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  1. Tendon injuries occur frequently in human and equine athletes. Treatment options are limited, and the prognosis is often poor with functionally deficient scar tissue resulting. Fetal tendon injuries in contras...

    Authors: Y. Z. Paterson, A. Cribbs, M. Espenel, E. J. Smith, F. M. D. Henson and D. J. Guest
    Citation: Stem Cell Research & Therapy 2020 11:184
    Content type: Research Published on:

  2. Mesenchymal stem cells (MSCs) are considered to be an effective tool for regenerative medicine with promising applications for clinical therapy. However, incongruent data has been reported partially owing to t...

    Authors: Xiao Yi, Feng Chen, Fenghua Liu, Qing Peng, Yang Li, Shao Li, Jiang Du, Yi Gao and Yifeng Wang
    Citation: Stem Cell Research & Therapy 2020 11:183
    Content type: Research Published on:

  3. Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 ge...

    Authors: Xiaojie Xian, Roksana Moraghebi, Henrik Löfvall, Anders Fasth, Kim Henriksen, Johan Richter, Niels-Bjarne Woods and Ilana Moscatelli
    Citation: Stem Cell Research & Therapy 2020 11:179
    Content type: Research Published on:

  4. Mesenchymal stem cells (MSCs) have become a promising treatment for spinal cord injury (SCI) due to the fact that they provide a favorable environment. Treatment using MSCs results in a better neurological fun...

    Authors: Peiwen Song, Tianyu Han, Xia Xiang, Ying Wang, Huang Fang, Yang Niu and Cailiang Shen
    Citation: Stem Cell Research & Therapy 2020 11:178
    Content type: Research Published on:

  5. Since cartilage-derived stem/progenitor cells (CSPCs) were first identified in articular cartilage using differential adhesion to fibronectin, their self-renewal capacity and niche-specific lineage preference ...

    Authors: Zita M. Jessop, Ayesha Al-Sabah, Irina N. Simoes, Stephanie E. A. Burnell, Ina Laura Pieper, Catherine A. Thornton and Iain S. Whitaker
    Citation: Stem Cell Research & Therapy 2020 11:177
    Content type: Research Published on:

  6. Cell-based therapy products are supposed to be the most complex medicine products in the history of human medical care. In this study, we established a safety evaluation system for therapeutic stromal cells ba...

    Authors: Yuanyuan Xie, Wei Liu, Shuo Liu, Liudi Wang, Dan Mu, Yi Cui, Yanyan Cui and Bin Wang
    Citation: Stem Cell Research & Therapy 2020 11:176
    Content type: Research Published on:

  7. Advances in regenerative medicine with stem cells have led to clinical trials. Dental/oral tissues are emerging as promising cellular sources of human mesenchymal stem cells. Recently, dental tissue-derived ce...

    Authors: Yoichi Yamada, Sayaka Nakamura-Yamada, Ryutaro Konoki and Shunsuke Baba
    Citation: Stem Cell Research & Therapy 2020 11:175
    Content type: Review Published on:

  8. Skin wounding is very common and may be slow to heal. Increasing evidence shows that exosomes derived from mesenchymal stem cells (MSCs) dramatically enhance skin wound healing in a paracrine manner. However, ...

    Authors: Guifang Zhao, Feilin Liu, Zinan Liu, Kuiyang Zuo, Bo Wang, Yuying Zhang, Xing Han, Aobo Lian, Yuan Wang, Mingsheng Liu, Fei Zou, Pengdong Li, Xiaomei Liu, Minghua Jin and Jin Yu Liu
    Citation: Stem Cell Research & Therapy 2020 11:174
    Content type: Research Published on:

  9. A commentary to “Hertegård, S., Nagubothu, S.R., Malmström, E. et al. Treatment of vocal fold scarring with autologous bone marrow-derived human mesenchymal stromal cells - first phase I/II human clinical stud...

    Authors: Alexia Mattei, Jérémy Magalon, Mélanie Velier, Françoise Dignat-George, Antoine Giovanni and Florence Sabatier
    Citation: Stem Cell Research & Therapy 2020 11:173
    Content type: Commentary Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:128

    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:235

  10. Cardiovascular diseases are the main cause of morbidity and mortality worldwide. Restoring blood supply to ischemic tissues is an essential goal for the successful treatment of these diseases. Growth factor or...

