation by i...

    Authors: Zhihui Liu, Chao Wu, Xinliang Zou, Weiming Shen, Jiacai Yang, Xiaorong Zhang, Xiaohong Hu, Haidong Wang, Yi Liao and Tao Jing
    Citation: Stem Cell Research & Therapy 2020 11:220
    Content type: Research Published on:

  13. This study tested the optimal time point for left intra-carotid arterial (LICA) administration of circulatory-derived autologous endothelial progenitor cells (EPCs) for improving the outcome in rat after acute...

    Authors: Kun-Chen Lin, Han-Tan Chai, Kuan-Hung Chen, Pei-Hsun Sung, John Y. Chiang, Pei-Lin Shao, Chi-Ruei Huang, Yi-Chen Li, Sheung-Fat Ko and Hon-Kan Yip
    Citation: Stem Cell Research & Therapy 2020 11:219
    Content type: Research Published on:

  14. Donation after circulatory death (DCD) liver grafts have a poor prognosis after transplantation. We investigated whether the outcome of DCD donor organs can be improved by heme oxygenase 1 (HO-1)-modified bone...

    Authors: Huan Cao, Liu Yang, Bin Hou, Dong Sun, Ling Lin, Hong-Li Song and Zhong-Yang Shen
    Citation: Stem Cell Research & Therapy 2020 11:218
    Content type: Research Published on:

  15. A marked egg-induced CD4+ T cell programmed inflammation and subsequent hepatic fibrosis characterize the pathogenesis of schistosomiasis. Mesenchymal stem cell (MSC) has been extensively studied for the treatmen...

    Authors: Chao Liu, Yi-shu Zhang, Fang Chen, Xiao-ying Wu, Bei-bei Zhang, Zhong-dao Wu and Jun-xia Lei
    Citation: Stem Cell Research & Therapy 2020 11:217
    Content type: Research Published on:

  17. In periodontal tissue engineering, periodontal ligament stem cells derived from patients with periodontitis (P-PDLSCs) are among the most promising and accessible stem cells for repairing disrupted alveolar bo...

    Authors: Han Li, Yuejia Deng, Minmin Tan, Ge Feng, Yunchun Kuang, Jie Li and Jinlin Song
    Citation: Stem Cell Research & Therapy 2020 11:215
    Content type: Research Published on:

  18. Multiple studies have reported that mesenchymal stem cell (MSC) therapy has beneficial effects in experimental models of sepsis. However, this finding remains inconclusive. This study was performed to systemat...

    Authors: Xue-Yi Sun, Xian-Fei Ding, Huo-Yan Liang, Xiao-Juan Zhang, Shao-Hua Liu, Bing-Han, Xiao-Guang Duan and Tong-Wen Sun
    Citation: Stem Cell Research & Therapy 2020 11:214
    Content type: Research Published on:

  19. Idiopathic pulmonary fibrosis is a chronic, progressive, and severe disease with a limited response to currently available therapies. Epithelial cell injury and failure of appropriate healing or regeneration a...

    Authors: Belén Alvarez-Palomo, Luis Ignacio Sanchez-Lopez, Yuben Moodley, Michael J. Edel and Anna Serrano-Mollar
    Citation: Stem Cell Research & Therapy 2020 11:213
    Content type: Research Published on:

  20. The therapeutic effects of adipose-derived mesenchymal stem cell (ADSC) transplantation have been demonstrated in several models of central nervous system (CNS) injury and are thought to involve the modulation...

    Authors: Zhilai Zhou, Xiaobo Tian, Biling Mo, Huali Xu, Li Zhang, Lishan Huang, Shun Yao, Zixiang Huang, Yeyang Wang, Huan Xie, Liwei Xu and Hui Zhang
    Citation: Stem Cell Research & Therapy 2020 11:212
    Content type: Research Published on:

  22. The differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts (OBs) is a prerequisite for bone formation. However, little is known about the definitive surface markers for OBs during osteogenesis.