    Authors: Richard Proust, Anne-Charlotte Ponsen, Valérie Rouffiac, Chantal Schenowitz, Florent Montespan, Karine Ser-Le Roux, Frédéric De Leeuw, Corinne Laplace-Builhé, Philippe Mauduit, Edgardo D. Carosella, Sébastien Banzet, Jean-Jacques Lataillade, Nathalie Rouas-Freiss, Georges Uzan and Juliette Peltzer
    Citation: Stem Cell Research & Therapy 2020 11:172
    Content type: Research Published on:

  11. Rheumatoid arthritis (RA) is characterized by joint inflammation and damage to the cartilage and bone in collagen-induced arthritis (CIA). Mesenchymal stem cells (MSCs) can improve articular symptoms and reduc...

    Authors: Jinfang Gao, Gailian Zhang, Ke Xu, Dan Ma, Limin Ren, Jingjing Fan, Jianwen Hou, Jian Han and Liyun Zhang
    Citation: Stem Cell Research & Therapy 2020 11:171
    Content type: Research Published on:

  12. Cancer stem cells (CSCs) have been proposed to be responsible for tumor recurrence and chemo-resistance. Previous studies suggested that miR-153 played essential roles in lung cancer. However, the molecular me...

    Authors: Guoli Zhao, Yueying Zhang, Zhonghua Zhao, Haibo Cai, Xiaogang Zhao, Tong Yang, Weijun Chen, Chengfang Yao, Zhaopeng Wang, Zhaoxia Wang, Chen Han and Hengxiao Wang
    Citation: Stem Cell Research & Therapy 2020 11:170
    Content type: Research Published on:

  13. The outbreak of 2019 novel coronavirus disease (COVID-19) worldwide is becoming rapidly a major concern. The number of severe cases has increased dramatically worldwide, while specific treatment options are sc...

    Authors: Shan Liu, Danyi Peng, Huijun Qiu, Ke Yang, Zhou Fu and Lin Zou
    Citation: Stem Cell Research & Therapy 2020 11:169
    Content type: Commentary Published on:

  14. Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available.

    Authors: Cristian De Gregorio, David Contador, Diego Díaz, Constanza Cárcamo, Daniela Santapau, Lorena Lobos-Gonzalez, Cristian Acosta, Mario Campero, Daniel Carpio, Caterina Gabriele, Marco Gaspari, Victor Aliaga-Tobar, Vinicius Maracaja-Coutinho, Marcelo Ezquer and Fernando Ezquer
    Citation: Stem Cell Research & Therapy 2020 11:168
    Content type: Research Published on:

  15. Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and lon...

    Authors: Fabio S. Aguiar, André S. Melo, Ana Maria S. Araújo, Alexandre P. Cardoso, Sergio Augusto L. de Souza, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Debora G. Xisto, Karina D. Asensi, Lanuza Faccioli, Anna Beatriz S. Salgado, Maria Carolina P. P. Landesmann, Regina C. S. Goldenberg, Bianca Gutfilen, Marcelo M. Morales, Patricia R. M. Rocco…
    Citation: Stem Cell Research & Therapy 2020 11:167
    Content type: Research Published on:

  16. Fibroblasts are crucial for supporting normal wound healing. However, the functional state of these cells is impaired in diabetics because of a high-glucose (HG) microenvironment. Small extracellular vesicles ...

    Authors: Xiaowei Bian, Bingmin Li, Jie Yang, Kui Ma, Mengli Sun, Cuiping Zhang and Xiaobing Fu
    Citation: Stem Cell Research & Therapy 2020 11:166
    Content type: Research Published on:

  17. Mesenchymal stromal cell (MSC)-enriched products showed positive clinical outcomes in regenerative medicine, where tissue restoration and inflammation control are needed. GMP-expanded MSCs displayed an even hi...

    Authors: Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Carlotta Mondadori, Marco Viganò, Alessandra Colombini and Laura de Girolamo
    Citation: Stem Cell Research & Therapy 2020 11:165
    Content type: Research Published on:

  18. CD18 is the common beta subunit of β2 integrins, which are expressed on hematopoietic cells. β2 integrins are essential for cell adhesion and leukocyte trafficking.

    Authors: Cristina Mesa-Núñez, Diego Leon-Rico, Montserrat Aldea, Carlos Damián, Raquel Sanchez-Baltasar, Rebeca Sanchez, Omaira Alberquilla, José Carlos Segovia, Juan Antonio Bueren and Elena Almarza
    Citation: Stem Cell Research & Therapy 2020 11:164
    Content type: Research Published on:

  19. Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem ...