    Authors: Hyun Min Lee, Se-Ri Seo, Jeeseung Kim, Min Kyu Kim, Hyosun Seo, Kyoung Soo Kim, Young-Joo Jang and Chun Jeih Ryu
    Citation: Stem Cell Research & Therapy 2020 11:210
    Content type: Research Published on:

  23. Noonan syndrome (NS) is a developmental disorder caused by mutations of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2). Although NS patients have diverse neurological manifestations, th...

    Authors: Younghee Ju, Jun Sung Park, Daejeong Kim, Bumsoo Kim, Jeong Ho Lee, Yoonkey Nam, Han-Wook Yoo, Beom Hee Lee and Yong-Mahn Han
    Citation: Stem Cell Research & Therapy 2020 11:209
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:282

  25. The novel coronavirus disease 2019 (COVID-19) has grown to be a global public health emergency since patients were first detected in Wuhan, China. Thus far, no specific drugs or vaccines are available to cure ...

    Authors: Yingxin Zhang, Jie Ding, Shaoda Ren, Weihua Wang, Yapei Yang, Shuangjing Li, Min Meng, Tiejun Wu, Daliang Liu, Suochen Tian, Hui Tian, Shuangfeng Chen and Changhui Zhou
    Citation: Stem Cell Research & Therapy 2020 11:207
    Content type: Short report Published on:

  26. Exosomes derived from mesenchymal stem cells (MSC-exos) have been demonstrated with great potential in the treatment of multiple human diseases including acute kidney injury (AKI) by virtue of their intrinsic ...

    Authors: Jingyuan Cao, Bin Wang, Taotao Tang, Linli Lv, Zhaoying Ding, Zuolin Li, Ruoyu Hu, Qing Wei, Anran Shen, Yuqi Fu and Bicheng Liu
    Citation: Stem Cell Research & Therapy 2020 11:206
    Content type: Research Published on:

  27. Mesenchymal stromal cell conditioned medium (MSC-CM) contains a cocktail of bioactive factors that act synergistically to induce therapeutic effects. This has been clearly demonstrated by in vivo applications ...

    Authors: K. Shoma Suresh, Samatha Bhat, Bharath Raja Guru, Manjunatha S. Muttigi and Raviraja N. Seetharam
    Citation: Stem Cell Research & Therapy 2020 11:205
    Content type: Research Published on:

  28. Polydatin (PD), extracted from Polygonum cuspidatum, has shown potential therapeutic applications due to its antiosteoporotic and anti-inflammatory activities. Our previous study suggested that PD promotes the os...

    Authors: Ying-Shan Shen, Xiao-Jun Chen, Sha-Na Wuri, Fan Yang, Feng-Xiang Pang, Liang-Liang Xu, Wei He and Qiu-Shi Wei
    Citation: Stem Cell Research & Therapy 2020 11:204
    Content type: Research Published on:

  29. Retinal and/or optic nerve injury is one of the leading causes of blindness due to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress this neurodegeneration. Various somati...

    Authors: Seyedeh-Zahra Seyedrazizadeh, Sara Poosti, Abdoreza Nazari, Mehdi Alikhani, Faezeh Shekari, Farzad Pakdel, Koorosh Shahpasand, Leila Satarian and Hossein Baharvand
    Citation: Stem Cell Research & Therapy 2020 11:203
    Content type: Research Published on:

  30. Increasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization. As a critical process for dentin formation, odontoblastic differentiation is regulated by...

    Authors: Jialin Zhong, Xinran Tu, Yuanyuan Kong, Liyang Guo, Baishun Li, Wenchao Zhong, Ying Cheng, Yiguo Jiang and Qianzhou Jiang
    Citation: Stem Cell Research & Therapy 2020 11:202
    Content type: Research Published on:

  31. The original article omits an affiliation for authors, He Zhang and Dongjin Wang. The omitted affiliation can be viewed in this Correction article.