    Authors: Fei He, Ning Li, Hai-Bo Huang, Jing-Bo Wang, Xiao-Fei Yang, Hua-Dong Wang, Wei Huang and Fu-Rong Li
    Citation: Stem Cell Research & Therapy 2020 11:163
    Content type: Research Published on:

  20. M2 macrophages and exosomes from adipose-derived stem cells (ASCs) are both reported to promote angiogenesis. However, the possible synergistic effects between exogenous exosomes and endogenous M2 macrophages ...

    Authors: Dihan Zhu, Takerra K. Johnson, Yang Wang, Miracle Thomas, Ky Huynh, Qinglin Yang, Vincent C. Bond, Y. Eugene Chen and Dong Liu
    Citation: Stem Cell Research & Therapy 2020 11:162
    Content type: Research Published on:

  21. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to have therapeutic potential for ischemic diseases and are considered an alternative to cell therapy. However, the low retentio...

    Authors: Yue Liu, Jian Cui, Hongfen Wang, Kamal Hezam, Xiaotong Zhao, Haoyan Huang, Shang Chen, Zhibo Han, Zhong-Chao Han, Zhikun Guo and Zongjin Li
    Citation: Stem Cell Research & Therapy 2020 11:161
    Content type: Research Published on:

  22. Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of rad...

    Authors: Linqing Zou, Haoming Li, Xiao Han, Jianbing Qin and Guoqi Song
    Citation: Stem Cell Research & Therapy 2020 11:160
    Content type: Research Published on:

  23. Human amniotic epithelial cell (hAEC) transplantation holds great promise in treating premature ovarian insufficiency (POI). However, some deficient biological characteristics of hAECs restrict their application.

    Authors: Shunyu Hou, Chenyue Ding, Han Shen, Chunfeng Qian, Qinyan Zou, Jiafeng Lu, Boxian Huang, Jichun Tan and Hong Li
    Citation: Stem Cell Research & Therapy 2020 11:159
    Content type: Research Published on:

  24. Mesenchymal stromal cells (MSCs) represent an interesting tool to improve pancreatic islet transplantation. They have immunomodulatory properties and secrete supportive proteins. However, the functional proper...

    Authors: Orianne Villard, Mathieu Armanet, Guilhem Couderc, Claire Bony, Jerome Moreaux, Daniele Noël, John DeVos, Bernard Klein, Jean-Luc Veyrune and Anne Wojtusciszyn
    Citation: Stem Cell Research & Therapy 2020 11:158
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:190

  25. The development of somatic reprogramming, especially purely chemical reprogramming, has significantly advanced biological research. And chemical-induced extraembryonic endoderm-like (ciXEN) cells have been con...

    Authors: Xia He, Guangfan Chi, Meiying Li, Jinying Xu, Lihong Zhang, Yaolin Song, Lina Wang and Yulin Li
    Citation: Stem Cell Research & Therapy 2020 11:157
    Content type: Research Published on:

  26. Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of ...

    Authors: Amandda Évelin Silva-Carvalho, Leane Perim Rodrigues, Josiane Lilian Schiavinato, Marcos Rodrigo Alborghetti, Gustavo Bettarello, Belinda Pinto Simões, Francisco de Assis Rocha Neves, Rodrigo Alexandre Panepucci, Juliana Lott de Carvalho and Felipe Saldanha-Araujo
    Citation: Stem Cell Research & Therapy 2020 11:156
    Content type: Research Published on:

  27. The limited neuronal differentiation of the endogenous or grafted neural stem cells (NSCs) after brain injury hampers the clinic usage of NSCs. Panax notoginseng saponins (PNS) were extensively used for their cli...

    Authors: Liu-Lin Xiong, De-Lu Qiu, Guang-Hui Xiu, Mohammed Al-Hawwas, Ya Jiang, You-Cui Wang, Yue Hu, Li Chen, Qing-Jie Xia and Ting-Hua Wang
    Citation: Stem Cell Research & Therapy 2020 11:155
    Content type: Research Published on:

  28. Hepatocyte-like cells (iHEPs) generated by transcription factor-mediated direct reprogramming of somatic cells have been studied as potential cell sources for the development of novel therapies targeting liver...

    Authors: Iasmim Diniz Orge, Victoria L. Gadd, Judah Leão Barouh, Erik Aranha Rossi, Rejane Hughes Carvalho, Ian Smith, Kyan James Allahdadi, Bruno Diaz Paredes, Daniela Nascimento Silva, Patrícia Kauanna F. Damasceno, Gabriela Louise Sampaio, Stuart J. Forbes, Milena Botelho Pereira Soares and Bruno Solano de Freitas Souza
    Citation: Stem Cell Research & Therapy 2020 11:154
    Content type: Research Published on:

  29. To date, it has repeatedly been demonstrated that infusing bone marrow-derived stem cells (BMSCs) into acellular nerve scaffolds can promote and support axon regeneration through a peripheral nerve defect. How...

    Authors: Li Na Zhou, Jia Chuan Wang, Prince Last Mudenda Zilundu, Ya Qiong Wang, Wen Ping Guo, Sai Xia Zhang, Hui Luo, Jian Hong Zhou, Ru Dong Deng and Dong Feng Chen
    Citation: Stem Cell Research & Therapy 2020 11:153
    Content type: Research Published on:

  31. Chronic rhinosinusitis (CRS) is characterized by persistent symptomatic inflammation of the nasal passage and sinus mucosa. Various microRNAs (miRs) have been implicated in CRS. Hence, the current study was co...

    Authors: Jinzhang Cheng, Junjun Chen, Yin Zhao, Jingpu Yang, Kai Xue and Zonggui Wang
    Citation: Stem Cell Research & Therapy 2020 11:151
    Content type: Research Published on:

  32. Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue r...

    Authors: Xiu-Ru Zhang, Yi-Zhou Huang, Hong-Wei Gao, Yan-Lin Jiang, Jun-Gen Hu, Jin-Kui Pi, An-Jing Chen, Yi Zhang, Li Zhou and Hui-Qi Xie
    Citation: Stem Cell Research & Therapy 2020 11:150
    Content type: Research Published on:

  33. Mesenchymal stem/stromal cells (MSCs) are multipotent cells with a promising application potential in regenerative medicine and immunomodulation. However, MSCs cultured in vitro exhibit functional heterogeneit...

    Authors: Changbin Sun, Lei Wang, Hailun Wang, Tingrun Huang, Wenwen Yao, Jing Li and Xi Zhang
    Citation: Stem Cell Research & Therapy 2020 11:149
    Content type: Research Published on:

  34. Adipose-derived stem cell (ADSC) transplantation is a promising strategy to promote wound healing because of the paracrine function of stem cells. However, glucose-associated effects on stem cell paracrine fun...

    Authors: Jin Xu, Xiaoyu Liu, Feng Zhao, Ying Zhang and Zhe Wang
    Citation: Stem Cell Research & Therapy 2020 11:148
    Content type: Research Published on:

  35. Strategies of generating functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful due to the lack of a comprehensive understanding of hematopoietic development. Endothelial-...

    Authors: Hongtao Wang, Mengge Wang, Yu Wang, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2020 11:147
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:242

  36. Mesenchymal stem/stromal cells (MSCs) can replenish the aged cells of the musculoskeletal system in adult life. Stem cell exhaustion and decrease in their regenerative potential have been suggested to be hallm...

    Authors: Klemen Čamernik, Anže Mihelič, Rene Mihalič, Gregor Haring, Simon Herman, Darja Marolt Presen, Andrej Janež, Rihard Trebše, Janja Marc and Janja Zupan
    Citation: Stem Cell Research & Therapy 2020 11:146
    Content type: Research Published on:

  37. Bone marrow mesenchymal stem cells (BMSCs) have shown their therapeutic potential in cytotherapy for liver fibrosis. However, the insufficient homing of BMSCs and undefined proliferation of BMSCs represent a s...

    Authors: Ting Sun, Hualin Li, Yun Bai, Min Bai, Feng Gao, Jie Yu, Rong Wu, Lianfang Du and Fan Li
    Citation: Stem Cell Research & Therapy 2020 11:145
    Content type: Research Published on:

  38. Cultured epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs) were capable of reconstituting functional hair follicles after implantation, while the signaling pathways that regulate neogenic hair ...

    Authors: Yu Chen, Zhimeng Fan, Xiaoxiao Wang, Miaohua Mo, Shu Bin Zeng, Ren-He Xu, Xusheng Wang and Yaojiong Wu
    Citation: Stem Cell Research & Therapy 2020 11:144
    Content type: Short report Published on:

  39. Factors such as poor engraftment, retention, and survival of the transplanted stem cells are deemed to limit their therapeutic efficacy for wound regeneration. Hence, it is necessary to explore these issues in...