    Authors: Xumin Guan, Wanzi Xu, He Zhang, Qian Wang, Jiuyang Yu, Ruyi Zhang, Yamin Chen, Yunlong Xia, Jiaxian Wang and Dongjin Wang
    Citation: Stem Cell Research & Therapy 2020 11:201
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:73

  32. Accidentally removed parathyroid glands are still challenging in neck surgery, leading to hypoparathyroidism characterized with abnormally low levels of parathyroid hormone. Parathyroid auto-transplantation is...

    Authors: Qiuxia Cui, Dan Zhang, Deguang Kong, Jianing Tang, Xing Liao, Qian Yang, Jiangbo Ren, Yan Gong and Gaosong Wu
    Citation: Stem Cell Research & Therapy 2020 11:200
    Content type: Research Published on:

  33. Osteoarthritis (OA) is a major cause of limb dysfunction, and distraction arthroplasty which generates intermittent hydrostatic pressure (IHP) is an effective approach for OA treatment. However, the result was...

    Authors: Hanhao Dai, Ran Chen, Chang Gui, Tianqi Tao, Yingbin Ge, Xilian Zhao, Ran Qin, Wangxiang Yao, Song Gu, Yiqiu Jiang and Jianchao Gui
    Citation: Stem Cell Research & Therapy 2020 11:199
    Content type: Research Published on:

  34. Cutaneous wound healing represents a morphogenetic response to injury and is designed to restore anatomic and physiological function. Human bone marrow mesenchymal stem cell-derived exosomes (hBM-MSC-Ex) are a...

    Authors: Tiechao Jiang, Zhongyu Wang and Ji Sun
    Citation: Stem Cell Research & Therapy 2020 11:198
    Content type: Research Published on:

  35. The inevitable side effects caused by lifelong immunosuppressive agents in kidney transplantation patients spurred the exploration of novel immunosuppressive strategies with definite curative effects and minim...

    Authors: Lingfei Zhao, Chenxia Hu, Fei Han, Fanghao Cai, Junni Wang and Jianghua Chen
    Citation: Stem Cell Research & Therapy 2020 11:197
    Content type: Review Published on:

  36. Mesendodermal formation during early gastrulation requires the expression of lineage-specific genes, while the regulatory mechanisms during this process have not yet been fully illustrated. TATA box-binding pr...

    Authors: He Liang, Peng Zhang, Hua-Jun Bai, Jijun Huang and Huang-Tian Yang
    Citation: Stem Cell Research & Therapy 2020 11:196
    Content type: Research Published on:

  37. Temperature is an important microenvironmental factor that functions epigenetically in normal embryonic development. However, the effect of hyperthermia in the stem cells is not fully understood. Oct4 is a tig...

    Authors: Mo-bin Cheng, Xue Wang, Yue Huang and Ye Zhang
    Citation: Stem Cell Research & Therapy 2020 11:195
    Content type: Letter Published on:

  38. Recent studies suggest that circulating endothelial progenitor cells (EPCs) may influence the response to cardiac resynchronization therapy (CRT). The aim of this study was to evaluate the effect of CRT on EPC...

    Authors: Gonçalo Cristóvão, James Milner, Pedro Sousa, Miguel Ventura, João Cristóvão, Luís Elvas, Artur Paiva, Lino Gonçalves, Carlos Fontes Ribeiro and Natália António
    Citation: Stem Cell Research & Therapy 2020 11:194
    Content type: Research Published on:

  39. RNA-binding protein, musashi1 (MSI1), is a main protein in asymmetric cell division of the sensory organ precursor cells, whereas its expression is reported to be upregulated in cancers. This protein is a crit...

    Authors: Mahboobeh Forouzanfar, Liana Lachinani, Kianoush Dormiani, Mohammad Hossein Nasr-Esfahani, Ali Osmay Gure and Kamran Ghaedi
    Citation: Stem Cell Research & Therapy 2020 11:193
    Content type: Review Published on:

  40. Acute lung injury (ALI), an increasingly devastating human disorder, is characterized by a multitude of lung changes arising from a wide variety of lung injuries. Viral infection is the main cause of morbidity...

    Authors: Jiang Du, Han Li, Jie Lian, Xinxing Zhu, Liang Qiao and Juntang Lin
    Citation: Stem Cell Research & Therapy 2020 11:192
    Content type: Review Published on:

  41. Some children who have survived cancer will be azoospermic in the future. Performing isolation and purification procedures for spermatogonial stem cells (SSC) is very critical. In this regard, performing the p...

    Authors: Behnaz Ashtari, Azar Shams, Narges Esmaeilzadeh, Sara Tanbakooei, Morteza Koruji, Mojtaba Johari Moghadam, Javad Mohajer Ansari, Adel Johari Moghadam and Ronak Shabani
    Citation: Stem Cell Research & Therapy 2020 11:191
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:543

  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Orianne Villard, Mathieu Armanet, Guilhem Couderc, Claire Bony, Jerome Moreaux, Daniele Noël, John De Vos, Bernard Klein, Jean-Luc Veyrune and Anne Wojtusciszyn
    Citation: Stem Cell Research & Therapy 2020 11:190
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:158

  43. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yong Yao, Liang Yang, Li-feng Feng, Zhi-wei Yue, Nian-huan Zhao, Zongjin Li and Zuo-xiang He
    Citation: Stem Cell Research & Therapy 2020 11:189
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:136

  44. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Chen-Fei Zhou, Min-Juan Liu, Wei Wang, Sha Wu, Yu-Xin Huang, Guo-Bin Chen, Li-Min Liu, Dong-Xian Peng, Xue-Feng Wang, Xu-Zi Cai, Xiao-Xuan Li, Wan-Qin Feng and Ying Ma
    Citation: Stem Cell Research & Therapy 2020 11:188
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2019 10:287

  45. Similar to humans, the horse is a long-lived, athletic species. The use of mesenchymal stromal cells (MSCs) is a relatively new frontier, but has been used with promising results in treating joint diseases, e....

    Authors: Louise Bundgaard, Allan Stensballe, Kirstine Juul Elbæk and Lise Charlotte Berg
    Citation: Stem Cell Research & Therapy 2020 11:187
    Content type: Research Published on:

  46. The therapeutic effects of mesenchymal stem cells (MSCs) have been limited by their apoptosis induced by oxidative stress after delivery into the injured sites. Therefore, strategies designed to improve the MS...

    Authors: Lianshuang Zhang, Xifeng Wang, Xueyan Lu, Yanchao Ma, Xin Xin, Xiaomin Xu, Siyuan Wang and Yun Hou
    Citation: Stem Cell Research & Therapy 2020 11:186
    Content type: Research Published on:

  47. Human induced pluripotent stem cells (hiPSCs) represent a potentially unlimited source of pancreatic endocrine lineage cells. Although insulin-producing β cells derived from hiPSCs have been successfully induc...

    Authors: Xiao-Fei Yang, Shu-Yan Zhou, Ce Wang, Wei Huang, Ning Li, Fei He and Fu-Rong Li
    Citation: Stem Cell Research & Therapy 2020 11:185
    Content type: Research Published on:

  48. ARDS and ALI are life-threatening diseases with extremely high mortality in patients. Different sources of MSCs could mitigate the symptoms of ALI from diverse mechanisms. Liraglutide is an activator of glucag...

    Authors: Xiaotong Yang, Xiaoying Ma, Ocholi Don, Yuanlin Song, Xiaoyan Chen, Jianwen Liu, Jieming Qu and Yun Feng
    Citation: Stem Cell Research & Therapy 2020 11:182
    Content type: Research Published on:

  50. The dedifferentiation of chondrocytes and the unstable chondrogenic differentiation status of pluripotent mesenchymal stem cells (MSCs) are immense issues in cell-based articular cartilage repair and regenerat...

    Authors: Yu Zhang, Chunxiang Hao, Weimin Guo, Xiaoyu Peng, Mingjie Wang, Zhen Yang, Xu Li, Xueliang Zhang, Mingxue Chen, Xiang Sui, Jiang Peng, Shibi Lu, Shuyun Liu, Quanyi Guo and Qing Jiang
    Citation: Stem Cell Research & Therapy 2020 11:180
    Content type: Research Published on:
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