    Authors: Qingzha Deng, Sunxing Huang, Jinkun Wen, Yiren Jiao, Xiaohu Su, Guang Shi and Junjiu Huang
    Citation: Stem Cell Research & Therapy 2020 11:143
    Content type: Research Published on:

  40. Retinal degeneration is a leading cause of blindness in the world; its etiology is complex and involves genetic defects and stress-associated aging. In addition to gene therapies for known genetically defectiv...

    Authors: Xiao Liu, Fenghua Chen, Yao Chen, Huayi Lu, Xiaoqin Lu, Xiaoyan Peng, Henry J. Kaplan, Douglas C. Dean, Ling Gao and Yongqing Liu
    Citation: Stem Cell Research & Therapy 2020 11:142
    Content type: Research Published on:

  41. Three-dimensional (3D) cultivation with biomaterials was proposed to facilitate stem cell epithelial differentiation for wound healing. However, whether human adipose-derived stem cells (hASCs) on collagen spo...

    Authors: Minxiong Li, Jun Ma, Yanbin Gao, Mengru Dong, Zijun Zheng, Yuchen Li, Rongwei Tan, Zhending She and Lei Yang
    Citation: Stem Cell Research & Therapy 2020 11:141
    Content type: Research Published on:

  42. Glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) is the most common in non-traumatic ONFH. Despite a strong relationship between GC and ONFH, the detailed mechanisms have remained elusiv...

    Authors: Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo and Yaping Ye
    Citation: Stem Cell Research & Therapy 2020 11:140
    Content type: Research Published on:

  43. To date, many attempts are employed to increase the regenerative potential of stem cells. In this study, we evaluated the hypothesis of whether an autophagy modulation could alter differentiation potency of CD146

    Authors: Mehdi Hassanpour, Jafar Rezaie, Masoud Darabi, Amirataollah Hiradfar, Reza Rahbarghazi and Mohammad Nouri
    Citation: Stem Cell Research & Therapy 2020 11:139
    Content type: Research Published on:

  45. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) plays a key role in bone formation, but its signaling pathway is not completely understood. Signal transducer and activator of transcription 3 (Stat3) tak...

    Authors: Lizhen Lei, Zhuwei Huang, Jingyi Feng, Zijing Huang, Yiwei Tao, Xiaoli Hu and Xiaolei Zhang
    Citation: Stem Cell Research & Therapy 2020 11:137
    Content type: Research Published on:

  46. Due to the low survival rate of cell transplantation, stem cell has not been widely used in clinical treatment of acute myocardial infarction (AMI). In this study, we immobilized the C domain peptide of insuli...

    Authors: Yong Yao, Liang Yang, Li-feng Feng, Zhi-wei Yue, Nian-huan Zhao, Zongjin Li and Zuo-xiang He
    Citation: Stem Cell Research & Therapy 2020 11:136
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:189

  47. Bone defects are a common clinical condition that has gained an increasing amount of attention in recent years. Causes of bone defect include tumors, inflammation, and fractures. Bone tissue engineering is a n...

    Authors: Yuan Zhu, Xiao Zhang, Ranli Gu, Xuenan Liu, Siyi Wang, Dandan Xia, Zheng Li, Xiaomin Lian, Ping Zhang, Yunsong Liu and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2020 11:135
    Content type: Research Published on:

  48. Human deciduous pulp stem cells (hDPSCs) have remarkable stem cell potency associated with cell proliferation, mesenchymal multipotency, and immunosuppressive function and have shown beneficial effects in a va...

    Authors: Tsuyoshi Iwanaka, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Shouichi Ohga, Yoshinao Oda and Tomoaki Taguchi
    Citation: Stem Cell Research & Therapy 2020 11:134
    Content type: Research Published on:

  49. In our previous research, we found that mesenchymal stem cell (MSC) transplantation therapy can inhibit intimal hyperplasia and enhance endothelial function in arterialized vein grafts in rats. However, whethe...

    Authors: Qingxi Qu, Yingxin Pang, Chunmei Zhang, Linghong Liu and Yanwen Bi
    Citation: Stem Cell Research & Therapy 2020 11:133
    Content type: Research Published on:

  50. Myelodysplastic syndrome (MDS) represents a heterogeneous group of clonal hematopoietic disorders, which is characterized by cytopenias in the peripheral blood and bone marrow dysplasia due to ineffective hema...

    Authors: Khaja Syed, Sara Naguib, Zhao-Jun Liu, Luisa Cimmino and Feng-Chun Yang
    Citation: Stem Cell Research & Therapy 2020 11:132
    Content type: Review Published on:
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